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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | Selective laser melting 3D printing of Ni-based superalloy: understanding thermodynamic mechanisms显示文摘A mesoscopic model has been established to investigate the thermodynamic mechanisms and densification behavior of nickel-based superalloy during additive manufacturing/three-dimensional(3D) printing(AM/3DP)by numerical simulation, using a finite volume method(FVM). The influence of the applied linear energy density(LED) on dimensions of the molten pool, thermodynamic mechanisms within the pool, bubbles migration and resultant densification behavior of AM/3DP-processed superalloy has been discussed. It reveals that the center of the molten pool slightly shifts with a lagging of 4 lm towards the center of the moving laser beam. The Marangoni convection, which has various flow patterns, plays a crucial role in intensifying the convective heat and mass transfer, which is responsible for the bubbles migration and densification behavior of AM/3DP-processed parts. At an optimized LED of 221.5 J/m, the outward convection favors the numerous bubbles to escape from the molten pool easily and the resultant considerably high relative density of 98.9 % is achieved. However, as the applied LED further increases over 249.5 J/m, the convection pattern is apparently intensified with the formation of vortexes and the bubbles tend to be entrapped by the rotating flow within the molten pool, resulting in a large amount of residual porosity and a sharp reduction in densification of the superalloy. The change rules of the relative density and the corresponding distribution of porosity obtained by experiments are in accordance with the simulation results. | Mujian Xia Dongdong Gu Guanqun Yu Donghua Dai Hongyu Chen Qimin Shi | 2016 | Science Bulletin2016，61，13： | 13 |
| 3 | Analysis of microscopic pore structures of rocks before and after water absorption显示文摘岩石的吸水的特征被他们的显微镜的毛孔结构影响,它清楚地在水吸收以后变化。水吸收测试和扫描电子显微镜(SEM ) 在岩石上试验样品,在西藏在一个地点定位了,中国,被执行。在水吸收前后的岩石毛孔结构的变化与毛孔尺寸的分发和毛孔的分数维的特征被学习。因为新小毛孔的数字生产了,表面孔,毛孔的分数维的尺寸和毛孔结构的复杂性增加了的结果表演增加了或在岩石吸收了水以后,原来的 macropore 流动隧道被扩展。有他们的水吸收曲线上的变化的点。在另外的岩石的水吸收以后,当原来的毛孔流动隧道变得充满,表面孔和毛孔的分数维的尺寸和毛孔结构的复杂性减少了。水吸收曲线没变化。表面孔和岩石的毛孔分数维图形尺寸在水吸收前后有好线性关系。 | Li Dejian Wang Guilian Han Liqiang Liu Peiyu He Manchao Yang Guoxing Tai Qimin Chen Cheng | 2011 | Mining Science and Technology2011，21，2： | 6 |
| 4 | Eigen microstates and their evolutions in complex systems显示文摘Emergence refers to the existence or formation of collective behaviors in complex systems.Here,we develop a theoretical framework based on the eigen microstate theory to analyze the emerging phenomena and dynamic evolution of complex system.In this framework,the statistical ensemble composed of M microstates of a complex system with N agents is defined by the normalized N×M matrix A,whose columns represent microstates and order of row is consist with the time.The ensemble matrix A can be decomposed as■,where r=min(N,M),eigenvalueσIbehaves as the probability amplitude of the eigen microstate U_I so that■and U_I evolves following V_I.In a disorder complex system,there is no dominant eigenvalue and eigen microstate.When a probability amplitudeσIbecomes finite in the thermodynamic limit,there is a condensation of the eigen microstate UIin analogy to the Bose–Einstein condensation of Bose gases.This indicates the emergence of U_I and a phase transition in complex system.Our framework has been applied successfully to equilibrium threedimensional Ising model,climate system and stock markets.We anticipate that our eigen microstate method can be used to study non-equilibrium complex systems with unknown orderparameters,such as phase transitions of collective motion and tipping points in climate systems and ecosystems. | Yu Sun Gaoke Hu Yongwen Zhang Bo Lu Zhenghui Lu Jingfang Fan Xiaoteng Li Qimin Deng Xiaosong Chen | 2021 | Communications in Theoretical Physics2021，73，6： | 5 |
| 5 | Borf-1 protein identified as a transcriptional trans-activator of bovine foamy virus显示文摘Bovine foamy virus (BFV), a member of the spumavirus subfamily of retroviruses,contains two open reading frames (ORF-1 and ORF-2) in addition to the genes coding for gag,po/and env. Borf-1 protein, encoded by BFV ORF-1, is identified as a transcriptional transactivator, which augments gene expression directed by the viral long terminal repeat (LTR).Further investigations in transient expression assays reveal that the Borf-1 responsive elements are located in the U3 domain of the LTR, upstream from position -140 ( + 1 represents the transcription initiation site), and the BFV RU5 region has an inhibitory effect in LTR-directed gene expression. | Jiajian Liu Shuhong Liu Qimin Chen Yunqi Geng | 1999 | Chinese Science Bulletin1999，44，11： | 3 |
| 6 | cis-acting element located in the bovine foamy virus internal promoter possesses the properties of a transcrip-tional enhancer显示文摘Bovine foamy virus encodes a transcriptional transactivitor, Tas or Borf-1, which governs the level of viral transcripts initiated by both the promoter in the long terminal repeat (LTR) and the internal promoter (IP) located in the env gene through their cis-acting targets. We have identified and characterized a 72 bp TBS (Borf-1) responsive element located in BFV3026, internal promoter (TREIP) by deletion mutant and transient expression assay. This cis-acting target element in the internal promoter has the properties of a transcriptional enhancer which functions independently of its orientation, position and also in heterologous promoters (BFV LTR and bovine immunodeficiency virus, BIV LTR). Alignments reveal that there are positional similarity and sequence homology among BFV TREIP, SFV-1 TREIP proximal element and SFV-3 TREIPH, which suggests that this kind of cis-acting elements possesses some common functional character. | Wentao Qiao Chunguang Guo Shuhui Wang Jinzhong Wang Qimin Chen Yunqi Geng | 2002 | Chinese Science Bulletin2002，47，13： | 2 |
| 7 | Wireless/wired integrated transmission for industrial cyber-physical systems:risk-sensitive co-design of 5G and TSN protocols显示文摘The growing popularity of intelligent manufacturing is driven by deterministic transmission demands of applications in industrial cyber-physical systems(ICPS).However,the ossified shortages of industrial wireless communication such as diverse quality of service(Qo S)and complex signaling processes incur a severe long tail of transmission delay distribution.As a solution,the 5th generation(5 G)wireless communication technology provides ultra-reliable and low-latency communication(URLLC)for industry scenarios.Moreover,the newly proposed time-sensitive networking(TSN)standards guarantee the transmission determinacy by gate mechanism.In this paper,we propose a heterogeneous time-sensitive network(HTSN)co-designed by 5 G and TSN.We first develop a predictive multi-priority wireless scheduling mechanism based on semi-persistent scheduling(SPS)to reduce signaling delay by reserving resources in advance.Then we propose an adaptive data injection mechanism for TSN based on per-stream filtering and policing(PSFP),which dynamically adjusts the priority of data for queue injection in TSN.To further reduce the long tail of delay,we employ a risk-sensitive learning method to improve the worst-case delay.Simulations on a hot rolling production scenario demonstrate that the proposed mechanisms under HTSN achieve great performance in terms of integrated delay and resource utilization. | Yajing ZHANG Qimin XU Xinping GUAN Cailian CHEN Mingyan LI | 2022 | Science China(Information Sciences)2022，65，1： | 1 |
| 8 | Dramatic reduction of liver cancer incidence in young adults: 28 year follow-up of etiological interventions in an endemic area of China显示文摘 | Zongtang Sun Taoyang Chen Snorri S. Thorgeirsson Qimin Zhan Jianguo Chen Ju-Hyun Park Peixin Lu Chu Chieh Hsia Nengjin Wang Libin Xu Lingling Lu Fei Huang Yuanrong Zhu Jianhua Lu Zhengping Ni Qinan Zhang Yuying Wu Guoting Liu Zhiyuan Wu Chunfeng Qu Mitche | 2013 | Carcinogenesis2013，，8： | 1 |
| 9 | CDK7-YAP-LDHD axis promotes D-lactate elimination and ferroptosis defense to support cancer stem cell-like properties显示文摘Reprogrammed cellular metabolism is essential for maintaining cancer stem cells(CSCs)state.Here,we report that mitochondrial D-lactate catabolism is a necessary initiating oncogenic event during tumorigenesis of esophageal squamous cell carcinoma(ESCC).We discover that cyclin-dependent kinase 7(CDK7)phosphorylates nuclear Yes-associated protein 1(YAP)at S127 and S397 sites and enhances its transcription function,which promotes D-lactate dehydrogenase(LDHD)protein expression.Moreover,LDHD is enriched significantly in ESCC-CSCs rather than differentiated tumor cells and high LDHD status is connected with poor prognosis in ESCC patients.Mechanistically,the CDK7-YAP-LDHD axis helps ESCC-CSCs escape from ferroptosis induced by D-lactate and generates pyruvate to satisfy energetic demands for their elevated self-renewal potential.Hence,we conclude that esophageal CSCs adopt a D-lactate elimination and pyruvate accumulation mode dependent on CDK7-YAP-LDHD axis,which drives stemness-associated hallmarks of ESCC-CSCs.Reasonably,targeting metabolic checkpoints may serve as an effective strategy for ESCC therapy. | Mengzhu Lv Ying Gong Xuesong Liu Yan Wang Qingnan Wu Jie Chen Qingjie Min Dongyu Zhao Xianfeng Li Dongshao Chen Di Yang Danna Yeerken Rui Liu Jinting Li Weimin Zhang Qimin Zhan | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 1 |
| 10 | Defect of SLC38A3 promotes epithelial-mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma显示文摘Objective: Solute carrier family 38(SLC38 s) transporters play important roles in amino acid transportation and signaling transduction. However, their genetic alterations and biological roles in tumors are still largely unclear.This study aimed to elucidate the genetic signatures of SLC38 s transporters and their implications in esophageal squamous cell carcinoma(ESCC).Methods: Analyses on somatic mutation and copy number alterations(CNAs) of SLC38 A3 were performed as described. Immunohistochemistry(IHC) assay and Western blot assay were used to detect the protein expression level. MTS assay, colony formation assay, transwell assay and wound healing assay were used to explore the malignant phenotypes of ESCC cells. Immunofluorescence assay was used to verify the colocalization of two indicated proteins and immunopreciptation assay was performed to confirm the interaction of proteins.Results: Our findings revealed that SLC38 s family was significantly disrupted in ESCC, with high frequent CNAs and few somatic mutations. SLC38 A3 was the most frequent loss gene among them and was linked to poor survival and lymph node metastasis. The expression of SLC38 A3 was lower in tumor tissues compared to that in normal tissues, which was also significantly associated with worse clinical outcome. Further experiments revealed that depletion of SLC38 A3 could promote EMT in ESCC cell lines, and the interaction of SLC38 A3 and SETDB1 might lead to the reduced transcription of Snail. Pharmacogenomic analyses demonstrated that fifteen inhibitors were showed significantly correlated with SLC38 A3 expression.Conclusions: Our investigations have provided insights that SLC38 A3 could act as a suppressor in EMT pathway and serve as a prognostic factor and predictor of differential drug sensitivities in ESCC. | Rui Liu Ruoxi Hong Yan Wang Ying Gong Danna Yeerken Di Yang Jinting Li Jiawen Fan Jie Chen Weimin Zhang Qimin Zhan | 2020 | Chinese Journal of Cancer Research2020，32，5： | 1 |
| 11 | Reduced MTA1 Expression by RNAi Inhibits in Vitro Invasion and Migration of Esophageal Squamous Cell Carcinoma Cell Line显示文摘 | Haili Qian Ning Lu Liyan Xue Xiao Liang Xueyan Zhang Ming Fu Yongqiang Xie Qimin Zhan Zhihua Liu Chen Lin | 2005 | Clinical & Experimental Metastasis2005，，8： | 1 |
| 12 | Quiescence and attenuated DNA damage response promote survival of esophageal cancer stem cells显示文摘 | Yulin Chen Dan Li Dapeng Wang Xuefeng Liu Ning Yin Yongmei Song Shih Hsin Lu Zhenyu Ju Qimin Zhan | 2012 | J Cell Biochem2012，，12： | 1 |
| 13 | Fabrication of Anti-reflecting Si Nano-structures with Low Aspect Ratio by Nano-sphere Lithography Technique显示文摘Nano-structured photon management is currently an interesting topic since it can enhance the optical absorption and reduce the surface reflection which will improve the performance of many kinds of optoelectronic devices, such as Si-based solar cells and light emitting diodes. Here, we report the fabrication of periodically nano-patterned Si structures by using polystyrene nano-sphere lithography technique. By changing the diameter of nano-spheres and the dry etching parameters, such as etching time and etching power, the morphologies of formed Si nano-structures can be well controlled as revealed by atomic force microscopy.A good broadband antireflection property has been achieved for the formed periodically nano-patterned Si structures though they have the low aspect ratio(<0.53). The reflection can be significantly reduced compared with that of flat Si substrate in a wavelength range from 400 nm to 1200 nm. The weighted mean reflection under the AM1.5 solar spectrum irradiation can be as low as 3.92% and the corresponding optical absorption is significantly improved, which indicates that the present Si periodic nano-structures can be used in Si-based thin film solar cells. | Shenghua Sun Peng Lu Jun Xu Ling Xu Kunji Chen Qimin Wang Yuhua Zuo | 2013 | Nano-Micro Letters2013，5，1： | 1 |
| 14 | Research Methods of Computer-assisted Second Language Acquisition显示文摘 | Qimin Chen Quanyou Ruan | 2005 | Sino-US English Teaching2005，2，2： | 0 |
| 15 | Microstructure,oxidation behavior and tribological properties of AlCrN/Cu coatings deposited by a hybrid PVD technique显示文摘Achieving high hardness and low friction at elevated temperatures for nitride-based hard coatings has substantial scientific interest and application significance.In this study,AlCrN/Cu coatings were deposited by a hybrid PVD technique combining arc evaporation from an Al_(60)Cr_(40) target and magnetron sputtering from a Cu target in a mixed Ar and N_(2) atmosphere.The microstructure,oxidation behavior,and tribological properties of the coatings were investigated.AlCrN/Cu coatings show a dual-phase structure of(Al,Cr)N solid solution and Cu metallic phase.Excessive sputtering power of the Cu target induces the disintegration of interlayer interfaces of the nano-multilayered geometry,accompanied by a decline in hardness from above 30 GPa to 22.7 GPa.Moreover,the formation of fine CuO grains on the coating surface is conducive to reducing the friction coefficient of AlCrN/Cu when exposed to air at high temperatures.The AlCrN/Cu coating with a sputtering power of 0.5 kW obtains a friction coefficient of 0.39±0.05 after pre-oxidation at 800℃,distinctly lower than that of AlCrN,which exhibits a friction coefficient of~0.65.The further transformation of CuO to cubic Cu(Al,Cr)_(2)O_(4),which stems from the solid-state reaction of CuO,Al_(2)O_(3),and Cr_(2)O_(3),would cause a rise in friction coefficient and wear loss.The mechanism of oxidation and tribological behavior of the AlCrN/Cu coatings related to the temperature and Cu content was discussed. | Dongsen Geng Haiqing Li Ziliang Chen Yu.X.Xu Qimin Wang | 2022 | Journal of Materials Science & Technology2022，，5： | 0 |
| 16 | PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy显示文摘Stroma surrounding the tumor cells plays crucial roles for tumor progression.However,little is known about the factors that maintain the symbiosis between stroma and tumor cells.In this study,we found that the transcriptional regulator-signal transducer and activator of transcription 3(Stat3)was frequently activated in cancer-associated fibroblasts(CAFs),which was a potent facilitator of tumor malignancy,and formed forward feedback loop with platelet-activating factor receptor(PAFR)both in CAFs and tumor cells.Importantly,PAFR/Stat3 axis connected intercellular signaling crosstalk between CAFs and cancer cells and drove mutual transcriptional programming of these two types of cells.Two central Stat3-related cytokine signaling molecules-interleukin 6(IL-6)and IL-11 played the critical role in the process of PAFR/Stat3 axis-mediated communication between tumor and CAFs.Pharmacological inhibition of PAFR and Stat3 activities effectively reduced tumor progression using CAFs/tumor co-culture xenograft model.Our study reveals that PAFR/Stat3 axis enhances the interaction between tumor and its associated stroma and suggests that targeting this axis can be an effective therapeutic strategy against tumor malignancy. | Di Zhao Jing Zhang Lingyuan Zhang Qingnan Wu Yan Wang Weimin Zhang Yuanfan Xiao Jie Chen Qimin Zhan | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 0 |
| 17 | Synergetic roadmap of carbon neutrality and clean air for China显示文摘It is well recognized that carbon dioxide and air pollutants share similar emission sources so that synergetic policies on climate change mitigation and air pollution control can lead to remarkable co-benefits on greenhouse gas reduction,air quality improvement,and improved health.In the context of carbon peak,carbon neutrality,and clean air policies,this perspective tracks and analyzes the process of the synergetic governance of air pollution and climate change in China by developing and monitoring 18 indicators.The 18 indicators cover the following five aspects:air pollution and associated weather-climate conditions,progress in structural transition,sources,inks,and mitigation pathway of atmospheric composition,health impacts and benefits of coordinated control,and synergetic governance system and practices.By tracking the progress in each indicator,this perspective presents the major accomplishment of coordinated control,identifies the emerging challenges toward the synergetic governance,and provides policy recommendations for designing a synergetic roadmap of Carbon Neutrality and Clean Air for China. | Qiang Zhang Zhicong Yin Xi Lu Jicheng Gong Yu Lei Bofeng Cai Cilan Cai Qimin Chai Huopo Chen Hancheng Dai Zhanfeng Dong Guannan Geng Dabo Guan Jianlin Hu Cunrui Huang Jianing Kang Tiantian Li Wei Li Yongsheng Lin Jun Liu Xin Liu Zhu Liu Jinghui Ma Guofeng Shen Dan Tong Xuhui Wang Xuying Wang Zhili Wang Yang Xie Honglei Xu Tao Xue Bing Zhang Da Zhang Shaohui Zhang Shaojun Zhang Xian Zhang Bo Zheng Yixuan Zheng Tong Zhu Jinnan Wang Kebin He | 2023 | Environmental Science and Ecotechnology2023，，4： | 0 |
| 18 | Membrane-spanning domain of bovine foamy virus transmembrane protein having cytotoxicity显示文摘Foamy viruses(FVs)have broad cellular tropism infecting vertebrates from fish to human being,which indicates that Env protein has a high capability for membrane fusion.Conservative features in all FV transmembrane(TM)proteins include a region of hydrophobic domain called membrane-spanning domain(MSD),which contains several stretches of hydrophobic amino acids.To investigate whether these features were associated with the cytotoxicity effect of TM on Escherichia coli,a series of mutants were constructed and expressed in the E.coli BL21(DE3)using pET-32a(+)as expressing vector.The results showed that only TM3 without MSD was expressed in E.coli,whereas the other two containing full or part of the MSD(TM1 and TM2)could not be expressed.Furthermore,the bacterial amount and living bacteria analysis revealed that the cytotoxicity of TM was dependent on its MSD,especially on the stretches of hydrophobic amino acids.Western blotting analysis showed that TM3 protein was purified with affinity purification. | MA Yonggang YU Hong WANG Jinzhong CHEN Qimin GENG Yunqi | 2006 | Frontiers in Biology2006，1，4： | 0 |
| 19 | Tumor-associated macrophage(TAM)-derived CCL22 induces FAK addiction in esophageal squamous cell carcinoma(ESCC)显示文摘Tumor cell dependence on activated oncogenes is considered a therapeutic target,but protumorigenic microenvironment-mediated cellular addiction to specific oncogenic signaling molecules remains to be further defined.Here,we showed that tumor-associated macrophages(TAMs)produced an abundance of C-C motif chemokine 22(CCL22),whose expression in the tumor stroma was positively associated with the level of intratumoral phospho-focal adhesion kinase(pFAK Tyr^(397)),tumor metastasis and reduced patient survival.Functionally,CCL22-stimulated hyperactivation of FAK was correlated with increased malignant progression of cancer cells.CCL22-induced addiction to FAK was demonstrated by the persistent suppression of tumor progression upon FAK-specific inhibition.Mechanistically,we identified that diacylglycerol kinaseα(DGKα)acted as a signaling adaptor to link the CCL22 receptor C-C motif chemokine receptor 4(CCR4)and FAK and promoted CCL22-induced activation of the FAK/AKT pathway.CCL22/CCR4 signaling activated the intracellular Ca^(2+)/phospholipase C-γ1(PLC-γ1)axis to stimulate the phosphorylation of DGKαat a tyrosine residue(Tyr^(335))and promoted the translocation of DGKαto the plasma membrane to assemble the DGKα/FAK signalosome,which critically contributed to regulating sensitivity to FAK inhibitors in cancer cells.The identification of TAM-driven intratumoral FAK addiction provides opportunities for utilizing the tumor-promoting microenvironment to achieve striking anticancer effects. | Jie Chen Di Zhao Lingyuan Zhang Jing Zhang Yuanfan Xiao Qingnan Wu Yan Wang Qimin Zhan | 2022 | Cellular & Molecular Immunology2022，19，9： | 0 |
| 20 | MicroRNAs and their role in viral infection显示文摘Recently,a class of about 22 nucleotides(nt)small RNA has been discovered in many eukaryotes,termed microRNAs(miRNAs),which have a variety of functions.Many recent findings have demonstrated that viruses can also encode their own miRNAs.Meanwhile,other findings reveal a relationship between host miRNA and viral infection.These findings suggest a tight relationship between host and viral infection via miRNA pathway.This article introduces the miRNAs encoded by viruses and reviews the advances of the interaction of the mammalian host miRNAs and viral infection. | MU Junjie YAO Xue CHEN Qimin GENG Yunqi QIAO Wentao | 2007 | Frontiers in Biology2007，2，1： | 0 |
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