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| 1 | Microstructure Characteristics of Inconel 625 Superalloy Manufactured by Selective Laser Melting显示文摘Selective laser melting(SLM), an additive manufacturing process, is capable of manufacturing metallic parts with complex shapes directly from computer-aided design(CAD) models. SLM parts are created on a layer-by-layer manner, making it more flexible than traditional material processing techniques. In this paper, Inconel 625 alloy, a widely used material in the aerospace industry, were chosen as the build material. Scanning electron microscopy(SEM), electron back scattering diffraction(EBSD) and X-ray diffraction(XRD) analysis techniques were employed to analyze its microstructure. It was observed that the molten pool was composed of elongated columnar crystal. Due to the rapid cooling speed, the primary dendrite arm space was approximately 0.5 μm and the hardness of SLM state was very high(343 HV). The inverse pole figure(IPF) indicated that the growing orientation of the most grains was<001> due to the epitaxial growth and heat conduction. The XRD results revealed that the austenite structure with large lattice distortion was fully formed. No carbides or precipitated phases were found.After heat treatment the grains grew into two microstructures with distinct morphological characters,namely, rectangular grains and limited in the molten pool, and equiaxed grains along the molten boundaries. Upon experiencing the heat treatment, MC carbides with triangular shapes gradually precipitated. The results also identified that a large number of zigzag grain boundaries were formed. In this study, the grain formation and microstructure, and the laws of the molten pool evolution were also analyzed and discussed. | Shuai Li Qingsong Wei Yusheng Shi Zicheng Zhu Danqing Zhang | 2015 | Journal of Materials Science & Technology2015，31，9： | 24 |
| 2 | Novel CeO_2@TiO_2 core–shell nanostructure catalyst for selective catalytic reduction of NOx with NH_3显示文摘The CeO_2@TiO_2 core-shell nanostructure catalyst prepared by a two-step hydrothermal method was used for selective catalytic reduction(SCR) of NOx with NH_3 in this study.The catalyst presented the obvious core-shell structure,and the shell was amorphous TiO_2which could protect the active center from the SO_2 erosion.The catalyst showed high activity and stability,excellent N_2 selectivity and superior SO_2 resistance and H_2O tolerance.Characterizations such as TEM,HR-TEM,XRD,BET,XPS,NH_3-TPD,and H_2-TPR were carried out.The results indicated that the catalyst had large surface area and the active sites were well dispersed on the surface.The NH_3-TPD,H_2-TPR and XPS results implied that its increased SCR activity might be due to the enhancement of NH_3 chemisorption and the increase of active oxygen species,both of which were conductive to NH_3 activation.The excellent catalytic performance suggests that it is a promising candidate for SCR catalyst. | Bingjie Huang Danqing Yu Zhongyi Sheng Liu Yang | 2017 | Journal of Environmental Sciences2017，29，5： | 15 |
| 3 | Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy显示文摘 | Kefang Liu ShuguangTan Yan Chai Danqing Chen Hao Song Catherine Wei-Hong Zhang yi Shi Jun Liu Wenjie Tan Jianxin Lyu Shah Gao Jinghua Yan Jianxun Qi George F Gao | 2017 | Cell Research2017，27，1： | 11 |
| 4 | Acupuncture for Parkinson's Disease: a review of clinical,animal,and functional Magnetic Resonance Imaging studies显示文摘Acupuncture has been commonly used as an adjuvant therapy or monotherapy in the treatment of Parkinson's disease in China and in other countries.Animal studies have consistently show that this treatment is both neuroprotective, protecting dopaminergic neurons from degeneration and also restorative, restoring tyrosine hydroxylase positive dopaminergic terminals in striatum, resulting in improvements in motor performance in animal models of Parkinsonism. Studies show that this protection is mediated through the same common mechanisms as other neuroprotective agents, including anti-oxidative stress, anti-inflammatory and anti-apoptotic pathways at molecular and cellular levels. Restoration of function seems to involve activation of certain compensatory brain regions as a mechanism at the network level to correct the imbalances to the nervous system resulting from loss of dopaminergic neurons in substantia nigra. Clinical studies in China and Korea, in particular, have shown a positive benefit of acupuncture in treating Parkinson's disease, especially in reducing the doses of dopaminergic medications and the associated side effects. However, large and well-controlled clinical trials are still needed to further demonstrate the efficacy and effectiveness of acupuncture in the treatment of Parkinson's disease. | Xiao Danqing | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 11 |
| 5 | Hot compression deformation behavior of the Mg-Al-Y-Zn magnesium alloy显示文摘Mg-Al-Y- Zn 镁合金的热变丑行为被在从 523 ~ 673 K ,紧张率从 0.001 ~ 1 s 变化的温度的在一个 Gleeble-1500 热模拟器上的热压缩测试调查 ? 1。在流动应力,紧张率,和变丑温度之中的关系被分析,并且变丑激活精力和压力代表是计算的。在不同条件下面的合金的微观结构进化被检验。结果显示流动压力的最大的价值与变丑温度的减少或紧张率的增加增加了。在现在的变丑条件下面,动态再结晶(DRX ) 发生在合金,它在在提高的温度的变丑期间是主要弄软机制。变丑温度和紧张在合金的微观结构上有重要效果。 | FANG Xiya YI Danqing WANG Bin WU Chunping ZHANG Hong | 2008 | Rare Metals2008，27，2： | 10 |
| 6 | Development of genome-wide insertion/deletion markers in rice based on graphic pipeline platform显示文摘DNA markers play important roles in plant breeding and genetics.The Insertion/Deletion(InDel) marker is one kind of co-dominant DNA markers widely used due to its low cost and high precision.However,the canonical way of searching for InDel markers is time-consuming and laborintensive.We developed an end-to-end computational solution(InDel Markers Development Platform,IMDP) to identify genome-wide InDel markers under a graphic pipeline environment.IMDP constitutes assembled genome sequences alignment pipeline(AGA-pipe) and next-generation resequencing data mapping pipeline(NGS-pipe).With AGA-pipe we are able to identify 12,944 markers between the genome of rice cultivars Nipponbare and 93-11.Using NGS-pipe,we reported 34,794 InDels from re-sequencing data of rice cultivars Wu-Yun-Geng7 and Guang-Lu-Ai4.Combining AGApipe and NGS-pipe,we developed 205,659 InDels in eight japonica and nine indica cultivars and 2,681 InDels showed a subgroup-specific pattern.Polymerase chain reaction(PCR)analysis of subgroup-specific markers indicated that the precision reached 90%(86 of 95).Finally,to make them available to the public,we have integrated the InDels/markers information into a website(Rice InDel Marker Database,RIMD,http://gffzz71b3756633b74a6ehxvf5vcf0qfpw6qun.ffgz.tsg.suse.edu.cn/).The application of IMDP in rice will facilitate efficiency for development of genome-wide InDel markers,in addition it can be used in other species with reference genome sequences and NGS data. | Yang L Xiao Cui Rui Li Piaopiao Huang Jie Zong Danqing Yao Gang Li Dabing Zhang Zheng Yuan | 2015 | Journal of Integrative Plant Biology2015，57，11： | 9 |
| 7 | Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies显示文摘基于抗体的 PD-1/PD-L1 封锁治疗为癌症在免疫疗法拿了中心舞台,与多重临床的成功。发信号的 PD-1 在肿瘤驱动的 T 房间机能障碍起枢轴的作用。与优先的途径相对照产生或增加肿瘤特定的 T 房间回答,基于抗体的 PD-1/PD-L1 封锁指向导致肿瘤的 T 房间缺点并且恢复先存在调制 antitumor 免疫的 T 房间功能。在这评论,表达式规定和 PD-1 的禁止的函数和基于抗体的 PD-1/PD-L1 封锁治疗的现在的理解上的基本知识简短被总结。我们然后有关 PD-1/PD-Ls 相互作用的结构的基础集中于最近的突破工作并且怎么指向 PD-L1 的治疗学的抗体, pembrolizumab 指向 PD-1 和 avelumab,与 PD-1/PD-L1 的绑定竞争打断 PD-1/PD-L1 相互作用。我们相信这个结构的信息将有益于指向 PD-1 发信号的治疗学的抗体的设计和改进。 | ShuguangTan Danqing Chen Kefang Liu Mengnan He Hao Song Yi Shi Jun Liu Catherine W.-H. Zhang Jianxun Qi Jinghua Yan Shan Gao George F. Gao | 2016 | Protein & Cell2016，7，12： | 8 |
| 8 | Double-shell structure of Al_3(Zr,Sc) precipitate induced by thermomechanical treatment of Al-Zr-Sc alloy cable显示文摘A spheroidal Al_3(Zr,Sc) precipitate with a double-shell structure, comprising a Sc-enriched core enveloped by a Zr-enriched inner shell and a Sc-enriched outer shell(~9 nm in thickness), appears in an Al-0.2 Zr-0.1 Sc alloy cable after thermomechanical treatment. The average diameter of the spheroidal Al_3(Zr,Sc) precipitate is approximately 80 nm. The double-shelled Al_3(Zr,Sc) precipitate presents three different interfaces and is semi-coherent with the Al matrix. Atom probe tomography(APT) analyses further show that the outer shell of Al_3(Zr,Sc) precipitate is Sc element enrichment. The electrical conductivity of Al-0.2 Zr-0.1 Sc alloy cable increases by 6.5 MS/m within the aging time from 0.2 to 100 h at 350 ℃, with double-shelled Al_3(Zr,Sc)precipitate. | Jiayi Zhang Tao Hu Danqing Yi Hongxuan Wang Bin Wang | 2019 | Journal of Rare Earths2019，37，6： | 8 |
| 9 | Effects of grain size and secondary phase on corrosion behavior and electrochemical performance of Mg-3Al-5Pb-1Ga-Y sacrificial anode显示文摘Grains with size of 4.5—20.5μm were studied for their corrosion behavior and electrochemical performance in a Mg-3 Al-5 Pb-1 Ga-Y sacrificial anode using immersion testing,electrochemical measurements and microstructure analysis.The results show that fine-grained microstructure has higher chemical activity and more negative discharge potentials than coarse-grained samples.The sample with the smallest average grain size of 4.5μm exhibits corrosion current density of 7.473×10-5 A/cm2,and work potentials of-1.721 V at current density of 10 mA/cm2.The density of grain boundaries and LAGBs increases with grain refinement,which leads to higher rates of dissolution and diffusion for the atoms.The secondary phases promote the occurrence of corrosion and improve the chemical activity of alloy due to their higher potential than the substrate.Higher corrosion rate and discharge activity are directly attributed to the higher density of grain boundaries and LAGBs,as well as the secondary phase. | Qiang Cui Danqing Yi Hongxuan Wang Jiayi Zhang Jiao Xu Bin Wang | 2019 | Journal of Rare Earths2019，37，12： | 6 |
| 10 | A new strategy to iteratively update scalable universal quantitative models for the testing of azithromycin by near infrared spectroscopy显示文摘The training set of a universal near infrared (NIR) model for quantitative analysis of a drug should cover as many samples of this drug in the market as possible. Inevitably the model may fail for new products that have different excipients and production processes. In such circumstances the model should be updated. We here propose a new strategy to iteratively update a universal NIR quantitative model for azithromycin. We prove that universal quantitative models generated from this new strategy are comparably effective for azithromycin injection powders and azithromycin tablets, compared to the strategy using hierarchical clustering method which we reported previously. Furthermore, we establish the correlation coefficient r between a new sample and the training set samples can be used to decide whether or not the model should be updated. | ZOU WenBo FENG YanChun DONG JiXiong SONG DanQing HU ChangQin | 2013 | Science China Chemistry2013，56，4： | 5 |
| 11 | Decadal variation of different durations of continuous Meiyu precipitation and the possible cause显示文摘The features of the decadal evolution of different durations of continuous Meiyu precipitation and their possible cause from the viewpoint of the low-level intraseasonal oscillation(ISO) are examined in this study. It is found that the total frequency of Meiyu precipitation events of certain duration gradually decreases as the duration of the events increases,and the main center of the events moves from the northern Yangtze-Huaihe River Valley(YHRV) to the southern YHRV. The linear trends of different durations of continuous Meiyu precipitation indicate that longer-duration precipitation has become significantly less frequent since 2000,while 2-day and 3-4-day continuous precipitation processes have become more frequent. At the same time,a close relationship between the variation in the low-level ISO and the decadal evolution of frequency of longer-duration Meiyu precipitation is detected. Clearly,since 2000,the low-level ISO has significantly decreased,and a single peak of longer-duration events has been replaced by several peaks of shorter-duration events,which has resulted in a significant decrease in the frequency of longer-duration precipitation. Meanwhile,low-level baroclinicity increased(decreased) during each period,which is in accordance with the increasing(decreasing) frequency of longer-duration precipitation. It is confirmed that longer-duration precipitation has significantly decreased in recent years. | HUANG DanQing ZHU Jian KUANG XueYuan | 2011 | Chinese Science Bulletin2011，56，4： | 5 |
| 12 | Rupture process and aftershock focal mechanisms of the 2022 M6.8 Luding earthquake in Sichuan显示文摘According to the China Earthquake Networks Center,a strong earthquake of M6.8 occurred in Luding County,Ganzi Tibetan Autonomous Prefecture,Sichuan Province,China(102.08°E,29.59°N),on September 5,2022,with a focal depth of 16 km.Rapid determination of the source parameters of the earthquake sequence is vital for post-earthquake rescue,disaster assessment,and scientific research.Near-field seismic observations play a key role in the fast and reliable determination of earthquake source parameters.The numerous broadband seismic stations and strong-motion stations recently deployed by the National Earthquake Intensity Rapid Report and Early Warning project have provided valuable real-time near-field observation data.Using these near-field observations and conventional mid-and far-field seismic waveform records,we obtained the focal mechanism solutions of the mainshock and M≥3.0 aftershocks through the waveform fitting method.We were further able to rapidly invert the rupture process of the mainshock.Based on the evaluation of the focal mechanism solution of the mainshock and the regional tectonic setting,we speculate that the Xianshuihe fault formed the seismogenic structure of the M6.8 strong earthquake.The aftershocks formed three spatially separated clusters with distinctly different focal mechanisms,reflecting the segmented nature of the Xianshuihe fault.As more high-frequency information has been applied in this study,the absolute location of the fault rupture is better constrained by the near-field strong-motion data.The rupture process of the mainshock correlates well with the spatial distribution of aftershocks,i.e.,aftershock activities were relatively weak in the maximum slip area,and strong aftershock activities were distributed in the peripheral regions. | Zhigao Yang Danqing Dai Yong Zhang Xuemei Zhang Jie Liu | 2022 | Earthquake Science2022，35，6： | 5 |
| 13 | Synthesis and biological evaluation of 12-N-p-chlorobenzyl sophoridinol derivatives as a novel family of anticancer agents显示文摘Taking 12-N-p-chlorobenzyl sophoridinol 2 as a lead, a series of novel sophoridinic derivatives with various 30-substituents at the 11–side chain were synthesized and evaluated for their anticancer activity from sophoridine(1), a natural antitumor medicine. Among them, the sophoridinic ketones 5a–b, alkenes 7a–b and sophoridinic amines 14a–b displayed reasonable antiproliferative activity with IC50 values ranging from 3.8 to 5.4 μmol/L. Especially, compounds 5a and 7b exhibited an equipotency in both adriamycin(AMD)-susceptible and resistant MCF-7 breast carcinoma cells,indicating a different mechanism from AMD. The primary mechanism of action of 5a was to arrest the cell cycle at the G0/G1 phase, consistent with that of parent compound 1. Thus, we consider 12-chlorobenzyl sophoridinic derivatives with a tricyclic scaffold to be a new class of promising antitumor agents with an advantage of inhibiting drug-resistant cancer cells. | Chongwen Bi Cheng Ye Yinghong Li Wuli Zhao Rongguang Shao Danqing Song | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 4 |
| 14 | Synthesis and biological evaluation of 8-substituted berberine derivatives as novel anti-mycobacterial agents显示文摘Tuberculosis(TB)is a disease which kills two million people every year and infects over one-third of the world's population.Eighteen new 8-substituted berberine derivatives were synthesized and evaluated for their anti-mycobacterial activities against M ycobacterium tuberculosis(M.tuberculosis)strain H_(37)Rv.Among these compounds,compound 6i was the most effective antitubercular agent with an MIC of 1.0μg/mL.Most importantly,compound 6i also exhibited a potent effect against clinically isolated rifampicin-and isoniazid-resistant M.tuberculosis strains,suggesting a different mode of action from the current drugs.Therefore,it shows potential for the development of new anti-TB agents. | Yanxiang Wang Haigen Fu Yinghong Li Jiandong Jiang Danqing Song | 2012 | Acta Pharmaceutica Sinica B2012，2，6： | 4 |
| 15 | Synthesis and biological evaluation of sophocarpinic acid derivatives as anti-HCV agents显示文摘Chronic hepatitis C virus(HCV)infection has become a major public health burden worldwide.Twenty-two sophocarpinic acid or matrine derivatives were synthesized and their anti-HCV activities were evaluated in vitro.The structure-activity analysis revealed that(i)sophocarpinic acids with a D-seco 3-ring structure scaffold were more favorable than matrines with a 4-ring scaffold;(ii)the introduction of an electron-withdrawing group on the phenyl ring in 12-N-benzenesulfonylΔβγsophocarpinic acids was beneficial for the antiviral activity against HCV.Among them,compounds 9h and 9j exhibited the most potent inhibitory activities on HCV replication with selectivity indies of 70.3 and 30.9,respectively.Therefore,both were selected as antiviral candidates for further investigation. | Yinghong Li Zonggen Peng Limei Gao Danqing Song | 2014 | Acta Pharmaceutica Sinica B2014，4，4： | 4 |
| 16 | Settlement and metamorphosis of Styela canopus Savigny larvae in response to some neurotransmitters and thyroxin显示文摘The larvae of ascidian Styela canopus Savigny were treated with epinephrine, norepinephrine, L-DOPA, GABA and thyroxin to test the ability of these compounds to induce or inhibit larval settlement and metamorphosis. The results showed that epinephrine, norepinephrine and L-DOPA at the concentration of 1μmol/dm 3 induced larval settlement and metamorphosis in S. canopus, with short exposure (1 h) to 1 μmol/dm 3 of L-DOPA inducing rapid settlement. In contrast, GABA at the concentrations of 0.1 ~100.0 μmol/dm 3 significantly inhibited the settlement and metamorphosis of S. canopus larvae. In addition, thyroxin at 1~50 μg/dm 3 had no effect on larval settlement and metamorphosis in S. canopus. These results suggest the importance of neurotransmitters in the settlement and metamorphosis of S. canopus larvae. | FENG Danqing HUANG Ying KE Caihuan ZHOU Shiqiang LI Shaojing | 2006 | Acta Oceanologica Sinica2006，25，3： | 3 |
| 17 | Challenges for Implementation of Fair Value Accounting in Emerging Markets: Evidence from China*显示文摘 | XIANJIE HE T.J. WONG DANQING YOUNG | 2011 | Contemporary Accounting Research2011，，2： | 3 |
| 18 | Influence of electric field on the quenched-in vacancy and solute clustering during early stage ageing of Al-Cu alloy显示文摘The effects of electric field on the evolution of excess quenched-in vacancy as well as solute clustering in Al-4wt%Cu alloy, and on the vacancy migration and formation enthalpy of pure aluminum were investigated, using positron annihilation lifetime spectroscopy, high-angle annular dark-field scanning transmission electron microscopy, transmission electron microscopy, hardness measurement and four-probe electrical resistivity measurement. The results showed that the electric field improved age hardening response obviously and postponed the decay of excess vacancies for 30 min during the early stage ageing of Al-4wt%Cu alloy. A large number of 2–4 nm GP zones with dense distribution were observed after 1 min ageing with an electric field applied. The electric field-assisted-aged sample owned a lower coarsening rate of GP zone, which was about three fifths of that in the aged sample without an electric field, from 1 min to 120 min ageing. The electric field contributed 8% increase of the vacancy migration enthalpy(0.663 ± 0.021 e V) of pure Al, comparing with that(0.611 ± 0.023 e V) of pure Al without an electric field. The increase of vacancy migration enthalpy, induced by the electric field, was responsible for the difference on evolution of quenched-in vacancy, rapid solute clustering and age hardening improvement during the early stage ageing of Al-4wt%Cu alloy. | Shang Fu Ying Zhang Huiqun Liu Danqing Yi Bin Wang Yong Jiang Zhiquan Chen Ning Qi | 2018 | Journal of Materials Science & Technology2018，34，2： | 3 |
| 19 | Synthesis and biological evaluation of new 13-n-nonylprotoberberine derivatives as antitubercular agents显示文摘Tuberculosis is a serious threat to public health throughout the world.A series of new l3-n-nonylprotoberberine derivatives was designed,synthesized and evaluated for anti-mycobacterial activity against Mycobacterium tuberculosis strain H_(37)Rv.Several compounds(2,11a-c,11g,13d,15c)exhibited excellent anti-tubercular activity with an MIC below 1.0μg/mL.Notably,compound 13d showed potential antibacterial effect against both drug-susceptible and multidrug-resistant(MDR)M.tuberculosis with MIC ranges of 0.0625-1.0μg/mL.These results suggest a mode of action different from that of the current anti-mycobacterial drugs rifampicin and isoniazid.Hence,compound 13d is an attractive lead compound for the development of new antitubercular agents. | Yinghong Li Yanxin Liu Yanxiang Wang Sheng Tang Danqing Song | 2013 | Acta Pharmaceutica Sinica B2013，3，1： | 3 |
| 20 | Synthesis and biological evaluation of novel tricyclic matrinic derivatives as potential anti-filovirus agents显示文摘Twenty-six novel tricyclic sophoridinic and matrinic derivatives containing a common chlorinated benzene fragment were designed, synthesized and evaluated for their anti-ebolavirus(EBOV)activities. Structure–activity relationship analysis indicated:(i) 12 N-dichlorobenzyl motif was beneficial for the activity;(ii) the chiral configuration at C5 atom might not affect the activity much. Among the target compounds, compound 7d exhibited the most potent potency against EBOV with an IC_(50) value of 5.29 μmol/L and an SI value of over 37.8. Further in vivo anti-EBOV assay of 7d identified its high effectiveness, and in vivo anti-MARV assay of 7d suggested its inspiring broad-spectrum anti-filovirus activity. The results provided powerful information on further strategic optimization and development of this kind of compounds against filoviruses. | Xin Zhang Qiang Liu Qianqian Li Yinghong Li Zhandong Liu Hongbin Deng Sheng Tang Yanxiang Wang Youchun Wang Danqing Song | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 2 |
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