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| 1 | Colorectal liver metastases: Current management and future perspectives显示文摘The liver is the commonest site of metastatic disease for patients with colorectal cancer,with at least 25%developing colorectal liver metastases(CRLM)during the course of their illness.The management of CRLM has evolved into a complex field requiring input from experienced members of a multi-disciplinary team involving radiology(cross sectional,nuclear medicine and interventional),Oncology,Liver surgery,Colorectal surgery,and Histopathology.Patient management is based on assessment of sophisticated clinical,radiological and biomarker information.Despite incomplete evidence in this very heterogeneous patient group,maximising resection of CRLM using all available techniques remains a key objective and provides the best chance of long-term survival and cure.To this end,liver resection is maximised by the use of downsizing chemotherapy,optimisation of liver remnant by portal vein embolization,associating liver partition and portal vein ligation for staged hepatectomy,and combining resection with ablation,in the context of improvements in the functional assessment of the future remnant liver.Liver resection may safely be carried out laparoscopically or open,and synchronously with,or before,colorectal surgery in selected patients.For unresectable patients,treatment options including systemic chemotherapy,targeted biological agents,intraarterial infusion or bead delivered chemotherapy,tumour ablation,stereotactic radiotherapy,and selective internal radiotherapy contribute to improve survival and may convert initially unresectable patients to operability.Currently evolving areas include biomarker characterisation of tumours,the development of novel systemic agents targeting specific oncogenic pathways,and the potential reemergence of radical surgical options such as liver transplantation. | Jack Martin Angelica Petrillo Elizabeth C Smyth Nadeem Shaida Samir Khwaja HK Cheow Adam Duckworth Paula Heister Raaj Praseedom Asif Jah Anita Balakrishnan Simon Harper Siong Liau Vasilis Kosmoliaptsis Emmanuel Huguet | 2020 | World Journal of Clinical Oncology2020，11，10： | 5 |
| 2 | Successful surgical management of ruptured umbilical hernias in cirrhotic patients显示文摘Acute umbilical hernia rupture in patients with hepatic cirrhosis and ascites is an unusual,but potentially lifethreatening complication,with postoperative morbidity about 70% and mortality between 60%-80% after supportive care and 6%-20% after urgent surgical repair.Management options include primary surgical repair with or without concomitant portal venous system decompression for the control of the ascites.We present a retrospective analysis of our centre's experience over the last 6 years.Our cohort consisted of 11 consecutive patients(median age:53 years,range:36-63 years) with advanced hepatic cirrhosis and refractory ascites.Appropriate patient resuscitation and optimisation with intravenous fluids,prophylactic antibiotics and local measures was instituted.One failed attempt for conservative management was followed by a successful primary repair.In all cases,with one exception,a primary repair with non-absorbable Nylon,interrupted sutures,without mesh,was performed.The perioperative complication rate was 25% and the recurrence rate 8.3%.No mortality was recorded.Median length of hospital stay was 14 d(range:4-31 d).Based on our experience,the management of ruptured umbilical hernias in patients with advanced hepatic cirrhosis and refractory ascites is feasible without the use of transjugular intrahepatic portosystemic shunt routinely in the preoperative period,provided that meticulous patient optimisation is performed. | Nikolaos A Chatzizacharias J Andrew Bradley Simon Harper Andrew Butler Asif Jah Emmanuel Huguet Raaj K Praseedom Michael Allison Paul Gibbs | 2015 | World Journal of Gastroenterology2015，21，10： | 4 |
| 3 | Mood fluctuations, projection bias, and volatility of equity prices显示文摘 | Rajnish Mehra Raaj Sah | 2002 | Journal of Economic Dynamics and Control2002，，5： | 3 |
| 4 | Endoscopic Ultrasound-guided drainage of an abdominal fluid collection following Whipple's resection显示文摘Percutaneous aspiration and drainage of post-operative abdominal fluid collections is a well established standard technique. However,some fluid collections are not amenable to percutaneous drainage either due to location or the presence of surrounding visceral structures. Endoscopic Ultrasound (EUS) has been widely used for the drainage of pancreatitis-related abdominal fluid collections. However,there are no reports on the use of this technique in the post-operative setting. We report a case where the EUS-guided technique was used to drain a percutaneously inaccessible post-operative collection which had developed after Whipple's resection. | Asif Jah Neville Jamieson Emmanuel Huguet William Griffi ths Nicholas Carroll Raaj Praseedom | 2008 | World Journal of Gastroenterology2008，14，44： | 3 |
| 5 | Is there a difference in adenoma detection rates between gastroenterologists and surgeons?显示文摘AIM To compare the adenoma detection rate(ADR) between gastroenterologists and colorectal surgeons at Box Hill Hospital, Melbourne, Australia.METHODS A total of 300 colonoscopies performed by gastroenterologists and colorectal surgeons at Box Hill Hospital were retrospectively reviewed from May 2016 to June 2017. Exclusion criteria were: Patients ≤ 50 years old, colonoscopies with failure of caecal intubation, patients who previously had colon cancer and/or a colonic resection, history of polyposis syndromes or inflammatory bowel disease, or a colonoscopy within the last 10 years. Patient demographics, indications, symptoms and procedural-related outcomes were measured.RESULTS The ADR was not significantly different between gastroenterologists and colorectal surgeons(34% vs 34.67%; P = 0.90). The adjusted odds ratio correcting for gender, age, 1^(st) degree relative with colorectal cancer, previous colonoscopy, trainee involvement and caecal or terminal ileum intubation rate was 1.19(0.69-2.05).CONCLUSION Both specialties at our institution exceed benchmark standards suggested by published Australian and American guidelines. An association between endoscopist specialty and ADR was not observed. | Adele Hwee Hong Lee Nuttaradee Lojanapiwat Vikram Balakrishnan Raaj Chandra | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，6： | 2 |
| 6 | Incidental non-benign gallbladder histopathology after cholecystectomy in an United Kingdom population: Need for routine histological analysis?显示文摘AIM To analyse the range of histopathology detected in the largest published United Kingdom series of cholecystectomy specimens and to evaluate the rational for selective histopathological analysis.METHODS Incidental gallbladder malignancy is rare in the United Kingdom with recent literature supporting selective histological assessment of gallbladders after routine cholecystectomy.All cholecystectomy gallbladder specimens examined by the histopathology department at our hospital during a five year period between March 2008 and March 2013 were retrospectively analysed.Further data was collected on all specimens demonstrating carcinoma,dysplasia and polypoid growths.RESULTS The study included 4027 patients.The majority(97%) of specimens exhibited gallstone or cholecystitis related disease.Polyps were demonstrated in 44(1.09%),the majority of which were cholesterol based(41/44).Dysplasia,ranging from low to multifocal high-grade was demonstrated in 55(1.37%).Incidental primary gallbladder adenocarcinoma was detected in 6 specimens(0.15%,5 female and 1 male),and a single gallbladder revealed carcinoma in situ(0.02%).This large single centre study demonstrated a full range of gallbladder disease from cholecystectomy specimens,including more than 1% neoplastic histology and two cases of macroscopically occult gallbladder malignancies.CONCLUSION Routine histological evaluation of all elective and emergency cholecystectomies is justified in a United Kingdom population as selective analysis has potential to miss potentially curable life threatening pathology. | Krashna Patel Khaled Dajani Satheesh Iype Nikolaos A Chatzizacharias Saranya Vickramarajah Susan Davies Rebecca Brais Siong S Liau Simon Harper Asif Jah Raaj K Praseedom Emmanuel L Huguet | 2016 | World Journal of Gastrointestinal Surgery2016，8，10： | 2 |
| 7 | Mood fluctuatios,Projection Bias,and Volatility of Equity Prices显示文摘 | Mehra Rajnish and Raaj Sah | 2002 | Journal of Economic Dynamic and Control2002，，26： | 1 |
| 8 | Mood,projection bias and equity market volatility显示文摘 | Mehra Rajnish Raaj Sah | | 0，，26： | 1 |
| 9 | Supporting Tourist Activity Planning Decisions from an Urban Tourism Management Perspective显示文摘 | HAN Q DELLAERT B G C VAN RAAJ W F | 2004 | Tourism Analysis2004，8，： | 1 |
| 10 | Direct histological processing of EUS biopsies enables rapid molecular biomarker analysis for interventional pancreatic cancer trials显示文摘 | Rebecca J. Brais Susan E. Davies Maria O’Donovan Ben W. Simpson Natalie Cook Walter C. Darbonne Sian Chilcott Martijn P. Lolkema Albrecht Neesse Michelle Lockley Pippa G. Corrie Duncan I. Jodrell Raaj K. Praseedom Emmanuel L. Huguet Asif Jah Neville V. Ja | 2012 | Pancreatology2012，，1： | 1 |
| 11 | The implications of the presence of an aberrant right hepatic artery in patients undergoing a pancreaticoduodenectomy显示文摘 | Asif Jah Neville Jamieson Emmanuel Huguet Raaj Praseedom | 2009 | Surgery Today2009，，8： | 1 |
| 12 | Combined transplantation of the heart, lung, and liver显示文摘 | Raaj K Praseedom Keith D McNeil Christopher JE Watson Graeme J Alexander Roy Y Calne John Wallwork Peter J Friend | 2001 | The Lancet2001，，9284： | 1 |
| 13 | Staged liver resection for colorectal metastases:a valuable strategy or a waste of time?显示文摘BACKGROUND:The use of staged liver resections for colorectal metastases has been increasing in recent times.The aim of this study was to determine the practices and outcomes of those surgeons attending the Australia and New Zealand Hepatic, Pancreatic and Biliary Association(ANZHPBA)meeting in 2008 who perform staged resections. METHODS:A questionnaire was sent to all members of the ANZHPBA and the international faculty who were invited to attend the annual meeting held in Coolum,Queensland, Australia in October 2008. RESULTS:There were 30 responses from 7 centres across the UK,Germany and Australia.Twenty-eight patients completed treatment.The study population was predominantly male (n=20,67%),with an average age of 59.4 years.All patients had bilobar disease.A right-sided first resection was planned in 39%of cases.Seventeen percent of patients underwent portal vein embolization prior to first resection.A second operation was performed at an average of 2.8 months from the first resection.Overall,50%(n=14)of patients eventually achieved a complete(R0)staged procedure.Twelve complications after the first resection were seen in 32%patients(n=9).Twenty- three patients underwent a second liver resection.Twenty-five complications after the second resection were present in 57% (n=13). CONCLUSIONS:Two-stage liver resections are beneficial if both stages are completed and an R0 resection is achieved. While there is increased morbidity and mortality,we believe that staged liver resection for colorectal metastases is a valuable strategy in selected cases. | Raaj Chandra Charles HC Pilgrim Val Usatoff | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，6： | 1 |
| 14 | Surgical management of hepato-pancreatic metastasis from renal cell carcinoma显示文摘AIM To investigate the outcomes of liver and pancreatic resections for renal cell carcinoma(RCC) metastatic disease. METHODS This is a retrospective, single centre review of liver and/or pancreatic resections for RCC metastases between January 2003 and December 2015. Descriptive statistical analysis and survival analysis using the Kaplan-Meier estimation were performed.RESULTS Thirteen patients h ad 7 pancreatic and 7 liver resections, with median follow-up 33 mo(range: 3-98). Postoperative complications were recorded in 5 cases, with no postoperative mortality. Three patients after hepatic and 5 after pancreatic resection developed recurrent disease. Median overall survival was 94 mo(range: 23-94) after liver and 98 mo(range: 3-98) after pancreatic resection. Disease-free survival was 10 mo(range 3-55) after liver and 28 mo(range 3-53) after pancreatic resection. CONCLUSION Our study shows that despite the high incidence of recurrence, long term survival can be achieved with resection of hepatic and pancreatic RCC metastases in selected cases and should be considered as a management option in patients with oligometastatic disease. | Nikolaos A Chatzizacharias Anais Rosich-Medina Khaled Dajani Simon Harper Emmanuel Huguet Siong S Liau Raaj K Praseedom Asif Jah | 2017 | World Journal of Gastrointestinal Oncology2017，9，2： | 1 |
| 15 | Current status of fast - track recovery pathways in pancreatic surgery显示文摘 | Efthymios Ypsilantis Raaj K Praseedom | 2009 | JOP J Pancreas2009，10，6： | 1 |
| 16 | Modeling ice thickness distribution and storage volume of glaciers in Chandra Basin,western Himalayas显示文摘This article reports modeled ice thickness distribution and total ice volume of the 65 selected glaciers(>0.5 km^2)of Chandra basin,located in the Western Himalayas.This is a first-of-its-kind study that gives detailed insights about the current ice thickness distribution at an individual glacier level in the Western Himalayas.The estimates are obtained using an optimally parameterized Glab Top2_IITB[Glacier Bed Topography Indian Institute of Technology Bombay(IITB)version]model with highresolution Digital Elevation Model(DEM)as an input.The total estimated volume of all the 65 selected glaciers is about 55.32 km^3 covering a total area of about 591.03 km^2.Using hypsometric analysis,it is found that the maximum amount of ice volume,i.e.,about 12.79 km^3,is currently residing at the elevation range of 5200–5400 m a.s.l.Ice thickness estimates obtained in the current study are compared with the ensemble estimates obtained in the Global Glacier Thickness Initiative(G2TI)project for three large glaciers,namely,Bada Shigri,Samudra Tapu,and Gepang Gath glaciers.The obtained results indicate that the difference between both the studies is marginal in terms of mean ice thickness and maximum ice thickness estimates except Samudra Tapu glacier.Moreover,the uncertainty of the estimated glacier ice volume from this study is about±15%whereas,from the G2TI project,it is about 25%.The main reasons for the difference could be the quality of the inputs used,model structure,model parameterization as well as the time stamp of the input used.The obtained results from this study indicate that the use of appropriate shape factor and better DEM would result in more reliable glacier ice thickness estimates even by using a simple slopedependent model like Glab Top2_IITB. | Ankur PANDIT RAAJ RAMSANKARAN | 2020 | Journal of Mountain Science2020，17，8： | 1 |
| 17 | Pain during injec- tion of propofol : the effect of prior administration of bu- torphanol 显示文摘 | Agarwal A Raza M Dhi raaj S | 2004 | Anesth Analg2004，99，1： | 1 |
| 18 | The implications of the presence of an aberrant right hepatic artery in patients undergoing a pancreaticoduodenectomy显示文摘 | Asif Jah Neville Jamieson Emmanuel Huguet Raaj Praseedom | 2009 | Surgery Today2009，，8： | 1 |
| 19 | Occipital cervical sta- bilization using occipital condyles for cranial fixation: technical case report显示文摘 | URIBE J RAMOS E RAAJ A | 2009 | Neurosurg2009，65，6： | 1 |
| 20 | Extra-hepatic portal vein aneurysm: A case report, overview of the literature and suggested management algorithm显示文摘 | Ruichong Ma Anita Balakrishnan Teik Choon See Siong Seng Liau Raaj Praseedom Asif Jah | 2012 | International Journal of Surgery Case Reports2012，，11： | 1 |
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