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| 1 | Aerodynamic Design Methodology for Blended Wing Body Transport显示文摘This paper puts forward a design idea for blended wing body(BWB).The idea is described as that cruise point,maximum lift to drag point and pitch trim point are in the same flight attitude.According to this design idea,design objectives and constraints are defined.By applying low and high fidelity aerodynamic analysis tools,BWB aerodynamic design methodology is established by the combination of optimization design and inverse design methods.High lift to drag ratio,pitch trim and acceptable buffet margin can be achieved by this design methodology.For 300-passenger BWB configuration based on static stability design,as compared with initial configuration,the maximum lift to drag ratio and pitch trim are achieved at cruise condition,zero lift pitching moment is positive,and buffet characteristics is well.Fuel burn of 300-passenger BWB configuration is also significantly reduced as compared with conventional civil transports.Because aerodynamic design is carried out under the constraints of BWB design requirements,the design configuration fulfills the demands for interior layout and provides a solid foundation for continuous work. | LI Peifeng ZHANG Binqian CHEN Yingchun YUAN Changsheng LIN Yu | 2012 | Chinese Journal of Aeronautics2012，25，4： | 29 |
| 2 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 3 | Geochronologic constraints on magmatic intrusions and mineralization of the Zhunuo porphyry copper deposit in Gangdese,Tibet显示文摘In situ zircon U-Pb ages for the recently discovered Zhunuo porphyry copper deposit in the western part of the Gangdese metallogenic belt in Tibet were determined by sensitive high-resolution ion mi-croprobe(SHRIMP) . The ages can be divided into two separate groups,reflecting more than four major tectono-magmatic events in the area. The 62.5±2.5 Ma age of inherited zircons may be related to the volcanic eruption of the Linzizong Group formed shortly after the India-Asia continental collision. The 50.1±3.6 Ma age most likely corresponds to the time of underplating of mantle-derived mafic magma in Gangdese. The 15.6±0.6 Ma age obtained from magmatic zircons is interpreted as the age of crystalli-zation of the Zhunuo ore-forming porphyry. Finally,a molybdenite Re-Os isochron age of 13.72±0.62 Ma is consistent with another zircon U-Pb age of 13.3 ±0.2 Ma,representing the time of copper mineraliza-tion. These ages,in combination with available literature data,indicate that magmatic crystallization and copper mineralization in the Gangdese metallogenic belt became gradually younger westward,and further suggest that the Zhunuo porphyry copper deposit was formed in the same tectonic stage as other porphyry copper deposits in the eastern and central Gangdese belt. This conclusion provides critical information for future exploration of porphyry copper deposits in western Gangdese. | ZHENG YouYe ZHANG GangYang XU RongKe GAO ShunBao PANG YingChun CAO Liang DU AnDao SHI YuRuo | 2007 | Chinese Science Bulletin2007，52，22： | 17 |
| 4 | Geothermal data analysis at the high-temperature hydrothermal area in Western Sichuan显示文摘The western Sichuan hydrothermal area is located at the northeastern margin of the eastern syntaxis of the Qinghai-Tibet Plateau, which is also the eastern end of the Mediterranean-Himalayan geothermal activity zone. There are 248 warm or hot springs in this area, and 11 have temperatures beyond the local boiling temperature. Most of these hot springs are distributed along the Jinshajiang, Dege-Xiangcheng, Ganzi-Litang, and Xianshuihe faults, forming a NW-SE hydrothermal belt. A geothermal analysis of this high-temperature hydrothermal area is an important basis for understanding the deep geodynamic process of the eastern syntaxis of the Qinghai-Tibet Plateau. In addition, this study offers an a priori view to utilize geothermal resources, which is important in both scientific research and application. We use gravity, magnetic, seismic, and helium isotope data to analyze the crust-mantle heat flow ratio and deep geothermal structure. The results show that the background terrestrial heat flow descends from southwest to northeast. The crustal heat ratio is not more than 60%. The high temperature hydrothermal active is related to crustal dynamics processes. Along the Batang-Litang-Kangding line, the Moho depth increases eastward, which is consistent with the changing Qc/Qm(crustal/mantle heat flow) ratio trend. The geoid in the hydrothermal zone is 4–6 km higher than the surroundings, forming a local 'platform'. The NW-SE striking local tensile stress zone and uplift structure in the upper and middle crust corresponds with the surface hydrothermal active zone. There is an average Curie Point Depth(CPD) of 19.5–22.5 km in Batang, Litang, and Kangding. The local shear-wave(S-wave) velocity is relatively low in the middle and lower crust. The S-wave shows a low velocity trap(Vs<3.2 km s.1) at 15–30 km, which is considered a high-temperature partial melting magma, the crustal source of the hydrothermal active zone. We conclude that the hydrothermal system in this area can be divided into Batang-type and Kangding-type, both of which rely on a crustal heating cycle of atmospheric precipitation and surface water along the fracture zone. The heat is derived from the middle and lower crust: groundwater penetrates the deep faults bringing geothermal energy back to the surface and forming high-temperature springs. | ZHANG Jian LI WuYang TANG XianChun TIAN Jiao WANG YingChun GUO Qi PANG ZhongHe | 2017 | Science China Earth Sciences2017，60，8： | 17 |
| 5 | Constrained large-eddy simulation and detached eddy simulation of flow past a commercial aircraft at 14 degrees angle of attack显示文摘With the development of computational power and numerical algorithms,computational fluid dynamics(CFD) has become an important strategy for the design of aircraft,which significantly reduces the reliance on wind-tunnel and flight tests.In this paper,we conducted a numerical investigation on the flow past a full commercial aircraft at Mach number 0.2 and 14 degrees angle of attack by means of Reynolds-averaged Navier-Stokes(RANS),detached-eddy simulation(DES) and our newly developed constrained large-eddy simulation(CLES).The objective of this paper is to study the capability of these models in simulating turbulent flows.To our knowledge,this is the first large-eddy simulation method for full commercial aircraft simulation.The results show that the CLES can predict the mean statistical quantities well,qualitatively consistent with traditional methods,and can capture more small-scale structures near the surface of the aircraft with massive separations.Our study demonstrates that CLES is a promising alternative for simulating real engineering turbulent flows. | CHEN ShiYi CHEN YingChun XIA ZhenHua QU Kun SHI YiPeng XIAO ZuoLi LIU QiuHong CAI QingDong LIU Feng LEE Cunbiao ZHANG RiKui CAI JinSheng | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，2： | 14 |
| 6 | Aquaporin JcPIP2 is Involved in Drought Responses in Jatropha curcas显示文摘水隧道蛋白质, aquaporins,在在植物的 transmembranewater 运动的戏基础角色。编码 aquaporin 的新全身的 cDNA 从 Jatropha curcas 的幼苗被孤立。质膜的基因从 J 的内在的蛋白质(果仁) 。curcas (JcPIP2 ) 包含了 843 bp 编码 280 氨基酸的蛋白质的开的读框架。氨基酸顺序与 Ricinus communis 果仁显示出 94% 身份。JcPIP2 互补 RNA intoXenopus 卵母细胞的注射增加了 10 褶层卵母细胞的渗透的水渗透。有 anti-JcPIP2 抗体的 Immunodetection ofJcPIP2 显示这蛋白质无所不在地位于植物的所有测试纸巾。调查在 aquaporins 和干旱抵抗 inJ 之间的关系。curcas,许多 JcPIP2 在二 J 的幼苗被检验。curcas 人口, GaoYouCSC63 和 YanBian S1,在有 PEG6000 的水赤字下面。在地条件下面,那些二张人口, GaoYou CSC63 是抵抗的浇赤字,而是 YanBian S1 是敏感的浇剥夺。与干旱应力的增加的度, JcPIP2 水平在幼苗 ofGaoYou CSC63 增加了,而在 YanBian S1 的幼苗没有重要变化。比较 withYanBian S1, GaoYou CSC63 也显示出更高的根在在水赤字下面的幼苗的水力的电导率和更低的减少趋势。这些结果显示 JcPIP2 可能在 J 在干旱抵抗起了一个作用。curcas。 | Ying ZHANG Yunxiao WANG Luding JIANG Ying XU Yingchun WANG Daihua LU Fang CHEN | 2007 | Acta Biochimica et Biophysica Sinica2007，39，10： | 13 |
| 7 | New Progress on the Coal Fines Affecting the Development of Coalbed Methane显示文摘Objective The production of coal fines is very common in the development of coalbed methane(CBM)in the eastern margin of the Ordos Basin,China.A large amount of produced coal fines seriously affect the productivity of CBM wells(Wei Yingchun et al.,2013).Therefore,the production problems of CBM wells caused by coal fines have attracted extensive attention.The destruction | WEI Yingchun LI Chao CAO Daiyong ZHANG Aoxiang WANG Anmin XIANG Xinxuan | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 11 |
| 8 | Antimicrobial susceptibility of Gram-negative bacteria causing intra-abdominal infections in China: SMART China 2011显示文摘 | Zhang Hui Yang Qiwen Xiao Meng Chen Minjun Robert E. Badal Xu Yingchun | 2014 | Chinese Medical Journal2014，，13： | 10 |
| 9 | A Model Output Machine Learning Method for Grid Temperature Forecasts in the Beijing Area显示文摘In this paper, the model output machine learning (MOML) method is proposed for simulating weather consultation, which can improve the forecast results of numerical weather prediction (NWP). During weather consultation, the forecasters obtain the final results by combining the observations with the NWP results and giving opinions based on their experience. It is obvious that using a suitable post-processing algorithm for simulating weather consultation is an interesting and important topic. MOML is a post-processing method based on machine learning, which matches NWP forecasts against observations through a regression function. By adopting different feature engineering of datasets and training periods, the observational and model data can be processed into the corresponding training set and test set. The MOML regression function uses an existing machine learning algorithm with the processed dataset to revise the output of NWP models combined with the observations, so as to improve the results of weather forecasts. To test the new approach for grid temperature forecasts, the 2-m surface air temperature in the Beijing area from the ECMWF model is used. MOML with different feature engineering is compared against the ECMWF model and modified model output statistics (MOS) method. MOML shows a better numerical performance than the ECMWF model and MOS, especially for winter. The results of MOML with a linear algorithm, running training period, and dataset using spatial interpolation ideas, are better than others when the forecast time is within a few days. The results of MOML with the Random Forest algorithm, year-round training period, and dataset containing surrounding gridpoint information, are better when the forecast time is longer. | Haochen LI Chen YU Jiangjiang XIA Yingchun WANG Jiang ZHU Pingwen ZHANG | 2019 | Advances in Atmospheric Sciences2019，36，10： | 9 |
| 10 | The effect of cdk-5 overexpression on tau phosphorylation and spatial memory of rat显示文摘In Alzheimer抯 disease (AD), hyperphosphorylation of tau may be the underlying mechanism for the cytoskeletal abnormalities and neuronal death. It was reported that cy-clin-dependent kinase5 (cdk-5) could phosphorylate tau at most AD-related epitopes in vitro. In this study, we investigated the effect of cdk-5 overexpression on tau phosphorylation and spatial memory in rat. We demonstrated that 24 h after transfection into rat hippocampus, cdk-5 was overexpressed and induced a reduced staining with antibody tau-1 and an enhanced staining with antibodies 12e8 and PHF-1, suggesting hyperphosphorylation of tau at Ser199/202, Ser262/356 and Ser396/404 sites. Additionally, the cdk-5 transfected rats showed long latency to find the hidden platform in Morris water maze compared to the control rat. 48 h after transfection, the level of cdk-5 was decreased significantly, and the latency of rats to find the hidden platform was prolonged. It implies that in vivo overexpression of cdk-5 leads to impairment of spatial memory in rat and tau hyperphosphorylation may be the underlying mechanism. | LIAO Xiaomei ZHANG Yingchun WANG Yipeng WANG Jianzhi | 2004 | Science China(Life Sciences)2004，47，3： | 8 |
| 11 | Fatigue Property of Basalt Fiber-Modified Asphalt Mixture under Complicated Environment显示文摘The fatigue property of asphalt mixtures under complicated environment(low-temperature bending performance, chloride penetration, freezing-thawing cycle and their coupling effect) and the improvement effect for relevant property of basalt fiber-reinforcing asphalt mixture under complicated environment are studied. Two grading types of asphalt mixtures, AC-16 I and AC-13 I, are chosen, whose optimum asphalt-aggregate ratio and optimum dosage of basalt fiber are determined by the Marshall test. The standard specimens are made firstly, and then the low temperature bending tests of asphalt mixture and basalt fiber-reinforced asphalt mixture under the coupling effect of the chloride erosion and freezing-thawing cycle have been carried out. Finally, the fatigue property tests of asphalt mixture and basalt fiber-reinforced asphalt mixture under complex environment are performed on MTS material testing system. The results indicate that the tensile strength, the maximum curving tensile stress, the curving stiffness modulus, and fatigue properties of asphalt mixture are infl uenced by the coupling effect of the chloride erosion and freezing-thawing cycle. The low-temperature bending performance and fatigue property of asphalt mixtures under complicated environment can be greatly improved by adding moderate basalt fiber. The dense gradation asphalt mixture possesses stronger ability to resist adverse environmental effects under the same condition. | 郑元勋 CAI Yingchun ZHANG Guanghai FANG Hongyuan | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，5： | 8 |
| 12 | Satellite fault diagnosis method based on predictive filter and empirical mode decomposition显示文摘A novel satellite fault diagnosis scheme is presented based on the predictive filter and empirical mode composition(EMD).First,the predictive filter is utilized to obtain the fault estimation,which is corrupted by noise.Then the EMD method is introduced to decompose the fault estimation into a finite number of intrinsic mode functions and extract the trend of faults for fault diagnosis.The proposed scheme has the ability of diagnosing both abrupt and incipient faults of the actuator in a satellite attitude control subsystem.A mathematical simulation is given to illustrate the effectiveness of the proposed scheme. | Yi Shen Yingchun Zhang Zhenhua Wang | 2011 | Journal of Systems Engineering and Electronics2011，22，1： | 8 |
| 13 | mTERF5 Acts as a Transcriptional Pausing Factor to Positively Regulate Transcription of Chloroplast psbEFLJ显示文摘RNA polymerase transcriptional pausing represents a major checkpoint in transcription in bacteria and metazoans,but it is unknown whether this phenomenon occurs in plant organelles.Here,we report that transcriptional pausing occurs in chloroplasts.We found that mTERF5 specifically and positively regulates the transcription of chloroplast psbEFLJ in Arabidopsis thaliana that encodes four key subunits of photosystem II.We found that mTERF5 causes the plastid-encoded RNA polymerase(PEP)complex to pause at psbEFLJ by binding to the+30 to+51 region of double-stranded DNA.Moreover,we revealed that mTERF5 interacts with pTAC6,an essential subunit of the PEP complex,although pTAC6 is not involved in the transcriptional pausing at psbEFLJ.We showed that mTERF5 recruits additional pTAC6 to the transcriptionally paused region of psbEFLJ,and the recruited pTAC6 proteins could be assembled into the PEP complex to regulate psbEFLJ transcription.Taken together,our findings shed light on the role of transcriptional pausing in chloroplast transcription in plants. | Shunhua Ding Yi Zhang Zhi Hu Xiahe Huang Bohan Zhang Qingtao Lu Xiaogang Wen Yingchun Wang Congming Lu | 2019 | Molecular Plant2019，12，9： | 6 |
| 14 | Centro-parietal N200: An event-related potential component specific to Chinese visual word recognition显示文摘Almost all written languages currently used in the world are alphabetic or phonologically-based scripts (e.g., English) whose word recognition involves discrimination of one-dimensional linear combinations of several dozens of letters or phonological units, except written Chinese whose vocabulary consists of a large number of block characters, the analysis of which relies on the extraction of 2-dimensional form information at multiple levels including radical, character, and multiple-character word. Whether the dramatic contrast between the 2 types of orthography leads to distinctive mental processes is a fundamental question in psycholinguistic research unanswered in the past three decades. Using event-related potentials and visual lexical decision tasks, we asked native Chinese speakers to discriminate between real Chinese words and pseudoor non-words and observed a widespread negative deflection with centro-parietal focus elicited 200 ms post-stimulus onset. This N200 response showed a clear and large amplitude enhancement upon word repetition and seems to be specific to Chinese as no similar effects had been reported in word recognition studies involving alphabetic scripts under similar experimental conditions. Further evidence showed that this N200 could not be attributed to non-linguistic sensori-perceptual processes, nor phonological or semantic processes, but likely reflects very early identification of the orthography of individual words involving extensive and higher-level visual analysis. Recently the first author proposed a meaning-spelling theory of written Chinese vocabulary proposing that the Chinese and alphabetic scripts are the only 2 possible logical types of mature human writing systems, and that the former is more thoroughly a visual language compared with the latter and thus shall emphasize more of visual processing. Reinforcing each other, the meaning-spelling theory and the discovery of the centro-parietal N200 reveal the uniqueness of Chinese both theoretically and empirically, and provide strong arguments for the intrinsic distinction between written Chinese and alphabetic scripts. | ZHANG John X FANG Zhuo DU YingChun KONG LingYue ZHANG Qin XING Qiang | 2012 | Chinese Science Bulletin2012，57，13： | 6 |
| 15 | Synthesis, characterization and dielectric properties of a novel temperature stable(1-x)CoTiNb2O8-xZnNb2O6 ceramic显示文摘(1-x)CoTiNb2O8-x ZnNb2O6 microwave dielectric ceramics were prepared via the conventional solid-state reaction route with the aim of reducing thetf value and improving the thermal stability.The phase composition and the microstructure were investigated using X-ray diffraction,Raman spectra,and scanning electron microscopy.A set of phase transitions which were induced by composition had been confirmed via the sequence:rutile structure→coexistence of rutile and columbite phase→columbite phase.For(1-x)CoTiNb2O8-x ZnNb2O6 microwave dielectric ceramics,the addition of ZnNb2O6 content(x=0–1)led to the decrease ofer from 62.98 to 23.94.As a result of the high Q×?of ZnNb2O6 ceramics,the increase of ZnNb2O6 content also led to the lower sintering temperatures and the higher Q×?values.Thetf value was reduced from+108.04(x=0)to–49.31 ppm/℃(x=1).Among them,high density 0.5CoTiNb2O8-0.5ZnNb2O6 ceramics were obtained at 1175℃with excellent microwave dielectric properties of εr 39.2,Q×? 40013 GHz,and tf+3.57 ppm/℃. | Mengjuan WU Yingchun ZHANG Maoqiao XIANG | 2019 | Journal of Advanced Ceramics2019，8，2： | 6 |
| 16 | Structure,rheology and electrospinning of zein and poly(ethylene oxide) in aqueous ethanol solutions显示文摘Electrospun fiber mats (EFM) integrated proteins and biocompatible polymers have been widely used as tissue scaffold, wound dressing and food packaging. The morphology of EFM has strong correlation with the structure and rheology of the solutions. We studied the structure and rheology of polyethylene oxide (PEO) and zein in 80% ethanol aqueous solutions and the resulted EFM. In solutions, zein with rod-like conformation tends to aggregate and form oligomer, the number of proteins in the oligomer spans from 2.5 to 55.2, while PEO always behaves like Gaussian chain in good solvent. Zein preferred to distribute along PEO chains in their mixed solutions, and the structures decomposed from small angle X-ray scattering have consistent relaxation spatial-temporal characteristics with rheological behaviors.Further, the aging of zein solutions enhanced shear thinning and resulted thicker fibers in EFM, which are attributed to the rod-like growth of zein aggregates. Aggregates in viscous media with long enough relaxation time are probably crucial for the formation of continuous electrospun fibers or ribbons. This study provides a clear correlation of the structure, rheology of solutions with the morphologies of EFM made up of proteins and polymers. | Ce Shi Shixia Xi Yingchun Han Hao Zhang Jingsheng Liu Yunqi Li | 2019 | Chinese Chemical Letters2019，30，2： | 5 |
| 17 | Multiple Dolomitization and Fluid Flow Events in the Precambrian Dengying Formation of Sichuan Basin, Southwestern China显示文摘The Precambrian Dengying Formation is a set of large-scale, extensively dolomitized, carbonate reservoirs occurring within the Sichuan Basin. Petrographic and geochemical studies reveal dolomitization was a direct result of precipitation by chemically distinct fluids occurring at different times and at different intensities. Based on this evidence, dolomitization and multiple fluid flow events are analyzed, and three types of fluid evolution models are proposed. Results of analysis show that Precambrian Dengying Formation carbonates were deposited in a restricted peritidal environment(630–542 Ma). A high temperature and high Mg^(2+) concentration seawater was a direct result of dolomitization for the micrite matrix, and for fibrous aragonite in primary pores. Geochemical evidence shows low δ^(18)O values of micritic dolomite varying from-1.29‰ to-4.52‰ PDB, abundant light rare earth elements(REEs), and low dolomite order degrees. Microbes and meteoric water significantly altered dolomite original chemical signatures, resulting in algal micritic dolomite and the fine-grained, granular, dolosparite dolomite having very negative δ^(18)O values. Finely crystalline cement dolomite(536.3–280 Ma) and coarsely crystalline cement dolomite have a higher crystallization degree and higher order degree. The diagenetic sequence and fluid inclusion evidence imply a linear correlation between their burial depth and homogenization temperatures, which closely resemble the temperature of generated hydrocarbon. Compared with finely crystalline dolomite, precipitation of coarsely crystalline dolomite was more affected by restricted basinal fluids. In addition, there is a trend toward a more negative δ^(18)O value, higher salinity, higher Fe and Mn concentrations, REE-rich. Two periods of hydrothermal fluids are identified, as the exceptionally high temperatures as opposed to the temperatures of burial history, in addition to the presence of high salinity fluid inclusions. The early hydrothermal fluid flow event was characterized by hot magnesium-and silicon-rich fluids, as demonstrated by the recrystallized matrix dolomite that is intimately associated with flint, opal, and microcrystalline quartz in intergranular or intercrystalline pores. This event was likely the result of a seafloor hydrothermal chimney eruption during Episode I of the Tongwan Movement(536.3±5.5 Ma). In contrast, later hydrothermal fluids, which caused precipitation of saddle dolomite, were characterized by high salinity(15–16.05 wt% NaCl equivalent) and homogenization temperatures(250 to 265°C), δ^(18)O values that were more enriched, and REE signatures. Geochemical data and the paragenetic sequence indicate that this hydrothermal fluid was related to extensive Permian large igneous province activity(360–280 Ma). This study demonstrates the presence of complicated dolomitization processes occurring during various paleoclimates, tectonic cycles, and basinal fluids flow; results are a useful reference for these dolomitized Precambrian carbonates reservoirs. | PENG Bo LI Zongxing LI Guorong LIU Chenglin ZHU Shifa ZHANG Wang ZUO Yinhui GUO Yingchun WEI Xiaojie | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 5 |
| 18 | Subcutaneous and intramuscular fat transcriptomes show large differences in network organization and associations with adipose traits in pigs显示文摘Subcutaneous fat(SCF)and intramuscular fat(IMF)deposition is relevant to health in humans,as well as meat production and quality in pigs.In this study,we generated RNA sequence data for 122 SCF,120 IMF,and 87 longissimus dorsi muscle(LDM)samples using 155 F6 pigs from a specially designed heterogeneous population generated by intercrossing four highly selected European commercial breeds and four indigenous Chinese pig breeds.The phenotypes including waist back fat thickness and intramuscular fat content were also measured in the 155 F6 pigs.We found that the genes in SCF and IMF differed largely in both expression levels and network connectivity,and highlighted network modules that exhibited strongest gain of connectivity in SCF and IMF,containing genes that were associated with the immune process and DNA double-strand repair,respectively.We identified 215 SCF genes related to kinase inhibitor activity,mitochondrial fission,and angiogenesis,and 90 IMF genes related to lipolysis and fat cell differentiation,displayed a tissue-specific association with back fat thickness and IMF content,respectively.We found that cis-expression QTL for trait-associated genes in the two adipose tissues tended to have tissuedependent predictability for the two adipose traits.Alternative splicing of genes was also found to be associated with SCF or IMF deposition,but the association was much less extensive than that based on expression levels.This study provides a better understanding of SCF and IMF gene transcription and network organization and identified critical genes and network modules that displayed tissue-specific associations with subcutaneous and intramuscular fat deposition.These features are helpful for designing breeding programs to genetically improve the two adipose traits in a balanced way. | Yifeng Zhang Yingchun Sun Zhongzi Wu Xinwei Xiong Junjie Zhang Junwu Ma Shijun Xiao Lusheng Huang Bin Yang | 2021 | Science China(Life Sciences)2021，64，10： | 5 |
| 19 | Engineered Functional Surfaces by Laser Microprocessing for Biomedical Applications显示文摘Metallic biomaterials are increasingly being used in various medical applications due to their high strength,fracture resistance,good electrical conductivity,and biocompatibility.However,their practical applications have been largely limited due to poor surface performance.Laser microprocessing is an advanced method of enhancing the surface-related properties of biomaterials.This work demonstrates the capability of laser microprocessing for biomedical metallic materials including magnesium and titanium alloys,with potential applications in cell adhesion and liquid biopsy.We investigate laser-material interaction,microstructural evolution,and surface performance,and analyze cell behavior and the surface-enhanced Raman scattering(SERS)effect.Furthermore,we explore a theoretical study on the laser microprocessing of metallic alloys that shows interesting results with potential applications.The results show that cells exhibit good adhesion behavior at the surface of the laser-treated surface,with a preferential direction based on the textured structure.A significant SERS enhancement of 6×10^3 can be obtained at the laser-textured surface during Raman measurement. | Guoqing Hu Kai Guan Libin Lu Jiaru Zhang Nie Lu Yingchun Guan | 2018 | Engineering2018，4，6： | 5 |
| 20 | Guaranteed cost control for uncertain stochastic fuzzy systems with time delay显示文摘这篇论文学习与延期由 Takagi-Sugeno (T-s ) 代表了模糊模式的时间为不明确的非线性的随机的系统的一个类保证费用控制问题得到的一个延期依赖者,与不明确的参数。描述符系统方法和 Gu 是不平等被采用获得延期依赖者足够的条件以便剂量环系统与某个保证费用控制表演是 asymptotically 稳定的。建议方法的有效性被一个模拟例子显示出。 | ZHANG Huaguang WANG Yingchun | 2007 | Progress in Natural Science:Materials International2007，17，1： | 5 |
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