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| 1 | Early precut sphincterotomy and the risk of endoscopic retrograde cholangiopancreatography related complications: An updated meta-analysis显示文摘AIM: To study the cannulation and complication rates of early pre-cut sphincterotomy vs persistent attempts at cannulation by standard approach.METHODS: Systematic search of PubMed, EMBASE, Web of Science, and the Cochrane Library for relevant studies published up to February 2013. The main outcome measurements were cannulation rates and postendoscopic retrograde cholangiopancreatography(ERCP) complications. A comprehensive systematic search of the Cochrane library, PubMed, Google scholar, Scopus, National Institutes of Health, meta-register of controlled trials and published proceedings from major Gastroenterology journals and meetings until February 2013 was conducted using keywords. All Prospective randomized controlled trials(RCT) studies whichmet our inclusion criteria were included in the analysis. Prospective non-randomized studies and retrospective studies were excluded from our meta-analysis. The main outcomes of interest were post-ERCP pancreatitis, overall complication rates including cholangitis, ERCPrelated bleeding, perforation and cannulation success rates. RESULTS: Seven RCTs with a total of 1039 patients were included in the meta-analysis based on selection criteria. The overall cannulation rate was 90% in the pre-cut sphincterotomy vs 86.3% in the persistent attempts group(OR = 1.98; 95%CI: 0.70-5.65). The risk of post-ERCP pancreatitis(PEP) was not different between the two groups(3.9% in the pre-cut sphincterotomy vs 6.1% in the persistent attempts group, OR = 0.58, 95%CI: 0.32-1.05). Similarly, there was no statistically significant difference between the groups for overall complication rate including PEP, cholangitis, bleeding, and perforation(6.2% vs 6.9%, OR = 0.85, 95%CI: 0.51-1.41). CONCLUSION: This meta-analysis suggests that precut sphincterotomy and persistent attempts at cannulation are comparable in terms of overall complication rates. Early pre-cut implementation does not increase PEP complications. | Udayakumar Navaneethan Rajesh Konjeti Preethi GK Venkatesh Madhusudhan R Sanaka Mansour A Parsi | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，5： | 12 |
| 2 | Clostridium difficile infection and inflammatory bowel disease:Understanding the evolving relationship显示文摘Clostridium difficile(C.difficile)infection(CDI)is the leading identifiable cause of antibiotic-associated diarrhea.While there is an alarming trend of increasing incidence and severity of CDI in the United States and Europe,superimposed CDI in patients with inflammatory bowel disease(IBD)has drawn considerable attention in the gastrointestinal community.The majority of IBD patients appear to contract CDI as outpatients.C.difficile affects disease course of IBD in several ways,including triggering disease flares,sustaining activity,and in some cases,acting as an'innocent'bystander.Despite its wide spectrum of presentations,CDI has been reported to be associated with a longer duration of hospitalization and a higher mortality in IBD patients.IBD patients with restorative proctocolectomy or with diverting ileostomy are not immune to CDI of the small bowel or ileal pouch.Whether immunomodulator or corticosteroid therapy for IBD should be continued in patients with superimposed CDI is controversial.It appears that more adverse outcomes was observed among patients treated by a combination of immunomodulators and antibiotics than those treated by antibiotics alone.The use of biologic agents does not appear to increase the risk of acquisition of CDI.For CDI in the setting of underlying IBD,vancomycin appears to be more efficacious than metronidazole.Randomized controlled trials are required to clearly define the appropriate management for CDI in patients with IBD. | Udayakumar Navaneethan Preethi GK Venkatesh Bo Shen | 2010 | World Journal of Gastroenterology2010，16，39： | 12 |
| 3 | Factors predicting adverse short-term outcomes in patients with acute cholangitis undergoing ERCP: A single center experience显示文摘AIM: To identify potential factors that can predict adverse short-term outcomes in patients with acute cholangitis undergoing endoscopic retrograde cholangiopancreatography(ERCP). METHODS: Retrospective analysis of consecutive patients admitted to our center for acute cholangitis and underwent ERCP from 2001 to 2012. Involvement of two or more organ systems was termed as organ failure(OF). Cardiovascular failure was defined based on a systolic blood pressure of < 90 mmHg despite fluid replacement and/or requiring vasopressor treatment; respiratory failure if the Pa02 /Fi02 ratio was < 300 mmHg and/or required mechanical ventilation; coagulopathy if the platelet count was < 80; and renal insufficiency if serum creatinine was > 1.9 mg/dL. Variables associated with short term adverse clinical outcomes defined as persistent OF and/or 30-d mortality was determined. RESULTS: A total of 172 patients(median age 62 years, 56.4% female) were included. The median door to ERCP time was 17 h. Bile duct stones were the most common etiology(n = 67, 39.2%). In multivariate analysis, factors that were independently associated with persistent OF and/or 30-d mortality included American Society of Anesthesiology(ASA) physical classification score > 3(OR = 7.70; 95%CI: 2.73-24.40), presence of systemic inflammatory response syndrome(OR = 3.67; 95%CI: 1.34-10.3) and door to ERCP time greater than 72 h(OR = 3.36; 95%CI: 1.12-10.20). Door to ERCP time greater than 72 h was also associated with 70% increase in the mean length of stay(P < 0.001). Every one point increase in the ASA physical classification and every 1 mg/dL increase in the preERCP bilirubin level was associated with a 34% and 2% increase in the mean length of hospital stay, respectively. Transfer status did not impact clinical outcomes. CONCLUSION: Higher ASA physical classification and delays in ERCP are associated with adverse clinical outcomes and prolonged length of hospital stay in patients with acute cholangitis undergoing ERCP. | Udayakumar Navaneethan Norma G Gutierrez Ramprasad Jegadeesan Preethi GK Venkatesh Madhusudhan R Sanaka John J Vargo Mansour A Parsi | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，3： | 7 |
| 4 | 印度亚拉文眼科模式(英文)显示文摘印度亚拉文医院是世界卫生组织合作单位,创造了“大规模、高质量、低成本”的眼科医疗模式,2005年,医院门诊量达163万多,手术超过22万例,其中白内障手术达16万多例,为世界之最。如何有效地借鉴印度亚拉文的模式为我所用,成为中国眼科界同仁日益热烈讨论的一个话题。本刊特邀印度亚拉文医院的主要负责人就该模式的特点撰文介绍。 | Srinivasan M Thulasiraj RD Preethi Pradhan Veni G | 2006 | 眼视光学杂志2006，8，2： | 6 |
| 5 | Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer显示文摘 | Shinichi Yabuuchi Shweta G. Pai Nathaniel R. Campbell Roeland F. de Wilde Elizabeth De Oliveira Preethi Korangath Mirte M. Streppel Zeshaan A. Rasheed Manuel Hidalgo Anirban Maitra N.V. Rajeshkumar | 2013 | Cancer Letters2013，，1： | 5 |
| 6 | Function of flavonoids on different types of programmed cell death and its mechanism:a review显示文摘Cell death in the living system plays a vital role in maintaining the homeostasis and balancing the cell count in the body.Programmed cell death(PCD)is a crucial component of several development and defense mechanisms.PCD is also important in terms of aging which avoids the accumulation of cellular damage by maintaining cell division.Depending on the execution of cell death and its role in destruction,PCD is categorized into several subtypes.The major different forms of PCD in animals are apoptosis,autophagy and necrosis,which can be distinct in morphological terms.More intense investigations of cell death have given close insight showing other important types of cellular destruction and their pivotal roles in treating disease conditions like cancer.Flavonoids have been acquired a great interest for disease therapies and chemoprevention through activation of several PCD mechanisms.The significant potential of natural flavonoids in the induction of distinct signaling cascades is being a massive approach for targeting uncontrolled cell growth.For these reasons,understanding PCD mechanisms is a promising approach for the interventions in treating cancer.Thus,it is intriguing that understanding the different forms of PCD mechanism induced by flavonoids with more accurate descriptions on the biochemical and cellular processes are gaining more significance in cancer research.Here,we provide a brief overview on the different types of PCD and aim to discuss the functional role of flavonoids in promoting different types of cell death as well as an extensive brief review on their mechanism of action has been highlighted. | Preethi Vetrivel Seong Min Kim Venu Venkatarame Gowda Saralamma Sang Eun Ha Eun Hee Kim Tae Sun Min Gon Sup Kim | 2019 | The Journal of Biomedical Research2019，33，6： | 3 |
| 7 | A fractlonal-order delay differential model for Ebola infection and CD8+ T-cells response: Stability analysis and Hopf bifurcation显示文摘 | V. Preethi Latha R. Rakkiyappan G. Velmurugan | 2017 | International Journal of Biomathematics2017，10，8： | 3 |
| 8 | Characterization and optimization of EPSproducing and diesel oil-degrading Ochrobactrum anthropi MP3 isolated from refinery wastewater显示文摘Petroleum refinery wastewater(PRW) containing hydrocarbon is highly toxic to the environment and the surrounding ecosystem. Proper treatment of the PRW effluent is necessary to remove the pollutants before discharge. Bioremediation is considered to be a promising approach as it is ecofriendly and efficient. The exopolysaccharide(EPS) produced by the O. anthropi acts as a bioemulsifier and showed the highest emulsification activity of 60% on diesel. An EPS yield of about 0.42 g/L was obtained under optimized conditions. The carbohydrate and protein content of the EPS was found to be 71.1% and 19.7% respectively, showing the glycoprotein nature. The structural properties of EPS were analyzed by FT-IR and 1H NMR. The batch degradation of oil in PRW by O. anthropi was studied gravimetrically, and showed about 53% degradation in 7 days, indicating the strong ability of the isolated strain to degrade the hydrocarbons in PRW. | Sugumar Ramasamy Prabhakaran Mathiyalagan Preethy Chandran | 2014 | Petroleum Science2014，11，3： | 3 |
| 9 | A comparative study of sequential vs.simultaneous type Ⅰ tympanoplasty in patients with bilateral chronic otitis media-Mucosal type显示文摘Background:Patients with bilateral chronic otitis media-mucosal type have been conventionally treated with sequential tympanoplasty.Bilateral simultaneous tympanoplasty is usually not preferred because of the theoretical risk of iatrogenic sensorineural hearing loss.With the advent of modern surgical instruments and surgical techniques,the risk is expected to be lower.This study compares the clinical outcomes in typeⅠtympanoplasty performed simultaneously and sequentially.Materials&methods:This randomized prospective study was carried out in a tertiary care hospital between August 2015 and July 2017.A total of 30 patients were divided into two groups of 15 each.This study analyzed the graft uptake,pure tone audiogram findings pre-and post-operatively,duration of surgery and number of hospital visit for each patient and the outco mes were co mpared between both the groups.Result:Patients undergoing bilateral simultaneous tympanoplasty had significantly lesser mean duration of surgery and number of hospital visits than the patients undergoing sequential tympanoplasty.Graft uptake and postoperative wound infections were similar in both the groups.Postoperative hearing improvement was significantly better in the bilateral simultaneous tympanoplasty group.However,further studies are needed to authenticate this observation.None of the patients had a postoperative deterioration of hearing or sensorineural hearing loss.Conclusion:Bilateral simultaneous tympanoplasty is not only feasible but also better than sequential tympanoplasty,especially in terms of operating time,follow-up and overall financial implications on the patient. | Preethi Umamaheswaran Sanjeev Mohanty Vinoth Manimaran Sathishkumar Jayagandhi Shiva Priya Jeyabalakrishnan | 2020 | Journal of Otology2020，15，2： | 3 |
| 10 | Progressive Primary Sclerosing Cholangitis Requiring Liver Transplantation Is Associated With Reduced Need for Colectomy in Patients With Ulcerative Colitis显示文摘 | Udayakumar Navaneethan Preethi G.K. Venkatesh Saurabh Mukewar Bret A. Lashner Feza H. Remzi Arthur J. McCullough Ravi P. Kiran Bo Shen John J. Fung | 2012 | Clinical Gastroenterology and Hepatology2012，，5： | 2 |
| 11 | Dual-targeted hybrid nanoparticles of synergistic drugs for treating lung metastases of triple negative breast cancer in mice显示文摘 | Tian ZHANG Preethy PRASAD Ping CAI Chunsheng HE Dan SHAN Andrew Michael RAUTH Xiao Yu WU | 2017 | Acta Pharmacologica Sinica2017，38，6： | 2 |
| 12 | Clostridium difficile infection is associated with worse long term outcome in patients with ulcerative colitis显示文摘 | Udayakumar Navaneethan Saurabh Mukewar Preethi GK Venkatesh Rocio Lopez Bo Shen | 2011 | Journal of Crohn’s and Colitis2011，，3： | 2 |
| 13 | Impact of Clostridium difficile infection in patients with ulcerative colitis显示文摘 | Revital Kariv Udayakumar Navaneethan Preethi G.K. Venkatesh Rocio Lopez Bo Shen | 2010 | Journal of Crohn’s and Colitis2010，，1： | 2 |
| 14 | 12-钨磷酸在AlSBA-15上的固定化及其乙酰化催化活性(英文)显示文摘12-Tungstophosphoric heteropoly acid(TPA) with a Keggin structure was introduced into Al-incorporated mesoporous molecular sieves(AlSBA-15) by the incipient wetness method.The materials were characterized by X-ray diffraction,nitrogen adsorption,scanning electron microscopy,UV-Vis diffuse reflectance and Raman spectroscopy,which confirmed the Keggin and mesopore structure.Its catalytic activity was evaluated under solvent-free conditions in the liquid phase at 333-383 K for the propionylation of anisole with propionic anhydride.The catalysts used were AlSBA-15,10%,20%,and 40% TPA/AlSBA-15,and 20% TPA/MCM-48.In the propionylation of anisole with propionic anhydride,the substitution occurred predominantly at the para position.The 20% TPA/AlSBA-15 catalyst gave a total product yield of 48% with 98% selectivity towards 4-methoxypropiophenone.The regenerability of the catalyst was also studied and was found to be excellent. | S.REVATHI M.Esther Leena PREETHI D.MANIKANDAN D.DIVAKAR A.Valentine RUPA T.SIVAKUMAR | 2008 | 催化学报2008，29，12： | 2 |
| 15 | Monocyte-derived Wnt5a regulates inflammatory ymphangiogenesis显示文摘 | Roberto Sessa Don Yuen Stephanie Wan Michael Rosner Preethi Padmanaban Shaokui Ge April Smith Russell Fletcher Ariane Baudhuin-Kessel Terry P Yamaguchi Richard A Lang LuChen | 2016 | Cell Research2016，26，2： | 2 |
| 16 | Structural Modes of Stabilization of Permissive Phosphorylation Sites in Protein Kinases: Distinct Strategies in Ser/Thr and Tyr Kinases显示文摘 | A. Krupa G. Preethi N. Srinivasan | 2004 | Journal of Molecular Biology2004，，5： | 2 |
| 17 | Toxicity profile of lutein and lutein ester isolated from marigold flowers( Tagetes erecta)显示文摘 | Harikumar KB Nimita CV Preethi KC Kuttan R Shankaranarayaria ML Deshpande J | 2008 | Int J Toxicol2008，27，1： | 1 |
| 18 | Sol-gel derived cobalt doped nano-titania photocatalytic system for solar light induced degradation of crystal vi- olet显示文摘 | PREETHI T ABARNA B VIDHYA K N | 2014 | Ceramics International2014，40，13： | 1 |
| 19 | Reprint of “influence of chitosan-PEG binary template on the crystallite characteristics of sol-gel synthesised mesoporous nanotitania photocatalyst”显示文摘 | PREETHI T ABARNA B RAJARAJESWARI G R | 2014 | Applied Surface Science2014，319，： | 1 |
| 20 | Killing of Enteric Bacteria in Drinking Water by a Copper Device for Use in the Home:Laboratory Evidence显示文摘 | Preethi Sudha V B Ojit Singh K Prasad S R | 2009 | Transactions of the Royal Society of Tropical Medicine and Hygiene2009，103，8： | 1 |
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