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| 1 | Colorectal liver metastases: Current management and future perspectives显示文摘The liver is the commonest site of metastatic disease for patients with colorectal cancer,with at least 25%developing colorectal liver metastases(CRLM)during the course of their illness.The management of CRLM has evolved into a complex field requiring input from experienced members of a multi-disciplinary team involving radiology(cross sectional,nuclear medicine and interventional),Oncology,Liver surgery,Colorectal surgery,and Histopathology.Patient management is based on assessment of sophisticated clinical,radiological and biomarker information.Despite incomplete evidence in this very heterogeneous patient group,maximising resection of CRLM using all available techniques remains a key objective and provides the best chance of long-term survival and cure.To this end,liver resection is maximised by the use of downsizing chemotherapy,optimisation of liver remnant by portal vein embolization,associating liver partition and portal vein ligation for staged hepatectomy,and combining resection with ablation,in the context of improvements in the functional assessment of the future remnant liver.Liver resection may safely be carried out laparoscopically or open,and synchronously with,or before,colorectal surgery in selected patients.For unresectable patients,treatment options including systemic chemotherapy,targeted biological agents,intraarterial infusion or bead delivered chemotherapy,tumour ablation,stereotactic radiotherapy,and selective internal radiotherapy contribute to improve survival and may convert initially unresectable patients to operability.Currently evolving areas include biomarker characterisation of tumours,the development of novel systemic agents targeting specific oncogenic pathways,and the potential reemergence of radical surgical options such as liver transplantation. | Jack Martin Angelica Petrillo Elizabeth C Smyth Nadeem Shaida Samir Khwaja HK Cheow Adam Duckworth Paula Heister Raaj Praseedom Asif Jah Anita Balakrishnan Simon Harper Siong Liau Vasilis Kosmoliaptsis Emmanuel Huguet | 2020 | World Journal of Clinical Oncology2020，11，10： | 5 |
| 2 | Successful surgical management of ruptured umbilical hernias in cirrhotic patients显示文摘Acute umbilical hernia rupture in patients with hepatic cirrhosis and ascites is an unusual,but potentially lifethreatening complication,with postoperative morbidity about 70% and mortality between 60%-80% after supportive care and 6%-20% after urgent surgical repair.Management options include primary surgical repair with or without concomitant portal venous system decompression for the control of the ascites.We present a retrospective analysis of our centre's experience over the last 6 years.Our cohort consisted of 11 consecutive patients(median age:53 years,range:36-63 years) with advanced hepatic cirrhosis and refractory ascites.Appropriate patient resuscitation and optimisation with intravenous fluids,prophylactic antibiotics and local measures was instituted.One failed attempt for conservative management was followed by a successful primary repair.In all cases,with one exception,a primary repair with non-absorbable Nylon,interrupted sutures,without mesh,was performed.The perioperative complication rate was 25% and the recurrence rate 8.3%.No mortality was recorded.Median length of hospital stay was 14 d(range:4-31 d).Based on our experience,the management of ruptured umbilical hernias in patients with advanced hepatic cirrhosis and refractory ascites is feasible without the use of transjugular intrahepatic portosystemic shunt routinely in the preoperative period,provided that meticulous patient optimisation is performed. | Nikolaos A Chatzizacharias J Andrew Bradley Simon Harper Andrew Butler Asif Jah Emmanuel Huguet Raaj K Praseedom Michael Allison Paul Gibbs | 2015 | World Journal of Gastroenterology2015，21，10： | 4 |
| 3 | Adult duodenal intussusception associated with congenital malrotation显示文摘Enteroenteric intussusception is a condition in which full-thickness bowel wall becomes telescoped into the lumen of distal bowel. In adults, there is usually an abnormality acting as a lead point, usually a Meckels' diverticulum, a hamartoma or a tumour. Duodeno-duodenal intussusception is exceptionally rare because the retroperitoneal situation fixes the duodenal wall. The aim of this report is to describe the first published case of this condition. A patient with duodeno-duodenal intussusception secondary to an ampullary lesion is reported. A 66 year-old lady presented with intermittent abdominal pain, weight loss and anaemia. Ultrasound scanning showed dilated bile and pancreatic ducts. CT scanning revealed intussusception involving the full-thickness duodenal wall. The lead point was an ampullary villous adenoma. Congenital partial (type Ⅱ) malrotation was found at operation and this abnormality permitted excessive mobility of the duodenal wall such that intussusception was possible. This condition can be diagnosed using enhanced CT. Intussusception can be complicated by bowel obstruction, ischaemia or bleeding, and therefore the underlying cause should be treated as soon as possible. | J Gardner-Thorpe RH Hardwick NR Carroll P Gibbs NV Jamieson RK Praseedom | 2007 | World Journal of Gastroenterology2007，13，28： | 3 |
| 4 | Endoscopic Ultrasound-guided drainage of an abdominal fluid collection following Whipple's resection显示文摘Percutaneous aspiration and drainage of post-operative abdominal fluid collections is a well established standard technique. However,some fluid collections are not amenable to percutaneous drainage either due to location or the presence of surrounding visceral structures. Endoscopic Ultrasound (EUS) has been widely used for the drainage of pancreatitis-related abdominal fluid collections. However,there are no reports on the use of this technique in the post-operative setting. We report a case where the EUS-guided technique was used to drain a percutaneously inaccessible post-operative collection which had developed after Whipple's resection. | Asif Jah Neville Jamieson Emmanuel Huguet William Griffi ths Nicholas Carroll Raaj Praseedom | 2008 | World Journal of Gastroenterology2008，14，44： | 3 |
| 5 | Incidental non-benign gallbladder histopathology after cholecystectomy in an United Kingdom population: Need for routine histological analysis?显示文摘AIM To analyse the range of histopathology detected in the largest published United Kingdom series of cholecystectomy specimens and to evaluate the rational for selective histopathological analysis.METHODS Incidental gallbladder malignancy is rare in the United Kingdom with recent literature supporting selective histological assessment of gallbladders after routine cholecystectomy.All cholecystectomy gallbladder specimens examined by the histopathology department at our hospital during a five year period between March 2008 and March 2013 were retrospectively analysed.Further data was collected on all specimens demonstrating carcinoma,dysplasia and polypoid growths.RESULTS The study included 4027 patients.The majority(97%) of specimens exhibited gallstone or cholecystitis related disease.Polyps were demonstrated in 44(1.09%),the majority of which were cholesterol based(41/44).Dysplasia,ranging from low to multifocal high-grade was demonstrated in 55(1.37%).Incidental primary gallbladder adenocarcinoma was detected in 6 specimens(0.15%,5 female and 1 male),and a single gallbladder revealed carcinoma in situ(0.02%).This large single centre study demonstrated a full range of gallbladder disease from cholecystectomy specimens,including more than 1% neoplastic histology and two cases of macroscopically occult gallbladder malignancies.CONCLUSION Routine histological evaluation of all elective and emergency cholecystectomies is justified in a United Kingdom population as selective analysis has potential to miss potentially curable life threatening pathology. | Krashna Patel Khaled Dajani Satheesh Iype Nikolaos A Chatzizacharias Saranya Vickramarajah Susan Davies Rebecca Brais Siong S Liau Simon Harper Asif Jah Raaj K Praseedom Emmanuel L Huguet | 2016 | World Journal of Gastrointestinal Surgery2016，8，10： | 2 |
| 6 | Leiomyosarcoma of the retrohepatic vena cava treated by excision and Reconstruction with an aortic homograft:a case report and review of literature显示文摘 | Praseedom RK Dhar P Jamieson NV | | 0，，04： | 1 |
| 7 | Direct histological processing of EUS biopsies enables rapid molecular biomarker analysis for interventional pancreatic cancer trials显示文摘 | Rebecca J. Brais Susan E. Davies Maria O’Donovan Ben W. Simpson Natalie Cook Walter C. Darbonne Sian Chilcott Martijn P. Lolkema Albrecht Neesse Michelle Lockley Pippa G. Corrie Duncan I. Jodrell Raaj K. Praseedom Emmanuel L. Huguet Asif Jah Neville V. Ja | 2012 | Pancreatology2012，，1： | 1 |
| 8 | Current Status of Fast-Track Recovery Pathways in Pancreatic Surgery 显示文摘 | Ypsilantis E Praseedom RK | 2009 | JOP2009，10，6： | 1 |
| 9 | Molecular pathogenesis of hepatic adenomas and its implications for surgical management 显示文摘 | LIAU SS QURESHI MS PRASEEDOM R | 2013 | J Gastrointest Surg2013，17，： | 1 |
| 10 | Combinedtransplantation of the heart, lung, and liver 显示文摘 | Praseedom RK? McNeil KD Watson CJ? | 2001 | Lancet2001，358，9284： | 1 |
| 11 | The implications of the presence of an aberrant right hepatic artery in patients undergoing a pancreaticoduodenectomy显示文摘 | Asif Jah Neville Jamieson Emmanuel Huguet Raaj Praseedom | 2009 | Surgery Today2009，，8： | 1 |
| 12 | Combined transplantation of the heart, lung, and liver显示文摘 | Raaj K Praseedom Keith D McNeil Christopher JE Watson Graeme J Alexander Roy Y Calne John Wallwork Peter J Friend | 2001 | The Lancet2001，，9284： | 1 |
| 13 | Surgical management of hepato-pancreatic metastasis from renal cell carcinoma显示文摘AIM To investigate the outcomes of liver and pancreatic resections for renal cell carcinoma(RCC) metastatic disease. METHODS This is a retrospective, single centre review of liver and/or pancreatic resections for RCC metastases between January 2003 and December 2015. Descriptive statistical analysis and survival analysis using the Kaplan-Meier estimation were performed.RESULTS Thirteen patients h ad 7 pancreatic and 7 liver resections, with median follow-up 33 mo(range: 3-98). Postoperative complications were recorded in 5 cases, with no postoperative mortality. Three patients after hepatic and 5 after pancreatic resection developed recurrent disease. Median overall survival was 94 mo(range: 23-94) after liver and 98 mo(range: 3-98) after pancreatic resection. Disease-free survival was 10 mo(range 3-55) after liver and 28 mo(range 3-53) after pancreatic resection. CONCLUSION Our study shows that despite the high incidence of recurrence, long term survival can be achieved with resection of hepatic and pancreatic RCC metastases in selected cases and should be considered as a management option in patients with oligometastatic disease. | Nikolaos A Chatzizacharias Anais Rosich-Medina Khaled Dajani Simon Harper Emmanuel Huguet Siong S Liau Raaj K Praseedom Asif Jah | 2017 | World Journal of Gastrointestinal Oncology2017，9，2： | 1 |
| 14 | RoLe of contrast CT in acute Lower gastrointestinaL bLeeding显示文摘 | Rajan R Dhar P Praseedom RK | 2004 | Dig Surg2004，21，： | 1 |
| 15 | Current status of fast-track recovery pathways in pancreatic surgery 显示文摘 | Ypsilantis E Praseedom RK | 2009 | JOP2009，10，6： | 1 |
| 16 | Current status of fast - track recovery pathways in pancreatic surgery显示文摘 | Efthymios Ypsilantis Raaj K Praseedom | 2009 | JOP J Pancreas2009，10，6： | 1 |
| 17 | Leiomyosarcoma of the retrohepatic vena eava treated by excision and reconstruction with an aortic homograft: a case report and review of literature 显示文摘 | Praseedom RK Dhar P Jamieson NV | 2007 | Surg Innov2007，14，： | 1 |
| 18 | The implications of the presence of an aberrant right hepatic artery in patients undergoing a pancreaticoduodenectomy显示文摘 | Asif Jah Neville Jamieson Emmanuel Huguet Raaj Praseedom | 2009 | Surgery Today2009，，8： | 1 |
| 19 | Molecular pathogene- sis of hepatic adenomas and its implications for surgical man- agement显示文摘 | Liau SS Qureshi MS Praseedom R | 2013 | J Gastrointest Surg2013，17，10： | 1 |
| 20 | Extra-hepatic portal vein aneurysm: A case report, overview of the literature and suggested management algorithm显示文摘 | Ruichong Ma Anita Balakrishnan Teik Choon See Siong Seng Liau Raaj Praseedom Asif Jah | 2012 | International Journal of Surgery Case Reports2012，，11： | 1 |
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