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| 1 | Laboratory markers in ulcerative colitis: Current insights and future advances显示文摘Ulcerative colitis(UC)and Crohn’s disease(CD)are the major forms of inflammatory bowel diseases(IBD)in man.Despite some common features,these forms can be distinguished by different genetic predisposition,risk factors and clinical,endoscopic and histological characteristics.The aetiology of both CD and UC remains unknown,but several evidences suggest that CD and perhaps UC are due to an excessive immuneresponse directed against normal constituents of the intestinal bacterial flora.Tests sometimes invasive are routine for the diagnosis and care of patients with IBD.Diagnosis of UC is based on clinical symptoms combined with radiological and endoscopic investigations.The employment of non-invasive biomarkers is needed.These biomarkers have the potential to avoid invasive diagnostic tests that may result in discomfort and potential complications.The ability to determine the type,severity,prognosis and response to therapy of UC,using biomarkers has long been a goal of clinical researchers.We describe the biomarkers assessed in UC,with special reference to acute-phase proteins and serologic markers and thereafter,we describe the new biological markers and the biological markers could be developed in the future:(1)serum markers of acute phase response:The laboratory tests most used to measure the acute-phase proteins in clinical practice are the serum concentration of C-reactive protein and the erythrocyte sedimentation rate.Other biomarkers of inflammation in UC include platelet count,leukocyte count,and serum albumin and serum orosomucoid concentrations;(2)serologic markers/antibodies:In the last decades serological and immunologic biomarkers have been studied extensively in immunology and have been used in clinical practice to detect specific pathologies.In UC,the presence of these antibodies can aid as surrogate markers for the aberrant host immune response;and(3)future biomarkers:The development of biomarkers in UC will be very important in the future.The progress of molecular biology tools(microarrays,proteomics and nanotechnology)have revolutionised the field of the biomarker discovery.The advances in bioinformatics coupled with cross-disciplinary collaborations have greatly enhanced our ability to retrieve,characterize and analyse large amounts of data generated by the technological advances.The techniques available for biomarkers development are genomics(single nucleotide polymorphism genotyping,pharmacogenetics and gene expression analyses)and proteomics.In the future,the additionof new serological markers will add significant benefit.Correlating serologic markers with genotypes and clinical phenotypes should enhance our understanding of pathophysiology of UC. | Michele Cioffi Antonella De Rosa Rosalba Serao Ilaria Picone Maria Teresa Vietri | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，1： | 14 |
| 2 | Vitamin D receptor gene polymorphisms and hepatocellular carcinoma in alcoholic cirrhosis显示文摘AIM: To assess the relationship between vitamin D re-ceptor (VDR) gene polymorphisms and the presence of hepatocellular carcinoma (HCC). METHODS: Two-hundred forty patients who underwent liver transplantation were studied. The etiologies of liver disease were hepatitis C (100 patients), hepatitis B (37) and alcoholic liver disease (103). A group of 236 healthy subjects served as controls. HCC in the explanted liver was detected in 80 patients. The following single nucle-otide gene polymorphisms of the VDR were investigatedby polymerase chain reaction and restriction fragment length polymorphism: FokI C>T (F/f), BsmI A>G (B/b), ApaI T>G (A/a) and TaqI T>C (T/t) (BAT). RESULTS: The frequencies of genotypes in patients without and with HCC were for FokI F/F = 69, F/f = 73, f/f = 18 and F/F = 36, F/f = 36, f/f = 8; BsmI b/b = 45, B/b = 87, B/B = 28 and b/b = 33, B/b = 35, B/B = 12; for ApaI A/A = 53, A/a = 85, a/a = 22 and A/A = 27, A/a = 38, a/a = 15; for TaqI T/T = 44, T/t = 88, t/t = 28 and T/T = 32, T/t = 38, t/t = 10. Carriage of the b/b genotype of BsmI and the T/T genotype of TaqI was signif icantly associated with HCC (45/160 vs 33/80, P < 0.05 and 44/160 vs 32/80, P < 0.05, respectively). The absence of the A-T-C protective allele of BAT was signif i-cantly associated with the presence of HCC (46/80 vs 68/160, P < 0.05). A strong association was observed between carriage of the BAT A-T-C and G-T-T haplotypes and HCC only in alcoholic liver disease (7/46 vs 12/36 vs 11/21, P < 0.002, respectively).CONCLUSION: VDR genetic polymorphisms are sig-nificantly associated with the occurrence of HCC in patients with liver cirrhosis. This relationship is more specific for patients with an alcoholic etiology. | Edmondo Falleti Davide Bitetto Carlo Fabris Annarosa Cussigh Elisabetta Fontanini Ezio Fornasiere Elisa Fumolo Sara Bignulin Sara Cmet Rosalba Minisini Mario Pirisi Pierluigi Toniutto | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 3 | Adjuvant chemotherapy for gastric cancer:Current evidence and future challenges显示文摘Gastric cancer still represents one of the major causes of cancer mortality worldwide.Patients survival is mainly related to stage,with a high proportion of patients with metastatic disease at presentation.Thus,the cure rate largely depend upon surgical resection.Despite the additional,albeit small,benefit of adjuvant chemotherapy has been clearly demonstrated,no general consensus has been reached on the best treatment option.Moreover,the narrow therapeutic index of adjuvant chemotherapy(i.e.,limited survival benefit with considerable toxicity)requires a careful assessment of expected risks and benefits for individual patients.Treatment choices vary widely based on the different geographic areas,with chemotherapy alone more often preferred in Europe or Asia and chemoradiotherapy in the United States.In the present review we discuss the current evidence and future challenges regarding adjuvant chemotherapy in curatively resected gastric cancer with particular emphasis on the recently completed landmark studies and meta-analyses.The most recent patient-level meta-analysis demonstrated the benefit of adjuvant chemotherapy over curative surgery;the same Authors also showed that disease free survival may be used as a surrogate end-point for overall survival.We finally discuss future research issues such as the need of economic evaluations,development of prognostic or predictive biomarkers,and the unmet clinical need of trials comparing perioperative chemotherapy with adjuvant treatment. | Rosalba Miceli Gianluca Tomasello Giacomo Bregni Maria Di Bartolomeo Filippo Pietrantonio | 2014 | World Journal of Gastroenterology2014，20，16： | 12 |
| 4 | 甜菜夜蛾的迁徙导致对蛾类生物多样的估计过低(英文)显示文摘由于蛾类易于采集和鉴定,因而在进行生物多样性调查时,它们成为研究最多的动物类群之一。由于大多数蛾类可以通过灯光诱捕,因此生物多样性研究中普遍采用灯光诱捕法。在抽样样本中,夜蛾科常常所占个体比例最多,该科包括一些著名的迁徙物种,有时捕获的个体数量相当高。本文阐述了2003年发生在托斯卡纳的甜菜夜蛾(Spodoptera exigua)迁徙事件。我们在抽样中发现了大批甜菜夜蛾的标本,从而使这一地区的生物多样性实际值发生了很大改变。因此,我们认为,在对蛾类进行生物多样性调查时,在分析时应该剔除可能涉及到迁徙的物种[动物学报51 (5) : 909 -911 , 2005]。 | Leonardo DAPPORTO Francesca MAGI Stefania NAPPINI Rosalba BANCHETTI | 2005 | 动物学报2005，51，5： | 5 |
| 5 | Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis显示文摘 | Vincenzo Mazzaferro Josep M Llovet Rosalba Miceli Sherrie Bhoori Marcello Schiavo Luigi Mariani Tiziana Camerini Sasan Roayaie Myron E Schwartz Gian Luca Grazi René Adam Peter Neuhaus Mauro Salizzoni Jordi Bruix Alejandro Forner Luciano De Carlis Umberto | 2009 | Lancet Oncology2009，，1： | 4 |
| 6 | Strongly enhanced light trapping in a two-dimensional silicon nanowire random fractal array显示文摘We report on the unconventional optical properties exhibited by a two-dimensional array of thin Si nanowires arranged in a random fractal geometry and fabricated using an inexpensive,fast and maskless process compatible with Si technology.The structure allows for a high light-trapping efficiency across the entire visible range,attaining total reflectance values as low as 0.1%when the wavelength in the medium matches the length scale of maximum heterogeneity in the system.We show that the random fractal structure of our nanowire array is responsible for a strong in-plane multiple scattering,which is related to the material refractive index fluctuations and leads to a greatly enhanced Raman scattering and a bright photoluminescence.These strong emissions are correlated on all length scales according to the refractive index fluctuations.The relevance and the perspectives of the reported results are discussed as promising for Si-based photovoltaic and photonic applications. | Barbara Fazio Pietro Artoni Maria Antonia Iatì Cristiano D’Andrea Maria JosèLo Faro Salvatore Del Sorbo Stefano Pirotta Pietro Giuseppe Gucciardi Paolo Musumeci Cirino Salvatore Vasi Rosalba Saija Matteo Galli Francesco Priolo Alessia Irrera | 2016 | Light(Science & Applications)2016，5，1： | 4 |
| 7 | The diagnosis, treatment, and follow-up of cesarean scar pregnancy显示文摘 | Ilan E. Timor-Tritsch Ana Monteagudo Rosalba Santos Tanya Tsymbal Grace Pineda Alan A. Arslan | 2012 | American Journal of Obstetrics and Gynecology2012，，1： | 3 |
| 8 | Medical plant extracts and natural compounds with a hepatoprotective effect against damage caused by antitubercular drugs: A review显示文摘Drug-induced liver injury encompasses a spectrum of diseases ranging from mild biochemical abnormalities to acute liver failure; example of this scenery is hepatotoxicity caused by the first-line antituberculous drugs isoniazid, rifampin and pyrazinamide, which are basic for treatment of drug-sensible and drug-resistant tuberculosis. In the search for pharmacological alternatives to prevent liver damage, antitubercular drugs have been the subject of numerous studies and published reviews, a great majority of them carried out by Asian countries. At the same time, hepatoprotectors from plant source are now emerging as a possible alternative to counteract the toxic effects of these therapeutic agents. The present review aims to highlight the most recent studies on the subject, based information published in scientific databases such as Scopus and Pub Med. | María Adelina Jiménez-Arellanes Gabriel Alfonso Gutiérrez-Rebolledo Mariana Meckes-Fischer Rosalba León-Díaz | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，12： | 3 |
| 9 | Radiofrequency Ablation of Small Hepatocellular Carcinoma in Cirrhotic Patients Awaiting Liver Transplantation: A Prospective Study显示文摘 | Vincenzo Mazzaferro Carlo Battiston Stefano Perrone Andrea Pulvirenti Enrico Regalia Raffaele Romito Dario Sarli Marcello Schiavo Francesco Garbagnati Alfonso Marchianò Carlo Spreafico Tiziana Camerini Luigi Mariani Rosalba Miceli Salvatore Andreola | 2004 | Annals of Surgery2004，，5： | 3 |
| 10 | Nature:研究鉴定出侵袭性胰腺癌细胞及其弱点显示文摘在一项新的研究中,来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植(patient—derived tumorxenograft,PDx)和模式小鼠开展一系列临床前实验,鉴定出一种门卫蛋白(gatekee Perprotein)阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型,并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。 | Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, Maria Nezi, Luigi Corti, Denise Minelli, Rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin Seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar Dal Molin, Marco Ying, Haoqiang Kwong, Lawrence N. Colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia Muller, Florian Dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong Zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, Michael G. Wood, Laura D. Sgambato, Alessandro Agaimy, Abbas Maitra, Anirban Roberts, Charles W. M. Wang, Huamin Viale, Andrea DePinho, Ronald A. Draetta, Giulio F. Chin, Lynda | 2017 | 现代生物医学进展2017，17，14： | 2 |
| 11 | Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients显示文摘 | Giuseppe Marazzi Luca Cacciotti Francesco Pelliccia Luigi Iaia Maurizio Volterrani Giuseppe Caminiti Barbara Sposato Rosalba Massaro Fabrizia Grieco Giuseppe Rosano | 2011 | Advances in Therapy2011，，12： | 2 |
| 12 | Multi-target prediction of wheat flour quality parameters with near infrared spectroscopy显示文摘Near Infrared(NIR)spectroscopy is an analytical technology widely used for the nondestructive characterisation of organic samples,considering both qualitative and quantitative attributes.In the present study,the combination of Multi-target(MT)prediction approaches and Machine Learning algorithms has been evaluated as an effective strategy to improve prediction performances of NIR data from wheat flour samples.Three different Multi-target approaches have been tested:Multi-target Regressor Stacking(MTRS),Ensemble of Regressor Chains(ERC)and Deep Structure for Tracking Asynchronous Regressor Stack(DSTARS).Each one of these techniques has been tested with different regression methods:Support Vector Machine(SVM),Random Forest(RF)and Linear Regression(LR),on a dataset composed of NIR spectra of bread wheat flours for the prediction of qualityrelated parameters.By combining all MT techniques and predictors,we obtained an improvement up to 7%in predictive performance,compared with the corresponding Single-target(ST)approaches.The results support the potential advantage of MT techniques over ST techniques for analysing NIR spectra. | Sylvio Barbon Junior Saulo Martielo Mastelini Ana Paula ACBarbon Douglas Fernandes Barbin Rosalba Calvini Jessica Fernandes Lopes Alessandro Ulrici | 2020 | Information Processing in Agriculture2020，7，2： | 2 |
| 13 | Femtosecond laser deposition of TiO_2 nanoparticleassembled films with embedded CdS nanoparticles显示文摘Based on the normal pulsed laser ablation method,femtosecond pulsed laser deposition(fs-PLD)is adopted in vacuum for the production of TiO2nanoparticle-assembled films.We study the morphology and electronic characteristics of TiO2nanoparticle-assembled films deposited at different oxygen background gas pressures from high vacuum(~10-4Pa)to 100 Pa and different deposition time.Our results show that TiO2nanoparticle-assembled films obtained in high vacuum present both a mixture with rutile phase and anatase phase and a pure rutile phase.At the same time,there are more mesoporous structures in the film after annealing,which is beneficial for the enhancement of photocatalytic activity.In water splitting experiment,part of the TiO2nanoparticle-assembled films embedded with a small mass fraction of CdS nanoparticles(~5%)present an interesting photocurrent enhancement with a maximum value of^0.2mA/cm2under a solar simulator. | 倪晓昌 桑丽霞 张洪杰 Anoop Kiliyanam-kandy Salvatore Amoruso 王宣 Rosalba Fittipaldi 李彤 胡明列 徐丽娟 | 2014 | Optoelectronics Letters2014，10，1： | 2 |
| 14 | Subtotal Versus Total Gastrectomy for Gastric Cancer: Five-Year Survival Rates in a Multicenter Randomized Italian Trial显示文摘 | Federico Bozzetti Ettore Marubini Giuliano Bonfanti Rosalba Miceli Chiara Piano Leandro Gennari | 1999 | Annals of Surgery1999，，： | 2 |
| 15 | Current Treatment and Outcome of Esophageal Perforations in Adults: Systematic Review and Meta-Analysis of 75 Studies显示文摘 | Fausto Biancari Vito D’Andrea Rosalba Paone Carlo Marco Grazia Savino Vesa Koivukangas Juha Saarnio Ersilia Lucenteforte | 2013 | World Journal of Surgery2013，，5： | 2 |
| 16 | Comparative paralytic shellfish toxin profiles in two marine bivalves during outbreaks of Gymnodinium catenatum (Dinophyceae) in the Gulf of California显示文摘 | ISMAEL Gárate-Lizárraga JOS J Bustillos-Guzmán ROSALBA Alonso-Rodríguez | 2004 | Marine Pollution Bulletin2004，48，： | 1 |
| 17 | Role of chemo kines in angiogenesis:CXCL12/SDF-1 and CXCR4 in teraction,a key regulator o{ endothelial cell responses 显示文摘 | Rosalba Salcedo Joost J Oppenheim | 2003 | Microcirculation2003，10，： | 1 |
| 18 | Growth/no growth interfaces of Bacillus cereus,Staphylococcus aureus and Salmonella enteritidis in model systems based on water activity,pH,temperature and ethanol concentration显示文摘 | Rosalba Lanciotti Milena Sinigaglia Fansto Gardini | 2001 | Food Microbiology2001，18，2： | 1 |
| 19 | Enhancing density-based clustering:parameter reduction and outlier detection显示文摘 | CASSISI C FERRO A ROSALBA G | | 0，，03： | 1 |
| 20 | Vascular endothelial growth factor and basic flbroblast growth factor induce expression of CX- CR4 on human endothelial ceils 显示文摘 | Rosalba S Ken W Howard A | 1999 | Am J Pathol1999，154，4： | 1 |
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