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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Intracellular localization of hyaluronan in proliferating cells显示文摘 | Evanko S P Wight T N | 1999 | J Histochem Cytochem1999，47，10： | 2 |
| 3 | Thermal decomposition of solid RDX begins with nitrogen-nitrogen bond scission显示文摘 | Wight C A Botcher T R | | 0，，21： | 1 |
| 4 | Wide beam - column connections under earthquake - type loading显示文摘 | Wight J K | 1994 | Earthquake Spectra1994，10，4： | 1 |
| 5 | 2001 Consensus guidelines for the management of women with cervical intraepithelial neoplasia 显示文摘 | Wight TC Cox T Massad LS | 2003 | Am J Obstet Gynecol2003，189，4： | 1 |
| 6 | Effects of the menopause transition and hormone use on cognitive performa- nce in midlife women显示文摘 | H M Greendale GA Wight RG Seeman T | 2009 | nerology2009，72，21： | 1 |
| 7 | Transient thin film laser pyrolysis of RDX显示文摘 | Botcher T R Wight C A | | 0，，36： | 1 |
| 8 | Hyaluronan-cell interactions in cancer and vascular disease 显示文摘 | TOOLE B WIGHT T TAMMI M | 2002 | Biol Chem2002，277，7： | 1 |
| 9 | Hyaluronan-cell in- teractions in cancer and vau|ar disea 显示文摘 | TOOLE B P WIGHT T N TAMMI M I | 2002 | J Biol Chem2002，277，7： | 1 |
| 10 | Thermal decomposition kinetics of PBAN-binder and composite solid rocket propellants显示文摘 | Sell T Vyazovkin S Wight C A | 1999 | Combustion and Flame1999，119，： | 1 |
| 11 | Lamivudine for decompensated cirrhosis resulting form chronic hepatitis B显示文摘 | Wight T Rakela J | 2000 | Hepatology2000，31，： | 1 |
| 12 | Maintenance of ehondroitin sulfation balanee by ehondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis显示文摘 | Kltippel M Wight T N Chan C | 2005 | Development2005，132，17： | 1 |
| 13 | Lamivudine for decompensated cirrhosis resulting form chronic hepatitis B显示文摘 | Villeneuve JP Wight T Rakela J | 2000 | Hepatology2000，31，： | 1 |
| 14 | Proteoglycans in atherosclerosis andrestenosis:key roles for versican显示文摘 | WIGHT T N MERRILEES M J | 2004 | Circ Res2004，94，9： | 1 |
| 15 | Transgenic mice: a decade of progress in technology and research 显示文摘 | WAGNER T E | 1994 | Mut Res1994，307，2： | 1 |
| 16 | Wide beam-column connections under earthquake-type loading 显示文摘 | GENTRY T R WIGHT J K | 1994 | Earthquake Spectra1994，10，4： | 1 |
| 17 | Hyaluronan-cell interac-tions in cancer and vascular disease显示文摘 | Toole B P Wight T N Tammi M I | 2002 | J Biol Chem2002，277，7： | 1 |
| 18 | Successful 48-hour preservation of the rat liver by continuoushypothermic perfusion withhaemaccel-iso- tonic citrate solution 显示文摘 | Tamaki T Kamada N Wight DG | 1987 | Transplantation1987，43，4： | 1 |
| 19 | Lamivudine for decompen-sated cirrhosis resulting form chronic hepatitis B显示文摘 | Villeneuve JP Wight T Rakela J | 2000 | Hepatology2000，31，： | 1 |
| 20 | Versiean: a versatile extracellular matrix proteoglycan in cell biology 显示文摘 | WIGHT T N | 2002 | Current Opinion in Cell Biology2002，14，5： | 1 |
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