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| 1 | Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa显示文摘AIM: To analyze possible relationships between CA ⅠⅩ/CA Ⅻ and pVHL expression in normal and neoplastic colorectal mucosa.METHODS: Immunohistochemical staining of 42 tissue specimens obtained from 17 cancer patients was performed to evaluate the distribution and semi-quantitatively assess the levels of CA ⅠⅩ, CA Ⅻ and pVHL. VHL mRNAs from 14 fresh-frozen tumors was amplified by RT-PCR and subjected to sequencing. CA9 and CA12 mRNA levels were analyzed by semi-quantitative RT-PCR in comparison with VEGFas an indicator of hypoxia that uncouples the pVHL control.RESULTS: Tumor tissues were associated with a borderline increase of CA ⅠⅩ staining signal and slight but significant decrease of CA Ⅻ immunoreactivity, whereas no association was found for pVHL. Sequence analysis of RT-PCR-amplified VHL mRNAs revealed no deletions/mutations, suggesting that they were VHL-competent. We did not observe any correlation between pVHL and CA ⅠⅩ/CA Ⅻ proteins as well as between VEGF and CA9 mRNAs, but the tumor-associated changes in mRNA levels of VEGF and CA12 showed a significant inverse relationship.CONCLUSION: Our results indicate that CA9 and CA12 are regulated by different intratumoral factors and that lack of apparent relationship between the levels of CA ⅠⅩ/CA Ⅻ and pVHL cannot be fully assigned to uncoupling of negative regulatory function of pVHL by tumor hypoxia signified by induced VEGF transcription. The interplay between the functional pVHL and CA ⅠⅩ/CA Ⅻ in colorectal tumors seems rather complex and is not evident merely at the expression levels. | Antti J. Kivela Seppo Parkkila Juha Saarnio Tuomo J. Karttunen Jyrki Kivela Anna-Kaisa Parkkila Maria Bartosova Vojtech Mucha Michal Novak Abdul Waheed William S. Sly Hannu Rajaniemi Silvia Pastorekova Jaromir Pastorek | 2005 | World Journal of Gastroenterology2005，11，17： | 10 |
| 2 | Carbonic anhydrases in normal gastrointestinal tract and gastrointestinal tumours显示文摘Carbonic anhydrases (CAs) catalyse the hydration of CO2to bicarbonate at physiological pH. This chemical interconversion is crucial since HCO3- is the substrate for several biosynthetic reactions. This review is focused on the distribution and role of CA isoenzymes in both normal and pathological gastrointestinal (GI) tract tissues. It has been known for many years that CAs are widely present in the GI tract and play important roles in several physiological functions such as production of saliva, gastric acid, bile, and pancreatic juice as well as in absorption of salt and water in intestine. New information suggests that these enzymes participate in several processes that were not envisioned earlier. Especially, the recent reports on plasma membranebound isoenzymes Ⅸ and Ⅻ have raised considerable interest since they were reported to participate in cancer invasion and spread. They are induced by tumour hypoxia and may also play a role in von Hippel-Lindau (VHL)-mediated carcinogenesis. | Antti J. Kivel Jyrki Kivel Juha Saarnio Seppo Parkkila | 2005 | World Journal of Gastroenterology2005，11，2： | 4 |
| 3 | HIF-1α and VEGF are Associated with Disease Progression in Esophageal Carcinoma显示文摘 | Heikki Takala Juha Saarnio Heikki Wiik Pasi Ohtonen Ylermi Soini | 2011 | Journal of Surgical Research2011，，1： | 2 |
| 4 | Current Treatment and Outcome of Esophageal Perforations in Adults: Systematic Review and Meta-Analysis of 75 Studies显示文摘 | Fausto Biancari Vito D’Andrea Rosalba Paone Carlo Marco Grazia Savino Vesa Koivukangas Juha Saarnio Ersilia Lucenteforte | 2013 | World Journal of Surgery2013，，5： | 2 |
| 5 | Claudins-1,3,4,5 and 7in esophageal cancer:loss of claudin-3 and 4 expression is associatedwith metastatic behavior AP显示文摘 | Takala H Saarnio J Wiik H | 2007 | MIS2007，115，7： | 1 |
| 6 | Winter CH4, CO2 and N2O fluxes on some natural and drained boreal peatlands显示文摘 | Aim J Saarnio S Nykanen H | 1999 | Biogeochemistry1999，44，2： | 1 |
| 7 | Galactomannan from soy bean hulls显示文摘 | Whistler R L Saarnio J | 1957 | Journal of American Chemistry Society1957，79，22： | 1 |
| 8 | Carbonic anhydrase IX, MN/CA IX: Analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts显示文摘 | S Pastorekova S Parkkila AK Parkkila R Opavsky V Zelnik J Saarnio J Pastorek | 1997 | Gastroenterology1997，，2： | 1 |
| 9 | Maternal vitamin D status determines bone variables in the newborn 显示文摘 | Viljakainen HT Saarnio E Hytinantti T | 2010 | J Clin Endocrinol Metab2010，95，4： | 1 |
| 10 | Immunohistochemical Study of Colorectal Tumors for Expression of a Novel Transmembrane Carbonic Anhydrase, MN/CA IX, with Potential Value as a Marker of Cell Proliferation显示文摘 | Juha Saarnio Seppo Parkkila Anna-Kaisa Parkkila Kari Haukipuro Silvia Pastoreková Jaromir Pastorek Matti I. Kairaluoma Tuomo J. Karttunen | 1998 | The American Journal of Pathology1998，，1： | 1 |
| 11 | Organ system dysfunction following open cholecystectomy for acute acalculous cholecystitis in critically ill patients显示文摘 | Laurila J Laurila PA Saarnio J | 2006 | Acta Anaesthesiol Scand2006，50，2： | 1 |
| 12 | Reconstruction of the carbon balance for microsites in a boreal oligotrophic pine fen, Finland显示文摘 | Alm J Talanov A Saarnio S Silvola J | 1997 | Oecologia1997，110，： | 1 |
| 13 | Seasonal variation in CH4 emissions and production and oxidation potentials at microsite on an oligotrophic pine fen显示文摘 | Saarnio S Alm J Silvola J | 1997 | Oecologia1997，110，3： | 1 |
| 14 | Effects of raised CO2 on potential CH4 production and oxidation in, and CH4 emission from, a boreal mire显示文摘 | Saarnio S Alto J Martikainen P J | 1998 | Clinical & Experimental Allergy1998，86，2： | 1 |
| 15 | Treatment of malignant gastroduodenal obstruction with a nitinol self-expanding metal stent: An international prospective multicentre registry显示文摘 | Guido Costamagna Andrea Tringali Julius Spicak Massimiliano Mutignani John Shaw Andre Roy Erik Johnsson Eduardo G.H. De Moura Spencer Cheng Thierry Ponchon Max Bittinger Helmut Messmann Horst Neuhaus Brigitte Schumacher Rene Laugier Juha Saarnio Francisco | 2011 | Digestive and Liver Disease2011，，1： | 1 |
| 16 | Effects of raised CO2 on potential CH4 production and oxidation in, and CH4 emission from, a boreal mire显示文摘 | SAARNIO S ALM J MARTIKAINEN P J | 1998 | Ecology1998，86，： | 1 |
| 17 | Effects of increased CO2 and N on CH4 effiux from a boreal mire: a growth chamber experiment显示文摘 | SAARNIO S SILVOLA J | 1999 | Oecologia1999，119，： | 1 |
| 18 | Layereless communications: From dream to reality 显示文摘 | SAARNIO J AGUIAR R L KUMAR V | 2007 | Wireless Personal Communications2007，44，1： | 1 |
| 19 | A moderate increase in the annual CH4 efflux by raised CO2 or NH4NO3 supply in a boreal oligotrophic mire显示文摘 | SAARNIO S SAARINEN T VASANDER H | 2000 | Global Change Biology2000，6，： | 1 |
| 20 | A moderate increase in the annual CH4 efflux by raised CO2 or NH4NO3 supply in boreal oligotrophic mire 显示文摘 | Saarnio S Saarinen T Vasander H | 2000 | Global Change Biology2000，6，： | 1 |
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