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| 1 | Impaired T-cell differentiation in diabetic foot ulceration显示文摘Foot ulceration is one of the most debilitating complications associated with diabetes,but its cause remains poorly understood.Several studies have been undertaken to understand healing kinetics or find possible therapies to enhance healing.However,few studies have been directed at understanding the immunological alterations that could influence wound healing in diabetes.In this study,we analysed the T-cell receptor(TCR)repertoire diversity in TCR-αβ^(+)T cells.We also analysed the distribution and phenotype of T cells obtained from the peripheral blood of healthy controls and diabetic individuals with or without foot ulcers.Our results showed that diabetic individuals,especially those with foot ulcers,have a significantly lower naive T-cell number and a poorer TCR-Vβrepertoire diversity.We also showed that the reduced TCR-Vβrepertoire diversity in diabetic individuals was mainly owing to the accumulation of effector T cells,the major source of tumour necrosis factor-αproduction,which was even more pronounced in patients with acute foot ulceration.Moreover,the expression of several inflammatory chemokine receptors was significantly reduced in diabetic patients.In conclusion,effector T-cell accumulation and TCR repertoire diversity reduction appear to precede the development of foot ulcers.This finding may open new immunological therapeutic possibilities and provide a new prognostic tool in diabetic wound care. | João Moura João Rodrigues Marta Gonçalves Cláudia Amaral Margarida Lima Eugénia Carvalho | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Clinical prognostic factors for disabling Crohn's disease: A systematic review and meta-analysis显示文摘AIM: To identify demographic and clinical factors asso-ciated with disabling Crohn's disease (CD). METHODS: A systematic review and meta-analysisof observational studies, focusing on the factors that can predict the prognosis of different outcomes of CD was undertaken. PubMed, ISI Web of Knowledge and Scopus were searched to identify studies investigat-ing the above mentioned factors in adult patients with CD. Studies were eligible for inclusion if they describe prognostic factors in CD, with inclusion and exclusion criteria defined as follows. Studies with adult patients and CD, written in English and studying association between clinical factors and at least one prognosis out-come were included. Meta-analysis of effects was un-dertaken for the disabling disease outcome, using odds ratio (OR) to assess the effect of the different factors in the outcome. The statistical method used was Mantel-Haenszel for fixed effects. The 16-item quality assess-ment tool (QATSDD) was used to assess the quality of the studies (range: 0-42). RESULTS: Of the 913 papers initially selected, sixty studies were reviewed and three were included in the systematic review and meta-analysis. The global QA-TSDD scores of papers were 18, 21 and 22. Of a total of 1961 patients enrolled, 1332 (78%) were classified with disabling disease five years after diagnosis. In two studies, age at diagnosis was a factor associated with disabling disease five years after diagnosis. Individu-als under 40 years old had a higher risk of developing disabling disease. In two studies, patients who were treated with corticosteroids on the first flare developed disabling disease five years after diagnosis. Further, perianal disease was found to be relevant in all of the studies at two and five years after diagnosis. Finally, one study showed localization as a factor associated with disabling disease five years after diagnosis, with L3 being a higher risk factor. This meta-analysis showed a significantly higher risk of developing disabling dis-ease at five years after initial diagnosis among patients younger than 40 years of age (OR=2.47, 95%CI: 1.74-3.51), with initial steroid treatment for first flare (OR=2.42, 95%CI: 1.87-3.11) and with perianal dis-ease (OR = 2.00, 95%CI: 1.41-2.85).CONCLUSION: Age at diagnosis, perianal disease, ini-tial use of steroids and localization seem to be indepen-dent prognostic factors of disabling disease. | Cláudia Camila Dias Pedro Pereira Rodrigues Altamiro da Costa Pereira Fernando Magro | 2013 | World Journal of Gastroenterology2013，19，24： | 2 |
| 4 | ADAMTS13 and Von Willebrand factor in patients undergoing hemodialysis显示文摘 | Danyelle Rios Maria Carvalho Roberta Figueiredo Cláudia Ferreira Valério Rodrigues Regina Souza Ana Silva Ana Fernandes Karina Gomes Luci Dusse | 2012 | Journal of Thrombosis and Thrombolysis2012，，1： | 1 |
| 5 | Barriers and facilitators to caring for individuals with stroke in the community:the family's experience显示文摘 | White CL Korner-Bitensky N Rodrigue N | 2007 | Can J Neurosci Nurs2007，29，2： | 1 |
| 6 | Clinical concepts of dry socket显示文摘 | Cardoso CL Rodrigues MT Ferreira Jfinior O | 2010 | J Oral Maxillofac Surg2010，68，8： | 1 |
| 7 | Preparation and characterization of collagen-nanohydroxyapatite biocompos- ite sca~~olds by cryogelation method for bone tissue engineer- ing applications 显示文摘 | Rodrigues SC Salgado CL Sahu A | 2013 | J Biomed Mater Res A2013，101，4： | 1 |
| 8 | Clinicalconcepts of dry socket显示文摘 | Cardoso CL Rodrigues MT Ferreira Júnior O | 2010 | J Oral Maxillofac Surg2010，68，8： | 1 |
| 9 | Principal components analysis applied to performance and carcass traits in the chicken显示文摘 | Luís Fernando Batista P Irineu Umberto P Cláudio Manoel Rodrigues D M M^onica Corrêa L Luiz Lehmann C | 2006 | Anim Res2006，55，： | 1 |
| 10 | Antiulcerogenic activity of Alchornea castaneaefolia : Effects on somatostatin, gastrin and prostaglandin显示文摘 | Clélia Akiko Hiruma-Lima Tamara Roberta Calvo Clenilson Martins Rodrigues Fábio Donizete Pezzuto Andrade Wagner Vilegas Alba Regina Monteiro Souza Brito | 2005 | Journal of Ethnopharmacology2005，，1： | 1 |
| 11 | Immunotherapy with plasmid DNA encoding mycobacterial hsp65 in association with chemotherapy is a more rapid and efficient form of treatment for tuberculosis in mice显示文摘 | Silva CL Bonato VL Coelho-Castelo AA Souza1 AD Santos1 SA Lima1 KM Faccioli LH Rodrigues JM | 2005 | Gene Ther2005，12，3： | 1 |
| 12 | Immunotherapy with plasmid DNA encoding mycobacterial hsp65 in association with chemotherapy is a more rapid and efficient form of treatment for tuberculosis in mice显示文摘 | Silva CL Bonato VL Coelho-Castelo AA De Souza AO Santos SA Lima KM Faccioli LH Rodrigues JM | 2005 | Gene Ther2005，12，3： | 1 |
| 13 | Acute kidney injury risk in patients with ST-segment elevation myocardial infarction at presentation to the ED显示文摘 | Rafaela Elizabeth Bayas Queiroz Leilane Siqueira Nobre de Oliveira Cláudio Alves de Albuquerque Caroline de Alencar Santana Patrícia Maia Brasil Luzia Layla Rodrigues Carneiro Alexandre Braga Libório | 2012 | American Journal of Emergency Medicine2012，，9： | 1 |
| 14 | Comparison of two- and three-dimensional ultrasonography in the evaluation of fetal heart: image quality and time spent in the exam显示文摘 | Hélio Antonio Guimar?es Filho Lavoisier Linhares Dias da Costa Edward Araujo Júnior Sebasti?o Marques Zanforlin Filho Cláudio Rodrigues Pires Luciano M. M. Nardozza Antonio Fernandes Moron Rosiane Mattar | 2007 | Archives of Gynecology and Obstetrics2007，，3： | 1 |
| 15 | Stem cell cultivation in bioreactors显示文摘 | Carlos A.V. Rodrigues Tiago G. Fernandes Maria Margarida Diogo Cláudia Lobato da Silva Joaquim M.S. Cabral | 2011 | Biotechnology Advances2011，，6： | 1 |
| 16 | Effects of age,genes, and pulse pressure on executive functions in healthyadults 显示文摘 | Raz N Dahle CL Rodrigue KM | 2011 | Neurobiol Aging2011，32，： | 1 |
| 17 | Neural mechanisms involved in the delay of gastric emptying and gastrointestinal transit of liquid after thoracic spinal cord transection in awake rats 显示文摘 | Gandim FA Rodrigues CL da Graca JR | 2001 | Auton Neurosci2001，87，1： | 1 |
| 18 | Accuracy of Cone Beam Computed Tomography and Panoramic and Periapical Radiography for Detection of Apical Periodontitis显示文摘 | Carlos Estrela Mike Reis Bueno Cláudio Rodrigues Leles Bruno Azevedo José Ribamar Azevedo | 2008 | Journal of Endodontics2008，，3： | 1 |
| 19 | Effects of age,genes,andpulse pressure on executive functions in healthy adults显示文摘 | Raz N Dahle CL Rodrigue KM | 2011 | Neu-robiol Aging2011，32，6： | 1 |
| 20 | A stereological analysis of fibrosis and inflammatory reaction induced by four different synthetic slings显示文摘 | Thiel M Rodrigues Palma PC Riccetto CL | 2005 | BJU Int2005，95，6： | 1 |
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