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| 1 | Dopaminergic modulation of synaptic plasticity in rat prefrontal neurons显示文摘The prefrontal cortex(PFC) is thought to store the traces for a type of long-term memory – the abstract memory that determines the temporal structure of behavior often termed a 'rule' or 'strategy'. Long-term synaptic plasticity might serve as an underlying cellular mechanism for this type of memory. We therefore studied the induction of synaptic plasticity in rat PFC neurons, maintained in vitro, with special emphasis on the functionally important neuromodulator dopamine. First, the induction of long-term potentiation(LTP) was facilitated in the presence of tonic/background dopamine in the bath, and the dose-dependency of this background dopamine followed an 'inverted-U' function, where too high or too low dopamine levels could not facilitate LTP. Second, the induction of long-term depression(LTD) by low-frequency stimuli appeared to be independent of background dopamine, but required endogenous, phasically-released dopamine during the stimuli. Blockade of dopamine receptors during the stimuli and exaggeration of the effect of this endogenouslyreleased dopamine by inhibition of dopamine transporter activity both blocked LTD. Thus, LTD induction also followed an inverted-U function in its dopamine-dependency. We conclude that PFC synaptic plasticity is powerfully modulated by dopamine through inverted-U-shaped dose-dependency. | Satoru Otani Jing Bai Kevin Blot | 2015 | Neuroscience Bulletin2015，31，2： | 3 |
| 2 | A Functional Polymorphism of Toll-Like Receptor 4 Gene Increases Risk of Gastric Carcinoma and Its Precursors显示文摘 | Georgina L. Hold Charles S. Rabkin Wong–Ho Chow Malcolm G. Smith Marilie D. Gammon Harvey A. Risch Thomas L. Vaughan Kenneth E.L. McColl Jolanta Lissowska Witold Zatonski Janet B. Schoenberg William J. Blot N. Ashley G. Mowat Joseph F. Fraumeni Emad M. El | 2007 | Gastroenterology2007，，3： | 2 |
| 3 | Coordinate regulation of the mother centriole component Nlp by Nek2 and Plkl protein kinases显示文摘 | Rapley J Baxter JE Blot J | 2005 | Mol CeU Biol2005，25，4： | 1 |
| 4 | Effects of diclofenac, aceclofenae and meloxicam on the metabolism of proteoglycans and hyaluronin in osteoarthritic human cartilage显示文摘 | BLOT L | 2000 | Br J Pharmcol2000，131，7： | 1 |
| 5 | Theory of Propagation of Elastic Waves ina Fluid -saturated Porous Solid, Part I: Low - frequency Range; Part II: High - frequency Range 显示文摘 | BlOT M A | 1956 | Journal of the Acoustical Society of America1956，，2： | 1 |
| 6 | Offspring heahh risk after cosmetic breast implantation in Sweden 显示文摘 | Signorello LB Fryzek JP Blot WJ | 2001 | Ann Hast Surg2001，46，3： | 1 |
| 7 | Nutrition intervention trials in Linxian,China:supplementation with specific vitamin/mineral combinations,cancer incidence,and disease-specific mortality in the general population 显示文摘 | BLOT W J LI J Y TAYLOR P R | 1993 | Journal of the National Cancer Institute1993，85，18： | 1 |
| 8 | Theory of propagation of elastic waves in a fluid-saturated porous solid显示文摘 | BlOT M A | 1956 | The Journal of the Acoustical Society of America1956，28，2： | 1 |
| 9 | Prevention of ventilator-associated pneumonia with oral antiseptics: a systematic review and meta-analysis显示文摘 | Sonia O Labeau Katrien Van de Vyver Nele Brusselaers Dirk Vogelaers Stijn I Blot | 2011 | The Lancet Infectious Diseases2011，，11： | 1 |
| 10 | Thrombocytopenia and outcome in critically ill patients with bloodstream infection显示文摘 | Vandijck DM Blot SI De Waele JJ | 2010 | Heart Lung2010，39，1： | 1 |
| 11 | Diet and high risk of stomach cancer in shandong, China 显示文摘 | You W C Blot W J Chang Y S | 1998 | Cancer Re- search1998，48，： | 1 |
| 12 | Smoking and drinking in relation to oral and pharyngeal cancer 显示文摘 | Blot WJ McLaughlin JK Winn DM | 1988 | Cancer Resesrch1988，48，： | 1 |
| 13 | Fungal infections in patients with severe acute pancreatitis and the use of prophylactic therapy显示文摘 | De Waele JJ Vogelaers D Blot S | 2003 | Clin Infect Dis2003，37，2： | 1 |
| 14 | The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficieney virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor显示文摘 | Wyss S Berlioz-Torrent C Boge M Blot G Honing S Benarous R Thali M | 2001 | J Virol2001，75，6： | 1 |
| 15 | Improved survival in rats adminis-tered Ng-nitro-L-arginine methyl ester due to converting enzymeinhibition显示文摘 | Michel JB Xu Y Blot S | 1996 | J Cardiovasc Pharmacol1996，28，1： | 1 |
| 16 | Changing patterns in the incidence of esophageal and gastric carcinoma in the United States显示文摘 | Devesa SS Blot WJ Fraumeni JF Jr | 1998 | Cancer1998，83，10： | 1 |
| 17 | Clinical and economic out- comes in critically ill patients with nosocomial catheter - related blood- stream infections显示文摘 | Blot SI Depuydt P Annemans L | 2005 | Clin Infect Dis2005，41，11： | 1 |
| 18 | Oral care of intubated patients显示文摘 | Blot Stijn Vandijck Dominique Labeau Sonia | 2008 | Clinical Practice Management2008，15，3： | 1 |
| 19 | Mechanics of deformation and acoustic propagation in porous media 显示文摘 | Blot M A | 1962 | Journal of Applied Physics1962，33，4： | 1 |
| 20 | Changing patterns in the incidence of esophageal and gastric carcinoma in the United States显示文摘 | Devesa SS Blot WJ Fraumeni JF Jr | 1998 | Cancer1998，83，10： | 1 |
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