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| 1 | China National Medical Products Administration approval summary:anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy显示文摘Background:On May 8,2018,the China National Medical Products Administration(NMPA)approved anlotinib,an orally administered anti-angiogenesis inhibitor,for the treatment of patients with advanced non-small cell lung can-cer(NSCLC)who have progressed after treatment with two or more lines of prior systemic chemotherapy.Main body of the abstract:China NMPA reviewed and inspected a regional double-blinded,placebo-controlled,Phase III trial comparing the overall survival(OS)of NSCLC patients between the anlotinib and placebo arms.A total of 437 patients were randomized(2:1)to receive either anlotinib(n=294)or placebo(n=143)once daily on a 2-week on and 1-week off schedule.Patients with epidermal growth factor receptor(EGFR)or activating anaplastic lymphoma kinase(ALK)genomic tumor aberrations should have disease progression on NMPA-approved therapy.Anlotinib is the first NMPA-approved drug for patients with advanced NSCLC who have progressed on at least two lines of prior systemic chemotherapies in China.The approval was based on a statistically and clinically significant improvement in median OS with anlotinib(9.46 months)compared with placebo[6.37 months;hazard ratio(HR])=0.70,95%confidence interval(CI)=0.55-0.89;two-sided log-rank P=0.002].The confirmed objective response rate(ORR)was 9.2%in the anlotinib arm and 0.7%in the placebo arm.The median duration of response(DoR)was 4.83 months,with a 95%CI of 3.31-6.97 months.The toxicity profile of anlotinib was consistent with that of known anti-angiogenesis inhibitors.Common adverse drug reactions(ADRs)in anlotinib-treated patients included hypertension(67.4%),hand-foot syndrome(43.9%),hemoptysis(14.0%),thyroid stimulating hormone(TSH)elevation(46.6%),and corrected QT interval(QTc)prolongation(26.2%).Short conclusion:Anlotinib demonstrated a clinically significant OS prolongation as a novel therapeutic option for advanced or metastatic NSCLC following at least two lines of chemotherapy. | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | Cancer Communications2019，39，1： | 35 |
| 2 | p53 upregulated by HIF-la promotes hypoxiainduced G2/M arrest and renal fibrosis in vitro and in vivo显示文摘Hypoxia plays an important role in the genesis and progression of renal fibrosis.The underlying mechanisms, however, have not been sufficiently elucidated. We examined the role of p53 in hypoxia-induced renal fibrosis in cell culture (human and rat renal tubular epithelial cells) and a mouse unilateral ureteral obstruction (UUO) model. Cell cycle of tubular cells was determined by flow cytometry, and the expression of profibrogenic factors was determined by RT-PCR, immunohistochemistry, and western blotting. Chromatin immunoprecipitation and luciferase reporter experiments were performed to explore the effect of HIF-lα on p53 expression. We showed that, in hypoxic tubular cells, p53 upregulation suppressed the expression of CDK1 and cyclins Bl and DI, leading to cell cycle (G2/M) arrest (or delay) and higher expression of TGF-β, CTGF, collagens, and fibronectin. p53 suppression by siRNA or by a specific p53 inhibitor (PIF-α) triggered opposite effects preventing the G2/M arrest and profibrotic changes. In vivo experiments in the UUO model revealed similar antifibrotic results following intraperitoneal administration of PIF-α(2.2 mg/kg). Using gain-of-function, loss-of-function, and luciferase assays, we further identified an HRE3 region on the p53 promoter as the HIF-lα-binding site. The HIF-la-HRE3 binding resulted in a sharp transcriptional activation of p53. Collectively, we show the presence of a hypoxia-activated, p53-responsive profibrogenic pathway in the kidney. During hypoxia, p53 upregulation induced by HIF-la suppresses cell cycle progression, leading to the accumulation of G2/M cells, and activates profibrotic TGF-β and CTGF-mediated signaling pathways, causing extracellular matrix production and renal fibrosis. | Limin Liu Peng Zhang Ming Bai Lijie He Lei Zhang Ting Liu Zhen Yang Menglu Duan Minna Liu Baojian Liu Rui Du Qi Qian Shiren Sun | 2019 | Journal of Molecular Cell Biology2019，11，5： | 18 |
| 3 | H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2显示文摘H5N1 流行性感冒病毒的感染在所有流行性感冒病毒之中引起最高的死亡。位于如此的高病毒的致病力下面的机制不完全地被理解。这里,我们报导 H5N1 流行性感冒病毒编码象 microRNA 一样小 RNA, miR-HA-3p,它从茎被处理由 Argonaute 2 的包含环的病毒的 RNA 先锋,和戏在在 H5N1 感染期间提高 cytokine 生产的一个角色。miR-HA-3p poly 指向的机械学的学习表演(rC ) 有约束力的蛋白质 2 (PCBP2 ) 并且压制它的表达式。与 PCBP2 being 一致 RIG-I/MAVS-mediated 抗病毒的天生的免疫的一个重要否定管理者,由 miR-HA-3p 的 PCBP2 表示的抑制在感染 H5N1 的人的巨噬细胞和老鼠支持 cytokine 生产病毒。我们断定 miR-HA-3p 是首先识别的流行性感冒编码病毒的象 microRNA 一样功能的 RNA 碎片和贡献导致 H5N1 的 cytokine 暴风雨和死亡的一个新奇毒力因素。 | Xihan Li Zheng Fu Hongwei Liang Yanbo Wang Xian Qi Meng Ding Xinlei Sun Zhen Zhou Ying Huang Hongwei Gu Limin Li Xi Chen Donghai Li Quan Zhao Fenyong Li Hua Wang Jin Wang Ke Zen Chen-Yu Zhang | 2018 | Cell Research2018，28，2： | 12 |
| 4 | Inhibition of growth and metastasis of triple-negative breast cancer targeted by Traditional Chinese Medicine Tubeimu in orthotopic mice models显示文摘Objective: Triple-negative breast cancer(TNBC) is highly invasive and metastatic, which is in urgent need of transformative therapeutics. Tubeimu(TBM), the rhizome of Bolbostemma paniculatum(Maxim.) Franquet, is one of the Chinese medicinal herbs used for breast diseases since the ancient times. The present study evaluated the efficacy, especially the anti-metastatic effects of the dichloromethane extract of Tubeimu(ETBM) on TNBC orthotopic mouse models and cell lines.Methods: We applied real-time imaging on florescent orthotopic TNBC mice model and tested cell migration and invasion abilities with MDA-MB-231 cell line. Digital gene expression sequencing was performed and Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis applied to explore the pathways influenced by ETBM.Moreover, quantitative real-time polymerase chain reactions(q RT-PCR) and Western blot were delivered to confirm the gene expression changes.Results: ETBM exhibited noticeable control on tumor metastasis and growth of TNBC tumors with no obvious toxicity. In compliance with this, it also showed inhibition of cell migration and invasion in vitro. Its impact on the changed biological behavior in TNBC may be a result of decreased expression of integrin β1(ITGβ1), integrin β8(ITGβ8) and Rho GTPase activating protein 5(ARHGAP5), which disabled the focal adhesion pathway and caused change in cell morphology.Conclusions: This study reveals that ETBM has anti-metastatic effects on MDA-MB-231-GFP tumor and may lead to a new therapeutic agent for the integrative treatment of highly invasive TNBC. | Jingxiao Wang Xinjie Yang Haibo Han Limin Wang Weiqian Bao Shanshan Wang Robert M.Hoffman Meng Yang Hui Qi Chao An Kaiwen Hu | 2018 | Chinese Journal of Cancer Research2018，30，1： | 8 |
| 5 | Effects of insoluble dietary fiber from wheat bran on noodle quality显示文摘Benefiting from its favorable effects in promoting intestinal peristalsis,increasing satiety and reducing postprandial blood sugar,wheat bran insoluble dietary fiber(IDF)could be added to noodles to improve the nutrition value of noodle products.However,the addition of IDF usually results in an adverse effect on the quality characteristics of fiber fortified products,leading to unfavorable texture and consumption drop.It was found that IDF could weaken dough characteristics,thereby causing the quality deterioration of noodles,but the mechanism is unclear as yet.This study aimed to investigate the effects of different amounts of IDF on the texture quality and cooking quality of noodles.The water distribution,rheological properties,pasting properties and cooking properties of the noodles were determined by low-field nuclear magnetic resonance(LF-NMR),dynamic rheometer,and rapid visco-analyzer.The results of the LF-NMR showed that the increased IDF in the noodles resulted in a contraction of relaxation time and an increase in the proportion of loosely bound water.At a high amount of IDF,the water absorption and tensile distance of the noodles significantly decreased and the cooking loss rate increased,with a downward trend in peak viscosity,final viscosity and setback values.Moreover,IDF could improve the storage modulus and loss modulus of sheeted dough and enhance the texture of noodles.Furthermore,the correlations between IDF addition amounts and rheological properties as well as cooking properties were analyzed,and the results confirmed that noodles with the IDF amount of 2%–4%had higher nutrition and quality.This study provides the basis for future development and improvement of IDF-enriched health foods. | Mengxu Lei Jihong Huang Xiaoling Tian Peng Zhou Qi Zhu Limin Li Li Li Sen Ma Xiaoxi Wang | 2021 | Grain & Oil Science and Technology2021，4，1： | 8 |
| 6 | 中国国家药品监督管理局批准安罗替尼用于经两种系统化疗后疾病进展的晚期非小细胞肺癌的治疗显示文摘背景2018年5月8日,中国国家药品监督管理局(National Medical Products Administration,NMPA)批准了小分子多靶点抗血管抑制剂盐酸安罗替尼,用于既往经过至少两种系统化疗后疾病进展的晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的治疗。概要中国NMPA审查了一项随机双盲、安慰剂对照的III期临床试验,该临床试验的主要终点为总生存期(overall survival,OS)。试验共纳入437例患者随机分组(2∶1)接受安罗替尼(n=294)或安慰剂(n=143)治疗,每日1次,连服2周,停药1周。表皮生长因子受体(epidermal growth factor receptor,EGFR)基因敏感突变或间变性淋巴瘤激酶(activating anaplasticlymphomakinase,ALK)阳性的患者须经过NMPA已批准的药物治疗后出现疾病进展。安罗替尼为中国NMPA批准的用于治疗既往经过两种及以上系统化疗后疾病进展的晚期NSCLC患者的首个药物。安罗替尼组的中位OS(9.46个月)较安慰剂组[6.37个月;风险比(hazard ratio,HR)=0.70,95%置信区间(confidence Interval,CI):0.55–0.89;双侧log-rank P=0.002]显著延长。安罗替尼组的客观缓解率(objective responserate,ORR)为9.2%,安慰剂组为0.7%。安罗替尼组的中位缓解持续时间(durationofresponse,DoR)为4.83个月,95%CI为3.31–6.97个月。安罗替尼的常见不良反应(adverse drug reactions,ADRs)包括高血压(67.4%)、手足综合征(43.9%)、咳血(14.0%)、促甲状腺激素(thyroid stimulating hormone,TSH)升高(46.6%)、心电图QT间期(corrected QT Interval,QTc)延长(26.2%)。结论安罗替尼显著延长了患者的OS,可作为经二线及以上化疗后晚期或转移性非小细胞肺癌的一种新的治疗方案。 | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | 癌症2019，38，12： | 7 |
| 7 | Carbon Stock of Larch Plantations and Its Comparison with an Old-growth Forest in Northeast China显示文摘The overall goal of this study was to understand carbon(C) stock dynamics in four different-aged Japanese larch(Larix kaempferi) plantations in Northeast China that were established after clear-cutting old-growth Korean pine deciduous forests. Four Japanese larch plantations which were at 10, 15, 21, and 35 years old and an old-growth Korean pine deciduous forest which was 300 years old in Northeast China were selected and sampled. We compared the C pools of biomass(tree, shrub and herb), litterfall(LF), and soil organic carbon(SOC) among them. The biomass C stock of larch plantation at 10, 15, 21, and 35 years old was 26.8, 37.9, 63.6, and 83.2 Mg/ha, respectively, while the biomass C stock of the old-growth Korean pine deciduous forest was 175.1 Mg/ha. The SOC stock of these larch plantations was 172.1, 169.7, 140.3, and 136.2 Mg/ha respectively, and SOC stock of 170.4 Mg/ha in the control of old-growth forest. The biomass C stock increased with stand age of larch plantations, whereas SOC stock decreased with age, and C stock of LF did not change significantly(P > 0.05). The increase of biomass C offset the decline of SOC stock with age, making total carbon stock(TCS) of larch plantations stable from stand ages of 10–35 years. The TCS in larch plantations was much smaller than that in the old-growth forest, suggesting that the conversion of old-growth forests to young larch plantations releases substantial C into the atmosphere. | QI Guang CHEN Hua ZHOU Li WANG Xinchuang ZHOU Wangming QI Lin YANG Yuhua YANG Fengling WANG Qingli DAI Limin | 2016 | Chinese Geographical Science2016，26，1： | 6 |
| 8 | Recent advances in fabrication of monolayer colloidal crystals and their inverse replicas显示文摘Monolayer colloidal crystals(MCCs)are two-dimensional(2D)colloidal crystals consisting of a monolayer of monodisperse colloidal particles arrayed with a 2D periodic order.In recent years,MCCs have attracted intensive interest because they can act as 2D photonic crystals and be used as versatile templates for fabrication of various 2D nanostructure arrays.In this review,we provide an overview of the recent progress in the controllable fabrication of MCCs and their inverse replicas.First,some newly-developed methods for the self-assembly of MCCs based on different strategies including interfacial assembly and convective assembly are introduced.Second,some representative novel methods regarding the fabrication of various functional2D inverse replicas of MCCs,such as 2D arrays of nanobowls,nanocaps,and hollow spheres,as well as 2D monolayer inverse opals(MIOs),are described.In addition,the potential applications of MCCs and their inverse replicas are discussed. | YE XiaoZhou QI LiMin | 2014 | Science China Chemistry2014，57，1： | 5 |
| 9 | Solution-phase synthesis of inorganic nanostructures by chemical transformation from reactive templates显示文摘The solution-phase synthesis by chemical transformation from reactive templates has proved to be very effective in morphology-controlled synthesis of inorganic nanostructures. This review paper summarizes the recent progress in solution-phase synthesis of one-dimensional and hollow inorganic nanostructures via reactive templates, focusing on the approaches developed in our lab. The formation mechanisms based on reactive templates are discussed in depth to show the general concepts for the preparation processes. An outlook on the future development in this area is also presented. | HUANG Teng & QI LiMin* Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry, Peking University, Beijing 100871, China | 2010 | Science China Chemistry2010，53，2： | 4 |
| 10 | TiO_2 mesocrystals: Synthesis, formation mechanisms and applications显示文摘Mesocrystals, which are assemblies of crystallographically oriented nanocrystals, have received increasing attention due to their unique properties such as high crystallinity, high porosity, oriented subunit alignment, and similarity to highly sophisticated biominerals. However, the controlled synthesis of TiO 2 mesocrystals has not been realized until recently, probably because of the difficulty in accurately controlling the reaction processes that produce TiO 2 crystals. In this review, recent advances in the synthesis and applications of TiO 2 mesocrystals are summarized with particular attention paid to the mechanisms of their formation. Three typical pathways for the preparation of TiO 2 mesocrystals are discussed, namely topotactic transformation, direct synthesis in solution, and growth on supports. The potential applications of TiO 2 mesocrystals in lithium ion batteries, photocatalysis, enzyme immobilization, and antireflection materials are also described. | CAI JinGuang QI LiMin | 2012 | Science China Chemistry2012，55，11： | 3 |
| 11 | Reversible self-assembly of gold nanorods mediated by photoswitchable molecular adsorption显示文摘Stimuli-responsive self-assembly of nanoparticles represents a powerful strategy to achieve reconfigurable materials with novel functionalities and promising applications.In this regard,light-induced reversible self-assembly (LIRSA) of nanoparticles is most attractive but it is usually limited by the prerequisite yet cumbersome chemical functionalizations of the particle surface.Here we describe an innovative method to realize LIRSA of gold nanorods (GNRs) without surface functionalization through photoswitchable adsorption of an anionic azobenzene derivate AzoNa.The LIRSA of GNRs is caused by the reversible change between a nearly neutral state and a highly charged state of the GNRs arising from the photoswichable adsorption of AzoNa triggered by photoisomerization.The LIRSA behavior can be readily adjusted by changing the concentration of AzoNa and the aspect ratio of the GNRs.This new LIRSA strategy may provide a convenient and efficient route toward light-triggered reversibly reconfigurable nanomaterials. | Qian Wang Di Li Junyan Xiao Fucheng Guo Limin Qi | 2019 | Nano Research2019，12，7： | 2 |
| 12 | Degradation of acid fuchsine by a modified electro-Fenton system with magnetic stirring as oxygen supplying显示文摘The current modified electro-Fenton system was designed to develop a more convenient and efficient undivided system for practical wastewater treatment.The system adopted a cathode portion that employed magnetic stirring instead of common oxygen gas difflusion or gas sparging to supply oxygen gas for the electrolyte solution.Key factors influencing the cathode fabrication and activity were investigated.The degradation of acid fuchsine with a self-made graphite-polytetrafluorethylene cathode was studied using a spectrophotometer.It was found that the cathode generated hydrogen peroxide with high current efficiency and the hydrogen peroxide yield of the cathode did not decay after 10 times reuse.With the Pt anode at a ferrous ion concentration of 0.5 mmol/L,a pH of 3,and using magnetic stirring,dye decolorization could be rapidly accomplished but the destruction of benzene rings and intermediates was fairly difficult.With a Fe anode,dye degradation was more complete. | Yiping Sheng,Limin Zhen,Xiuli Wang,Ning Li,Qi Tong College of Environmental and Chemical Engineering,Yanshan University,Qinhuangdao,Hebei 066004,China. | 2010 | Journal of Environmental Sciences2010，22，4： | 2 |
| 13 | Helically Grooved Gold Nanoarrows: Controlled Fabrication, Superhelix, and Transcribed Chiroptical Switching显示文摘Plasmonic chiroptical materials,coupled by chirality and surface plasmons,have been attracting great interest due to their potential applications,such as photonics,chiral recognition,asymmetric catalysis and biosensing.Herein,we constructed a new chiral plasmonic nanostructure—helically grooved gold nanoarrows(HeliGNAs)by introducing L-/Dcysteine(L-/D-Cys)during the growth of the gold nanoarrows(GNAs).The variation of the concentration of L-/D-Cys leads to the HeliGNAs with a tunable plasmonic circular dichroism(PCD). | Song Wang Liheng Zheng Wenjie Chen Lukang Ji Li Zhang Wensheng Lu Zheyu Fang Fucheng Guo Limin Qi Minghua Liu | 2021 | CCS Chemistry2021，3，9： | 2 |
| 14 | Single-atom Sn-Zn pairs in CuO catalyst promote dimethyldichlorosilane synthesis显示文摘Single-atom catalysts are of great interest because they can maximize the atom-utilization efficiency and generate unique catalytic properties;however,much attention has been paid to single-site active components,rarely to catalyst promoters.Promoters can significantly affect the activity and selectivity of a catalyst,even at their low concentrations in catalysts.In this work,we designed and synthesized CuO catalysts with atomically dispersed co-promoters of Sn and Zn.When used as the catalyst in the Rochow reaction for the synthesis of dimethyldichlorosilane,this catalyst exhibited much-enhanced activity,selectivity and stability compared with the conventional CuO catalysts with promoters in the form of nanoparticles.Density functional theory calculations demonstrate that single-atomic Sn substitution in the CuO surface can enrich surface Cu vacancies and promote dispersion of Zn to its atomic levels.Sn and Zn single sites as the co-promoters cooperatively generate electronic interaction with the CuO support,which further facilitates the adsorption of the reactant molecules on the surface,thereby leading to the superior catalytic performance. | Qi Shi Yongjun Ji Wenxin Chen Yongxia Zhu Jing Li Hezhi Liu Zhi Li Shubo Tian Ligen Wang Ziyi Zhong Limin Wang Jianmin Ma Yadong Li Fabing Su | 2020 | National Science Review2020，7，3： | 2 |
| 15 | Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration显示文摘 | Yujing Zhang Danqing Liu Xi Chen Jing Li Limin Li Zhen Bian Fei Sun Jiuwei Lu Yuan Yin Xing Cai Qi Sun Kehui Wang Yi Ba Qiang Wang Dongjin Wang Junwei Yang Pingsheng Liu Tao Xu Qiao Yan Junfeng Zhang Ke Zen Chen-Yu Zhang | 2010 | Molecular Cell2010，，1： | 2 |
| 16 | Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration显示文摘 | Yujing Zhang Danqing Liu Xi Chen Jing Li Limin Li Zhen Bian Fei Sun Jiuwei Lu Yuan Yin Xing Cai Qi Sun Kehui Wang Yi Ba Qiang Wang Dongjin Wang Junwei Yang Pingsheng Liu Tao Xu Qiao Yan Junfeng Zhang Ke Zen Chen-Yu Zhang | 2010 | Molecular Cell2010，，1： | 1 |
| 17 | Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease显示文摘 | Jiang Changtao Xie Cen Li Fei Zhang Limin Nichols Robert G Krausz Kristopher W Cai Jingwei Qi Yunpeng Fang Zhong-Ze Takahashi Shogo Tanaka Naoki Desai Dhimant Amin Shantu G Albert Istvan Patterson Andrew D Gonzalez Frank J | 2015 | Journal of Clinical Investigation2015，，1： | 1 |
| 18 | Preparation of BaSO4 nanoparticles in non-ionic w/o microemulsions显示文摘 | MAjiming CHENG Humin | 1996 | Colloids and Surfaces A:PhysicochemEngAspects1996，108，： | 1 |
| 19 | Studies on nylon 6/ clay nanocomposites by melt-intercalation process显示文摘 | Liu Limin Qi Zongneng Zhu Xiaoguang | 1999 | Journal of Applied Polymer Science1999，71，： | 1 |
| 20 | Effect of hapten structures on specific and sensitive enzyme-linked immunosorbent assays for N-methylcarbamate insecticide metolcarb显示文摘 | ZHANG Qi WU Yunru WANG Limin | 2008 | Analytica Chimica Acta2008，625，1： | 1 |
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