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| 1 | 大别造山带磷灰石裂变径迹(AFT)年代学研究显示文摘大别山花岗岩与变质岩的AFT热年代分布于96.4~41.9Ma之间,围限径迹长度为11.5~14.0μm.热年代代表岩石差异通过100℃等温面时的冷却时代,这种差异性主要受控于NNE向区域构造,在北淮阳与合肥盆地,沉积岩样品(侏罗纪~早第三纪)AFT年代为128.8~62.0Ma,围限径迹长度为8.6~11.9μm,它们更多反映盆地埋藏加热的信息,合肥盆地与大别造山带之间存在构造耦合关系,95~90Ma属于大别山构造推隆取代伸展热窿的转折期,其成因可能与西太平洋域汇聚变化特性有关:商城-麻城与郯-庐两断裂之间左旋差异走滑与构造推隆作用,使得大别腹地伸展热窿在晚白垩世急剧萎缩.早第三纪时期,受西太平洋域汇聚速率急剧下降的影响,欧亚东缘表现出广泛的拉张环境,大别山60~40Ma带状热异常应与这种拉张作用有关;郯-庐热中心的冷却(70~40Ma)要比商城-麻城热中心(60~55Ma)缓慢,而大别腹地热隆区(60~40Ma)属于伸展热窿萎缩之残留.大别山早第三纪还遭受喜马拉雅山碰撞域的远场影响,这种影响多通过NWW向断裂来实现构造传递:进入渐新世一中新世,大别山冷却波动仍显现区域差异性,它们在时间上与南海盆地扩张、关闭事件相近. | 许长海 周祖翼 P.Van Den Haute R.A.Donelick J.De Grave 马昌前 P.W.Reiners | 2004 | 中国科学(D辑)2004，34，7： | 27 |
| 2 | 中国南海蜂海绵Haliclona cymae formis的化学成分研究显示文摘目的研究中国南海蜂海绵属Haliclona cymaeformis的化学成分。方法运用正相硅胶、反相硅胶(ODS)和凝胶(Sephadex LH-20)等多种柱色谱手段对化合物进行分离纯化;通过理化性质和波谱数据,结合文献对照,鉴定化合物的结构。结果从海绵H.cymaeformis的乙醇提取物中共分离鉴定了11个单体化合物:24-亚甲基胆甾醇(1),5α,8β-epidioxy-cholesta-6-en-3-ol(2),cholesta-7-en-3β,5α,6β,9α-tetraol(3),胆甾醇(4),3-吲哚甲酸(5),尿嘧啶(6),胸腺嘧啶(7),尿嘧啶核苷(8),胸腺嘧啶核苷(9),尿嘧啶脱氧核苷(10)和胸腺嘧啶脱氧核苷(11)。结论化合物1~11均为首次从该海绵中分离得到。细胞毒活性测试结果表明,化合物3对慢性髓原白血病细胞(K562)和人肝癌细胞(SMMC-7721)的增殖显示了较强的生长抑制活性。 | 吴旭东 梅文莉 邵长伦 Nicole J.de Voogd 王辉 王长云 戴好富 | 2011 | 中国海洋药物2011，30，5： | 17 |
| 3 | 建筑环境热适应文献综述显示文摘给出了以建筑环境热适应为题的详尽文献综述成果。热舒适研究的适应观点认为,人们在真实环境中的热感觉受其以往热经历和文化与技术行为的综合影响。适应模型的一个重要前提是,人不再是给定热环境的被动接受者,而是通过多重反馈循环与人-环境系统交互作用的主动参与者。热适应可分为三种不同的过程——行为调节、生理习服和心理适应或期望。气候室和现场的证据均表明,较慢的习服过程与较为适中的建筑环境中发生的热适应关系不大,而行为调节和期望的影响则大得多。现场证据调查中的一个最重要的发现是空调建筑和自然通风建筑中热舒适反应存在差别,这可能是由人们以往在建筑中的热经历和不同的感知控制度共同导致的。 | Gail S.Brager Richard J.de Dear 翟永超 张宇峰 陈慧梅 | 2011 | 暖通空调2011，41，7： | 15 |
| 4 | New frontiers for the materials genome initiative显示文摘The Materials Genome Initiative(MGI)advanced a new paradigm for materials discovery and design,namely that the pace of new materials deployment could be accelerated through complementary efforts in theory,computation,and experiment.Along with numerous successes,new challenges are inviting researchers to refocus the efforts and approaches that were originally inspired by the MGI.In May 2017,the National Science Foundation sponsored the workshop“Advancing and Accelerating Materials Innovation Through the Synergistic Interaction among Computation,Experiment,and Theory:Opening New Frontiers”to review accomplishments that emerged from investments in science and infrastructure under the MGI,identify scientific opportunities in this new environment,examine how to effectively utilize new materials innovation infrastructure,and discuss challenges in achieving accelerated materials research through the seamless integration of experiment,computation,and theory.This article summarizes key findings from the workshop and provides perspectives that aim to guide the direction of future materials research and its translation into societal impacts. | Juan J.de Pablo Nicholas E.Jackson Michael A.Webb Long-Qing Chen Joel E.Moore Dane Morgan Ryan Jacobs Tresa Pollock Darrell G.Schlom Eric S.Toberer James Analytis Ismaila Dabo Dean M.DeLongchamp Gregory A.Fiete Gregory M.Grason Geoffroy Hautier Yifei Mo Krishna Rajan Evan J.Reed Efrain Rodriguez Vladan Stevanovic Jin Suntivich Katsuyo Thornton Ji-Cheng Zhao | 2019 | npj Computational Materials2019，，1： | 7 |
| 5 | Distribution and risk factors of hand, foot, and mouth disease in Changchun, northeastern China显示文摘Hand,foot,and mouth disease(HFMD)is a public health problem,and there have been increasing numbers of outbreaks in China's Mainland since 2008.Over17,000 HFMD cases have been reported in Changchun between 2008 and 2011.This study characterized the temporal and spatial distribution of the disease and identified the risk factors for HFMD.The main findings were as follows:(i)there were significant differences in HFMD incidence among age groups,with 86.8%of reported cases in children younger than 5 years old,and boys showed a higher incidence than girls(\6 years);(ii)The disease affected the whole region and spanned a large geographic area,but there was a higher incidence in urban areas(median=242 per 10,000 persons)and urban–rural border areas(median=135 per 10,000 persons),compared with rural areas(median=75 per 10,000 persons);and(iii)the incidence of HFMD in Changchun was significantly associated with the distance to the nearest freeway,GDP per capita,and the type of township. | Li Yan Xinlou Li Yaqin Yu Sake J.de Vlas Yapin Li Dandan Wang Yanli Li Yuan Yin Jing Wu Hong Liu Hong Yang Bo Li Liqun Fang Wuchun Cao | 2014 | Chinese Science Bulletin2014，59，5： | 7 |
| 6 | Gene expression changes in spleens of the wildlife reservoir species,Eurasian wild boar(Sus scrofa),naturally infected with Brucella suis biovar 2显示文摘Brucella suis is responsible for swine brucellosis worldwide.Of the five different B.suis biovars(bv.),bv.2 appears restricted to Europe where it is frequently isolated from wild boar and hares,can infect pigs and can cause human brucellosis.In this study,the differential gene expression profile was characterized in spleens of Eurasian wild boar naturally infected with B.suis bv.2.Of the 20,201 genes analyzed in the microarray,633 and 1,373 were significantly(fold change > 1.8;P < 0.01) upregulated and downregulated,respectively,in infected wild boar.The analysis was focused on genes that were over represented after conditional test for biological process gene ontology.Upregulated genes suggested that B.suis bv.2 infection induced cell maturation,migration and/or proliferation in infected animals.The genes downregulated in infected wild boar impaired the activity of several important cellular metabolic pathways such as metabolism,cytoskeleton organization and biogenesis,immune response and lysosomal function and vesicle-mediated transport.In addition,the response to stress,sperm fertility,muscle development and apoptosis seemed to be also impaired in infected animals.These results suggested that B.suis bv.2 may use strategies similar to other smooth brucellae to facilitate intracellular multiplication and the development of chronic infections.To our knowledge,this is the first report of the analysis of gene expression profile in hosts infected with B.suis bv.2,which is important to understand the molecular mechanisms at the host-pathogen interface in the main reservoir species with possible implications in the zoonotic cycle of the pathogen. | Ruth C.Galindo Pilar M.Muoz María J.de Miguel Clara M.Marin Javier Labairu Miguel Revilla José M.Blasco Christian Gortazar José de la Fuente | 2010 | Journal of Genetics and Genomics2010，37，11： | 6 |
| 7 | 标准化——多学科领域研究显示文摘本文通过一个系统的科学清单与标准化的特性相对照,指出了能够对标准化研究有贡献的学科,并且论证了标准化需要一个多学科的特殊方法来进行研究,其中管理学研究能够把其他学科的研究集成起来。 | Henk J.de Vries | 2011 | 中国标准化2011，，9： | 5 |
| 8 | 一种中国南海海绵Xestospongia testudinaria中化学成分的研究显示文摘综合运用正相和反相硅胶柱层析、Sephadex LH-20凝胶柱层析以及制备HPLC等分离方法,从1种中国南海海绵Xestospongia testudinaria中追踪分离抗肿瘤活性次级代谢产物。从95%乙醇提取物中分离获得8个单体化合物,通过NMR,MS等波谱技术鉴定其结构分别为:E-18,18-二溴-9,17-二烯-5,7-二炔硬脂酸甲酯(1),E-18,18-二溴-9,17-二烯-5,7-二炔硬脂酸乙酯(2),麦角甾-5,7,22-三烯-3-醇(3),麦角甾-4,6,8(14),22-四烯-3-酮(4),胆甾-4-烯-3-酮(5),3-吲哚醛(6),3-吲哚酸(7)和5-吲哚醛(8)。其中,化合物2-5和8为首次从该属海绵中分离得到。化合物1对肿瘤细胞株HCT116和A549显示较强的抑制活性。 | 孔雯雯 韩磊 李亮 邵长伦 章蓉 Nicole J.de Voogd 王长云 | 2011 | 中国海洋大学学报(自然科学版)2011，41，11： | 3 |
| 9 | 缝合伤口时应用曲马多的术后疗效显示文摘这项前瞻性,随机、双盲的试验旨在研究手术结束时使用大剂量镇痛剂曲马多对拔管时,镇静和麻醉后寒战的效果.40名ASA Ⅰ、Ⅱ级的成年患者接受了约1小时的腹腔镜手术,用含异氟醚的O2/N2O维持标准麻醉.开始缝合伤口时静脉给曲马多3mG/kg(n=20),以盐水做对照(n=20).接受曲马多治疗的患者无一出现麻醉后寒战,而对照组有60%的患者发生麻醉后寒战(P<0.001).曲马多对于拔管时间和镇静没有不良影响,曲马多组的出院期缩短(与对照组相比P<0.05).在麻醉后监护病房(PACU)里的两组患者的疼痛评分没有统计学差异,但对照组显然需要使用较多的辅助性措施才能治疗寒战和/或疼痛.结论:手术结束时使用大剂量曲马多可避免麻醉后寒战而不延长拔管时间,并可缩短麻醉后监护病房(PACU)的观察期. | J.De Witte G.W.Rietman | 2001 | 中国疼痛医学杂志2001，7，3： | 2 |
| 10 | Utilizing the ultrasensitive Schistosoma up-converting phosphor lateral flow circulating anodic antigen(UCP-LF CAA)assay for sample pooling-strategies显示文摘Background:Methodological applications of the high sensitivity genus-specific Schistosoma CAA strip test,allowing detection of single worm active infections(ultimate sensitivity),are discussed for efficient utilization in sample pooling strategies.Besides relevant cost reduction,pooling of samples rather than individual testing can provide valuable data for large scale mapping,surveillance,and monitoring.Method:The laboratory-based CAA strip test utilizes luminescent quantitative up-converting phosphor(UCP)reporter particles and a rapid user-friendly lateral flow(LF)assay format.The test includes a sample preparation step that permits virtually unlimited sample concentration with urine,reaching ultimate sensitivity(single worm detection)at 100%specificity.This facilitates testing large urine pools from many individuals with minimal loss of sensitivity and specificity.The test determines the average CAA level of the individuals in the pool thus indicating overall worm burden and prevalence.When requiring test results at the individual level,smaller pools need to be analysed with the pool-size based on expected prevalence or when unknown,on the average CAA level of a larger group;CAA negative pools do not require individual test results and thus reduce the number of tests.Results:Straightforward pooling strategies indicate that at sub-population level the CAA strip test is an efficient assay for general mapping,identification of hotspots,determination of stratified infection levels,and accurate monitoring of mass drug administrations(MDA).At the individual level,the number of tests can be reduced i.e.in low endemic settings as the pool size can be increased as opposed to prevalence decrease.Conclusions:At the sub-population level,average CAA concentrations determined in urine pools can be an appropriate measure indicating worm burden.Pooling strategies allowing this type of large scale testing are feasible with the various CAA strip test formats and do not affect sensitivity and specificity.It allows cost efficient stratified testing and monitoring of worm burden at the sub-population level,ideally for large-scale surveillance generating hard data for performance of MDA programs and strategic planning when moving towards transmission-stop and elimination. | Paul L.A.M.Corstjens Pytsje T.Hoekstra Claudia J.de Dood Govert J.van Dam | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 11 | Climate warming shifts the time interval between flowering and leaf unfolding depending on the warming period显示文摘The timing of flowering(FL)and leaf unfolding(LU)determine plants’reproduction and vegetative growth.Global warming has substantially advanced FL and LU of temperate and boreal plants,but their responses to warming differ,which may influence the time interval between FL and LU(ΔLU-FL),thereby impacting plant fitness and intraspecific physiological processes.Based on twigs collected from two flowering-first tree species,Populus tomentosa and Amygdalus triloba,we conducted a manipulative experiment to investigate the effects of winter chilling,spring warming and photoperiod on theΔLU-FL.We found that photoperiod did not affect theΔLU-FL of Amygdalus triloba,but shortenedΔLU-FL by 5.1 d of Populus tomentosa.Interestingly,spring warming and winter chilling oppositely affected theΔLU-FL of both species.Specifically,low chilling accumulation extended theΔLU-FL by 3.8 and 9.4 d for Populus tomentosa and Amygdalus triloba,but spring warming shortened theΔLU-FL by 4.1 and 0.2 d℃^(-1).Our results indicate that climate warming will decrease or increase theΔLU-FL depending on the warming periods,i.e.,spring or winter.The shifted time interval between flowering and leaf unfolding may have ecological effects including affecting pollen transfer efficiency and alter the structure and functioning of terrestrial ecosystem. | Shuxin Wang Zhaofei Wu Yufeng Gong Shubiao Wang Wei Zhang Shanshan Zhang Hans J.De Boeck Yongshuo H.Fu | 2022 | Science China(Life Sciences)2022，65，11： | 2 |
| 12 | Two new diterpene alkaloids from the South China Sea Sponge Agelas aff. nemoechinata显示文摘Two new N-methyladenine-containing diterpenes,nemoechines F(l)and G(2),were isolated from the South China Sea sponge Agelas aff.nemoechinata.The structures were assigned on the basis of spectroscopic date.Compound 2 showed weak activity against Jurkat cell lines with IC_(50) of 17.1 | Tao Li Bin Wang Nicole J.de Voogd Xu-Li Tang Qi Wang Mei-Jun Chu Ping-Lin Li Guo-Qiang Li | 2016 | Chinese Chemical Letters2016，27，7： | 2 |
| 13 | Late Palaeogene emplacement and late Neogene-Quaternary exhumation of the Kuril island-arc root (Kunashir island) constrained by multi-method thermochronometry显示文摘The Kuril islands constitute a volcanic island arc-trench system,stretching from eastern Hokkaido(Japan)to Kamchatka(Russia) along the northwestern Pacific subduction system.The current arc consists of several volcanic islands mainly with Neogene basement and capped by several,predominantly andesitic,active subduction stratovolcanoes.Kunashir Island is the southwestern-most island of the arc,just off the Hokkaido coast and represents the study area in this paper.The island is composed of a Lower Complex of mainly late Miocene to Pliocene volcanic rocks,covered by an Upper Complex of younger(basaltic)andesitic lava flows and tuffs on which currently four active volcanic edifices are built.In the Lower Complex sub-volcanic and deeper-seated intrusives of the so-called Prasolov and Dokuchaev magmatic complexes are found.More differentiated,tonalitic-granodioritic rocks were collected from these small intrusive bodies.An early Oligocene zircon LA-ICP-MS U/Pb age of 31 Ma for the Prasolov Complex was obtained,showing that the basement of Kunashir Island is older than previously thought.Thermochronometry(apatite fission-track and U-Th-Sm/He and zircon U-Th/He analyses) further shows that the magmatic basement of the island was rapidly exhumed in the Pleistocene to present levels in a differential pattern,with He-ages ranging from 1.9 to 0.8 Ma.It is shown that the northern section of the island was hereby exhumed more intensely. | J.De Grave F.I.Zhimulev S.Glorie G.V.Kuznetsov N.Evans F.Vanhaecke B.McInnes | 2016 | Geoscience Frontiers2016，7，2： | 2 |
| 14 | Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis显示文摘Background:Liver regeneration following partial hepatectomy(PHx)is a complicated process involving multiple organs and several types of signaling networks.The bile acid-activated metabolic pathways occupy an auxiliary yet important chapter in the entire biochemical story.PHx is characterized by rapid but transient bile acid overload in the liver,which constitutes the first wave of proliferative signaling in the remnant hepatocytes.Bile acids trigger hepatocyte proliferation through activation of several nuclear receptors.Following biliary passage into the intestines,enterocytes reabsorb the bile acids,which results in the activation of farnesoid X receptor(FXR),the consequent excretion of fibroblast growth factor(FGF)19/FGF15,and its release into the enterohepatic circulation.FGF19/FGF15 subsequently binds to its cognate receptor,fibroblast growth factor receptor 4(FGFR4)complexed withβ-klotho,on the hepatocyte membrane,which initiates the second wave of proliferative signaling.Because some bile acids are toxic,the remnant hepatocytes must resolve the potentially detrimental state of bile acid excess.Therefore,the hepatocytes orchestrate a bile acid detoxification and elimination response as a protective mechanism in concurrence with the proliferative signaling.The response in part results in the excretion of(biotransformed)bile acids into the canalicular system,causing the bile acids to end up in the intestines.Relevance for patients:Recently,FXR agonists have been shown to promote regeneration via the gut-liver axis.This type of pharmacological intervention may prove beneficial for patients with hepatobiliary tumors undergoing PHx.In light of these developments,the review provides an in-depth account of the pathways that underlie post-PHx liver regeneration in the context of bile acid homeostasis in the liver and the gut-liver signaling axis. | Lianne de Haan Sarah Jvan der Lely Anne-Loes K.Warps Quincy Hofsink Pim B.Olthof Mark J.de Keijzer Daniel A.Lionarons Lionel Mendes-Dias Bote G.Bruinsma Korkut Uygun Hartmut Jaeschke Geoffrey C.Farrell Narci Teoh Rowan Fvan Golen Tiangang Li Michal Heger | 2018 | Journal of Clinical & Translational Research2018，4，1： | 2 |
| 15 | Quality of life, health‐related quality of life and health status in patients having restorative proctocolectomy with ileal pouch‐anal anastomosis for ulcerative colitis: a systematic review显示文摘 | J. T.Heikens J.de Vries C. J. H. M.van Laarhoven | 2012 | Colorectal Disease2012，，5： | 2 |
| 16 | Does international openness affect the productivity of local firms显示文摘 | J.P.Damijan J.De Sousa O.Lamotte | | 0，，03： | 1 |
| 17 | Liver resection of colorectal metastases in elderly patients显示文摘 | R.Adam A.Frilling D.Elias C.Laurent E.Ramos L.Capussotti G. J.Poston D. A.Wicherts R. J.de Haas | 2010 | Br J Surg2010，，3： | 1 |
| 18 | Long‐term outcomes after hepatic resection for colorectal metastases in young patients显示文摘 | Robbert J.de Haas Dennis A.Wicherts ChadiSalloum PaolaAndreani DobromirSotirov RenéAdam DenisCastaing DanielAzoulay | 2010 | Cancer2010，，3： | 1 |
| 19 | Crigler‐Najjar syndrome in The Netherlands: Identification of four novel UGT1A1 alleles, genotype–phenotype correlation, and functional analysis of 10 missense mutants显示文摘 | NinaSneitz Conny T.Bakker Robert J.de Knegt Dicky J.J.Halley MosheFinel Piter J.Bosma | 2009 | Hum Mutat2009，，1： | 1 |
| 20 | Correlation and synchrony transfer in integrate-fire neurons:basic properties and consequences for coding显示文摘 | E.Shea-Brown K.Josic J.de la Rocha | | 0，，： | 1 |
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