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| 1 | A randomized controlled trial of postoperative tumor lysate-pulsed dendritic cells and cytokine-induced killer cells immunotherapy in patients with localized and locally advanced renal cell carcinoma显示文摘 | ZHAN Hai-lun GAO Xin PU Xiao-yong LI Wei LI Zhi-jian ZHOU Xiang-fu QIU Jian-guang | 2012 | Chinese Medical Journal2012，，21： | 48 |
| 2 | Type V CRISPR-Cas Cpfl endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition显示文摘 | Pu Gao Hui Yang Kanagalaghatta R Rajashankar Zhiwei Huang Dinshaw J Patel | 2016 | Cell Research2016，26，8： | 28 |
| 3 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 4 | Spin-decoupled metasurface for simultaneous detection of spin and orbital angular momenta via momentum transformation显示文摘With inherent orthogonality,both the spin angular momentum(SAM)and orbital angular momentum(OAM)of photons have been utilized to expand the dimensions of quantum information,optical communications,and information processing,wherein simultaneous detection of SAMs and OAMs with a single element and a single-shot measurement is highly anticipated.Here,a single azimuthal-quadratic phase metasurface-based photonic momentum transformation(PMT)is illustrated and utilized for vortex recognition.Since different vortices are converted into focusing patterns with distinct azimuthal coordinates on a transverse plane through PMT,OAMs within a large mode space can be determined through a single-shot measurement.Moreover,spin-controlled dual-functional PMTs are proposed for simultaneous SAM and OAM sorting,which is implemented by a single spin-decoupled metasurface that merges both the geometric phase and dynamic phase.Interestingly,our proposed method can detect vectorial vortices with both phase and polarization singularities,as well as superimposed vortices with a certain interval step.Experimental results obtained at several wavelengths in the visible band exhibit good agreement with the numerical modeling.With the merits of ultracompact device size,simple optical configuration,and prominent vortex recognition ability,our approach may underpin the development of integrated and high-dimensional optical and quantum systems. | Yinghui Guo Shicong Zhang Mingbo Pu Qiong He Jinjin Jin Mingfeng Xu Yaxin Zhang Ping Gao Xiangang Luo | 2021 | Light(Science & Applications)2021，10，4： | 14 |
| 5 | 腹腔镜前列腺癌切除术:中国单一研究机构对126例患者最少三年的肿瘤和功能性随访结果显示文摘本文评估了在中国最大样本的腹腔镜前列腺癌切除术对126例患者最少三年的肿瘤和功能性随访结果。从2000年10月到2004年5月,126例患者(平均年龄62.5岁,56.78岁之间)接受了腹腔镜前列腺癌根治术,其前列腺癌特异性抗原平均水平为13.4ng/mL,Gleason评分6分,27例患者接受了单侧或双侧勃起神经保留术,29例患者接受了盆腔淋巴结清扫术。生化复发定义为PSA〉0.2ngmL^-1。Logistic和Cox多元回归模型用于比较临床病理参数和无生化复发进展(bPFS)之间的关系。平均手术时间为250分钟(110—660分钟),平均失血量354毫升(150-1100毫升)。无转为开放手术。4例主要并发症,包括直肠损伤2例,输尿管损伤1例和活动性出血1例。总体的切缘阳性率(PSM)为20.6%以及与病理分期相关。在超过3年(平均4.6年)的随访中,98.4%的患者能够控尿,2例患者腹压增加时需要尿垫。在3年的随访中,22例(81.5%)患者接受勃起神经保留的患者术后恢复了勃起功能。3年的随访期间,总体的生存率为100%,无生化复发率为81.0%。本研究为中国首次报道大于三年的腹腔镜前列腺癌根治术的结果,与以前文献报道的开放手术和腹腔镜手术具有相似的肿瘤随访结果和发病率。 | Xin Gao Jian-Hua Zhou Liao-Yuan Li Jian-Guang Qiu Xiao-Yong Pu | 2009 | Asian Journal of Andrology2009，11，5： | 13 |
| 6 | De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome显示文摘 | Yongyi Yuan Jianguo Zhang Qing Chang Jin Zeng Feng Xin Jianjun Wang Qingyan Zhu Jing Wu Jingqiao Lu Weiwei Guo Xukun Yan Hui Jiang Binfei Zhou Qi Li Xue Gao Huijun Yuan Shiming Yang Dongyi Han Zixu Mao Ping Chen Xi Lin Pu Dai | 2014 | Cell Research2014，24，11： | 13 |
| 7 | Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse non- alcoholic steatohepatitis显示文摘Dicer1 是为 microRNA (miRNA ) 的酶必需品成熟。miRNAs 的损失源于 Dicer1 缺乏极大地贡献许多疾病的前进,包括在在非酒精的 steatohepatitis (NASH ) 的发展是批评的免费胆固醇(FC ) 的肝的累积的类脂化合物 dysregulation,而是它的角色遗体逃犯。在这研究,我们使用了肝特定的 Dicer1 大美人老鼠识别涉及肝的 FC 累积的 miRNAs。在一个广泛地使用的饮食的 NASH 模型,老鼠被喂 methionine-choline-deficient (MCD ) 节食 3 个星期,它在肝象 Dicer1 mRNA 层次的减少一样导致了肝的 FC 层次的重要增加。肝特定的 Dicer1 大美人在 5-6 星期导致了肝的 FC 累积,由增加的 mRNA 和 3-hydroxy-3-methylglutaryl 辅酶的蛋白质层次伴随了 reductase (HMGCR ) ,在肝的胆固醇合成的限制率的酶。十一预言 miRNAs 被屏蔽,表明 miR-29a/b/c 显著地压制了由指向 HMGCR mRNA 3-UTR 的 HMGCR 表示。在 SMMC-7721 房间的 miR-29a 的 Overexpression,脂肪变性肝的房间模型,显著地减少的 HMGCR 表示和 FC 铺平。而且, miR-29a 的表达式层次相反地与在 MCD 食谱鼠标的表达式层次在 vitro 在 vivo 并且在肝的房间建模的 2 脂肪变性(SMMC-7721 和 HL-7702 房间) 建模的 HMGCR 被相关。我们的结果证明那 Dicer1/miR-29/HMGCR 轴在老鼠 NASH 贡献肝的免费胆固醇累积,并且 miR-29 可以用作肝的胆固醇动态平衡的一个重要管理者。因此, miR-29a 能为非酒精的脂肪肝疾病的处理以及为与 FC 累积联系的另外的肝疾病作为一个潜在的治疗学的目标被利用。 | Ming-xia LIU Man GAO Chun-zhu LI Cun-zhi YU Hong YAN Chun PENG Yu LI Cheng-gang LI Ze-long MA Yang ZHAO Meng-fan PU Ling-ling MIAO Xin-ming QI Jin RENI | 2017 | Acta Pharmacologica Sinica2017，38，5： | 12 |
| 8 | E)NA sensor cGAS-mediated immune recognition显示文摘 | Pengyan Xia Shuo Wang Pu Gao Guangxia Gao Zusen Fan | 2016 | Protein & Cell2016，7，11： | 11 |
| 9 | Inheritance and molecular characterization of resistance to AHAS- inhibiting herbicides in rapeseed显示文摘Rapeseed is a very important oil crop in China;however,its production is challenging due to the absence of effective weed management strategies.This is predominantly because of a shortage of herbicide resistance genes.Acetohydroxyacid synthase(AHAS) herbicides inhibit AHAS,a key enzyme involved in branched-chain amino acid synthesis that is required for plant growth.A rapeseed line designated M342 with AHAS herbicide resistance was developed through seed mutagenesis and was studied to assess the level and mode of inheritance of the resistance and to identify the molecular basis of resistance.M342 possessed a high level of cross-resistance to sulfonylureas(SUs) and imidazolinones(IMIs).This resistance was due to AHAS insensitivity to these herbicides and was inherited as a dominant trait conferred by a single nuclear-encoded gene.Molecular analysis revealed the presence of a Trp574 Leu mutation in M342,and an allele-specific cleaved amplified polymorphic sequence(AS-CAPS) marker was developed and cosegregated with herbicide resistance in the F2,BC1,and BC2 populations.This mutation altered the transcript levels of Bn AHAS1 and Bn AHAS3 in M342 compared with those in the wild type,but it did not affect the agronomic or quality traits.The simple genetic inheritance of this mutation and the availability of the cleaved amplified polymorphic sequence(CAPS) marker and herbicide resistance gene should facilitate the development of herbicide-resistant rapeseed cultivars for effective weed control in China. | HU Mao-long PU Hui-ming GAO Jian-qin LONG Wei-hua CHEN Feng ZHOU Xiao-ying ZHANG Wei PENG Qi CHEN Song ZHANG Jie-fu | 2017 | Journal of Integrative Agriculture2017，16，11： | 11 |
| 10 | Influence of plant architecture on maize physiology and yield in the Heilonggang River valley显示文摘The size and distribution of leaf area determine light interception in a crop canopy and influence overall photosynthesis and yield. Optimized plant architecture renders modern maize hybrids(Zea mays L.) more productive, owing to their tolerance of high plant densities. To determine physiological and yield response to maize plant architecture, a field experiment was conducted in 2010 and 2011. With the modern maize hybrid ZD958, three plant architectures, namely triangle, diamond and original plants, were included at two plant densities, 60,000 and 90,000 plants ha-1. Triangle and diamond plants were derived from the original plant by spraying the chemical regulator Jindele(active ingredients,ethephon, and cycocel) at different vegetative stages. To assess the effects of plant architecture, a light interception model was developed. Plant height, ear height, leaf size,and leaf orientation of the two regulated plant architectures were significantly reduced or altered compared with those of the original plants. On average across both plant densities and years, the original plants showed higher yield than the triangle and diamond plants,probably because of larger leaf area. The two-year mean grain yield of the original and diamond plants were almost the same at 90,000 plants ha-1(8714 vs. 8798 kg ha-1). The yield increase(up to 5%) of the diamonds plant at high plant densities was a result of increased kernel number per ear, which was likely a consequence of improved plant architecture in the top and middle canopy layers. The optimized light distribution within the canopy can delay leaf senescence, especially for triangle plants. The fraction of incident radiation simulated by the interception model successfully reflected plant architecture traits. Integration of canopy openness is expected to increase the simulation accuracy of the present model. Maize plant architecture with increased tolerance of high densities is probably dependent on the smaller but flatter leaves around the ear. | Shoubing Huang Yingbo Gao Yebei Li Lina Xu Hongbin Tao Pu Wang | 2017 | The Crop Journal2017，5，1： | 11 |
| 11 | Soil Organic Carbon Accumulation Increases Percentage of Soil Olsen-P to Total P at Two 15-Year Mono-Cropping Systems in Northern China显示文摘Soil organic carbon(SOC) and soil Olsen-P are key soil fertility indexes but information on their relationships is limited particularly under long-term fertilization. We investigated the relationships between SOC and the percentage of soil Olsen-P to total P(PSOPTP) under six different 15-yr(1990-2004) long-term fertilizations at two cropping systems in northern China. These fertilization treatments were(1) unfertilized control(control);(2) chemical nitrogen(N);(3) N plus chemical P(NP);(4) NP plus chemical potassium(NPK);(5) NPK plus animal manure(NPKM) and(6) high NPKM(hNPKM). Compared with their initial values in 1989 at both sites, during the 11th to 15th fertilization years annual mean SOC contents were significantly increased by 39.4-47.0% and 58.9-93.9% at Gongzhuling, Jilin Province, and Urumqi, Xinjiang, China, under the two NPKM fertilizations, respectively, while no significant changes under the no-P or chemical P fertilization. During the 11th to 15th fertilization years, annual mean PSOPTP was respectively increased by 2.6-4.2 and 5.8-14.1 times over the initial values under the two chemical P fertilizations and the two NPKM fertilizations, but was unchanged in their initial levels under the two no-P fertilizations at both sites. Over the 15-yr long-term fertilization SOC significantly positively correlated with PSOPTP(r2=0.55-0.79, P<0.01). We concluded that the combination of chemical P plus manure is an effective way to promote SOC accumulation and the percentage of soil Olsen-P to total P at the two mono-cropping system sites in northern China. | SHEN Pu HE Xin-hua XU Ming-gang ZHANG Hui-min PENG Chang GAO Hong-jun LIU Hua XU Yong-mei QIN Song XIAO Hou-jun | 2014 | Journal of Integrative Agriculture2014，13，3： | 10 |
| 12 | Comorbidity Burden of Dementia:A Hospital-Based Retrospective Study from 2003 to 2012 in Seven Cities in China显示文摘Dementia is increasing dramatically and imposes a huge burden on society. To date, there is a lack of data on the health status of patients with dementia in China. In an attempt to investigate the comorbidity burden of dementia patients in China at the national level, we enrolled 2,938 patients with Alzheimer's disease(AD), vascular dementia(Va D), or other types of dementia, who were admitted to tertiary hospitals in seven regions of China from January2003 to December 2012. The Charlson Comorbidity Index(CCI) was used to evaluate the comorbidity burden of the patients with dementia. Among these patients, 53.4% had AD, 26.3% had Va D, and 20.3% had other types of dementia. The CCI was 3.0 ± 1.9 for all patients,3.4 ± 1.8 for those with Va D, and 3.0 ± 2.1 for those with AD. The CCI increased with age in all patients, andthe length of hospital stay and daily expenses rose with age and CCI. Males had a higher CCI and a longer stay than females. Moreover, patients admitted in the last 5 years of the study had a higher CCI than those admitted in the first 5 years. We found that the comorbidity burden of patients with dementia is heavy. These findings provide a better understanding of the overall health status of dementia patients, and help to increase the awareness of clinicians and policy-makers to improve medical care for patients. | Qing-Hua Wang Xin Wang Xian-Le Bu Yan Lian Yang Xiang Hong-Bo Luo Hai-Qiang Zou Jie Pu Zhong-He Zhou Xiao-Ping Cui Qing-Song Wang Xiang-Qun Shi Wei Han Qiang Wu Hui-Sheng Chen Hang Lin Chang-Yue Gao Li-Li Zhang Zhi-Qiang Xu Meng Zhang Hua-Dong Zhou Yan-Jiang Wang | 2017 | Neuroscience Bulletin2017，33，6： | 10 |
| 13 | Curent Situation of “Candidatus Liberibacter asiaticus” in Guangdong,China,Where Citrus Huanglongbing Was First Described显示文摘Citrus Huanglongbing (HLB,yellow shoot disease) was first observed in the coastal Chaoshan Plain of Guangdong Province,China,in the late 19th century based on descriptions of yellow shoot symptoms. 'Candidatus Liberibacter asiaticus' has been considered as a putative pathogen associated with HLB since 1994.Information about the curent prevalence of this bacterium is important for HLB control in Guangdong and also provides useful reference for HLB study elsewhere.In 2007,we collected HLB symptomatic citrus samples from 16 cultivars in 12 prefecture cities,mostly in the north and west regions of Guangdong,where major citrus fruits are currently produced.Among the 359 samples collected,241 (67.1%) were positive for 'Ca.L.asiaticus',distributed in 15 out of the 16 cultivars from all 12 cities,indicating the widespread prevalence of 'Ca.L.asiaticus' in Guangdong Province.The detection rates varied from 16.7 to 100% depending on location and cultivar.Lower detection rates were found in newer citrus cultivation cities among the previously less popular but now promoted cultivars.In reviewing the citrus management and pest control practice,we believe that infected nursery stocks play a key role in the current spread of 'Ca.L.asiaticus'. | DENG Xiao-ling GAO Yi-di CHEN Jian-chi PU Xue-lian KONG Wei-wen LI Hua-ping | 2012 | Journal of Integrative Agriculture2012，11，3： | 10 |
| 14 | Trends in herbgenomics显示文摘From Shen Nong's Herbal Classic(Shennong Bencao Jing) to the Compendium of Materia Medica(Bencao Gangmu) and the first scientific Nobel Prize for the mainland of China, each milestone in the historical process of the development of traditional Chinese medicine(TCM) involves screening, testing and integrating. After thousands of years of inheritance and development,herbgenomics(bencaogenomics) has bridged the gap between TCM and international advanced omics studies, promoting the application of frontier technologies in TCM. It is a discipline that uncovers the genetic information and regulatory networks of herbs to clarify their molecular mechanism in the prevention and treatment of human diseases. The main theoretical system includes genomics, functional genomics, proteomics, transcriptomics, metabolomics, epigenomics, metagenomics, synthetic biology, pharmacogenomics of TCM, and bioinformatics, among other fields. Herbgenomics is mainly applicable to the study of medicinal model plants, genomic-assisted breeding, herbal synthetic biology, protection and utilization of gene resources, TCM quality evaluation and control, and TCM drug development. Such studies will accelerate the application of cutting-edge technologies, revitalize herbal research, and strongly promote the development and modernization of TCM. | Tianyi Xin Yu Zhang Xiangdong Pu Ranran Gao Zhichao Xu Jingyuan Song | 2019 | Science China(Life Sciences)2019，62，3： | 10 |
| 15 | Comparative Genome Analysis of Scutellaria baicalensis and Scutellaria barbata Reveals the Evolution of Active Flavonoid Biosynthesis显示文摘Scutellaria baicalensis(S.baicalensis)and Scutellaria barbata(S.barbata)are common medicinal plants of the Lamiaceae family.Both produce specific flavonoid compounds,including baicalein,scutellarein,norwogonin,and wogonin,as well as their glycosides,which exhibit antioxidant and antitumor activities.Here,we report chromosome-level genome assemblies of S.baicalensis and S.barbata with quantitative chromosomal variation(2 n=18 and 2 n=26,respectively).The divergence of S.baicalensis and S.barbata occurred far earlier than previously reported,and a whole-genome duplication(WGD)event was identified.The insertion of long terminal repeat elements after speciation might be responsible for the observed chromosomal expansion and rearrangement.Comparative genome analysis of the congeneric species revealed the species-specific evolution of chrysin and apigenin biosynthetic genes,such as the S.baicalensis-specific tandem duplication of genes encoding phenylalanine ammonia lyase and chalcone synthase,and the S.barbata-specific duplication of genes encoding 4-Co A ligase.In addition,the paralogous duplication,colinearity,and expression diversity of CYP82 D subfamily members revealed the functional divergence of genes encoding flavone hydroxylase between S.baicalensis and S.barbata.Analyzing these Scutellaria genomes reveals the common and species-specific evolution of flavone biosynthetic genes.Thus,these findings would facilitate the development of molecular breeding and studies of biosynthesis and regulation of bioactive compounds. | Zhichao Xu Ranran Gao Xiangdong Pu Rong Xu Jiyong Wang Sihao Zheng Yan Zeng Jun Chen Chunnian He Jingyuan Song | 2020 | Genomics, Proteomics & Bioinformatics2020，18，3： | 10 |
| 16 | miR-93-5p Transferred by Exosomes Promotes the Proliferation of Esophageal Cancer Cells via Intercellular Communication by Targeting PTEN显示文摘Objective To investigate the relationship between plasma miR-93-5p and the risk of esophageal cancer, as well as the influence of miR-93-5p on the biological function of esophageal cancer cells,exerted through exosomes.Methods The expression of plasma miR-93-5p in esophageal cancer patients and healthy controls was analysed by real-time quantitative PCR. The influence of miR-93-5p on the risk and prognosis of esophageal carcinoma was analyzed by conditional logistic regression and survival analysis. The effect of miR-93-5p on the biological function of recipient cells was investigated by establishing an in vitro donor cell co-culture model. The target gene of miR-93-5p was validated by luciferase reporter assay and Western Blotting.Results Upregulation of plasma miR-93-5p expression significantly increases the risk of esophageal cancer and is associated with poor prognosis. miR-93-5p transferred by exosomes promotes the proliferation of recipient esophageal cancer cells and affects the expression of PTEN and its downstream proteins p21 and cyclin D1.Conclusion Our study provides a reference for the identification of biomarkers for the diagnosis and prognosis of esophageal cancer. | LIU Meng Xin LIAO Juan XIE Ming GAO Zhi Kui WANG Xiang Hu ZHANG Ying SHANG Mu He YIN Li Hong PU Yue Pu LIU Ran | 2018 | Biomedical and Environmental Sciences2018，31，3： | 10 |
| 17 | Recently developed strategies to restrain dendrite growth of Li metal anodes for rechargeable batteries显示文摘Lithium metal has been regarded as one of the most promising anode materials for high-energy-density batteries due to its extremely high theoretical gravimetric capacity of 3860 mAh·g^-1 along with its low electrochemical potential of-3.04 V.Unfortunately,uncontrollable Li dendrite growth and repetitive destruction/formation of the solid electrolyte interphase layer lead to poor safety and low Coulombic efficiencies(CEs)for long-term utilization,which largely restricts the practical applications of lithium metal anode.In this review,we comprehensively summarized important progresses achieved to date in suppressing Li dendrite growth.Strategies for protection of Li metal anodes include designing porous structured hosts,fabricating artificial solid electrolyte interface(SEI)layers,introducing electrolyte additives,using solid-state electrolytes and applying external fields.The protection of Li metal anodes can be achieved by regulating the stripping and deposition behaviours of Li ions.Finally,the challenges remaining for lithium metal battery systems and future perspectives for Li metal anodes in practical applications are outlined,which are expected to shed light on future research in this field. | Kai-Chao Pu Xin Zhang Xiao-Lei Qu Jian-Jiang Hu Hai-Wen Li Ming-Xia Gao Hong-Ge Pan Yong-Feng Liu | 2020 | Rare Metals2020，39，6： | 8 |
| 18 | Characteristics of air pollution by polychlorinated dibenzo-p-dioxins and dibenzofurans in the typical industrial areas of Tangshan City,China显示文摘The ambient air in vicinity of different industrial sources for PCDD/PCDFs was sampled by TSP/PM 10 active samplers and passive PUF disk samplers in Tangshan City,a metropolis containing clusters of various industrial plants.The ΣTEQ concentrations of ΣPCDD/ΣPCDFs ranged from 44.2 to 394.1 fg I-TEQ/m 3 with an average of 169.9 fg I-TEQ/m 3.2,3,4,7,8-PeCDF was the dominant contributor to TEQ,contributing 41% (12% to 55%),while 1,2,3,4,6,7,8-HpCDF,OCDD and OCDF were the major congeners for the total concentrations.The ratios of PCDF/PCDD reached 2.54 on average,suggesting that de novo synthesis in thermal processes played an important role to the airborne pollution of PCDD/PCDFs.The similarities congener profiles indicated that TSP and PM 10 active sampling methods are comparable for the determination of the PCDD/PCDFs in ambient air,and the ratios of concentrations determined by the two methods suggested that the PCDD/PCDFs tended to stay in fine particles.It was found that 2,3,7,8-TCDF and OCDD were the dominating congeners in the passive PUF disks samples.Through principal components analysis,the coke industry was suggested to be a relatively high potential emission source for PCDD/PCDFs in the ambient air of Tangshan,which was possibly formed by de novo synthesis mechanism.In this study,the atmospheric impacts to the environment from different industrial sources could be ranked as follows (from high to low):coking,iron sintering,steel making,power generation and chlorinate alkali chemical production industries. | Zhiyuan Ren Bing Zhang Pu Lu Cheng Li Lirong Gao Minghui Zheng | 2011 | Journal of Environmental Sciences2011，23，2： | 8 |
| 19 | Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a global crisis,urgently necessitating the development of safe,efficacious,convenient-to-store,and low-cost vaccine options.A major challenge is that the receptor-binding domain(RBD)-only vaccine fails to trigger long-lasting protective immunity if used alone for vaccination. | Shiyu Sun Yueqi Cai Tian-Zhang Song Yang Pu Lin Cheng Hairong Xu Jing Sun Chaoyang Meng Yifan Lin Haibin Huang Fang Zhao Silin Zhang Yu Gao Jian-Bao Han Xiao-Li Feng Dan-Dan Yu Yalan Zhu Pu Gao Haidong Tang Jincun Zhao Zheng Zhang Jiaming Yang Zhenxiang Hu Yang-Xin Fu Yong-Tang Zheng Hua Peng | 2021 | Cell Research2021，31，9： | 7 |
| 20 | Snaill is involved in de novo cardiac fibrosis after myocardial infarction in mice显示文摘Epithelialmesenchymal 转变(EMT ) 是在心肌的梗塞(MI ) 以后的心脏的纤维变性的重要机制。然而,它仍然保持不清楚是否 Snail1, EMT 的一个重要管理者,涉及心脏的纤维变性。在这研究,我们在老鼠探索了 Snail1 和心脏的纤维变性 markerperiostinafter MI 的表示模式然后在老鼠在 MI 以后调查了在 Snail1 和 periostin 之间的合作表示。我们的结果证明 Snail1 和 periostin 的 mRNA 和蛋白质层次显著地在梗塞区域被增加。Snail1 表示模式看起来在在 MI 以后的 14 天以内寓言。另外在 MI 以后,所有 Snail1 积极的房间能表示 periostin。这些结果显示 Snail1 主要在梗塞区域被激活并且涉及 de novo 在在老鼠的 MI 以后的心脏的纤维变性。因此,它是在为在 MI 以后的室的改变的药干预的发展的一个潜在的分子的目标。 | Yajie Liu Jianlin Du Jin Zhang Minjie Weng Xiaoqun Li Di Pu Lingzhi Gao Songbai Deng Shuang Xia Qiang She | 2012 | Acta Biochimica et Biophysica Sinica2012，44，11： | 7 |
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