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| 1 | Vitamin D receptor gene polymorphisms and hepatocellular carcinoma in alcoholic cirrhosis显示文摘AIM: To assess the relationship between vitamin D re-ceptor (VDR) gene polymorphisms and the presence of hepatocellular carcinoma (HCC). METHODS: Two-hundred forty patients who underwent liver transplantation were studied. The etiologies of liver disease were hepatitis C (100 patients), hepatitis B (37) and alcoholic liver disease (103). A group of 236 healthy subjects served as controls. HCC in the explanted liver was detected in 80 patients. The following single nucle-otide gene polymorphisms of the VDR were investigatedby polymerase chain reaction and restriction fragment length polymorphism: FokI C>T (F/f), BsmI A>G (B/b), ApaI T>G (A/a) and TaqI T>C (T/t) (BAT). RESULTS: The frequencies of genotypes in patients without and with HCC were for FokI F/F = 69, F/f = 73, f/f = 18 and F/F = 36, F/f = 36, f/f = 8; BsmI b/b = 45, B/b = 87, B/B = 28 and b/b = 33, B/b = 35, B/B = 12; for ApaI A/A = 53, A/a = 85, a/a = 22 and A/A = 27, A/a = 38, a/a = 15; for TaqI T/T = 44, T/t = 88, t/t = 28 and T/T = 32, T/t = 38, t/t = 10. Carriage of the b/b genotype of BsmI and the T/T genotype of TaqI was signif icantly associated with HCC (45/160 vs 33/80, P < 0.05 and 44/160 vs 32/80, P < 0.05, respectively). The absence of the A-T-C protective allele of BAT was signif i-cantly associated with the presence of HCC (46/80 vs 68/160, P < 0.05). A strong association was observed between carriage of the BAT A-T-C and G-T-T haplotypes and HCC only in alcoholic liver disease (7/46 vs 12/36 vs 11/21, P < 0.002, respectively).CONCLUSION: VDR genetic polymorphisms are sig-nificantly associated with the occurrence of HCC in patients with liver cirrhosis. This relationship is more specific for patients with an alcoholic etiology. | Edmondo Falleti Davide Bitetto Carlo Fabris Annarosa Cussigh Elisabetta Fontanini Ezio Fornasiere Elisa Fumolo Sara Bignulin Sara Cmet Rosalba Minisini Mario Pirisi Pierluigi Toniutto | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 2 | Recipient Interleukin-28B Rs12979860 C/T Polymorphism and Acute Cellular Rejection After Liver Transplantation: Role of the Calcineurin Inhibitor Used显示文摘 | Davide Bitetto Carlo Fabris Edmondo Falleti Ezio Fornasiere Claudio Avellini Sara Cmet Annarosa Cussigh Elisabetta Fontanini Mario Pirisi Stefano Ginanni Corradini Manuela Merli Antonio Molinaro Pierluigi Toniutto | 2012 | Transplantation Journal2012，，10： | 2 |
| 3 | Risk factors for hepatocellular carcinoma recurrence after liver transplantation显示文摘Liver transplantation(LT)provides an excellent option for the long-term survival of patients with unresectable hepatocellular carcinoma(HCC)based on the Milan criteria.Despite careful selection of patients,HCC may still recur after LT,which represents the most important negative predictor of post-transplant survival.The growing demand for LT in HCC has led to the expansion of patient selection criteria,with a resultant increase in the risk of post-transplant HCC recurrence.Numerous tumor and host factors predict HCC recurrence.The morphological,histological,and serological characteristics of tumors in predicting HCC recurrence have been extensively studied.Furthermore,the type and duration of anticancer response before LT has also been considered a surrogate marker of tumor aggressiveness and is associated with the risk of recurrence.The demographic and clinical characteristics of recipients,as well as the type and duration of exposure to immunosuppressive therapy,represent the main host-related risk factors.Many studies have attempted to describe predictive models for the risk of HCC recurrence,considering evaluable parameters both before and after LT.Although many models have been proposed,relatively few have been externally validated on different patient populations.This paper aims to comprehensively summarize the available data on the predictive factors of HCC recurrence after LT,and to examine and discuss those that have been externally validated. | Pierluigi Toniutto Ezio Fornasiere Elisa Fumolo Davide Bitetto | 2020 | Hepatoma Research2020，6，8： | 1 |
| 4 | IL-28B rs12979860 C/T allele distribution in patients with liver cirrhosis: Role in the course of chronic viral hepatitis and the development of HCC显示文摘 | Carlo Fabris Edmondo Falleti Annarosa Cussigh Davide Bitetto Elisabetta Fontanini Sara Bignulin Sara Cmet Ezio Fornasiere Elisa Fumolo Stefano Fangazio Andrea Cerutti Rosalba Minisini Mario Pirisi Pierluigi Toniutto | 2010 | Journal of Hepatology2010，，4： | 1 |
| 5 | Excess body weight, liver steatosis, and early fibrosis progression due to hepatitis C recurrence after liver transplantation显示文摘AIM: To investigate how weight gain after OLT affects the speed of fibrosis progression (SFP) during recurrent hepatitis C virus (HCV) infection of the graft.METHODS: Ninety consecutive patients (63 males,median age 53 years; 55 with HCV-related liver disease),transplanted at a single institution, were studied. All were followed for at least 2 years after OLT and had at least one follow-up graft biopsy, performed not earlier than 1 year after the transplant operation. For each biopsy, a single,experienced pathologist gave an estimate of both the staging according to Ishak and the degree of hepatic steatosis.The SFP was quantified in fibrosis units/month (FU/mo).The lipid metabolism status of patients was summarized by the plasma triglycerides/cholesterol (T/C) ratio. Body mass index (BMI) was measured before OLT, and 1 and 2 years after it.RESULTS: In the HCV positive group, the highest SFP was observed in the first post-OLT year. At that time point,a SFP ≤0.100 FU/mo was observed more frequently among recipients who had received their graft from a young donor and had a pre-transplant BMI value >26.0 kg/m2. At completion of the first post-transplant year, a BMI value >26.5 kg/m2 was associated with a T/C ratio ≤1. The proportion of patients with SFP >0.100 FU/mo descended in the following order: female recipients with a high T/C ratio, male recipients with high T/C ratio, and recipients of either gender with low T/C ratio. Hepatic steatosis was observed more frequently in recipients who, in the first post-transplant year, had increased their BMI ≥1.5 kg/m2 in comparison to the pre-transplant value. Hepatic steatosis was inversely associated with the staging score.CONCLUSION: Among HCV positive recipients, excessweight gain post-OLT does not represent a factor favoring early liver fibrosis development and might even be protective against it. | Pierluigi Toniutto Carlo Fabris Claudio Avellini Rosalba Minisini Davide Bitetto Elisabetta Rossi Carlo Smirne Mario Pirisi | 2005 | World Journal of Gastroenterology2005，11，38： | 1 |
| 6 | Recipient perioperative cholesterolaemia and graft cholesterol metabolism gene expression predict liver transplant outcome显示文摘 | Stefano Ginanni Corradini Maria Siciliano Lucia Parlati Antonio Molinaro Alfredo Cantafora Edoardo Poli Gianluca Mennini Fabio Melandro Anna Rita Vestri Manuela Merli Paolo Bianco Alessandro Corsi Pierluigi Toniutto Davide Bitetto Edmondo Falleti Adolfo F | 2014 | Liver Int2014，，7： | 1 |
| 7 | IL-28B rs12979860 C/T allele distribution in patients with liver cirrhosis: Role in the course of chronic viral hepatitis and the development of HCC显示文摘 | Carlo Fabris Edmondo Falleti Annarosa Cussigh Davide Bitetto Elisabetta Fontanini Sara Bignulin Sara Cmet Ezio Fornasiere Elisa Fumolo Stefano Fangazio Andrea Cerutti Rosalba Minisini Mario Pirisi Pierluigi Toniutto | 2010 | Journal of Hepatology2010，，4： | 1 |
| 8 | Gene polymorphism at the interleukin 6 -174 G>C locus affects the outcome of chronic hepatitis B显示文摘 | Carlo Fabris Pierluigi Toniutto Davide Bitetto | 2009 | Journal of Infection2009，，2： | 1 |
| 9 | TGF-β1 genotypes in cirrhosis: Relationship with the occurrence of liver cancer显示文摘 | Edmondo Falleti Carlo Fabris Pierluigi Toniutto Elisabetta Fontanini Annarosa Cussigh Davide Bitetto Ezio Fornasiere Claudio Avellini Rosalba Minisini Mario Pirisi | 2008 | Cytokine2008，，： | 1 |
| 10 | Genetic polymorphisms of interleukin-6 modulate fibrosis progression in mild chronic hepatitis C显示文摘 | Edmondo Falleti Carlo Fabris Carmen Vandelli Cosimo Colletta Annarosa Cussigh Carlo Smirne Elisabetta Fontanini Sara Cmet Rosalba Minisini Davide Bitetto Pierluigi Toniutto Mario Pirisi | 2010 | Human Immunology2010，，10： | 1 |
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