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| 1 | 血浆游离DNA水平增高可作为预测重型颅脑损伤患者死亡率的独立指标(英文)显示文摘Trauma is the leading cause of death under 45 years worldwide and up to 50% of trauma fatalities are due to brain injury.Prediction of outcome is one of the major problems associated with severe TBI and research efforts have focused on the investigation of biomarkers with prognostic value following TBI. Therefore,our aim was to investigate whether cell-free DNA concentrations correlated to short-term primary outcome( survivor or death) and GCS scores following severe TBI. A total of 188 victims of severe TBI were enrolled in this prospective study,outcome variables comprised: survival and neurological assessment using the GCS at ICU discharge. Control blood samples were obtained from 25 healthy volunteers. Peripheral venous blood was collected at admission in the ICU. Plasma DNA was measured using a real-time quantitative PCR assay for the β-globin gene. There was correlation between higher DNA levels and both fatal outcome and lower hospital admission GCS scores. Plasma DNA concentrations at the chosen cut- off point( ≥171,381 kilogenomesequivalents /L) predicted mortality with a specificity of 90% and a sensitivity of 43%. Logistic regression analysis showed that elevated plasma DNA levels were independently associated with death( P < 0. 001). In conclusion,high cell-free DNA concentration was a predictor of short-term mortality following severe TBI. | Rodrigues Filho EM1 Simon D Ikuta N Klovan C Dannebrock F de Oliveira CO Regner A | 2014 | 中华神经外科疾病研究杂志2014，13，3： | 6 |
| 2 | Helicobacter pylori and EBV in gastric carcinomas:Methylation status and microsatellite instability显示文摘AIM:To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr virus (EBV) infections in gastric adenocarcinomas.METHODS: Methylation-specific PCR (MSP) assay was performed in 89 primary gastric carcinomas (intestinal and diffuse types). Microsatellite instability (MSI) analysis was performed using the BAT26 primer set and PCR products were analyzed with the ABI PRISM 3100 Genetic Analyzer using Genescan 3.7 software (Applied Biosystems). Detection of H. pylori and genotyping were performed by PCR, using specifi c primers for ureaseC and cagA genes. The presence of EBV was assessed by in situ hybridization. Statistical analyses were performed using the χ2 or Fisher's exact test.RESULTS: The most frequent hypermethylated gene was COX-2 (63.5%) followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). Intestinal and diffuse adenocarcinomas showed different methylation profiles and there was an association between methylation of E-CDH1 and H. pylori-cagA+ in the intestinal adenocarcinoma type. MSI was correlated with hMLH1 methylation. There was an inverse correlation between DAPK hypermethylation and MSI.CONCLUSION: We found a strong association between CDH1 methylation and H. pylori-cagA+ in intestinal-type gastric cancer, association of MSI and better prognosis and an heterogeneous COX-2 overexpression. | Adriana Camargo Ferrasi Nídia Alice Pinheiro Silvia Helena Barem Rabenhorst Otávia Luisa Caballero Maria Aparecida Marchesan Rodrigues Fabrício de Carvalho Celso Vieira de Souza Leite Marcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Maria Inês de Moura Campos Pardini | 2010 | World Journal of Gastroenterology2010，16，3： | 6 |
| 3 | Abscisic acid inhibits type 2C protein phosphatases via the PYR/ PYL family of START proteins显示文摘 | PARK S Y FUNG P NISHIMURA N JENSEN D R FFUJII ZHAO Y LUMBA S SANTIAGO J RODRIGUES A CHOW T F | 2009 | Science2009，324，： | 1 |
| 4 | Colon perforation following percutaneous nephrolithotomy显示文摘 | Rodrigues Netto N Lemos GC Fiuza JL | 1988 | Urology1988，32，2： | 1 |
| 5 | An expeditiousmethod for the determ ination of organochlorine pesticides resi-dues in estuarine sediments using microwave assisted pre-ex-traction an d automa ted headspace solid phase microextractioncoupled to gas chromatography-mass spectrometry显示文摘 | Carvalho P N Rodrigues P N R Alves F | 2008 | Talan-ta2008，76，5： | 1 |
| 6 | Optimization of the production of biodiesel from soybean oil by ultrasound assisted methanolysis显示文摘 | SANTOS F F P RODRIGUES S FERNANDES F A N | | 0，，： | 1 |
| 7 | Microcomposites theophylline/hydrogenated palm oil from a PGSS process for controlled drug delivery systems显示文摘 | Peirico N Matos H | 2004 | The Journal of Supercritical Fluids2004，29，12： | 1 |
| 8 | Novel core (polyester)-shell (polysaccharide) nanoparticles :protein loading and surface modification with leetins显示文摘 | Rodrigues J S Santos-Magalhaes N S Coelho L C B B | 2003 | Journal of Controlled Release2003，92，： | 1 |
| 9 | Novel core (polyester) -shell (polysaccharide) nanoparticles:protein loading and surface modification with lectins显示文摘 | Rodrigues J S Santos-Magalhes N S Coelho L C B B | 2003 | J Controlled Release2003，92，12： | 1 |
| 10 | Dehydration of melons in a ternary system followed by air-drying显示文摘 | Rodrigues S Fernandes F A N | 2007 | Journal of food engineering2007，80，2： | 1 |
| 11 | Experimental and FE shear-bonding strength at core/veneer interfaces in bilayered ceramics显示文摘 | Ereifej N Rodrigues FP Silikas N | 2011 | Dent Mater2011，27，6： | 1 |
| 12 | Differential aging of' the human striatum: longitudinal eidence显示文摘 | Raz N Rodrigue K M Kennedy K M | 2003 | American Jouna of Neuroradiology2003，24，9： | 1 |
| 13 | Outcome of sleepiness and fatigue scores in obstructive sleep apnea syndrome patients with and without resdess legs syndrome after nasal CPAP显示文摘 | RODRIGUES R N RODRIGUES A PRATESI R | 2007 | Arq Neuropsiquiatr2007，65，1： | 1 |
| 14 | An SPME-GC-MS method for determination of organochlorine pesticide residues in medicinal plant infusions显示文摘 | RODRIGUES M V N | 2005 | Chromatographia2005，61，3： | 1 |
| 15 | Heat storage rate and acute fatigue in rats显示文摘 | Rodrigues L O Oliveira A Lima N R | 2003 | Braz J Med Biol Res2003，36，1： | 1 |
| 16 | GeoSpray:A Geographic Routing Protocol for Vehicular Delay-tolerant Networks显示文摘 | Soares V N G J Rodrigues J J P C Farahmand F | 2014 | Information Fusion2014，15，： | 1 |
| 17 | In situ extracorporeal shock wave lithotripsy for ureteral calculi显示文摘 | Lemos GC Claro JF | 1990 | J Urol1990，144，21： | 1 |
| 18 | Species identi- fication of Aspergillus section Flavi isolates from Portuguese al- monds using phenotypic, including MALDI-TOF ICMS, and molecular approaches 显示文摘 | Rodrigues P Santos C Venancio A Lima N | 2011 | Journal of applied microbiology2011，111，4： | 1 |
| 19 | 显示文摘 | Dhawan S K Singh N Rodrigues D | 2003 | Sci Technol Adv Mat2003，4，： | 1 |
| 20 | Hypertension and the brain: vulnerability of the prefrontal regions and executive function显示文摘 | Raz N Rodrigue KM Acker JD | 2003 | Behav Neurosci2003，117，6： | 1 |
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