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| 1 | 青藏高原东部上地幔各向异性及相关的壳幔耦合型式显示文摘对国家数字地震台网和云南、四川、甘肃、青海区域数字地震台网,以及布设在川、滇、藏地区的宽频带流动地震台网共116个台站所记录的远震SKS波形资料作偏振分析,采用叠加分析方法求得每一个台站的SKS快波偏振方向和快慢波的时间延迟,获得青藏高原东部及其邻近地区的上地幔各向异性图像.将该地区全球定位系统(GPS)的观测结果与上地幔各向异性分布相结合作地壳一地幔耦合变形的分析,研究表明青藏高原内部和高原外部的云南地区具有不同的壳幔变形特征,在高原的东缘地区(大致位于川滇西部的26°-27°N之间)存在一个壳幔变形的横向过渡带.过渡带以南地区的快波偏振方向从滇西南的S60°-70°E逐渐转变到滇东南的近东西向,以北的滇西北部和川西南部,快波偏振方向为近似的南北向.高原内部表现为强壳幔耦合型,高原外部则属于壳幔解耦型.这一横向过渡带与地表的断裂走向不一致,但在地壳和上地幔,其地球物理场(如:地壳厚度,布格重力异常和构造应力方向等)都具有横向过渡的特征.该横向过渡带邻近东喜马拉雅构造结,在板块边界动力学上有着重要的意义. | 王椿镛 常利军 吕智勇 秦嘉政 苏伟 Paul Silver Lucy Flesch | 2007 | 中国科学(D辑)2007，37，4： | 68 |
| 2 | Risk for gastric neoplasias in patients with chronic atrophic gastritis:A critical reappraisal显示文摘Chronic atrophic gastritis (CAG) is an inflammatory condition characterized by the loss of gastric glandular structures which are replaced by connective tissue (non-metaplastic atrophy) or by glandular structures inappropriate for location (metaplastic atrophy).Epidemiological data suggest that CAG is associated with two different types of tumors:Intestinal-type gastric cancer (GC) and type Ⅰ gastric carcinoid (TⅠGC).The pathophysiological mechanisms which lead to the development of these gastric tumors are different.It is accepted that a multistep process initiating from Helicobacter pylori-related chronic inflammation of the gastric mucosa progresses to CAG,intestinal metaplasia,dysplasia and,finally,leads to the development of GC.The TⅠGC is a gastrin-dependent tumor and the chronic elevation of gastrin,which is associated with CAG,stimulates the growth of enterochromaffin-like cells with their hyperplasia leading to the development of TⅠGC.Thus,several events occur in the gastric mucosa before the development of intestinal-type GC and/or TⅠGC and these take several years.Knowledge of CAG incidence from superficial gastritis,its prevalence in different clinical settings and possible risk factors associated with the progression of this condition to gastric neoplasias are important issues.This editorial intends to provide a brief review of the main studies regarding incidence and prevalence of CAG and risk factors for the development of gastric neoplasias. | Lucy Vannella Edith Lahner Bruno Annibale | 2012 | World Journal of Gastroenterology2012，18，12： | 73 |
| 3 | 抗J亚群禽白血病病毒囊膜糖蛋白特异性单克隆抗体的研制及其特性显示文摘:J亚群禽白血病病毒 (ALV -J)是一种主要感染肉用型鸡的反转录病毒。本研究用表达ALV -J囊膜蛋白基因产物的Sf9细胞免疫Balb/c小鼠 ,取其脾脏细胞与骨髓瘤细胞NS1进行融合 ,获得了 4株特异性抗ALV -J的单克隆抗体。免疫荧光分析结果表明 ,3株单克隆抗体仅与所试验的ALV -J毒株反应 ,而不能与ALV的A、B、C、D和E亚群的毒株反应。有趣的是 ,有一株单克隆抗体可以与所有试验的外源性ALV毒株反应 ,但不与内源性的E亚群反应。WesternBlot和免疫沉淀试验结果表明 ,单克隆抗体识别的ALV -J囊膜糖蛋白的分子量为 90 - 94kD ,识别未糖基化的囊膜蛋白分子量约为 5 3kD。用这些单克隆抗体能检测出ALV -J病毒感染鸡胚成纤维细胞中的病毒抗原。这些结果提示这些单克隆抗体可用于ALV | 秦爱建 崔治中 LEE LUCY FADLY ALY | 2001 | 畜牧兽医学报2001，32，6： | 66 |
| 4 | 基于IMRT时代的第八版AJCC/UICC鼻咽癌临床分期建议显示文摘目的准确的分期系统对癌症的治疗至关重要。随着癌症分期和治疗方法的演变,需要不断评价分期的适用性和改进性。方法基于第7版AJCC/UICC分期回顾性分析香港和中国大陆2个肿瘤中心收治的1609例接受调强放射治疗的首诊无转移鼻咽癌患者临床资料,所有患者治疗前均行核磁共振分期评估。结果无其他T3、T4期解剖结构受侵患者中,伴有咀嚼肌间隙(翼内肌和/或翼外肌)侵犯、椎前肌侵犯及咽旁间隙侵犯的三组患者之间0s相近。伴广泛软组织(上述侵犯结构以外的软组织)受侵患者OS与伴有颅内侵犯或颅神经侵犯相似。仅2%患者锁骨上窝以上淋巴结转移者直径〉6cm,其0s率与下颈淋巴结转移者类似。用下颈(环状软骨尾侧缘水平以下)代替锁骨上窝并不影响N分期之间的风险差异性。采用推荐的T、N分期,T。N。、T。N,期0s相近。结论经AJCC/UICC分期筹备委员会审阅后,建议第8版分期应将翼内肌/翼外肌从T。降到T:期,增加椎前肌为L期,用下颈取代锁骨上窝,将淋巴结最大直径〉6cm合并归为N,期,将T。、N,期统一归为Ⅳ。期。这些改变不仅使得相邻分期间风险差异性更好,而且使得临床实践性与全球适用性之间达到最佳平衡。 | 潘建基 Wai Tong Ng 宗井凤 Lucy L.K.Chan Brian O' Sullivan 林少俊 Henry C.K.Sze 陈韵彬 Horace C.W.Choi 郭巧娟 Wai Kuen Kan 肖友平 Xu Wei Quynh Thu Le Christine M.Glastonbury A.Dimtrios Colevas Randal S.Weber Jatin P.Shah Anne W.M.Lee | 2016 | 中华放射肿瘤学杂志2016，25，3： | 65 |
| 5 | 用ALV-Jgp85单克隆抗体证明蛋鸡存在J亚群禽白血病显示文摘采用免疫组化法,对病理学初步诊断为蛋用型鸡 J亚群白血病的自然发病鸡的肿瘤、骨髓、肝脏、脾脏、肾脏、肺脏、心脏、胰脏、输卵管、卵巢、腺胃、骨骼肌、大脑、坐骨神经,用特异性抗 J亚群禽白血病病毒(ALV J)囊膜糖蛋白gp85的单克隆抗体进行检测,待检的组织切片中均检出阳性抗原,免疫组化的研究结果与病理学诊断结果相一致。在国内外首次发现并报道蛋用型鸡 J亚群禽白血病的自然病例。 | 徐镔蕊 董卫星 余春明 冯小宇 李宁 Lucy F.Lee Maoxiang Li | 2005 | 畜牧兽医学报2005，36，3： | 52 |
| 6 | 蛋鸡J亚群禽白血病的分子生物学诊断显示文摘根据J亚群白血病病毒(ALV-J)原型株HPRS-103的序列设计了一对针对外源性ALV-J引物H5和H7,从发生ML病死鸡的肿瘤、骨髓、肝脏、脾脏和输卵管组织中提取DNA作为模板,经PCR扩增得到长度为545bp的片段,对其序列进行测定后,与ALV-J原型株HPRS-103的序列进行了比较,发现其核苷酸同源性为97.4%,所编码氨基酸的同源性为96.1%。该片段含有ALV-Jgp85编码基因的部分序列和ALV-Jpol基因的部分序列,从分子水平上证实了蛋鸡发生J亚群禽白血病,进一步证明了此前根据病理学观察、免疫组化及免疫荧光诊断的结果。这是首次从分子水平上证明蛋用型鸡发生J亚群禽白血病。 | 徐镔蕊 董卫星 余春明 Lucy F.Lee Maoxiang Li | 2005 | 病毒学报2005，21，4： | 39 |
| 7 | Distinction between high-grade gliomas and solitary metastases using peritumoral 3-T magnetic resonance spectroscopy, diffusion, and perfusion imagings显示文摘This study compared the effectiveness of relative cerebral blood volume, apparent diffusion coefficient, and spectroscopic imaging in differentiating between primary high - grade gliomas and solitary metastases. A3.0 - T MR unit was used to perform proton MR spectroscopy, diffusion imaging, and conventional MR imaging on 26 patients who had solitary brain tumors (14 high - grade gliomas and | ChiangIC KuoYT LuCY YeungKW LinWC SheuFO LiuGC | 2004 | 中国神经肿瘤杂志2004，2，3： | 31 |
| 8 | Seismic anisotropy of upper mantle in eastern Tibetan Plateau and related crust-mantle coupling pattern显示文摘By using the polarization analysis of teleseismic SKS waveform data recorded at 116 seismic stations which respectively involved in China National Digital Seismograph Network, and Yunnan, Sichuan, Gansu and Qinghai regional digital networks, and portable broadband seismic networks deployed in Sichuan, Yunnan and Tibet, we obtained the SKS fast-wave direction and the delay time between fast and slow waves of each station by use of the stacking analysis method, and finally acquired the fine image of upper mantle anisotropy in the eastern Tibetan Plateau and its adjacent regions. We analyzed the crust-mantle coupling deformation on the basis of combining the GPS observation results and the upper mantle anisotropy distribution in the study area. The Yunnan region out of the plateau has dif-ferent features of crust-mantle deformation from the inside plateau. There exists a lateral transitional zone of crust-mantle coupling in the eastern edge of the Tibetan Plateau, which is located in the region between 26° and 27°N in the west of Sichuan and Yunnan. To the south of transitional zone, the fast-wave direction is gradually turned from S60°―70°E in southwestern Yunnan to near EW in south-eastern Yunnan. To the north of transitional zone in northwestern Yunnan and the south of western Sichuan, the fast-wave direction is nearly NS. From crust to upper mantle, the geophysical parameters (e.g. the crustal thickness, the Bouguer gravity anomaly, and tectonic stress direction) show the feature of lateral variation in the transitional zone, although the fault trend on the ground surface is inconsis-tent with the fast-wave direction. This transitional zone is close by the eastern Himalayan syntaxis, and it may play an important role in the plate boundary dynamics. | Paul SILVER Lucy FLESCH | 2007 | Science China Earth Sciences2007，50，8： | 33 |
| 9 | 中国大陆上地幔各向异性和壳幔变形模式显示文摘近10年来,中国布设的宽频带地震台站大幅度增加.宽频带地震记录中含有大量的剪切波分裂信息,它在揭示中国大陆上地幔的各向异性特征起重要作用.本文对这些台站的远震SKS和(或)SKKS记录,采用最小切向能量的分析方法,确定各台站剪切波分裂的快波偏振方向和延迟时间.此外,还收集了前人在中国大陆及其周边地区的剪切波分裂研究的部分结果,形成拥有1020个剪切波分裂参数对的数据集.这些分裂参数展示了复杂的上地幔各向异性图像.统计分析表明,中国大陆存在较强的上地幔各向异性,平均的剪切波时间延迟为0.95 s,其中西部地区为1.01 s,东部地区为0.92 s.西部地区的各向异性强度略大于东部地区.在大尺度意义下,青藏高原及天山地区,其SKS波分裂和地表变形数据共同支持岩石圈变形模式,即地壳与岩石圈地幔是连贯变形的;东部地区的平均快波偏振方向近似平行于绝对板块运动方向,上地幔各向异性归因于软流圈流动.中部的鄂尔多斯至四川盆地一带为东、西部两种变形模式的过渡带,各向异性结构较为复杂,表现为'化石'各向异性和(或)双层各向异性.印度板块和欧亚板块的碰撞是中国大陆西部上地幔各向异性的主要影响因素,东部地区则与太平洋板块和菲律宾板块向欧亚板块俯冲有关. | 王椿镛 常利军 丁志峰 刘琼林 廖武林 Lucy M FLESCH | 2014 | 中国科学:地球科学2014，44，1： | 31 |
| 10 | Upper mantle anisotropy and crust-mantle deformation pattern beneath the Chinese mainland显示文摘Over the past 10 years,the number of broadband seismic stations in China has increased significantly.The broadband seismic records contain information about shear-wave splitting which plays an important role in revealing the upper mantle anisotropy in the Chinese mainland.Based on teleseismic SKS and SKKS phases recorded in the seismic stations,we used the analytical method of minimum transverse energy to determine the fast wave polarization direction and delay time of shear-wave splitting.We also collected results of shear-wave splitting in China and the surrounding regions from previously published papers.From the combined dataset we formed a shear-wave splitting dataset containing 1020 parameter pairs.These splitting parameters reveal the complexity of the upper mantle anisotropy image.Our statistical analysis indicates stronger upper mantle anisotropy in the Chinese mainland,with an average shear-wave time delay of 0.95 s;the anisotropy in the western region is slightly larger(1.01 s)than in the eastern region(0.92 s).On a larger scale,the SKS splitting and surface deformation data in the Tibetan Plateau and the Tianshan region jointly support the lithospheric deformation mode,i.e.the crust-lithospheric mantle coherent deformation.In eastern China,the average fast-wave direction is approximately parallel to the direction of the absolute plate motion;thus,the upper mantle anisotropy can be attributed to the asthenospheric flow.The area from the Ordos block to the Sichuan Basin in central China is the transition zone of deformation modes between the east and the west regions,where the anisotropy images are more complicated,exhibiting'fossil'anisotropy and/or two-layer anisotropy.The collision between the Indian Plate and the Eurasian Plate is the main factor of upper mantle anisotropy in the western region of the Chinese mainland,while the upper mantle anisotropy in the eastern region is related to the subduction of the Pacific Plate and the Philippine Sea Plate beneath the Eurasian Plate. | WANG ChunYong CHANG LiJun DING ZhiFeng LIU QiongLin LIAO WuLin Lucy M FLESCH | 2014 | Science China Earth Sciences2014，57，1： | 18 |
| 11 | PTEN in liver diseases and cancer显示文摘The phosphoinositide 3-kinase (PI3K)/phosphatase and tensin homolog (PTEN)/Akt axis is a key signal transduction node that regulates crucial cellular functions, including insulin and other growth factors signaling, lipid and glucose metabolism, as well as cell survival and apoptosis. In this pathway, PTEN acts as a phosphoinositide phosphatase, which terminates PI3Kpropagated signaling by dephosphorylating PtdIns(3,4)P2 and PtdIns(3,4,5)P3. However, the role of PTEN does not appear to be restricted only to PI3K signaling antagonism, and new functions have been recently discovered for this protein. In addition to the well-established role of PTEN as a tumor suppressor, increasing evidence now suggests that a dysregulated PTEN expression and/or activity is also linked to the development of several hepatic pathologies. Dysregulated PTEN expression/activity is observed with obesity, insulin resistance, diabetes, hepatitis B virus/hepatitis C virus infections, and abusive alcohol consumption, whereas mutations/deletions have also been associated with the occurrence of hepatocellular carcinoma. Thus, it appears that alterations of PTEN expression and activity in hepatocytes are common and recurrent molecular events associated with liver disorders of various etiologies. These recent f indings suggest that PTEN might represent a potential common therapeutic target for a number of liver pathologies. | Marion Peyrou Lucie Bourgoin Michelangelo Foti | 2010 | World Journal of Gastroenterology2010，16，37： | 16 |
| 12 | 蛋鸡J亚群禽白血病病毒的分离与初步鉴定显示文摘 | 冯小宇 徐镔蕊 Lucy F.Lee Maoxiang Li | 2008 | 中国兽医杂志2008，44，1： | 14 |
| 13 | Turning rice meiosis into mitosis显示文摘通过在庄稼的种子(单性生殖) 的同种细胞的复制的介绍有潜力由允许任何精英变化的自我繁殖革命化农业,特别地 F1 混血儿。在性模型植物 Arabidopsis thaliana,通过种子的合成同种细胞的复制能被联合三个变化把成熟分裂变成有丝分裂(笑剧) 并且(的(i) 人工地实现 ii ) 穿过获得的同种细胞的配偶子,一根线表示修改了 CENH3 并且其染色体在接合子被消除。这里,我们证明变化的另外的联合能把 Arabidopsis 成熟分裂变成有丝分裂并且在米饭(Oryza sativa ) 的三个变化的联合高效地把成熟分裂变成有丝分裂,导致在这主要庄稼的男、女的同种细胞的双配偶子的生产。在种系发生地远的 eudicot Arabidopsis 和 monocot 米饭的笑剧技术的成功的实现为它的申请打开门到任何 flowering 植物并且为在庄稼种类介绍单性生殖铺平道路。 | Delphine Mieulet Sylvie Jolivet Maud Rivard Laurence Cromer Aurore Vemet Pauline Mayonove Lucie Pereira Gaetan Droc Brigitte Courtois Emmanuel Guiderdoni Raphael Mercier | 2016 | Cell Research2016，26，11： | 14 |
| 14 | Vascular cognitive impairment, a cardiovascular complication显示文摘Over the past two decades, the term vascular cognitive impairment(VCI) has been used to refer to a spectrum of cognitive decline characterized by executive dysfunction, associated with vascular pathology. With 30% of stroke survivors showing cognitive impairments, it is regarded as the most common cause of cognitive impairment. This is a narrative review of available literature citing sources from Pub Med, MEDLINE and Google Scholar. VCI has a high prevalence both before and after a stroke and is associated with great economic and caregiver burden. Despite this, there is no standardized diagnostic criteria for VCI. Hypertension has been identified as a risk factor for VCI and causes changes in cerebral vessel structure and function predisposing to lacuna infarcts and small vessel haemorrhages in the frontostriatal loop leading to executive dysfunction and other cognitive impairments. Current trials have shown promising results in the use of antihypertensive medications in the management of VCI and prevention of disease progression to vascular dementia. Prevention of VCI is necessary in light of the looming dementia pandemic. All patients with cardiovascular risk factors would therefore benefit from cognitive screening with screening instruments sensitive to executive dysfunction as well as prompt and adequate control of hypertension. | Adiukwu Frances Ofori Sandra Ugbomah Lucy | 2016 | World Journal of Psychiatry2016，6，2： | 14 |
| 15 | Neural EGF-like protein 1(NELL-1):Signaling crosstalk in mesenchymal stem cells and applications in regenerative medicine显示文摘Bone tissue regeneration holds the potential to solve both osteoporosis and large skeletal defects,two problems associated with significant morbidity.The differentiation of mesenchymal stem cells into the osteogenic lineage requires a specific microenvironment and certain osteogenic growth factors.Neural EGF Like-Like molecule 1(NELL-1)is a secreted glycoprotein that has proven,both in vitro and in vivo,to be a potent osteo-inductive factor.Furthermore,it has been shown to repress adipogenic differentiation and inflammation.NELL-1 can work synergistically with other osteogenic factors such as Bone Morphogenic Protein(BMP)2 and9,and has shown promise for use in tissue engineering and as a systemically administered drug for the treatment of osteoporosis.Here we provide a comprehensive up-to-date review on the molecular signaling cascade of NELL-1 in mesenchymal stem cells and potential applications in bone regenerative engineering. | Mikhail Pakvasa Alex Alverdy Sami Mostafa Eric Wang Lucy Fu Alexander Li Leonardo Oliveira Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Tong-Chuan He Guillermo A.Ameer Russell R.Reid | 2017 | Genes & Diseases2017，4，3： | 13 |
| 16 | Deep structure and origin of active volcanoes in China显示文摘我们综合在大陆中国的活跃火山的深结构和起源上的重要最近的结果。在西方的和平的弧和背弧区域的 Magmatism 被 subducting 平板的脱水并且由角落流动在披风楔引起,而在中国的 intraplate magmatism 有不同起源。在东北中国的活跃火山(例如 Changbai 和 Wudalianchi ) 被热 upwelling 也在披风转变地区和深平板脱水在停滞平板上面在大披风楔(BMW ) 引起。在西南中国的 Tengchong 火山被一个类似的过程在 subducting 缅甸 microplate 上面在 BMW 引起(或印度板) 。在极南的中国的海南火山是可以深与和平、菲律宾的海平板被联系的一根降低披风的羽毛喂的一个热点在东方和印度平板的 subduction 在西方在下面的深 subduction 到更低的披风。最后,倒塌击倒到披风的底部的停滞平板,它能在 subducting 平板下面从更低的披风触发热披风材料的 upwelling 到浅披风并且可以引起 slabplume 相互作用。 | Lucy Liu | 2010 | Geoscience Frontiers2010，1，1： | 13 |
| 17 | 卫生政策与体系研究概述显示文摘1卫生政策与体系研究的内涵
1.1定义与特点
卫生政策与体系研究(Health policy and systems research,HPSR)通常定义为“……通过提升社会组织能力来实现人群的健康目标,并研究不同社会角色对政策制定和执行的影响以及对政策成果的贡献。卫生政策与体系研究属于交叉学科,综合运用经济学、社会学、人类学、政治学、公共卫生和流行病学等学科,揭示卫生体系如何影响并适应卫生政策,以及卫生政策、健康相关因素与卫生体系之间如何相互影响”。 | Lucy Gilson | 2013 | 中国卫生政策研究2013，6，1： | 13 |
| 18 | TREM-1 multimerization is essential for its activation on monocytes and neutrophils显示文摘The triggering receptor expressed on myeloid cells-1(TREM-1)is a receptor expressed on innate immune cells.By promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptors(TLRs),TREM-1 has been characterized as a major player in the pathophysiology of acute and chronic inflammatory diseases,such as septic shock,myocardial infarction,atherosclerosis,and inflammatory bowel diseases.However,the molecular events leading to the activation of TREM-1 in innate immune cells remain unknown.Here,we show that TREM-1 is activated by multimerization and that the levels of intracellular Ca 2+release,reactive oxygen species,and cytokine production correlate with the degree of TREM-1 aggregation.TREM-1 activation on primary human monocytes by LPS required a two-step process consisting of upregulation followed by clustering of TREM-1 at the cell surface,in contrast to primary human neutrophils,where LPS induced a rapid cell membrane reorganization of TREM-1,which confirmed that TREM-1 is regulated differently in primary human neutrophils and monocytes.In addition,we show that the ectodomain of TREM-1 is able to homooligomerize in a concentration-dependent manner,which suggests that the clustering of TREM-1 on the membrane promotes its oligomerization.We further show that the adapter protein DAP12 stabilizes TREM-1 surface expression and multimerization.TREM-1 multimerization at the cell surface is also mediated by its endogenous ligand,a conclusion supported by the ability of the TREM-1 inhibitor LR12 to limit TREM-1 multimerization.These results provide evidence for ligand-induced,receptor-mediated dimerization of TREM-1.Collectively,our findings uncover the mechanisms necessary for TREM-1 activation in monocytes and neutrophils. | Kevin Carrasco Amir Boufenzer Lucie Jolly Helene Le Cordier Guanbo Wang Albert JR Heck Adelheid Cerwenka Emilie Vinolo Alexis Nazabal Alexandre Kriznik Pierre Launay Sebastien Gibot Marc Derive | 2019 | Cellular & Molecular Immunology2019，16，5： | 13 |
| 19 | Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame显示文摘导致的 pluripotent 的产生从体的细胞的茎(iPS ) 细胞被定义 reprogramming 抄写因素(TF ) 的同时的病毒的 transduction 成功地完成了。然而,这个过程为基因交货要求多重病毒的向量。作为结果,产生了 iPS 房间港口在他们的染色体的众多的病毒的集成地点。这能增加基因 mutagenesis 和 genomic 不稳定性的概率,并且介绍重要障碍给研究和 iPS 房间的临床的申请研究。在这篇论文,我们在场定义因素是的一个简单 lentivirus reprogramming 在系统经由自我劈开的 2A 序列熔化了在里面框架进一个单个开的读物框架(ORF ) 。一个 GFP 标记下游地被放 transgene 启用 transgene 表示追踪。我们证明这个 polycistronic 表示系统高效地产生 iPS 房间。产生 iPS 房间有正常 karyotypes 并且类似于鼠标在形态学和基因表示的胚胎的干细胞。而且,他们能在 vitro 并且在 vivo 试金在两个区分进三胚胎的细菌层的房间类型。显著地,大多数这些 iPS 房间仅仅怀有病毒的向量的一个单个拷贝。这个系统提供一个珍贵工具因为 iPS 房间的产生,和我们的数据建议在每个房间的 transduced reprogramming TF 的表示的平衡为 reprogramming 进程是必要的。更重要地,当由非集成的基因交货系统交付了时,这重新设计的单个 ORF 将没有基因修正便于人的 iPS 房间的有效产生。 | Lijian Shao Wei Feng Yan Sun Hao Bai Jun Liu Caroline Currie Jaejung Kim Rafael Gama Zack Wang Zhijian Qian Lucy Liaw Wen-Shu Wu | 2009 | Cell Research2009，19，3： | 12 |
| 20 | Seismic tomography of the Moon显示文摘We attempted to determine the first three-dimensional P and S wave velocity and Poisson's ratio structures of the lunar crust and mantle down to 1000 km depth under the near-side of the Moon by applying seismic tomography to the moonquake arrival-time data recorded by the Apollo seismic network operated during 1969 to 1977.Our results show that significant lateral heterogeneities may exist in the lunar interior.Because there is no plate tectonics in the Moon,the lateral heterogeneities may be produced at the early stage of the Moon formation and evolution,and they have been preserved till today.There seems to be a correlation between the distribution of deep moonquakes and lateral velocity variations in the lunar lower mantle,suggesting that the occurrence of deep moonquakes may be affected by the lunar structural heterogeneity in addition to the tidal stresses.Although this is an experimental work and the result is still preliminary,it indicates that tomographic imaging of the lunar interior is feasible. | ZHAO DaPeng LEI JianShe LIU Lucy | 2008 | Chinese Science Bulletin2008，53，24： | 11 |
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