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| 1 | Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system显示文摘允许的技术内长的基因的特定的规定为基因功能的学习是珍贵的并且在治疗学有大潜力。我们创造了在 CRISPR 上系统,由核酸酶死者 Cas9 (dCas9 ) 蛋白质组成的二部件的 transcriptional 使活跃之物与互补顺序与 transcriptional 激活域和单个指南 RNA (sgRNAs ) 熔化了到基因倡导者。我们证明在 CRISPR 上能高效地以一种悦耳的方式在人和老鼠房间激活外长的记者基因。另外,我们证明在 vivo 的柔韧的记者基因激活能被把系统部件注入老鼠接合子完成。而且,我们证明在 CRISPR 上能激活内长的 IL1RN, SOX2,和 OCT4 基因。最有效的基因激活被对近似倡导者有约束力的 3-4 sgRNAs 的簇完成,建议他们在基因正式就职的 synergistic 行动。显著地,当指向多重基因的 sgRNAs 同时被介绍进房间时,柔韧的多路的内长的基因激活被完成。染色体宽的表示介绍表明了系统的高特性。 | Albert W Cheng Haoyi Wang Hui Yang Linyu Shi Yarden Katz Thorold W Theunissen Sudharshan Rangarajan Chikdu S Shivalila Daniel B Dadon Rudolf Jaenisch | 2013 | Cell Research2013，23，10： | 65 |
| 2 | 美国退伍军人事务部/国防部成人脑卒中康复治疗管理临床实践指南(执行简写版)显示文摘背景专家委员会制定的卒中康复指南应用于退伍军人健康管理部门及国防部卫生保健系统。方法根据以前发表的指南,委员会利用美国预防服务特别工作组制定的标准,评价了截至到2002年发表的文献。指南根据临床随机化实验、非对照性研究等证据提出建议(如缺乏确定的数据则根据专家组的建议)。结果Ⅰ级水平的建议包括:在多学科康复环境中或卒中单元中传递卒中治疗,通过NI HSS对卒中患者进行评价,早期启动康复治疗,对吞咽困难患者进行吞咽功能筛查,积极进行二级预防,预防深静脉血栓等。推荐应用标准化的评价工具制定适合每个患者的全面的治疗计划。强烈建议进行抗抑郁及情感波动方面的治疗。语言治疗师应评价患者的交流及认知障碍,并在需要时提供治疗。患者、家属及护理者是康复小组的重要成员,应当介入康复的全部疗程。这些建议在以下网站可查询:http://gffzz5f80cf956d2d4616hkvcvpqxnk6pb6nb6.ffgz.tsg.suse.edu.cn/cgi/content/full/36/9/e100。并附有每项建议的全文证据表。结论这些建议应平等地应用于所有临床环境中的所有卒中康复患者,而不是仅针对联邦医疗系统的临床问题或资源。 | Barbara Bates John Y. Choi Pamela W. Duncan Jonathan J. Glasberg Glenn D. Graham Richard C. Katz Kerri Lamberty Dean Reker Richard Zorowitz 杨雅琴(译) 王拥军(译) | 2006 | 中国康复理论与实践2006，12，1： | 19 |
| 3 | Presence of Porphyromonas gingivalis in gingival squamous cell carcinoma显示文摘Periodontal disease has been recently linked to a variety of systemic conditions such as diabetes, cardio-vascular disease, preterm delivery, and oral cancer. The most common bacteria associated with periodontal disease, Porphyromonas gingivalis (P. gingivalis) has not yet been studied in the malignant gingival tissues. The objective of this study was to investigate the presence of P. gingivalis in specimens from squamous cell carcinoma patients. We have performed immunohistochemical staining to investigate the presence of P. gingivalis and Streptococcus gordonii (S. gordonii), a non invasive oral bacteria, in paraffin embedded samples of gingival squamous cell carcinoma (n=10) and normal gingiva (n=5). Staining for P. gingivalis revealed the presence of the bacteria in normal gingival tissues and gingival carcinoma, with higher levels (more than 33%, P<0.05) detected in the carcinoma samples. The staining intensity was also significantly enhanced in the malignant tissue by 2 folds (P<0.023) compared to specimens stained for the non-invasive S. gordonii. P. gingivalis is abundantly present in malignant oral epithelium suggesting a potential association of the bacteria with gingival squamous cell carcinoma. | Joseph Katz Mairelys D. Onate Kaleb M. Pauley Indraneel Bhattacharyya Seunghee Cha | 2011 | International Journal of Oral Science2011，3，4： | 19 |
| 4 | A view of cloud computing显示文摘 | Michael Armbrust Armando Fox Rean Griffith Anthony D. Joseph Randy Katz Andy Konwinski Gunho Lee David Patterson Ariel Rabkin Ion Stoica Matei Zaharia | 2010 | Communications of the ACM2010，，4： | 13 |
| 5 | 硝苯吡啶治疗贲门失弛缓症12例临床分析显示文摘贲门失弛缓症(AC)是食道运动障碍性疾病,以吞咽困难,胸骨后疼痛及食物返流为最常见症状。本文就硝苯吡啶(NF)治疗AC的临床效果报道如下。材料和方法 1.临床资料:AC12例,其中中国人8例,加拿大人4例。男7例,女5例,平均年龄41岁。平均病程48年。食道造影示食道下端狭窄,上段食道平均宽度为4.9cm。内镜示食道有潴留物,食道下段充血水肿。1例有溃疡。胃镜能通过者6例,不能通过者6例。 | 沈炳棣 Katz S | 1990 | 实用内科杂志1990，10，11： | 13 |
| 6 | A view of cloud computing显示文摘 | Michael Armbrust Armando Fox Rean Griffith Anthony D. Joseph Randy Katz Andy Konwinski Gunho Lee David Patterson Ariel Rabkin Ion Stoica Matei Zaharia | 2010 | Communications of the ACM2010，，4： | 5 |
| 7 | 素质教育政策、新自由主义与影子教育在中国的兴起显示文摘当前,我国影子教育治理正从“治标”向“治本”迈进。在此背景下,该文重新考察了素质教育政策对义务教育阶段影子教育兴起的影响机制,并就新自由主义是否在其中发挥作用的问题进行了重点探讨。该文通过对政策设计文本以及对政策执行典型案例的考察,发现该政策在设计时就忽视了影子教育,在执行中又通过减少在校备考时间,对正式教育进行了限制,使得学生难以仅通过在校上学就能满足不变的升学需求。供求失衡为影子教育市场创造了扩张空间。因此,素质教育政策是我国影子教育兴起的一项必要条件。过去的研究常将教育领域内的“公退民进”与新自由主义联系起来。然而,该文考察了素质教育政策出台前后的文本材料和财政数据,发现这些政策的主体内容可追溯到计划经济时代,且从未明显出现批判的马克思主义视角中的国家财政从公共教育中“大撤退”。因此,该文的结论是,作为民办教育的影子教育并非源于“新自由主义”治理策略。但基于研究发现,该文认为,“治本”仍须反“新自由主义”之道而行,配合最新的教育评价改革,以已有或新增的独立高考录取区为单位试点统一大幅增加在校时间以开展素质教育,从而缩减应试型影子教育的生存空间。 | 王捷 Ilan Katz 岳经纶 | 2021 | 中国青年研究2021，，7： | 5 |
| 8 | The chronology and intellectual trajectory of American entrepreneurship education显示文摘 | Jerome A Katz | 2002 | Journal of Business Venturing2002，，2： | 4 |
| 9 | How much does performance matter? A meta-analysis of CEO pay studies显示文摘 | Henry L. Tosi Steve Werner Jeffrey P. Katz Luis R. Gomez-Mejia | 2000 | Journal of Management2000，，2： | 4 |
| 10 | 关于与青光眼疾病严重性相关的资源使用和成本的一项多中心回顾性试验研究显示文摘目的:调查在不同疾病严重程度上青光眼治疗的资源消耗和直接成本。
设计:基于医学档案综述的观察性、回顾性的队列研究。 | Paul P. Lee John G. Walt John J. Doyle Sameer V. Kotak Stacy J. Evans Donald L. Budenz Philip P. Chen Anne L. Coleman Robert M. Feldman HenRY D. Jampel L.Jay Katz Richard P.Mills Jonathan S.Myers Robert J.Noecker Jody R.Piltz-Seymour Robert R.Ritch Paul N.Schacknow Janet B.Serle Gary L.Trick 范翔(译) | 2006 | 美国医学会眼科杂志(中文版)2006，18，4： | 4 |
| 11 | Borderline Resectable Pancreatic Cancer: Need for Standardization and Methods for Optimal Clinical Trial Design显示文摘 | Matthew H. G. Katz Robert Marsh Joseph M. Herman Qian Shi Eric Collison Alan P. Venook Hedy L. Kindler Steven R. Alberts Philip Philip Andrew M. Lowy Peter W. T. Pisters Mitchell C. Posner Jordan D. Berlin Syed A. Ahmad | 2013 | Annals of Surgical Oncology2013，，8： | 4 |
| 12 | 动脉粥样硬化多种族研究中代谢综合征和糖尿病作为主动脉瓣膜钙化预测因素的特点 | Katz R. Wong N.D. Kronmal R. K.D. O'Brien 刘少伟 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，0，7： | 4 |
| 13 | Antiviral therapy in cytomegalovirus-positive ulcerative colitis:A systematic review and meta-analysis显示文摘AIM:To evaluate the impact of antiviral treatment on cytomegalovirus(CMV)-positive ulcerative colitis patients.METHODS:We performed a systematic review and meta-analysis(MA)of comparative cohort and casecontrol studies published between January 1966 and March 2013.Studies focusing on colectomy series and studies including only less than 3 patients in the treated or non-treated arm were excluded.The primary outcome was colectomy within 30 d of diagnosis.Secondary outcomes included colectomy during the follow-up period Subgroup analyses by method of detection of CMV,study design,risk of bias and country of origin were performed.Quality of studies was evalu-ated according to modified New-Castle Ottawa Scale.RESULTS:After full-text review,nine studies with a total of 176 patients were included in our MA.All the included studies were of low to moderate quality.Patients who have received antiviral treatment had a higher risk of 30-d colectomy(OR=2.40;95%CI:1.05-5.50;I2=37.2%).A subgroup analysis including only patients in whom CMV diagnosis was based did not demonstrate a significant difference between the groups(OR=3.41;95%CI:0.39-29.83;I2=56.9%).Analysis of long-term colectomy rates was possible for 6 studies including110 patients.No statistically significant difference was found between the treated and untreated groups(OR=1.71;95%CI:0.71-4.13;6 studies,I2=0%).Analysis of mortality rate was not possible due to a very limited number of cases.Stratification of the outcomes by disease severity was not possible.CONCLUSION:No positive association between antiviral treatment and a favorable outcome was demonstrated.These findings should be interpreted cautiously due to primary studies’quality and potential biases. | Uri Kopylov Noa Eliakim-Raz Andrew Szilagy Ernest Seidman Shomron Ben-Horin Lior Katz | 2014 | World Journal of Gastroenterology2014，20，10： | 4 |
| 14 | A 10-year review of a minimally invasive technique for the correction of pectus excavatum显示文摘 | Donald Nuss Robert E Kelly Daniel P Croitoru Michael E Katz | 1998 | Journal of Pediatric Surgery1998，，4： | 4 |
| 15 | Reliability of the ocular trauma score for the predictability of traumatic and post-traumatic retinal detachment after open globe injury显示文摘AIM: To elucidate the question of whether the ocular trauma score(OTS) and the zones of injury could be used as a predictive model of traumatic and post traumatic retinal detachment(RD) in patients with open globe injury(OGI).METHODS: A retrospective observational chart analysis of OGI patients was performed. The collected variables consisted of age, date, gender, time of injury, time until repair, mechanism of injury, zone of injury, injury associated vitreous hemorrhage, trauma associated RD, post traumatic RD, aphakia at injury, periocular trauma and OTS in cases of OGI. RESULTS: Totally 102 patients with traumatic OGI with a minimum of 12 mo follow-up and a median age at of 48.6 y(range: 3-104 y) were identified. Final best corrected visual acuity(BCVA) was independent from the time of repair, yet a statistically significant difference was present between the final BCVA and the zone of injury. Severe trauma presenting with an OTS score Ⅰ(P<0.0001) or Ⅱ(P<0.0001) revealed a significantly worse BCVA at last follow up when compared to the cohort with an OTS score >Ⅲ. OGI associated RD was observed in 36/102 patients(35.3%), whereas post traumatic RD(defined as RD following 14 d after OGI) occurred in 37 patients(36.3%). OGI associated RD did not correlate with the OTS and the zone of injury(P=0.193), yet post traumatic RD correlated significantly with zone Ⅲ injuries(P=0.013). CONCLUSION: The study shows a significant association between lower OTS score and zone Ⅲ injury with lower final BCVA and a higher number of surgeries, but only zone Ⅲ could be significantly associated with a higher rate of RD. | Simon Dulz Vasilis Dimopoulos Toam Katz Robert Kromer Eileen Bigdon Martin Stephan Spitzer Christos Skevas | 2021 | International Journal of Ophthalmology(English edition)2021，14，10： | 4 |
| 16 | 中国人群长期饮水氟接触与骨折关系调查研究显示文摘国外有关饮水氟浓度与骨折关系的报道结果不一致 ,为深入研究饮水中不同浓度的氟对人群骨折的影响 ,采用环境流行病学回顾性调查方法 ,按统一设计的调查方法与询问表 ,调查了 6个饮水氟浓度不同地区人群 (氟浓度分别为 0 2 5~ 0 34、0 5 8~ 0 73、1 0 0~ 1 0 6、1 45~ 2 19、2 6 2~ 3 5 8、4 32~ 7 97mg L)的骨折发生情况及其影响因素。内容包括 :氟暴露水平、骨折情况、人口构成、病史、体格检查、吸烟史、饮酒史、饮水量和膳食营养等。各组≥ 5 0岁的调查人数分别为 136 3、140 7、1370、15 74、10 5 1、15 0 1人 ,共计 82 6 6人。统计分析结果表明 ,饮水中的氟是其主要摄氟来源。 6组人群的全部骨折率分别为 7 41%、6 40 %、5 11%、6 0 4%、6 0 9%和 7 40 % ;自然骨折率分别为 3 0 1%、2 2 1%、1 31%、1 6 5 %、1 43%和 3 6 6 % ,二者均与饮水氟浓度之间呈现U型曲线相关关系。其中以饮水氟为 1 0 0~ 1 0 6mg L组人群的骨折率最低 ,与最低和最高饮水氟组的骨折率比较有显著性差别 (P <0 0 1)。 6组人群髋部骨折率依次为 0 37%、0 43%、0 37%、0 89%、0 76 %和 1 2 0 % ,虽未出现U型曲线关系 ,但仍以饮水氟为 4 32~ 7 97mg L组人群的髋部骨折率最高 ,显著高于 1 0 0~ 1 0 | 梁超轲 吉荣娣 曹静祥 程溆 葛相金 高玉真 张淑兰 卢振明 王景占 马凤 吴云鹏 应波 张妍 孙淑庄 Li Yiming Barry P Katz | 2001 | 卫生研究2001，30，5： | 4 |
| 17 | The Cost-Effectiveness of Neoadjuvant Chemoradiation is Superior to a Surgery-First Approach in the Treatment of Pancreatic Head Adenocarcinoma显示文摘 | Daniel E. Abbott Ching-Wei David Tzeng Ryan P. Merkow Scott B. Cantor George J. Chang Matthew Harold Katz David J. Bentrem Karl Y. Bilimoria Christopher H. Crane Gauri R. Varadhachary James L. Abbruzzese Robert A. Wolff Jeffrey E. Lee Douglas B. Evans Jas | 2013 | Annals of Surgical Oncology2013，，3： | 3 |
| 18 | Operative Blood Loss Independently Predicts Recurrence and Survival After Resection of Hepatocellular Carcinoma显示文摘 | Steven C. Katz Jinru Shia Kui Hin Liau Mithat Gonen Leyo Ruo William R. Jarnagin Yuman Fong Michael I. D?Angelica Leslie H. Blumgart Ronald P. DeMatteo | 2009 | Annals of Surgery2009，，4： | 3 |
| 19 | 社交媒体影响社会和政治运作的方式和逻辑--美国知名新兴媒体研究专家James Katz教授访谈录显示文摘伴随可移动设备的广泛推广,社交媒体及其应用日益渗透进人们的日常生活,成为人际沟通不可或缺的信息来源。它的迅速发展与革新,不仅潜移默化地改变了人们的交往方式,形成并丰富了一种社会文化形态,甚至深刻影响了一个国家的政治运作模式与公民政治参与的可能性。除此以外,移动媒体及社交媒体的普遍使用,还塑造了包括视觉传播在内的各种传播活动中的个人身份认知,带来了用户群体间的代际差异与使用鸿沟等问题。2017年9月,美国知名新兴媒体研究专家James Katz教授受邀访问清华大学新闻与传播学院,就以上话题阐述观点与见解。 | 金兼斌 James Katz 杨虹艳(翻译) 杨颖(翻译) | 2018 | 全球传媒学刊2018，5，2： | 3 |
| 20 | SURGICAL MANAGEMENT OF RENAL TUMORS 4 CM. OR LESS IN A CONTEMPORARY COHORT显示文摘 | CHERYL T. LEE JARED KATZ WEIJI SHI HOWARD T. THALER VICTOR E. REUTER PAUL RUSSO | 2000 | The Journal of Urology2000，，： | 3 |
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