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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | China National Medical Products Administration approval summary:anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy显示文摘Background:On May 8,2018,the China National Medical Products Administration(NMPA)approved anlotinib,an orally administered anti-angiogenesis inhibitor,for the treatment of patients with advanced non-small cell lung can-cer(NSCLC)who have progressed after treatment with two or more lines of prior systemic chemotherapy.Main body of the abstract:China NMPA reviewed and inspected a regional double-blinded,placebo-controlled,Phase III trial comparing the overall survival(OS)of NSCLC patients between the anlotinib and placebo arms.A total of 437 patients were randomized(2:1)to receive either anlotinib(n=294)or placebo(n=143)once daily on a 2-week on and 1-week off schedule.Patients with epidermal growth factor receptor(EGFR)or activating anaplastic lymphoma kinase(ALK)genomic tumor aberrations should have disease progression on NMPA-approved therapy.Anlotinib is the first NMPA-approved drug for patients with advanced NSCLC who have progressed on at least two lines of prior systemic chemotherapies in China.The approval was based on a statistically and clinically significant improvement in median OS with anlotinib(9.46 months)compared with placebo[6.37 months;hazard ratio(HR])=0.70,95%confidence interval(CI)=0.55-0.89;two-sided log-rank P=0.002].The confirmed objective response rate(ORR)was 9.2%in the anlotinib arm and 0.7%in the placebo arm.The median duration of response(DoR)was 4.83 months,with a 95%CI of 3.31-6.97 months.The toxicity profile of anlotinib was consistent with that of known anti-angiogenesis inhibitors.Common adverse drug reactions(ADRs)in anlotinib-treated patients included hypertension(67.4%),hand-foot syndrome(43.9%),hemoptysis(14.0%),thyroid stimulating hormone(TSH)elevation(46.6%),and corrected QT interval(QTc)prolongation(26.2%).Short conclusion:Anlotinib demonstrated a clinically significant OS prolongation as a novel therapeutic option for advanced or metastatic NSCLC following at least two lines of chemotherapy. | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | Cancer Communications2019，39，1： | 35 |
| 3 | Detection of HBV DNA and its existence status in liver tissues and peripheral blood lymphocytes from chronic hepatitis B patients显示文摘INTRODUCTIONCumulativeclinicalandexperimentalevidenceindicatesthathostimmuneresponsestohepatitisBvirus(HBV)areresponsibleforl... | TANG Ren Xian, GAO Feng Guang, ZENG Ling Yu, WANG Ying Wei and WANG Yu Long | 1999 | World Journal of Gastroenterology1999，5，4： | 27 |
| 4 | Selection of Parents for Breeding Edible Varieties of Sweetpotato with High Carotene Content显示文摘Sweetpotato varieties with high carotene content have high value for human health. This work aims to improve the breeding efficiency of special varieties with high carotene content by combining molecular markers and agronomic traits to evaluate and screen the parents. The cluster analysis was carried out to identify and screen promising parents by utilizing phenotypic results of the agronomic and characteristic traits, and RAPD and ISSR markers of 15 parents and their offspring by group crossing. Among different parental materials, greater variations were observed in two important traits, the carotene content and the storage root yield. Negative correlation was found between the carotene content and both fresh and dried root yields. The most significant positive correlation was between the carotene content of parents and that of their offspring, with the coefficient of correlation value of 0.7932**. The relationship based on the agronomic characters of the trial materials was not in agreement with the known genealogy, while that based on the molecular marker data showed better result. Each primer amplified 13.8 bands of ISSR markers on average, in which the rate of polymorphic loci was 89.6%. 9.4 bands of RAPD markers were amplified per primer, in which the rate of polymorphic bands was 74.46%. Large genetic variation of carotene content was found among the parents. For analyzing the genetic diversity of sweetpotato, the molecular marker methods were better than morphological traits; ISSR markers were more efficient than RAPD markers. The combination of molecular markers and agronomic trait analysis may provide valuable theoretic basis for selection of parents to breed new varieties with high carotene content. | MA Dai-fu LI Qiang LI Xiu-ying LI Hong-min TANG Zhong-hou HU Ling CAO Qing-he XIE Yi-ping WANGXin | 2009 | Agricultural Sciences in China2009，8，10： | 28 |
| 5 | High-Strength and High-Plasticity TWIP Steel for Modern Vehicle显示文摘In this paper new high-strength and high-plasticity twinning induced plasticity (TWIP) steel for modern automobile body was investigated. Some basic experimental results were given. The results indicate the TWlP steel has excellent properties. It exhibits high ultimate tensile strength (600~1100 MPa) and extremely large elongation of 60% to 90%. In the future it would be capable of satisfying the requirements of new generation of vehicle. | Zhenli MI Di TANG Ling YAN Jin GUO | 2005 | Journal of Materials Science & Technology2005，21，4： | 25 |
| 6 | Pyroptosis: mechanisms and diseases显示文摘Currently,pyroptosis has received more and more attention because of its association with innate immunity and disease.The research scope of pyroptosis has expanded with the discovery of the gasdermin family.A great deal of evidence shows that pyroptosis can affect the development of tumors.The relationship between pyroptosis and tumors is diverse in different tissues and genetic backgrounds.In this review,we provide basic knowledge of pyroptosis,explain the relationship between pyroptosis and tumors,and focus on the significance of pyroptosis in tumor treatment.In addition,we further summarize the possibility of pyroptosis as a potential tumor treatment strategy and describe the side effects of radiotherapy and chemotherapy caused by pyroptosis.In brief,pyroptosis is a double-edged sword for tumors.The rational use of this dual effect will help us further explore the formation and development of tumors,and provide ideas for patients to develop new drugs based on pyroptosis. | Pian Yu Xu Zhang Nian Liu Ling Tang Cong Peng Xiang Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 26 |
| 7 | Glutamine and recombinant human growth hormone protect intestinal barrier function following portal hypertension surgery显示文摘瞄准:在肠的障碍功能追随者门静脉高血压外科上评估夫酸安(Gln ) 和 recombinant 人生长激素(rhGH ) 的联合治疗的效果。方法:这研究是被设计一未来,使随机化并且控制了临床的试用。在门静脉高血压外科以后的四十二个病人随机被分配进 2 个组:控制组(n = 20 ) 并且补加的组(增加的 Gln 和 rhGH, n = 22 ) 。每耐心的收到的 isocaloric 和 isonitrogenous 标准总计为 7 d 在外科以后开始 3 d 的非肠道的营养(TPN ) 。血样品在外科前并且在第三 and 被获得第 10 白天手术后地。主人免疫被测量 CD4, CD8, CD4/CD8, IgG, IgM 和 IgA 的层次评估,并且煽动性的回答被估计 IL-2, TNF-alpha 和 C 反应的蛋白质(CRP ) 决定层次。肠的渗透和正直被 L/M 测试和组织学的检查分别地评估。结果:在手术后的 d 上 10 ,在补加的组的 CD4 , CD4/CD8 , IgG 和 IL-2 层次比在控制组的那些显著地高( 33.7 +/- 5.5 对 31.0 +/- 5.4 , P <
0.05 ,( 1.17 +/- 0.32 对 1.05 +/- 0.15 , P <
0.05 , 13.94 +/- 1.09 对 12.33 +/- 1.33 , P <
0.05 ,和 368.12 +/- 59.25 对 318.12 +/- 45.65 , P <
0.05 ,分别地)而浆液 TNF-alpha 集中的增加显著地被减少( 41.02 +/- 27.56 对 160.09 +/- 35.17 , P <
0.05 )。L/M 比率的增加比在控制组在补加的组是显著地更低的(0.0166 +/- 0.0017 对 0.0339 +/- 0.0028, P <
0.05 ) 。而且,在补加的组的粘膜完整比在控制组好。结论:在门静脉高血压外科以后在病人与 Gln 和 rhGH 补充的 TPN 的手术后的管理改进有免疫力的功能,调制煽动性的反应,阻止肠的粘膜萎缩并且保存肠的正直。 | Zhao-Feng Tang Yun-Biao Ling Nan Lin Zheng Hao Rui-Yun Xu | 2007 | World Journal of Gastroenterology2007，13，15： | 22 |
| 8 | Dynamic Prediction Method of Production Logistics Bottleneck Based on Bottleneck Index显示文摘In modern manufacturing pattern,there are many uncertain factors in the modern manufacturing process,such as changes of product attribute,changes of manufacturing resources' state,and so on,which cause production logistics bottleneck frequently shift,and make decisions of production planning and control based on formed bottleneck deviated from practical production process.Considering these factors,present researches mainly apply afterwards control to optimize production process to passively adapt to bottleneck changes.If the direction of bottleneck shifting can be accurately forecasted,the transition from afterwards control of chasing bottleneck to beforehand control can be realized.Therefore,aiming at the phenomenon of production logistics bottleneck shifting under uncertain manufacturing circumstances,this paper starts off with dynamic property of capability and requirement and then builds the concepts of bottleneck degree and bottleneck index to describe dynamic bottleneck characteristic of production unit;taken production capability,production load and quality assurance capability into consideration,mathematical model of bottleneck index is established to measure bottleneck degree accurately,consequently,quantitative research on mechanism of production logistics shifting is achieved.Based on bottleneck index,the prediction model of production logistics bottleneck is founded to predict dynamic change of bottleneck accurately.Finally,an example of forecasting and monitoring the production logistics bottleneck in one manufacturing shop is given to testify the validation and practicability of the prediction method. | LIU Mingzhou TANG Juan GE Maogen JIANG Zengqiang HU Jing LING Lin | 2009 | Chinese Journal of Mechanical Engineering2009，22，5： | 22 |
| 9 | Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration显示文摘1. Introduction Drug-induced liver injury (DILI), defined as liver injury caused by a drug and/or its metabolites, is a common clinical adverse drug reaction1–4. This type of injury can cause acute liver failure and even death in severe cases5. | Xiaohe Xiao Jianyuan Tang Yimin Mao Xiuhui Li Jiabo Wang Chenghai Liu Kewei Sun Yong’an Ye Zhengsheng Zou Cheng Peng Ling Yang Yuming Guo Zhaofang Bai Tingting He Jing Jing Fengyi Li Na An | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 22 |
| 10 | Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway显示文摘This study aimed to verify the effects of berberine(BBR)on the fat metabolism proteins involved in the sirtuin 3(SIRT3)/adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK)/acetyl-CoA carboxylase(ACC)pathway in the liver tissues of rats with high-fat diet(HFD)-induced non-alcoholic fatty liver disease(NAFLD).Forty-eight rats were randomly divided into the normal control(NC)group,HFD group or BBR group,with 16 rats in each group.After 8 and 16 weeks of treatment,serum and liver samples were collected.Subsequently,body parameters,biochemical parameters and liver pathology were examined.The expression levels of proteins involved in the SIRT3/AMPK/ACC pathway in the liver were detected by Western blotting.After 8 and 16 weeks of a HFD,the successful establishment of rat models with different degrees of NAFLD was confirmed by hematoxylin and eosin(H&E)and Oil Red O staining.NAFLD rat models exhibited obesity and hyperlipidemia,and the protein expression levels of SIRT3,p-AMPK.p-ACC,and CPT-1A in the liver were significantly decreased compared to those in the NC group.The concurrent administration of BBR with the HFD effectively improved serum and liver lipid profiles and ameliorated liver injury.Furthermore,the protein expression levels of SIRT3,p-AMPK,p-ACC,and CPT-1 A in the liver were significantly increased in the BBR group as compared with those in the HFD group.In conclusion,our data suggest that the mechanism by which BBR ameliorates HFD-induced hepatic steatosis may be related to the activation of the SIRT3/AMPK/ACC pathway in the liver. | Yu-pei ZHANG Yuan-jun DENG Kai-rui TANG Run-sen CHEN Shu LIANG Yin-ji LIANG Li HAN Ling JIN Zi-en LIANG Yan-ning CHEN Qin-he YANG | 2019 | Current Medical Science2019，39，1： | 21 |
| 11 | Effect of cypermethrin insecticide on the microbial community in cucumber phyllosphere显示文摘Cucumber (Cucumis sativus) is one of the most widely used vegetable in the world,and different pesticides have been extensively used for controlling the insects and disease pathogens of this plant.However,little is known about how the pesticides affect the microbial community in cucumber phyllosphere.This study was the first attempt to assess the impact of pyrethroid insecticide cyperemethrin on the microbial communities of cucumber phyllosphere using biochemical and genetic approaches.Phospholipid fatty acid (PLFA) assay indicated that cyperemethrin insecticide treatment led to a significant increase in both total and bacterial biomass and a decrease in fungal biomass and the ratio of Gram-positive (GP) bacteria to Gram-negative (GN) bacteria within the cucumber phyllosphere.Principal-component analyses (PCA) suggested that the number of unsaturated and cyclopropane PLFAs (16:1ω9t,18:1ω7,cy17:0,cy19:0) increased with the insecticide treatment,whereas the saturated PLFA i16:0,i17:0 decreased.The increase of GN bacteria implied that the cypermethrin insecticide might be a nutrient for the growth of these phyllosphere microbes.Terminal restriction fragment length polymorphism (T-RFLP) reinforced the PLFA results.A significant change of bacterial community structure was observed in the separate dendrogram cluster between control and treated samples with the cucumber phyllosphere following cypermethrin insecticide treatment.Moreover,the increased terminal restriction fragments (T-RFs) (58,62,89,99,119,195,239,311,340,and 473 bp) indicated that some bacteria might play a significant role in the insecticide degradation within the cucumber phylosphere,whereas the disappeared T-RFs (44,51,96,223,306,and 338 bp) implied that some other bacteria might potentially serve as microbial indicator of cyperemethrin insecticide exposure. | Baoguo ZHANG Zhihui BAI | 2008 | Journal of Environmental Sciences2008，20，11： | 19 |
| 12 | Endothelial Nitric Oxide Synthase Gene Intron 4, 27 bp Repeat Polymorphism and Essential Hypertension in the Kazakh Chinese Population显示文摘为了调查在 27 bp 之间的关系,在内含子 4in 重复多型性 endothelial 在 KazakhChinese 人口的氮的氧化物合酶( eNOS4 )基因和必要高血压,有必要高血压和 138 个健康的人的 151 个病人在 Xinjiang uygur 从 Shawan 区域的 Boertonggu 农村被选择中国 in2006 的自治区域。在二个组的 eNOS 的多型性与聚合酶链反应试金被检测,在每个组的遗传型频率是计算的跟随 Hardy-Weinberg 法律。Fourand 27 bp 重复的五辆双人脚踏车是被指明一 and “ b' 分别地。b/b, b/a 和 eNOS4 基因的 a/a 遗传型的频率在控制组是 84.06% , 15.22% 和 0.72% ,这被发现,并且 81.46% , 15.89% 和 2.65% 分别地在高血压组织。基因的频率一 and “ b' 在控制组是 91.67% 和 8.33% , 89.40% 和 10.60% 分别地在高血压组织。血浆 eNOS 活动没与 eNOS 基因的遗传型和等位基因被联系,这被发现。在高血压组的血浆 eNOS 活动显著地与控制组(P<0.01 ) 相比被减少。结果建议 eNOS4 基因多型性是不大可能的是为在 Xinjiang 哈萨克人口的必要高血压的主要基因危险性因素。然而,在血浆 eNOS 活动之间的一个积极协会和必要高血压被揭示了。 | Fengmei DENG Qinghua HU Bin TANG Fang HE Shuxia GUO Jiang CHEN Feng LI Xuehua WU Jun ZHANG Huimin ZHANG Juan ZHAO Hua ZHONG Ling HE Jun LI Le ZHANG Shuren WANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，5： | 18 |
| 13 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 14 | NUMERICAL INVESTIGATION OF FLOW PATTERNS IN DIFFERENT PUMP INTAKE SYSTEMS显示文摘A 3-D numerical model for pump intake is established based on the Navier-Stokes equations with the RNG turbulence model and the VOF method to simulate the free surface.The applicability of the proposed model is validated by a test case of non-symmetric pump-intake bay.The predicted locations,structures and shapes of all vortices are in good agreement with those observed in experiments,though with some differences in vorticity strengths.The flow pattern and the efficiency of five types of pump intake systems are studied.The discharge and the velocity uniformity of the intake system are used as indices to evaluate its performance. | ZHAN Jie-min WANG Ben-cheng YU Ling-hui LI Yok-sheung TANG Ling | 2012 | Journal of Hydrodynamics2012，24，6： | 16 |
| 15 | Effects of aspirin on atherosclerosis and the cyclooxygenase-2 expression in atherosclerotic rabbits显示文摘Background Atherosclerosis is a complex vascular inflammatory disease. Aspirin is a mainstay in the prevention of vascular complications of atherosclerosis. In this study, the effectiveness of aspirin in suppressing atherosclerosis and the inflammation process was evaluated in rabbits fed with a high fat diet. Methods Eighteen male New Zealand rabbits were randomly divided into 3 groups: control group, untreated cholesterol-fed group, aspirin treated cholesterol-fed group, which were fed for 12 weeks. After 12 weeks, the aorta was harvested for pathologic morphology observation. Immunohistochemical analysis of cyclooxygenase-2 (COX-2), macrophage and vascular smooth muscle cell (VSMC) was performed. The statistical analysis was performed by the statistical program SPSS10.0. Results The aorta plaque/intima size (P/I) by pathologic morphology observation was 0%, (59.6±13.7)% and (36.3±16.5)% in the control, untreated cholesterol-fed group and aspirin treated group, respectively. The maximum plaque thickness, the degree of artery stenosis and the proportion of the intimal circumference occupied by atheroma of the 3 groups were significantly different from each other (P<0.01). The expression of COX-2 and macrophage in plaque of the aspirin treated group were decreased compared with that in untreated cholesterol-fed group. However, no difference was found in the expression of VSMC between the aspirin treated and the untreated cholesterol-fed group. Conclusion The mechanism of atherosclerosis suppression by aspirin in cholesterol-fed rabbits is related to the inhibition of COX-2 expression together with the reduced inflammation followed by, but not related to the hypolipidemic effects. | GUO Yi WANG Qi-zhang TANG Bing-shan ZUO Yan-fang LI Fang-ming JIANG Xin WANG Ling MA Ke-fu | 2006 | Chinese Medical Journal2006，，21： | 16 |
| 16 | Analysis of Epstein-Barr viral DNA load, EBV-LMP2 specific cytotoxic T-lymphocytes and levels of CD4^+CD25^+ T ceils in patients with nasopharyngeal carcinomas positive for IgA antibody to EBV viral capsid antigen显示文摘背景 Epstein-Barr 病毒(EBV ) 是通常包括鼻咽的癌(NPC ) 与几恶意的疾病联系的 herpesvirus,它是在 Southeastem 亚洲的普通癌症。以前的研究证明 EBV-DNA 的血浆层次可能是为诊断的敏感、可靠的 biomarker,阶段并且为 NPC 治疗评估。有 EBV 潜伏的膜蛋白质 2 的层次(LMP2 ) 的一些分析在有 NPC 的病人的特定的细胞毒素的 T 淋巴细胞(CTL ) 。这研究被进行从2006年2月在如此的 patients.Methods 调查 EBV-LMP2-specific CTL , EBV-DNA 负担和 CD4+CD25+T 房间的水平的层次到2006年4月,有 NPC 的 62 个病人,为 EBV 病毒的衣壳抗原( EBV-IgA-VCA )和 40 控制积极的 40 健康病毒 carders 在学习被注册。我们使用了高度敏感的 ELISPOT 试金,即时聚合酶链反应( PCR )和测量 EBV-LMP2-specific CTL 反应, EBV DNA 负担和 CD4+CD25+T 房间的水平的流动 cytometry , respectively.Results 从控制的样品的 EBV-LMP2-specific CTL 回答,有 NPC 的健康病毒 carders 和病人与 LMP2 epitopes 显著地不同,与控制和显示在三种情况中的更强壮的回答的健康病毒 carder 样品。在在在 NPC 和健康的组之间的浆液的 EBV DNA 负担有重要差别;有在阶段的 NPC 的病人或在阶段与那些相比喝了显著地更高的病毒的精液或。CD4+CD25+ T 淋巴细胞的一个显著地更高的百分比在病人被检测,与健康病毒搬运人和健康控制相比。而且,有 NPC 的先进阶段的病人(并且)与早阶段比病人有显著地更高的百分比(并且)有 NPC 的 .Conclusions 病人经常是不能的建立或维持足够的 immunosurveillance 到怀有 EBV 的控制增殖 B 房间并且破坏表示 immunodominant LMP2 proteins.Controlling 的肿瘤房间这项活动 CD4+CD25+T 房间和为 LMP2 epitopes 特定的提高的 CD8+calls 能是为病人 wi | MO Wu-ning TANG An-zhou ZHOU Ling HUANG Guang-wu WANG Zhan ZENG Yi | 2009 | Chinese Medical Journal2009，，10： | 15 |
| 17 | Liver Enzymes Concentrations Are Closely Related to Pre-diabetes:Findings of the Shanghai Diabetes Study Ⅱ (SHDS Ⅱ)显示文摘Objective To investigate the relationship of liver enzymes with hyperglycemia in a large population in Shanghai and identify the association between liver enzymes and insulin resistance.Methods A total of 3 756 participants were enrolled.Each participant underwent an oral glucose tolerance test and completed a questionnaire.Anthropometric indices were recorded and serum samples were collected for measurement.Results Liver enzymes concentrations were independently associated with i-IGT,IFG+IGT,and diabetes.With the increase of ALT and GGT concentrations,ORs for i-IGT,IFG+IGT,and diabetes increased gradually.By comparing patients in the highest quartile of GGT concentrations or ALT concentrations with those in the lowest quartile (Q1),ORs for i-IGT,IFG+IGT,or diabetes was significant after adjustment.Both ALT and GGT concentrations were linearly correlated with HOMA-IR and independently associated with HOMA-IR [ALT OR (95% CI):2.56 (1.51-4.34) P=0.00;GGT OR (95% CI):2.66 (1.53-4.65) P=0.00].Conclusion Serum ALT and GGT concentrations were closely related to pre-diabetes and diabetes in the Shanghai population and positively associated with insulin resistance. | GAO Fei PAN Jie Min HOU Xu Hong FANG Qi Chen LU Hui Juan TANG Jun Ling GU Hui Lin PAN Zhi Jian YAO You Hua SHEN Wei Zhen JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 15 |
| 18 | Shake table test of soil-pile groups-bridge structure interaction in liquefiable ground显示文摘This paper describes a shake table test study on the seismic response of low-cap pile groups and a bridge structure in liquefiable ground.The soil profile,contained in a large-scale laminar shear box,consisted of a horizontally saturated sand layer overlaid with a silty clay layer,with the simulated low-cap pile groups embedded.The container was excited in three E1 Centra earthquake events of different levels.Test results indicate that excessive pore pressure(EPP) during slight shaking only slightly accumulated,and the accumulation mainly occurred during strong shaking.The EPP was gradually enhanced as the amplitude and duration of the input acceleration increased.The acceleration response of the sand was remarkably influenced by soil liquefaction.As soil liquefaction occurred,the peak sand displacement gradually lagged behind the input acceleration;meanwhile,the sand displacement exhibited an increasing effect on the bending moment of the pile,and acceleration responses of the pile and the sand layer gradually changed from decreasing to increasing in the vertical direction from the bottom to the top.A jump variation of the bending moment on the pile was observed near the soil interface in all three input earthquake events.It is thought that the shake table tests could provide the groundwork for further seismic performance studies of low-cap pile groups used in bridges located on liquefiable groun. | Tang Liang Ling Xianzhang Xu Pengju Gao Xia Wang Dongsheng | 2010 | Earthquake Engineering and Engineering Vibration2010，9，1： | 14 |
| 19 | α-Asarone suppresses the proliferation and migration of ASMCs through targeting the IncRNA-PVT1/miR-203a/E2F3 signal pathway in RSV-infected rats显示文摘气喘是长期的煽动性的肺的疾病,呼吸 syncytial 病毒(RSV ) 感染是在婴儿和小孩子的更低的呼吸的道病的一个普通原因。-Asarone 介绍许多药理学效果并且被表明了在对待气喘有用。然而,在感染 RSV 的气喘的 -asarone 的功能的机制没被调查。长非编码的 RNA (lncRNAs ) 被报导了在许多生物过程起关键作用。尽管许多 lncRNAs 被描绘了,很少在气喘被报导,特别在导致 RSV 的气喘。当前,一条新奇 post-transcriptional 规定在哪个 lncRNAs 作为竞争内长的 RNA (ceRNAs ) 工作竞争地擦掉 miRNAs 被建议了,从而调整目标基因。在现在的学习,我们建立了一个感染 RSV 的 Sprague-Dawley 老鼠模型并且证明 lncRNA-PVT1 在对待导致 RSV 的气喘,和 lncRNA-PVT1 涉及 -asarone 的机制由作为竞争地擦掉 miR-203a 的 ceRNA 工作调整 E2F3 的表示。 | Xiao Yu Zhe Zhe Binqing Tang Shaobin Li Ling Tang Yingen Wu Xiaorong Chen Hong Fang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，7： | 14 |
| 20 | Numerical simulations of shake-table experiment for dynamic soil-pile-structure interaction in liquefi able soils显示文摘A shake-table experiment on pile foundations in liquefi able soils composed of liquefi able sand and overlying soft clay is studied. A three-dimensional(3D) effective stress fi nite element(FE) analysis is employed to simulate the experiment. A recently developed multi-surface elasto-plastic constitutive model and a fully coupled dynamic inelastic FE formulation(u-p) are used to model the liquefaction behavior of the sand. The soil domains are discretized using a solid-fl uid fully coupled(u-p) 20-8 noded brick element. The pile is simulated using beam-column elements. Upon careful calibration, very good agreement is obtained between the computed and the measured dynamic behavior of the ground and the pile. A parametric analysis is also conducted on the model to investigate the effect of pile-pinning, pile diameter, pile stiffness, ground inclination angle, superstructure mass and pile head restraints on the ground improvement. It is found that the pile foundation has a noticeable pinning effect that reduces the lateral soil displacement. It is observed that a larger pile diameter and fi xed pile head restraints contribute to decreasing the lateral pile deformation; however, a higher ground inclination angle tends to increase the lateral pile head displacements and pile stiffness, and superstructure mass seems to effectively infl uence the lateral pile displacements. | Tang Liang Baydaa Hussain Maula Ling Xianzhang Su Lei | 2014 | Earthquake Engineering and Engineering Vibration2014，13，1： | 13 |
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