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| 1 | Osteoblasts are inherently programmed to repel sensory innervation显示文摘Tissue innervation is a complex process controlled by the expression profile of signaling molecules secreted by tissue-resident cells that dictate the growth and guidance of axons.Sensory innervation is part of the neuronal network of the bone tissue with a defined spatiotemporal occurrence during bone development.Yet,the current understanding of the mechanisms regulating the map of sensory innervation in the bone tissue is still limited.Here,we demonstrated that differentiation of human mesenchymal stem cells to osteoblasts leads to a marked impairment of their ability to promote axonal growth,evidenced under sensory neurons and osteoblastic-lineage cells crosstalk.The mechanisms by which osteoblast lineage cells provide this nonpermissive environment for axons include paracrine-induced repulsion and loss of neurotrophic factors expression.We identified a drastic reduction of NGF and BDNF production and stimulation of Sema3A,Wnt4;and Shh expression culminating at late stage of OB differentiation.We noted a correlation between Shh expression profile,OB differentiation stages,and OB-mediated axonal repulsion.Blockade of Shh activity and signaling reversed the repulsive action of osteoblasts on sensory axons.Finally,to strengthen our model,we localized the expression of Shh by osteoblasts in bone tissue.Overall,our findings provide evidence that the signaling profile associated with osteoblast phenotype differentiating program can regulate the patterning of sensory innervation,and highlight osteoblast-derived Shh as an essential player in this cue-induced regulation. | Luis Leitao Estrela Neto Francisco Conceicao Ana Monteiro Marina Couto Cecilia JAlves Daniela MSousa Meriem Lamghari | 2020 | Bone Research2020，8，3： | 4 |
| 2 | A rapid and sensitive method for simultaneous determination of lamivudine and zidovudine in human serum by on-line solid phase extraction coupled to liquid chromatography/tandem mass spectrometry detection 显示文摘 | Estrela RdeC Salvadori MC Suarez Kurtz G | 2004 | Rapid Commun Mass Spectrom2004，18，10： | 1 |
| 3 | Mechanism of action of sodium hypochlorite显示文摘 | Estrela C Estrela CR Barbin EL | 2002 | Braz Dent J2002，13，2： | 1 |
| 4 | In vitro determination of drrect antimicrobial effect of calcium hydroxide显示文摘 | Estrela C Pimenta FC Ito IY | 1998 | J Endod1998，24，5： | 1 |
| 5 | Mesenchymal stem cells in the dental tissues:perspectives for tissue regeneration显示文摘 | Estrela C Alencar AH Kitten GT | 2011 | Braz Dent J2011，22，2： | 1 |
| 6 | Sodium hypochlorite chemical burn in an endodontists eye during canal treatment using operating microscope显示文摘 | Regalado Farreras DC Carlos Puente CG Estrela C | 2014 | J Endod2014，40，8： | 1 |
| 7 | Oxidative stress and pulmonary inflammation: pharmacolagical intervention with antiox- idants显示文摘 | MORCILLO EJ ESTRELA J CORTIJO J | 1999 | Pharmacol Res1999，40，： | 1 |
| 8 | Mechanism of action of calcium and hydroxyl ions of calcium hydroxide on tissue and bacteria显示文摘 | Estrela C Sydney GB Bammann LL | 1995 | Braz Dent J1995，6，： | 1 |
| 9 | A model system to study antimicrobial strategies in endodontic biofilms显示文摘 | Estrela C Sydney GB Figueiredo JA | 2009 | J Appl Oral Sci2009，17，2： | 1 |
| 10 | In vitro determination of direct antimicrobial effect of calcium hydroxide 显示文摘 | Estrela C Pimenta FC Ito IY | 1998 | J Endod1998，24，1： | 1 |
| 11 | Mesenchymal stem ceils in the dental tissues: perspectives for tissue regeneration 显示文摘 | Estrela C Alencar AH Kitten GT | 2011 | Braz Dent J2011，22，2： | 1 |
| 12 | Control of microor- ganisms in vitro by calcium hydroxide pastes 显示文摘 | Estrela C Bammann LL Pimenta FC | 2001 | Int Endod J2001，34，5： | 1 |
| 13 | Mesenchymal stem cells in the dental tissues:perspectives for tissue regeneration显示文摘 | Estrela C Alencar AH Kitten GT | 2011 | Braz Dent J2011，22，2： | 1 |
| 14 | Antimicrobial e- valuation of calciumhydroxide in infected dentinal tu-bules显示文摘 | Estrela C Pimenta F C Ito I I | 1999 | J Endodon1999，25，6： | 1 |
| 15 | Control of microor- ganisms in vitro by calcium hydroxide pastes 显示文摘 | Estrela C Bammann LL Pimenta FC | 2001 | Int Endod J2001，34，5： | 1 |
| 16 | Method to evaluate inflammatory root resorption by using cone beam computed tomography显示文摘 | Estrela C Bueno MR De Alencar AH | | 0，，11： | 1 |
| 17 | Glutamine potentiates TNF-α-induced tumor cytotoxicity显示文摘 | Elena Obrador Julian Carretero Juan M Esteve José A Pellicer Antonio Pascual Ignacio Petschen José M Estrela | 2001 | Free Radical Biology and Medicine2001，，5： | 1 |
| 18 | Mechanism of Action of Sodium Hypochlorite显示文摘 | Estrela C Esrela C R Barbin E L | 2002 | Braz Dent J2002，13，2： | 1 |
| 19 | Control of microo-rganism in vitro by calcium hydroxide pastes显示文摘 | Estrela C Bammann LL Pimenta FC | 2001 | Int Endod J2001，34，5： | 1 |
| 20 | In vitro determination of direct antimicrobial effect of calcium hydroxide显示文摘 | Carlos Estrela Fabiana Cristina Pimenta Izabel Yoko Ito Lili Luschke Bammann | 1998 | Journal of Endodontics1998，，1： | 1 |
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