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| 1 | Portal hypertension: Imaging of portosystemic collateral pathways and associated image-guided therapy显示文摘Portal hypertension is a common clinical syndrome, defined by a pathologic increase in the portal venous pressure. Increased resistance to portal blood flow, the primary factor in the pathophysiology of portal hypertension, is in part due to morphological changes occurring in chronic liver diseases. This results in rerouting of blood flow away from the liver through collateral pathways to low-pressure systemic veins. Through a variety of computed tomographic, sonographic, magnetic resonance imaging and angiographic examples, this article discusses the appearances and prevalence of both common and less common portosystemic collateral channels in the thorax and abdomen. A brief overview of established interventional radiologic techniques for treatment of portal hypertension will also be provided. Awareness of the various imaging manifestations of portal hypertension can be helpful for assessing overall prognosis and planning proper management. | Murad Feroz Bandali Anirudh Mirakhur Edward Wolfgang Lee Mollie Clarke Ferris David James Sadler Robin Ritchie Gray Jason Kam Wong | 2017 | World Journal of Gastroenterology2017，23，10： | 14 |
| 2 | Assessment of an Evapotranspiration Deficit Drought Index in Relation to Impacts on Ecosystems显示文摘Ecosystems have increasingly been subject to the challenge of heavy drought under global warming. To quantitatively evaluate the impacts of drought on ecosystems, it is necessary to develop a drought index that can sensitively depict the response of vegetation to drought evolution at a biological time scale. For the ability of direct connection between climate and ecosystem by deficit of evapotranspiration, in the present study, a drought index was defined based on standardized evapotranspiration deficit (SEDI), according to the difference between actual and potential evapotranspiration, to meet the need for highlighting drought impacts on ecological processes. Comparisons with traditional indices show that SEDI can reasonably detect droughts and climatic dry and wet transitions, especially at a monthly time scale, and can also regenerate long-term trends. Moreover, SEDI can more sensitively capture the biological changes of ecosystems in response to the dynamics of drought intensity, compared with the indices of precipitation and temperature. SEDI is more practical than the precipitation and temperature indices to highlight signals of biological effects in climate droughts. Hence, it has potential for use in assessments of climate change and its impact on ecosystems. | Xia ZHANG Mingxing LI Zhuguo MA Qing YANG Meixia LV Robin Clark | 2019 | Advances in Atmospheric Sciences2019，36，11： | 6 |
| 3 | 2021:A Year of Unprecedented Climate Extremes in Eastern Asia,North America,and Europe显示文摘The year 2021 was recorded as the 6th warmest since 1880.In addition to large-scale warming,2021 will be remembered for its unprecedented climate extremes.Here,a review of selected high-impact climate extremes in 2021,with a focus on China,along with an extension to extreme events in North America and Europe is presented.Nine extreme events that occurred in 2021 in China are highlighted,including a rapid transition from cold to warm extremes and sandstorms in spring,consecutive drought in South China and severe thunderstorms in eastern China in the first half of the year,extremely heavy rainfall over Henan Province and Hubei Province during summer,as well as heatwaves,persistent heavy rainfall,and a cold surge during fall.Potential links of extremes in China to four global-scale climate extremes and the underlying physical mechanisms are discussed here,providing insights to understand climate extremes from a global perspective.This serves as a reference for climate event attribution,process understanding,and high-resolution modeling of extreme events. | Tianjun ZHOU Wenxia ZHANG Lixia ZHANG Robin CLARK Cheng QIAN Qinghong ZHANG Hui QIU Jie JIANG Xing ZHANG | 2022 | Advances in Atmospheric Sciences2022，39，10： | 5 |
| 4 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 5 | Estimation of tropical forest structural characteristics using large-footprint lidar显示文摘 | Jason B Drake Ralph O Dubayah David B Clark Robert G Knox J.Bryan Blair Michelle A Hofton Robin L Chazdon John F Weishampel Steve Prince | 2001 | Remote Sensing of Environment2001，，2： | 1 |
| 6 | Implications of climate change for agricultural productivity in the early twenty-first century显示文摘 | Gornall Jemma Betts Richard Burke Eleanor Clark Robin Camp Joanne Willett Kate Wiltshire Andrew | 2010 | Philosophical Transactions of the Royal Society B . 2010 (1554)2010，，： | 1 |
| 7 | Mucosectomy With Handsewn Anastomosis Reduces the Risk of Adenoma Formation in the Anorectal Segment After Restorative Proctocolectomy for Familial Adenomatous Polyposis显示文摘 | Alexander C. von Roon Olivia C. C. Will Ripple F. Man Kay F. Neale Robin K. S. Phillips R. John Nicholls Susan K. Clark Paris P. Tekkis | 2011 | Annals of Surgery2011，，2： | 1 |
| 8 | Photocatalytic activities of N-doped nano-titanias and titanium nitride显示文摘 | Zhice Zhang Josephine B.M. Goodall David J. Morgan Sonal Brown Robin J.H. Clark Jonathan C. Knowles Nicola J. Mordan Julian R.G. Evans Albert F. Carley Michael Bowker Jawwad A. Darr | 2009 | Journal of the European Ceramic Society2009，，11： | 1 |
| 9 | Rail flaw detection:overview and needs for futrue developments显示文摘 | Robin Clark | 2003 | NDT and E International2003，37，2： | 1 |
| 10 | Psychosocial treatment in the 21st century 显示文摘 | Robin E Clark T Mihail S | 2005 | Intenational Journal of Law and Psychiatry2005，28，： | 1 |
| 11 | Rail flaw detection: overview and needs for future developments显示文摘 | Robin Clark | 2004 | NDT&E International2004，37，2： | 1 |
| 12 | The Impact of Technical Factors on Outcome of Restorative Proctocolectomy for Familial Adenomatous Polyposis显示文摘 | Alexander C. Roon Paris P. Tekkis Susan K. Clark Alexander G. Heriot Richard E. Lovegrove Simona Truvolo R. John Nicholls Robin K. S. Phillips | 2007 | Diseases of the Colon & Rectum2007，，7： | 1 |
| 13 | Atmospheric pressure chemical vapour deposition of thin films of Nb2O5 on glass 显示文摘 | Shane A O' Neill Ivan P Parkin Robin J H Clark | 2003 | Mater Chem2003，13，： | 1 |
| 14 | Features of Duodenal Cancer in Patients With Familial Adenomatous Polyposis显示文摘 | Andrew R. Latchford Kay F. Neale Allan D. Spigelman Robin K.S. Phillips Susan K. Clark | 2009 | Clinical Gastroenterology and Hepatology2009，，6： | 1 |
| 15 | Psychosocial treatment in the 21st Century 显示文摘 | Robin E Clark T Mihail S | 2005 | Int J Law Psychiatry2005，，28： | 1 |
| 16 | Rail flaw detection: overview and needs for future developments显示文摘 | Robin Clark | 2004 | NDT&E International2004，37，2： | 1 |
| 17 | Pigment analysis by Raman microscopy of the non - figurative illumination in 16th - to 18th - century Islamic manuscripts 显示文摘 | Lucia B Robin J H Clark Vania S F Muralha | 2008 | J Raman Spectr2008，39，10： | 1 |
| 18 | Increasing Flash Floods in a Drying Climate over Southwest China显示文摘In a globally warming world,subtropical regions are generally expected to become drier while the tropics and mid–high latitudes become wetter.In line with this,Southwest China,close to 25?N,is expected to become increasingly prone to drought if annual mean precipitation decreases.However,despite this trend,changes in the temporal distribution of moisture supply might actually result in increased extreme rainfall in the region,whose climate is characterized by distinct dry and wet seasons.Using hourly and daily gauge observations,rainfall intensity changes since 1971 are examined for a network of 142 locations in the region.From the analysis,dry season changes are negligible but wet season changes exhibit a significantly strong downward trend [-2.4%(10 yr)^(-1)],particularly during the past 15 years [-17.7%(10 yr)^(-1)].However,the intensity of events during the wettest of 5% hours appears to steadily increase during the whole period [1.4%(10 yr)^(-1)],tying in with government statistical reports of recent droughts and flooding.If the opposing trends are a consequence of a warming climate,it is reasonable to expect the contradictory trend to continue with an enhanced risk of flash flooding in coming decades in the region concerned. | Chan XIAO Peili WU Lixia ZHANG Robin T. CLARK | 2018 | Advances in Atmospheric Sciences2018，35，8： | 1 |
| 19 | Raman spectroscopic library of natural and synthetic pig- ments(pre--1850AD)显示文摘 | Ian M Bell Robin J H Clark Peter J Gibbs | 1997 | Spectrochimica Acta Part A1997，53，： | 1 |
| 20 | Nine patients with Xp22.31 microduplication, cognitive deficits, seizures, and talipes anomalies显示文摘 | Edward D. Esplin Ben Li Anne Slavotinek Antonio Novelli Agatino Battaglia Robin Clark Cynthia Curry Louanne Hudgins | 2014 | Am. J. Med. Genet2014，，8： | 1 |
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