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| 1 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 2 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 3 | 高危患者目标血压与心血管病预后显示文摘指南推荐血压目标值应〈140/90 mmHg(1mmHg=0.133kPa)以减少心血管事件的发生。但与其他心血管病预后(如冠状动脉事件)相比,包括脑卒中及心力衰竭在内的心血管病预后与收缩压下降关系更密切。一些心血管事件(如冠状动脉事件)风险在收缩压低时亦增高,风险-收缩压关系呈J形曲线,而脑卒中与血压不是J形曲线关系。 | B?hm M Schumacher H Teo KK Lonn EM Mahfoud F Mann JF Mancia G Redon J Schmieder RE Sliwa K Weber MA Williams BYusuf S 曲浥晨 叶鹏 | 2017 | 中华高血压杂志2017，25，6： | 14 |
| 4 | Pancreatic ductal system obstruction and acute recurrent pancreatitis显示文摘Acute recurrent pancreatitis is a clinical entity largely associated with pancreatic ductal obstruction. This latter includes congenital variants, of which pancreas divisum is the most frequent but also controversial, chronic pancreatitis, tumors of the pancreaticobiliary junction and sphincter of Oddi dysfunction. This review summarizes current knowledge about diagnostic work-up and therapy of these conditions. | M Delhaye C Matos M Arvanitakis J Devière | 2008 | World Journal of Gastroenterology2008，14，7： | 12 |
| 5 | 血管紧张素Ⅱ2型受体的基因多态性(+1675G/A)对已接受治疗高血压患者的左心室肥大和左心室构型的作用显示文摘已有报道显示血管紧张素Ⅱ2型受体的基因多态性(AGTR2+1675G/A)与左心室肥大(left ventric-ular hypertrophy,LVH)相关。研究者检验这种基因多态性是否影响已按高血压治疗指南治疗的原发性高血压和心血管疾病患者的LVH和左心室构型参数。 | 张玲玉 叶鹏 Huber M V ller H Jakob S Reibis R Do V Bol-brinker J Zergibel I Schmieder RE Treszl A Wegscheider K Kreutz R | 2010 | 中华高血压杂志2010，18，12： | 6 |
| 6 | Cultured keratinocyte grafting on various biologic matrices显示文摘1IntroductionCulturedkeratinocytesasrelativelydiferenti-atiedsheetgraftshaveimprovedthecareforburnsandotherwounds.Forthelastd... | Stark GB△ Horch RE Voigt M Kopp J Saied S Jiao XY | 1998 | 第二军医大学学报1998，19，S1： | 3 |
| 7 | Crohn’s Disease–Associated Adherent Invasive Escherichia coli Modulate Levels of microRNAs in Intestinal Epithelial Cells to Reduce Autophagy显示文摘 | Hang Thi Thu Nguyen Guillaume Dalmasso Stefan Müller Jessica Carrière Frank Seibold Arlette Darfeuille–Michaud | 2014 | Gastroenterology2014，，2： | 3 |
| 8 | Comparative Evaluation of 29 Commercial H elicobacter pylori Serological Kits显示文摘 | Christophe Burucoa Jean‐Charles Delchier Anne Courillon‐Mallet Jean‐Dominique Korwin Francis Mégraud Frank Zerbib Josette Raymond Jean‐Louis Fauchère | 2013 | Helicobacter2013，，3： | 3 |
| 9 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 10 | 开放或血管腔内修复腹主动脉瘤21178例的荟萃分析显示文摘目的已有几个研究比较择期开放和血管腔内方法治疗腹主动脉瘤的预后,而结果并不一致。方法进行随机效应meta分析对手术结果、术后并发症、30天死亡率和术后患者长期存活率进行比较。以优势比(ORs)、加权平均差异(WMDs)或者log风险比(HRs)等合适的方法来比较事件终点。结果42个研究共21178例患者(开放10855例;血管腔内10323例)被纳入。在择期手术组(20715例),血管腔内方法的重症监护时间较短(WMD-36h;P<0.001),术后总住院时间亦较短(WMD-5.4d;P<0.001)。心脏并发症(OR1.76;P=0.002)和呼吸系统并发症(OR4.01;P<0.001)在开放手术后更常见。在血管腔内组,30天死亡率较低(OR0.46;P<0.001)。血管腔内手术的远期动脉瘤相关死亡率也较低(HR0.39;P<0.001)。对于破裂性腹主动脉瘤(463例),这种微创手术的重症监护时间较短(WMD-100.4h;P=0.005),30天死亡率也明显为低(OR0.45;P=0.005)。结论血管腔内修复腹主动脉瘤在降低术后不良事件和30天死亡率等方面成效显著。对于更远期,其动脉瘤相关死亡率也明显降低,但总体死亡率没有降低。 | 李梓伦 刘仁斌 Lovegrove RE Javid M Magee TR | 2008 | 中华普通外科学文献(电子版)2008，2，5： | 2 |
| 11 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 12 | A next-generation marker genotyping platform(AmpSeq)in heterozygous crops:a case study for marker-assisted selection in grapevine显示文摘Marker-assisted selection(MAS)is often employed in crop breeding programs to accelerate and enhance cultivar development,via selection during the juvenile phase and parental selection prior to crossing.Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery.To bridge the gap between marker development and MAS implementation,this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery,low-cost genotyping through amplicon sequencing(AmpSeq)and decision making.The results document the development of a MAS package derived from genotyping-by-sequencing using three traits(flower sex,disease resistance and acylated anthocyanins)in grapevine breeding.The vast majority of sequence reads(⩾99%)were from the targeted regions.Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data,most amplicons(83 to 87%)had<10%missing data,and read depth had a median of 220–244×.Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy,flexibility,speed,high-throughput,low-cost and easily automated analysis. | Shanshan Yang Jonathan Fresnedo-Ramíre Minghui Wang Linda Cote Peter Schweitzer Paola Barba Elizabeth M Takacs Matthew Clark James Luby David C Manns Gavin Sacks Anna Katharine Mansfield Jason Londo Anne Fennell David Gadoury Bruce Reisch Lance Cadle-Davidson Qi Sun | 2016 | Horticulture Research2016，3，1： | 2 |
| 13 | 血管生成素样蛋白2水平与肾移植术后主动脉僵硬度和死亡率呈正相关显示文摘血管生成素样蛋白2(angiopoietin-like-2,ANGPTL2)是一种分泌性糖蛋白,可诱发血管内皮功能障碍、动脉粥样硬化和心血管病。循环ANGPTL2在慢性肾脏病(chronic kidney disease,CKD)患者中增加,加重患心血管病的风险。 | Desjardins MP Thorin-Trescases N Sidibé A Fortier C DeSerres SA Larivière R Thorin E Agharazii M 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 14 | Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin 显示文摘 | Itoh H Mukoyarna M Pratt RE | 1993 | Clin Invest1993，91，2： | 1 |
| 15 | Bactericidal oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes and Salmonella enterica 显示文摘 | Friedman M Henika PR activities of plant essential Mandrell RE | 2002 | J Food Prot2002，65，10： | 1 |
| 16 | Admission blood glucose level as risk indicator of death after myocardial infarction in patients with and without diabetes mellitus显示文摘 | Stranders I Diamant M van Gelder RE | 2004 | Arch Intern Med2004，164，： | 1 |
| 17 | The efficacy of metronidazole 1% cream once daily and compared with metronidazole 1% cream twice daily and their vehicles in rosacea:A double-blind clinical trial显示文摘 | Lebwohl M Tobey RE | 1998 | Am Acad Dermatol1998，39，： | 1 |
| 18 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | Wilkinson CP Fen'is FL Klein RE Lee PP Agardh CD Davis M | 2003 | Ophthalmology2003，110，5： | 1 |
| 19 | DeoxyArbutin:a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency显示文摘 | Boissy RE Visscher M DeLong MA | 2005 | Exp Dermatol2005，14，8： | 1 |
| 20 | Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center:an autopsy study over a 15-year period (1989-2003)显示文摘 | Chamilos G Luna M Lewis RE | 2006 | Haematologica2006，91，7： | 1 |
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