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| 1 | Expression profile of cholecystokinin type-A receptor in gallbladder cancer and gallstone disease显示文摘BACKGROUND:Regulatory peptide receptors have attracted the interest of oncologists as a new promising approach for cancer pathology,imaging and therapy.Although cholecystokinin (CCK) is a potent modulator of gallbladder contractility and plays a potential role in pancreatic carcinogenesis through CCK type-A receptor (CCKAR),its role in gallbladder cancer (GBC) is still unknown and immunohistochemical detection of CCKAR in the gallbladder has not yet been reported.This novel case-control study aimed to investigate the expression profile of CCKAR in GBC and gallstone disease (GSD).METHODS:This study included 162 samples of gallbladder:94 from GBC and 68 from GSD.Expression of CCKAR was analyzed by immunohistochemistry and immunoblotting.The results were statistically correlated with disease history including age,sex,presence of gallstone,stage and differentiation.RESULTS:CCKAR was positive in 30/68 (44.1%) of GSD and 72/94 (76.6%) of GBC samples.Fifty-one of the 72 (70.8%) CCKAR-positive GBC samples showed over-expression.Interestingly,consistent results also appeared in the immunoblotting study.CONCLUSIONS:CCKAR expression was significantly increased in GBC compared to GSD.Moreover,CCKAR expression was associated with the degree of tumor differentiation,i.e.,less expression in poorly-differentiated tumors.Thus,it has future prognostic and therapeutic implications in the management of GBC. | Rajani Rai Mallika Tewari Mohan Kumar Tej Bali Singh Hari S Shukla | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 7 |
| 2 | Species Richness, Diversity and Density of Understory Vegetation along Disturbance Gradients in the Himalayan Conifer Forest显示文摘We investigated whether species richness, diversity and density of understory herbaceous plants differed along logging(gap) and grazing(primarily by cattle) disturbance gradients, and sought to identify drivers of richness, diversity and density of understory vegetation of logged sites. A factorial experiment was conducted in the mixed conifer forest of Gidakom in Western Bhutan. Levels of the logging treatment included small(0.15 – 0.24 ha), medium(0.25 – 0.35 ha) and large(0.36 – 1.31 ha) gaps. The grazing treatment included grazed(primarily by cattle) and ungrazed(where herbivores were excluded by a fence) plots nested within each gap. Data were collected from 12 gaps(4 replicates at each level of logging) using the point intercept method. Shannon Weaver Diversity and Margalef's indices were used to estimate species diversity and describe species richness, respectively. Soil samples were analyzed for pH and nutrients. The interaction effect of logging and grazing was significant(p≤0.001) only on species diversity. Relative to ungrazed areas, species diversity was significantly higher(0.01≤p≤0.05) in medium grazed gaps. Under grazed conditions, soil P was negatively correlated with gap size and species diversity. While species diversity was positivelycorrelated(0.01≤p≤0.05) with soil N in grazed plots species richness was positively correlated(0.001≤p≤0.01) with soil N in ungrazed plots. Relative density of Yushania microphylla and Carex nubigena were higher under ungrazed conditions. Our study suggests that the combined effect of cattle grazing and logging results in higher species diversity of understory vegetation in medium and grazed gaps in mixed conifer forests of Bhutan,whereas increase or decrease in relative density of major species is determined primarily by the independent effects of grazing and logging. From management perspective, forest managers must refrain from creating large gaps to avoid loss of nutrients(mainly P and N), which may eventually affect tree regeneration. Managers intending to maintain understory vegetation diversity must consider the combined effects of grazing and logging, ensuring low to moderate grazing pressure. | Kesang WANGCHUK András DARABANT Prem Bahadur RAI Maria WURZINGER Werner ZOLLITSCH Georg GRATZER | 2014 | Journal of Mountain Science2014，11，5： | 2 |
| 3 | Factors Associated With Diagnosis of Obscure Gastrointestinal Bleeding by Video Capsule Enteroscopy显示文摘 | Lucie Lepileur Xavier Dray Michel Antonietti Isabelle Iwanicki–Caron Sébastien Grigioni Ulriikka Chaput Aude Di–Fiore Raied Alhameedi Philippe Marteau Philippe Ducrotté Stéphane Lecleire | 2012 | Clinical Gastroenterology and Hepatology2012，，12： | 2 |
| 4 | Presence of fetal DNA in maternal plasma and serum显示文摘 | Y M Dennis Lo Noemi Corbetta Paul F Chamberlain Vik Rai Ian L Sargent Christopher WG Redman James S Wainscoat | 1997 | The Lancet1997，，9076： | 2 |
| 5 | Development of high conductive lead(Pb)-free conducting adhesives显示文摘 | Kang S K Rai R S | 1998 | IEEE Trans Compon Packg Manuf Tech1998，21，1： | 2 |
| 6 | A survey of efficient reliability computation using disjoint products approach 显示文摘 | Rai S Veeraraghavan M Trlvedi K S | 1995 | Networks1995，25，1： | 1 |
| 7 | Comparative Assessment of Runoff Characteristics Under Different Land Use Patterns Within a Himalayan Watershed显示文摘 | RAI S C SHARMA E | 1998 | Hydrological Processes1998，12，5： | 1 |
| 8 | Random amplified poly morphic DNA of mosquito species and population (Diptera :Cull cidae) :techniques, statistical analysis, and applications显示文摘 | Kambhampati S Black WC Rai KS | 1992 | MedEntomology1992，29，6： | 1 |
| 9 | Characterization of microstructures in Inconel 625 using X-ray diffraction peak broad- ening and lattice parameter measurements显示文摘 | RAI S K KUMAR A SHANKAR V | 2004 | Scripta Materialia2004，51，1： | 1 |
| 10 | Removal of dyes from the effluent of textile and dyestuff manufacturing industry: A review of emerging techniques with reference to biological treatment 显示文摘 | Rai H S Bhattacharyya M S Singh J | 2005 | Critical Reviews in Environmental Science and Technology2005，35，： | 1 |
| 11 | Synthesis and characterization of new series substituted显示文摘 | Hussain S Jadhav S Rai M | | 0，，02： | 1 |
| 12 | Identification of genes involved in bamboo fiber development显示文摘 | Rai V Ghosh J S Pal A | | 0，，1： | 1 |
| 13 | Effect of coherent to incoherent structural transition on magnetic anisotropy in Co/Pt muhilayers 显示文摘 | Chowdhury P Kulkkarni P D Krishnan M Barshilia H C Sagdeo A Rai S K Lodha G S Rao D V S | 2012 | Journal of Applied Physics2012，112，02： | 1 |
| 14 | Morphology and functional properties of corn, potato and tapioca starches 显示文摘 | Mishra S Rai T | 2006 | Food Hydrocolloids2006，20，： | 1 |
| 15 | Candidate tumor suppressor HYAL2 is a glycosylphosphatldylinositol (GPI) -an- chored cell - surface receptor for jaagsiekte sheep retrovilaiS, the en- velope protein of which mediates oneogenic trandormation显示文摘 | RAI S K DUH F M VIGDOROVICH V | 2001 | Proc Natl Aead Sci USA2001，98，8： | 1 |
| 16 | Isolation of fungi from local bread of Chhindwara显示文摘 | Rai M K Upadhyaya S Andeo R M | 1990 | Indian Journal of Pathology & Microbiology1990，33，2： | 1 |
| 17 | Exposure to As, Cd and Pb-mixture impairs myelin and axon development in rat brain,optic nerve and retina显示文摘 | Rai N K Ashok A Rai A Tripathi S Nagar G K Mitra K | 2013 | Toxicology and Applied Pharmacology2013，273，2： | 1 |
| 18 | DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45 显示文摘 | Rai K Huggins I James S | 2008 | Cell2008，135，： | 1 |
| 19 | Antioxidant activity of Nelumbo nucifera (sacred lotus) seeds显示文摘 | Rai S Wahile A Mukherjee K | 2006 | J Ethnopharmacology2006，104，： | 1 |
| 20 | Reconfigurable implementation of wavelet integer lifting transforms for image compression显示文摘 | Bishop S L Rai S Gunturk B | 2006 | IEEE Transactions on Image Processing2006，4，5： | 1 |
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