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| 1 | Immune checkpoint inhibitor-induced colitis:A comprehensive review显示文摘Immune checkpoint inhibitors(ICIs) are monoclonal antibodies that target downregulators of the anti-cancer immune response: Cytotoxic T-lymphocyte antigen-4, programmed cell death protein-1, and its ligand programmed death-ligand 1.ICIs have revolutionized the treatment of a variety of malignancies. However,many immune-related adverse events have also been described which mainly occurs as the immune system becomes less suppressed, affecting various organs including the gastrointestinal tract and causing diarrhea and colitis. The incidence of immune-mediated colitis(IMC) ranges from 1%-25% depending on the type of ICI and if used in combination. Endoscopically and histologically there is a significant overlap between IMC and inflammatory bowel disease,however more neutrophilic inflammation without chronic inflammation is usually present in IMC. Corticosteroids are recommended for grade 2 or more severe colitis while holding the immunotherapy. About one third to two thirds of patients are steroid refractory and benefit from infliximab. Recently vedolizumab has been found to be efficacious in steroid and infliximab refractory cases. While in grade 4 colitis, the immunotherapy is permanently discontinued, the decision is controversial in grade 3 colitis. | Aniruddh Som Rohan Mandaliya Dana Alsaadi Maham Farshidpour Aline Charabaty Nidhi Malhotra Mark C Mattar | 2019 | World Journal of Clinical Cases2019，7，4： | 14 |
| 2 | Preoperative selection of patients with colorectal cancerliver metastasis for hepatic resection显示文摘Surgical resection of colorectal liver metastases(CRLM) has a well-documented improvement in survival. To benefit from this intervention, proper selection of patients who would be adequate surgical candidates becomes vital. A combination of imaging techniques may be utilized in the detection of the lesions. The criteria for resection are continuously evolving; currently, the requirements that need be met to undergo resection of CRLM are: the anticipation of attaining a negative margin(R0 resection), whilst maintaining an adequate functioning future liver remnant. The timing of hepatectomy in regards to resection of the primary remains controversial; before, after, or simultaneously. This depends mainly on the tumor burden and symptoms from the primary tumor. The role of chemotherapy differs according to the resectability of the liver lesion(s); no evidence of improved survival was shown in patients with resectable disease who received preoperative chemotherapy. Presence of extrahepatic disease in itself is no longer considered a reason to preclude patients from resection of their CRLM, providing limited extra-hepatic disease, although this currently is an area of active investigations. In conclusion, we review the indications, the adequate selection of patients and perioperative factors to be considered for resection of colorectal liver metastasis. | Rafif E Mattar Faisal A Al-alem Eve Simoneau Mazen Hassanain | 2016 | World Journal of Gastroenterology2016，22，2： | 13 |
| 3 | Computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection显示文摘AIM To evaluate the feasibility of reducing the dose of iodinated contrast agent in computed tomography pulmonary angiography(CTPA). METHODS One hundred and twenty-seven patients clinically suspected of having pulmonary embolism underwent spiral CTPA, out of whom fifty-seven received 75 mL and the remaining seventy a lower dose of 60 mL of contrast agent. Both doses were administered in a multiphasic injection. A minimum opacification threshold of 250 Hounsfield units(HU) in the main pulmonary artery is used for assessing the technical adequacy of the scans. RESULTS Mean opacification was found to be positively correlated to patient age(Pearson's correlation 0.4255, P < 0.0001) and independent of gender(male:female, 425.6 vs 450.4,P = 0.34). When age is accounted for, the study and control groups did not differ significantly in their mean opacification in the main(436.8 vs 437.9, P = 0.48),left(416.6 vs 419.8, P = 0.45) or the right pulmonary arteries(417.3 vs 423.5, P = 0.40). The number of sub-optimally opacified scans(the mean opacification in the main pulmonary artery < 250 HU) did not differ significantly between the study and control groups(7 vs 10).CONCLUSION A lower dose of iodine contrast at 60 mL can be feasibly used in CTPA without resulting in a higher number of sub-optimally opacified scans. | Mitchell Chen Gaith Mattar Jamal A Abdulkarim | 2017 | World Journal of Radiology2017，9，3： | 2 |
| 4 | Improving sessile serrated adenoma detection rates with high definition colonoscopy:A retrospective study显示文摘BACKGROUND Sessile serrated adenomas(SSAs)are important premalignant lesions that are difficult to detect during colonoscopy due to poor definition,concealment by mucous caps,and flat appearance.High definition(HD)colonoscopy may uniquely aid in the detection of these inconspicuous lesions compared to standard definition(SD)colonoscopes.In the absence of existing clinical guidelines to obligate the use of HD colonoscopy for colorectal cancer screening in average-risk patients,demonstrating the benefit of HD colonoscopy on SSA detection rate(SSADR)may help strengthen the evidence to recommend its use in all settings.AIM To evaluate the benefit of HD colonoscopy compared to SD colonoscopy on SSADR in average-risk patients undergoing screening colonoscopy.METHODS Data from screening colonoscopies for patients aged 50-76 years two years before and two years after the transition from SD colonoscopy to HD colonoscopy at our large,academic teaching center were collected.Patients with symptoms of colorectal disease,positive occult blood test,history of colon polyps,cancer,polyposis syndrome,inflammatory bowel disease or family history of colon cancer or polyps were excluded.Patients whose endoscopists did not perform colonoscopies both before and after scope definition change were also excluded.Differences in individual endoscopist SSADR,average SSADR,and overall SSADR with SD colonoscopy vs HD colonoscopy were also evaluated for significance.RESULTS A total of 3657 colonoscopies met eligibility criteria with 2012 colonoscopies from the SD colonoscopy period and 1645 colonoscopies from the HD colonoscopy period from a pool of 11 endoscopists.Statistically significant improvements of 2.30%in mean SSADR and 2.53%in overall SSADR were noted with HD colonoscopy(P=0.00028 and P=0.00849,respectively).On the individual level,three endoscopists experienced statistically significant benefit with HD colonoscopy(+5.74%,P=0.0056;+4.50%,P=0.0278;+4.84%,P=0.03486).CONCLUSION Our study suggests that HD colonoscopy statistically significantly improves sessile serrated adenoma detection rate in the screening of average risk patients during screening colonoscopy.By improving the detection and removal of these lesions,adoption of HD colonoscopy may reduce the significant premalignant burden of sessile serrated adenomas. | Abhinav Sehgal Soorya Aggarwal Rohan Mandaliya Thomas Loughney Mark C Mattar | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，4： | 2 |
| 5 | Polymorphisms in VEGF, progesterone receptor and IL-1 receptor genes in women with recurrent spontaneous abortion显示文摘 | évelyn Traina Silvia Daher Antonio Fernandes Moron Sue Yazaki Sun Camila Sommerauer Franchim Rosiane Mattar | 2010 | Journal of Reproductive Immunology2010，，： | 2 |
| 6 | Dynamic material balance oil or gas-in- place without shut-ins显示文摘 | Mattar L Anderson D | 2006 | Journal of Canadian Petroleum Tech- nology2006，45，11： | 1 |
| 7 | Mycophenolate Mofetil Prevents the Development of Glomerulau Injury in Experimental Diabetes显示文摘 | Utimura R Fujihara C K Mattar A L | 2003 | Kidney Int2003，63，1： | 1 |
| 8 | Influence of an altered methylation potential on mRNA methylation and gene expression in HepG2 cells显示文摘 | Hermes M Osswald H Mattar J | 2004 | Eacp Cell Res2004，294，32： | 1 |
| 9 | Renal artery perfusion modifies ischemia/reperfusion injury显示文摘 | HUGHES J D MATTAR S G CHEN C | 1996 | J Surg Res1996，60，2： | 1 |
| 10 | Prevalence of uterine defects in habitual abortion patients attended on at a university health service in Brazil 显示文摘 | Guimarhes Filho HA Mattar R | 2006 | Arch Gynecol Obstet2006，274，6： | 1 |
| 11 | Prevalence of uterine defects in habitual abortion patients attended on at a university health service in Brazil 显示文摘 | Guimaraes Filho HA Mattar R Pires CR | 2006 | Arch Gynecol Obstet2006，274，6： | 1 |
| 12 | Landslide characterisation in Canada using interferometric SAR and combined SAR and TM images显示文摘 | Singhroy V Mattar K E Gray A L | 1998 | Advances in Space Research1998，21，3： | 1 |
| 13 | Active surveillance of small renal masses:progression pattems of early stage kidney cancer显示文摘 | Jewett MA Mattar K Basiuk J Morash CG Pautler SE Siemens DR | | 0，，： | 1 |
| 14 | Atmospheric correction of optical imagery from MODIS and Reanalysis atmospheric products显示文摘 | Juan C. Jiménez-Mu?oz José A. Sobrino Cristian Mattar Belen Franch | 2010 | Remote Sensing of Environment2010，，10： | 1 |
| 15 | Deep sedation in natural orifice transluminal endoscopic surgery (NOTES): a comparative study with dogs显示文摘 | Mohammad Al-Haddad Daniel McKenna Jeff Ko Stuart Sherman Don J. Selzer Samer G. Mattar Thomas F. Imperiale Douglas K. Rex Attila Nakeeb Seong Mok Jeong Cynthia S. Johnson Lynetta J. Freeman | 2012 | Surgical Endoscopy2012，，11： | 1 |
| 16 | Preoperativeserum levels of CA 72-4, CEA, CA 19-9, and alpha-fetoprotein inpatients with gastric cancer显示文摘 | Mattar R Alves de Andrade CR DiFavero GM | 2002 | Rev Hosp Clin Fac Med Sao Paulo2002，57，3： | 1 |
| 17 | Laparoscopic sleeve gastrectomy as an initial weight-loss procedure for high-risk patients with morbid obesity 显示文摘 | Cottam D Qureshi FG Mattar SG | 2006 | Surg Endosc2006，20，6： | 1 |
| 18 | Simplified forecasting of tight/shale-gas production in line ar flow显示文摘 | NOBAKHT M MATTAR L MOGHADAM S | 2012 | Journal of Canadian Petroleum Technology2012，11，： | 1 |
| 19 | Profile of inflammatory mediators in gestational diabetes mellitus:phenotype and genotype显示文摘 | Gueuvoghlanian-Silva BY Torloni MR Mattar R | 2012 | Am J Reprod Immuno12012，67，3： | 1 |
| 20 | Cal- cium and osteoprotegerin regulate IGFlR expression to inhibit vascular calcification显示文摘 | DI BARTOLO BA SCHOPPET M MATTAR MZ | 2011 | Cardiovasc Res2011，91，3： | 1 |
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