|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling显示文摘The NLRP3-IL-1β pathway plays an important role in adipose tissue(AT)-induced inflammation and the development of obesityassociated comorbidities.We aimed to determine the impact of NLRP3 on obesity and its associated metabolic alterations as well as its role in adipocyte inflammation and extracellular matrix(ECM)remodeling.Samples obtained from 98 subjects were used in a case-control study.The expression of different components of the inflammasome as well as their main effectors and inflammation-and ECM remodeling-related genes were analyzed.The impact of blocking NLRP3 using siRNA in lipopolysaccharide(LPS)-mediated inflammation and ECM remodeling signaling pathways was evaluated.We demonstrated that obesity(P<0.01),obesity-associated T2D(P<0.01)and NAFLD(P<0.05)increased the expression of different com ponents of the inflammasome as well as the expression and release of IL-1β and IL-18 in AT.We also found that obese patients with T2D exhibited increased(P<0.05)hepatic gene expression levels of NLRP3,IL1B and IL18.We showed that NLRP3,but not NLRP1,is regulated by inflammation and hypoxia in visceral adipocytes.We revealed that the inhibition of NLRP3 in human visceral adipocytes significantly blocked(P<0.01)LPS-induced inflammation by downregulating the mRNA levels of CCL2,IL1B,IL6,IL8,S100A8,S100A9,TLR4 and TNF as well as inhibiting(P<0.01)the secretion of IL1-β into the culture medium.Furthermore,blocking NLRP3 attenuated(P<0.01)the LPS-induced expression of important molecules involved in AT fibrosis(COL1A1,COL4A3,COL6A3 and MMP2).These novel findings provide evidence that blocking the expression of NLRP3 reduces AT inflammation with significant fibrosis attenuation. | Xabier Unamuno Javier Gomez-Ambrosi Beatriz Ramirez Amaia Rodriguez Sara Becerril Victor Valenti Rafael Moncada Camilo Silva Javier Salvador Gema Fruhbeck Victoria Catalan | 2021 | Cellular & Molecular Immunology2021，18，4： | 9 |
| 2 | GOECP/SEOR radiotheraphy guidelines for non-small-cell lung cancer显示文摘Non-small cell lung cancer(NSCLC) is a heterogeneous disease accounting for approximately 85% of all lung cancers. Only 17% of patients are diagnosed at an early stage. Treatment is multidisciplinary and radiotherapy plays a key role in all stages of the disease. More than 50% of patients with NSCLC are treated with radiotherapy(curative-intent or palliative). Technological advancesincluding highly conformal radiotherapy techniques, new immobilization and respiratory control systems, and precision image verification systems-allow clinicians to individualize treatment to maximize tumor control while minimizing treatment-related toxicity. Novel therapeutic regimens such as moderate hypofractionation and advanced techniques such as stereotactic body radiotherapy(SBRT) have reduced the number of radiotherapy sessions. The integration of SBRT into routine clinical practice has radically altered treatment of early-stage disease. SBRT also plays an increasingly important role in oligometastatic disease. The aim of the present guidelines is to review the role of radiotherapy in the treatment of localized, locally-advanced, and metastatic NSCLC. We review the main radiotherapy techniques and clarify the role of radiotherapy in routine clinical practice. These guidelines are based on the best available evidence. The level and grade of evidence supporting each recommendation is provided. | Nuria Rodriguez De Dios Arturo Navarro-Martin Cristina Cigarral Rodolfo Chicas-Sett Rafael Garcia Virginia Garcia Jose Antonio Gonzalez Susana Gonzalo Mauricio Murcia-Mejia Rogelio Robaina Amalia Sotoca Carmen Vallejo German Valtuena Felipe Counago | 2022 | World Journal of Clinical Oncology2022，13，4： | 2 |
| 3 | Prediction of the airblast wave effects near a tunnel advanced by drilling and blasting 显示文摘 | RAFAEL RODRIGUEZ JAVIER TORANO MARIO MENENDEZ | 2007 | Tunnelling and Underground Space Technology2007，22，： | 1 |
| 4 | Expression of COX-2 on Reed-Sternberg cells is an independent unfavorable prognostic factor in Hodgkin lymphoma treated with ABVD显示文摘 | Francisco Mestre Antonio Gutierrez Rafael Ramos Jordi Martinez-Serra Lydia Sánchez Gabriel Matheu Teresa Ros Juan Fernando Garcia Jose Rodriguez | 2012 | Blood2012，，25： | 1 |
| 5 | Role of hepatitis B, C, and D viruses in dual and triple infection: Influence of viral genotypes and hepatitis B precore and basal core promoter mutations on viral replicative interference显示文摘 | Rosendo Jardi Francisco Rodriguez Maria Buti Xose Costa Montserrat Cotrina Roman Galimany Rafael Esteban Jaime Guardia | 2001 | Hepatology2001，，2： | 1 |
| 6 | 'Changes in the Intellectual Structure of Strategic Management Research: A Bibliometric Study of the Strategic Management Journal: 1980- 2000显示文摘 | Antonio - Rafael Ramos - Rodriguez and Jose Ruiz -Navarro | 2004 | Strategic Management Journal2004，，25： | 1 |
| 7 | Shri nking the room for invasive mechanical ventilation in acute chronic hy- percapnic respiratory failure: yes, but must be sure to have opened win- dows for noninvasive ventilation显示文摘 | Esquinas Rodriguez Antonio M Scala Rafaelle Ambrosino Nicolino | 2013 | International journal of chronic ob- structive pulmonary disease2013，11，8： | 1 |
| 8 | FEM models including randomness and its application to the blasting vibra- tions prediction 显示文摘 | Javier Torano Rafael Rodriguez Isidro Diego | 2006 | Computers and Geotechnics2006，，33： | 1 |
| 9 | Propranolol plus placebo versus propranolol plus isosorbide-5-mononitrate in the prevention of a first variceal bleed: A double-blind RCT显示文摘 | Juan Carlos Garc??a-Pagán Rosa Morillas Rafael Ba?ares Agustin Albillos Candido Villanueva Carme Vila Joan Genescà Manuel Jimenez Manuel Rodriguez Jose Luis Calleja Joaquin Balanzó Fernando Garcáa-Durán Ramón Planas Jaume Bosch | 2003 | Hepatology2003，，6： | 1 |
| 10 | High Roughness Time Series Forecasting Based on Energy Associated of Series显示文摘 | Cristian Rodriguez Rivero Rafael Martin Herrera Julian Anatonio Pucheta Josef Sylvester Baumgartner Hector Daniel Patino Victor Hugo Sauchelli | 2012 | 通讯和计算机(中英文版)2012，9，5： | 1 |
| 11 | Analysis of the complete Nucleotide Sequence of African Swine Fever virus显示文摘 | Rafael Yanez Javier M Rodriguez Maria L | 1995 | Virology1995，208，： | 1 |
| 12 | Comparison of emergence and discharge times between two Total Intravenous Anesthesia techniques : Remifentanil and Fentanyl 显示文摘 | Diana Carolina Perez Lepez Geovanny Rodriguez Sanchez Jose Rafael Tovar Cuevas | 2013 | Colombian Journal of Anesthesiology2013，41，4： | 1 |
| 13 | The Synthesis and Properties of Nanoscale Ionic Materials显示文摘 | Robert Rodriguez Rafael Herrera Emmanuel P Giannelis | 2010 | Applied Organometallic Chemistry2010，24，： | 1 |
| 14 | Nanoscale Ionic Materials显示文摘 | Robert Rodriguez Rafael Herrera Lynden A Archer Emmanuel P Giannelis | 2008 | Advanced Materials2008，20，： | 1 |
| 15 | Oral care practices in intensive care units: a?survey of 59 European ICUs显示文摘 | Jordi Rello Despoina Koulenti Stijn Blot Rafael Sierra Emili Diaz Jan J. Waele Antonio Macor Kemal Agbaht Alejandro Rodriguez | 2007 | Intensive Care Medicine2007，，6： | 1 |
| 16 | Capillary electrophoresis for the determination of pesticide residues显示文摘 | Yolanda Pico Rafael Rodriguez Jordi Manes | 2003 | Trends in Analytical Chemistry2003，22，3： | 1 |
| 17 | FEM models including randomness and its application to the blasting vibrations Predietion显示文摘 | Javier Torano Rafael Rodriguez Isidro Diego | | 0，，： | 1 |
| 18 | Adding Support for High- Level Skeletal Animation 显示文摘 | Francisco J Sewn Rafael Rodriguez | 2002 | IEEE Transactions on Visualization and Computer Graphics2002，8，4： | 1 |
| 19 | Intermittent Hypoxia Induces Hyperlipidemia in Lean Mice显示文摘 | Jianguo Li Laura N. Thorne Naresh M. Punjabi Cheuk-Kwan Sun Alan R. Schwartz Philip L. Smith Rafael L. Marino Annabelle Rodriguez Walter C. Hubbard Christopher P. O’Donnell Vsevolod Y. Polotsky | 2005 | Circulation Research2005，，7： | 1 |
| 20 | Mutations in the basic core promoter region of hepatitis B virus. Relationship with precore variants and HBV genotypes in a Spanish population of HBV carriers显示文摘 | Rosendo Jardi Francisco Rodriguez Maria Buti Xose Costa Auristela Valdes Helena Allende Melanie Schaper Roman Galimany Rafael Esteban Jaime Guardia | 2003 | Journal of Hepatology2003，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员