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| 1 | Vascular endothelial growth factor trap-eye(Aflibercept) for the management of diabetic macular edema显示文摘Diabetic retinopathy(DR)is the most common cause of visual loss among working age individuals.Diabetic macular edema(DME)is an important complication of DR that affects around one third of the patients with DR.Several treatments have been approved for DME ranging from blood pressure and glycemic control to photocoagulation and more recently the use of vascular endothelial growth factor(VEGF)antagonists.The index review discusses aflibercept(EYLEA-Regeneron Pharmaceuticals,Inc.,Tarrytown,New York,NY,and Bayer Healthcare Pharmaceuticals,Berlin,Germany)in the context of other VEGF antagonists currently available for the treatment of DME.A systematic search of literature was conducted on PubMed,Scopus,and Google Scholar with no limitation on language or year of publication.Pre-clinical studies of aflibercept have shown a higher affinity of this molecule for vascular endothelial growth factor A(VEGF-A)along with a longer duration of action as compared to other VEGF antagonists.Recent clinical trials have shown visual outcome results for aflibercept to be similarly favorable as compared to other available agents with the added benefit of fewer required injections and less frequent monitoring.Aflibercept presents a potential exciting new addition to the armamentarium of current VEGF antagonists available for the treatment of DME and other retinal vascular diseases.However,further studies are indicated to confirm the role,safety,and efficacy of aflibercept for DME. | Ahmadreza Moradi Yasir Jamal Sepah Mohammad Ali Sadiq Humzah Nasir Salima Kherani Raafay Sophie Diana V Do Quan Dong Nguyen | 2013 | World Journal of Diabetes2013，4，6： | 8 |
| 2 | 血管紧张素Ⅱ2型受体的基因多态性(+1675G/A)对已接受治疗高血压患者的左心室肥大和左心室构型的作用显示文摘已有报道显示血管紧张素Ⅱ2型受体的基因多态性(AGTR2+1675G/A)与左心室肥大(left ventric-ular hypertrophy,LVH)相关。研究者检验这种基因多态性是否影响已按高血压治疗指南治疗的原发性高血压和心血管疾病患者的LVH和左心室构型参数。 | 张玲玉 叶鹏 Huber M V ller H Jakob S Reibis R Do V Bol-brinker J Zergibel I Schmieder RE Treszl A Wegscheider K Kreutz R | 2010 | 中华高血压杂志2010，18，12： | 6 |
| 3 | 新兴的微乳技术(英)显示文摘从本世纪40年代初舒尔曼及其助手发现微乳以来,微乳已被广泛地应用于许多领域。微乳具有很高的界面面积,稳定的热力学特性及对难溶液体的强溶解性,所以它被广泛地用在化妆品、制药、润滑剂、食品、农业喷洒、涂料、环境治理、清洗、燃料、化学合成、微孔介质的合成、提高反应的动力学特性、化学分析等诸多领域。讨论了微乳在新兴技术中的应用研究。 | V贺哈布拉 ML弗里 PK坎 SE特鲁斯代尔 DO沙欣 于艳 | 1999 | 日用化学品科学1999，22，1： | 5 |
| 4 | Wavelet-based texture retrieval using generalized gaussian density and kullback-leibler distance显示文摘 | Do M N Martin V M | 2002 | IEEE Transactions on Image Processing (S1057-7149)2002，11，2： | 1 |
| 5 | The effect of wating for radiotherapy for grade/ N gliomss显示文摘 | Do V Gebski V Barton M | 2000 | Radiother Oncol2000，57，2： | 1 |
| 6 | Physicochemical properties of native and partially gelatinized high-amylose jackfruit (Artocarpus heterophyllus Lain)seed starch显示文摘 | Tran P L Dang H D N Do V H | 2015 | Lebensmittel- Wissenschaft und-Technologie2015，62，2： | 1 |
| 7 | Treatment of traumatic cervical arteriovenous fistulas with N-butyl-2- cyanoacrylate 显示文摘 | Jayaraman M V Do H M Marks M P | 2007 | Am J Neuroradiol2007，28，2： | 1 |
| 8 | Quantitative detection of goats' milk in sheep's milk by real-timePCR显示文摘 | LOPEZ-CALLEJA I GONZAEZ I FAJAR DO V | | 0，，： | 1 |
| 9 | A randomized clini- cal trial of repetitive transcranial magnetic stimulation in pa- tients with refractory epilepsy显示文摘 | Fregni F Otachi P T Do V A | 2006 | Ann Neurol2006，60，4： | 1 |
| 10 | Uterine papillary serous carcinoma: patterns of failure and survival显示文摘 | Wang W Do V Hogg R | 2009 | Aust N Z J Obstet Gynaecol2009，49，4： | 1 |
| 11 | A mathematical model for analyzing the thermal characteristics of a flat micro heat pipe with a grooved wick 显示文摘 | DO K H KIM S J GARIMELLA S V | 2008 | International Journal of Heat and Mass Transfer2008，51，1920： | 1 |
| 12 | Transforming growth factor-beta1,transforming growth factor-beta2,and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition显示文摘 | DO T V KUBBA L A DU H | 2008 | Mol Cancer Res2008，6，5： | 1 |
| 13 | NMDA receptor antagonists sustain LTP and spatial memory: active processes mediate LTP decay显示文摘 | Villarreal DM Do V Haddad E | 2002 | Nat Neurosci2002，5，1： | 1 |
| 14 | Aniline polymerization into montmorillonite clay:a spectroscopic investigation of the intercalated conducting polymer显示文摘 | Nascimento G M do Constantino V R L Landers R | 2004 | Macromolecules2004，37，25： | 1 |
| 15 | The effect of wating for radiotherapy for Ⅲ/Ⅳ grade gliomas显示文摘 | Do V Gebeski V Barton MB | 2000 | Radiother Oncol2000，57，2： | 1 |
| 16 | Escherichia coli strains causing edema disease in northern Vietnam share an identical verotoxin 2e显示文摘 | Oanh T K Nguyen V K Do T N | 2010 | Trop Anim Health Prod2010，42，8： | 1 |
| 17 | Biological nitrogen fixation associated with sugarcane 显示文摘 | Boddey R M Urquiaga S Reis V Do bereiner J | 1991 | Plant Soil1991，137，： | 1 |
| 18 | Corrosion monitoring system based on measurement and analysis of eletrochemlcal nosie 显示文摘 | Do|ocek L V | 1995 | Corrosion Sci1995，4，： | 1 |
| 19 | Postharvest quality of jelly palm fruits as a result of maturity stage at harvest and temperature management显示文摘 | do Amarante C V T Megguer C A | 2008 | Cienc Rural2008，38，1： | 1 |
| 20 | Dutasteride 266-7 provides sustained symptom relief following short term combination treatment with tamsulosin显示文摘 | Barkin J Guimaraes M Do Castelo V | 2002 | J Urol2002，167，： | 1 |
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