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| 1 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 2 | Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma显示文摘AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters.METHODS:β-actin is a housekeeping gene,frequently used as loading control,but,differentially expresses in cancer.In gastric cancer,an overall increased expression ofβ-actin has been reported using tissue disruptive techniques.At present,no histological data is available to indicate its cell type-specific expression and distribution pattern.In the present study,we analyzedβ-actin expression and distribution in paired normal and tumor tissue samples of gastric adenocarcinoma patients using immunohistochemistry(IHC),a tissue non-disruptive technique as well as tissue disruptive techniques like reverse transcriptase-polymerase chain reaction(RT-PCR)and western blotting.Correlation ofβ-actin level with clinicopathological parameters was done using univariate analysis.RESULTS:The results of this study showed significant overexpression,at both mRNA and protein level in tumor tissues as confirmed by RT-PCR(1.47±0.13 vs2.36±0.16;P<0.001)and western blotting(1.92±0.26 vs 2.88±0.32;P<0.01).IHC revealed thatβ-actin expression is majorly distributed between epithelial and inflammatory cells of the tissues.Inflammatory cells showed a significantly higher expression compared to epithelial cells in normal(2.46±0.13 vs 5.92±0.23,P<0.001),as well as,in tumor tissues(2.79±0.24 vs6.71±0.14,P<0.001).Further,comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpressβ-actin in tumor tissues,however,significant difference was observed only in inflammatory cells(5.92±0.23vs 6.71±0.14,P<0.01).Moreover,combined expression in epithelial and inflammatory cells also showed significant increase(4.19±0.15 vs 4.75±0.14,P<0.05)in tumor tissues.In addition,univariate analysis showed a positive correlation ofβ-actin level of inflammatory cells with tumor grade(P<0.05)while epithelial cells exhibited negative correlation(P>0.05).CONCLUSION:In gastric cancer,β-actin showed an overall higher expression predominantly contributed by inflammatory or tumor infiltrating immune cells of the tissue microenvironment and correlates with tumor grade. | Shafqat A Khan Monica Tyagi Ajit K Sharma Savio G Barreto Bhawna Sirohi Mukta Ramadwar Shailesh V Shrikhande Sanjay Gupta | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 3 | Asymptotic analysis of laminated composites with countersunk open- and fastened-holes 显示文摘 | Sangwook Sihn Endel V Iarve Ajit K Roy | 2006 | Composites Science And Technology2006，66，14： | 1 |
| 4 | Combined laparoscopic and percutaneous management of calcified renal hydatid cyst-a novel nephroscope- and lithotripter-assisted technique 显示文摘 | SuryaPrakash V Punit M Ajit V | 2012 | Urology2012，79，6： | 1 |
| 5 | Ethylene optimization system reaps operations and ma-intenance benefits显示文摘 | Apostolos Georgiou Ajit V Sapre Paulsboro N J | 1998 | Oil&Gas1998，，： | 1 |
| 6 | A mixed culture of endophytic fungi increases production of antifungal polyketides显示文摘 | Li J Zhao GZ Ajit V | 2012 | PLoS One2012，7，12： | 1 |
| 7 | Ethylene optimization system reaps operations and ma- intenance benefits 显示文摘 | Apostolos Georgiou Ajit V Sapre Paulsboro N J | 1998 | Oil & Gas1998，，： | 1 |
| 8 | The regulation and turnover of mitochondrial uncoupling proteins显示文摘 | Azzu V Martin J Ajit S | | 0，，6： | 1 |
| 9 | Biological roles of oligosaccharides: all of the theories are correct显示文摘 | Ajit V | 1993 | Glycobiology1993，3，： | 1 |
| 10 | Selectin ligands显示文摘 | Ajit V | 1994 | Proc Natl Acad Sci1994，91，16： | 1 |
| 11 | Production and characterization of xylanase from Bacillus thermoalkalophilus grown on agricultural wastes显示文摘 | Ajit V | 1990 | Applied Microbiology and Biotechnology1990，34，： | 1 |
| 12 | 4-E(energy,exergy,environment and economic)analysis of solar thermal aided coal-fired power plant显示文摘 | SURESH M V J J REDDY K S Ajit Kumar Kolar | 2014 | Energy for Sustainable Development2014，14，4： | 1 |
| 13 | Production and characterization of xylanase from Bacillus hermoalkalophilus grown on agricultural wastes显示文摘 | SRIDEVI R AJIT V | 1990 | Applied Microbiology and Biotechnology1990，34，： | 1 |
| 14 | Biological roles of the oligosaeeharides:all of the theories are correct显示文摘 | Ajit V | 1993 | Glycobilogy1993，13，2： | 1 |
| 15 | Expression of retinoic acid nuclear receptors and tissue transglutaminase is altered in various tissues of rats fed a Vitamin A deficient diet 显示文摘 | Ajit K V Alex S Ruby S | 1992 | Nutr1992，122，11： | 1 |
| 16 | Liquid Phase Oxidation of P-cresol Over Cobalt Saponite显示文摘 | VIKAS S KSHIRSAGAR AJIT C GARADE CHAND-RASHEKAR V RODE | 2009 | Top Catal2009，52，67： | 1 |
| 17 | Surface modification of graphitic foam显示文摘 | SHARMILA M MUKHOPADHYAY RAJASEKHAR V PULIKOLLU ERIK RIPBERGER AJIT K ROY | 2003 | Journal of Applied Physics2003，93，2： | 1 |
| 18 | Twelve-month, prospective, open-label study of repetitive transcranial magnetic stimulation for major depressive disor- der in partial remission显示文摘 | CHARNSIL C SUTI'AJIT S BOONYANARUTHEE V | 2012 | Neuropsychiatr Dis Treat2012，8，： | 1 |
| 19 | Combined laparoscopic and percutaneous management of calcified renal hydatid cyst-a novel nephroscope-and lithotripter-assisted technique显示文摘 | SuryaPrakash V Punit M Ajit V | 2012 | Urology2012，79，6： | 1 |
| 20 | Mutation of the iron-sulfur cluster assembly gene IBA57 causes severe myopathy and encephalopathy 显示文摘 | Ajit Bolar N Vanlander A V Wilbrecht C | 2013 | Hum Mol Genet2013，22，13： | 1 |
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