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| 1 | Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy显示文摘Background:Parkinson’s disease(PD)is a neurodegenerative disorder whose diagnosis is often challenging because symptoms may overlap with neurodegenerative parkinsonisms.PD is characterized by intraneuronal accumulation of abnormalα-synuclein in brainstem while neurodegenerative parkinsonisms might be associated with accumulation of eitherα-synuclein,as in the case of Multiple System Atrophy(MSA)or tau,as in the case of Corticobasal Degeneration(CBD)and Progressive Supranuclear Palsy(PSP),in other disease-specific brain regions.Definite diagnosis of all these diseases can be formulated only neuropathologically by detection and localization ofα-synuclein or tau aggregates in the brain.Compelling evidence suggests that trace-amount of these proteins can appear in peripheral tissues,including receptor neurons of the olfactory mucosa(OM).Methods:We have set and standardized the experimental conditions to extend the ultrasensitive Real Time Quaking Induced Conversion(RT-QuIC)assay for OM analysis.In particular,by using human recombinantα-synuclein as substrate of reaction,we have assessed the ability of OM collected from patients with clinical diagnoses of PD and MSA to induceα-synuclein aggregation,and compared their seeding ability to that of OM samples collected from patients with clinical diagnoses of CBD and PSP.Results:Our results showed that a significant percentage of MSA and PD samples inducedα-synuclein aggregation with high efficiency,but also few samples of patients with the clinical diagnosis of CBD and PSP caused the same effect.Notably,the final RT-QuIC aggregates obtained from MSA and PD samples owned peculiar biochemical and morphological features potentially enabling their discrimination.Conclusions:Our study provide the proof-of-concept that olfactory mucosa samples collected from patients with PD and MSA possess important seeding activities forα-synuclein.Additional studies are required for(i)estimating sensitivity and specificity of the technique and for(ii)evaluating its application for the diagnosis of PD and neurodegenerative parkinsonisms.RT-QuIC analyses of OM and cerebrospinal fluid(CSF)can be combined with the aim of increasing the overall diagnostic accuracy of these diseases,especially in the early stages. | Chiara Maria Giulia De Luca Antonio Emanuele Elia Sara Maria Portaleone Federico Angelo Cazzaniga Martina Rossi Edoardo Bistaffa Elena De Cecco Joanna Narkiewicz Giulia Salzano Olga Carletta Luigi Romito Grazia Devigili Paola Soliveri Pietro Tiraboschi Giuseppe Legname Fabrizio Tagliavini Roberto Eleopra Giorgio Giaccone Fabio Moda | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 2 | Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity显示文摘 | Aline Meda Charles Euloge Lamien Marco Romito Jeanne Millogo Odile Germaine Nacoulma | 2004 | Food Chemistry2004，，3： | 5 |
| 3 | Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity显示文摘 | Aline Meda Charles Euloge Lamien Marco Romito Jeanne Millogo Odile Germaine Nacoulma | 2004 | Food Chemistry2004，，3： | 3 |
| 4 | Radiofrequency Ablation of Small Hepatocellular Carcinoma in Cirrhotic Patients Awaiting Liver Transplantation: A Prospective Study显示文摘 | Vincenzo Mazzaferro Carlo Battiston Stefano Perrone Andrea Pulvirenti Enrico Regalia Raffaele Romito Dario Sarli Marcello Schiavo Francesco Garbagnati Alfonso Marchianò Carlo Spreafico Tiziana Camerini Luigi Mariani Rosalba Miceli Salvatore Andreola | 2004 | Annals of Surgery2004，，5： | 3 |
| 5 | Yttrium‐90 radioembolization for intermediate‐advanced hepatocellular carcinoma: A phase 2 study显示文摘 | Vincenzo Mazzaferro Carlo Sposito Sherrie Bhoori Raffaele Romito Carlo Chiesa Carlo Morosi Marco Maccauro Alfonso Marchianò Marco Bongini Rodolfo Lanocita Enrico Civelli Emilio Bombardieri Tiziana Camerini Carlo Spreafico | 2013 | Hepatology2013，，： | 2 |
| 6 | Developments in automation system design for steelplants显示文摘 | Romito L Cozzi A | 1995 | Steel Times International1995，19，2： | 1 |
| 7 | Is cancer-related fatigue more strongly correlated to haematological or to psychological factors in cancer patients显示文摘 | Romito F Montanaro R Corvasce C | | 0，，08： | 1 |
| 8 | Determi- nation of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity显示文摘 | LAMIEN-MEDA ALINE LAMIEN C E ROMITO M | 2005 | Food Chem2005，91，3： | 1 |
| 9 | Cardiac resynchronization therapy tailored by echocardiography evaluation of ventricular asynchrony显示文摘 | Pitzalis MV Iacoviello M Romito R | 2002 | J Am Coll Cardiol2002，40，9： | 1 |
| 10 | Prevention of hepatocel- lular carcinoma recurrence with alpha-interferon after liver resec- tion in HCV cirrhosis显示文摘 | Mazzaferro V Romito R Schiavo M | 2006 | Hepatology2006，44，6： | 1 |
| 11 | Prevention of hepato- cellular carcinoma recurrence with alpha-interferon after liver re- section in HCV cirrhosis 显示文摘 | Mazzaferro V Romito R Schiavo M | 2006 | Hepatology2006，44，6： | 1 |
| 12 | Do elderly cancer pa tients have different care needs compared with younger ones? 显示文摘 | Romito F Corvasce C Montanaro R | 2011 | Tumori2011，97，： | 1 |
| 13 | Is cancer - relat- ed fatigue more strongly correlated to haematological or to psychological factors in cancer patients 显示文摘 | Romito F Montanaro R Corvasce C | 2008 | Support Care Cancer2008，16，8： | 1 |
| 14 | Periodontal thera- py and biomarkers related to cardiovascular risk 显示文摘 | Moura Foz A Alexandre Romito G Manoel Bispo C | 2010 | Minerva Stomatol2010，59，5： | 1 |
| 15 | Replacement of do- paminergic medication with subthalamic nucleus stimulation in Parkinson's disease:Long-term observation显示文摘 | Romito LM Contarino MF Vanacore N | 2009 | Mov Disord2009，24，： | 1 |
| 16 | Ventricular Repolarization Dynamicity Provides Independent Prognostic Information Toward Major Arrhythmic Events in Patients With Idiopathic Dilated Cardiomyopathy显示文摘 | Massimo Iacoviello Cinzia Forleo Pietro Guida Roberta Romito Antonio Sorgente Sandro Sorrentino Silvana Catucci Filippo Mastropasqua Mariavittoria Pitzalis | 2007 | Journal of the American College of Cardiology2007，，3： | 1 |
| 17 | Ventricular asynchrony predicts a better outcome in patients with chronic heart failure receiving cardiac resynchronization therapy 显示文摘 | Pitzalis MV Iacoviello M Romito R | 2005 | J Am Coll Cardiol2005，45，： | 1 |
| 18 | Chronic subthalamic nucleus stimulation reduces medication requirements in Parkinson's disease 显示文摘 | Scerrati M Romito LM | 1999 | Neurology1999，53，1： | 1 |
| 19 | Determination of the total phenolic,flavonoid and proline contents in Burkina Fasan honey,as well as their radical scavenging activity显示文摘 | Meda A LamienCE Romito | 2005 | Food Chemistry2005，91，： | 1 |
| 20 | The influence of titania/hydroxyapatite composite coatings on in vitro osteoblasts behaviour显示文摘 | Ramires P A Romito A Cosentino P | 2001 | Biomalerials2001，22，12： | 1 |
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