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| 1 | Esophageal tuberculosis presenting with hematemesis显示文摘Esophageal tuberculosis is rare, constituting about 0.3% of gastrointestinal tuberculosis. It presents commonly with dysphagia, cough, chest pain in addition to fever and weight loss. Complications may include hemorrhage from the lesion, development of arterioesophageal fistula, esophagocutaneous fistula or tracheoesophageal fistula. There are very few reports of esophageal tuberculosis presenting with hematemesis due to ulceration. We report a patient with hematemesis that was due to the erosion of tuberculous subcarinal lymph nodes into the esophagus. A 15-year-old boy presented with hemetemesis as his only complaint. Esophagogastroduodenoscopy(EGD) revealed an eccentric ulcerative lesion involving 50% of circumference of the esophagus. Biopsy showed caseating epitheloid granulomas with lymphocytic infiltrates suggestive of tuberculosis. Computerised tomography of the thorax revealed thickening of the mid-esophagus with enlarged mediastinal lymph nodes in the subcarinal region compressing the esophagus along with moderate right sided pleural effusion. Patient was treated with anti-tuberculosis therapy(Rifampicin, Isoniazid, Pyrazinamide, Ethambutol) for 6 mo. Repeat EGD showed scarring and mucosal tags with complete resolution of the esophageal ulcer. | Samit S Jain Piyush O Somani Rajeshkumar C Mahey Dharmesh K Shah Qais Q Contractor Pravin M Rathi | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 6 |
| 2 | Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer显示文摘 | Shinichi Yabuuchi Shweta G. Pai Nathaniel R. Campbell Roeland F. de Wilde Elizabeth De Oliveira Preethi Korangath Mirte M. Streppel Zeshaan A. Rasheed Manuel Hidalgo Anirban Maitra N.V. Rajeshkumar | 2013 | Cancer Letters2013，，1： | 5 |
| 3 | Effect of Storage Temperature on Vitamin C, Total Phenolics,UPLC Phenolic Acid Profile and Antioxidant Capacity of Eleven Potato(Solanum tuberosum) Varieties显示文摘Storage of potato tubers at low temperature affects their metabolism and may alter their phytochemical properties. There is a need to elucidate the changes in antioxidant compounds, activity and enzymes during storage of tubers. Eleven Indian potato varieties were evaluated for antioxidant parameters, after 0, 30, 60 and 90 days of storage at room temperature, 15 °C and 4 °C. Total phenolics(0.0786–0.1546 mg gallic acid equivalents·g^(-1)FW) and vitamin C content(0.0828–0.2416 mg·g^(-1)FW) varied among the varieties and were different with storage temperature; their levels fluctuated during storage but remained above the initial level until the last day of observation. Phenolic acid profiling by UPLC identified 12 compounds among which the most abundant was chlorogenic acid followed by gallic acid, sinapic acid and ellagic acid. Except para-coumaric acid which decreased at 4 °C, all the phenolic acids increased with storage. Caffeic acid, chlorogenic acid, protocatechuic acid and gallic acid mostly correlated with total phenolic content(r = 0.456, 0.482, 0.588 and 0.620, respectively). Antioxidant activity against both DPPH and ABTS radicals increased during the initial days of storage and then dropped to a level comparable or lower than the original value,irrespective of the storage temperature. Correlation study revealed that chlorogenic acid, gallic acid and ferulic acid mostly contributed to antioxidant activity. Activity of both antioxidant enzymes, superoxide dismutase and ascorbate peroxidase, increased initially but then decreased to values lower than the initial level and were not influenced by storage temperature. Correlation with antioxidant activity indicated that the enhancement of reactive oxygen scavenging species in cold stored tubers could result mainly from ascorbate peroxidase activity. Our results demonstrate that storage temperature adversely influences the metabolism and the content of antioxidant compounds in potato tubers, with subsequent increase on their antioxidant capacity. | Joseph Hubert Yamdeu Galani Pooja M.Mankad Avadh K.Shah Nilesh J.Patel Rajeshkumar R.Acharya Jayant G.Talati | 2017 | Horticultural Plant Journal2017，3，2： | 2 |
| 4 | Integrated preclinical and clinical development of S- trans, trans -farnesylthiosalicylic acid (FTS, Salirasib) in pancreatic cancer显示文摘 | Daniel Laheru Preeti Shah N. V. Rajeshkumar Florencia McAllister Gretchen Taylor Howard Goldsweig Dung T. Le Ross Donehower Antonio Jimeno Sheila Linden Ming Zhao Dongweon Song Michelle A. Rudek Manuel Hidalgo | 2012 | Investigational New Drugs2012，，6： | 2 |
| 5 | Androgen receptor muta- tions in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663 显示文摘 | Taplin ME Rajeshkumar B Halabi S | 2003 | Clin Oncol2003，21，： | 1 |
| 6 | Modulation of carcinogenic response and antioxidant enzymes of rats administered with 1,2 -dimethylhydrazine by Picroliv显示文摘 | RAJESHKUMAR N V KUTTAN R | 2003 | Cancer Lett2003，191，： | 1 |
| 7 | Nickel-induced oxidative stress in testis of mice: evidence of DNA damage and genotoxic effects显示文摘 | Doreswamy K Shrilatha B Rajeshkumar T | 2004 | J Androl2004，25，6： | 1 |
| 8 | Effect of Picror- rhiza kurroa extract on transplanted tumours and chemical car- cinogenesis in mice显示文摘 | Joy KL Rajeshkumar NV Kuttan G | 2000 | J Ethnopharmacol2000，71，12： | 1 |
| 9 | A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer显示文摘 | Jimeno A Rubio-Viqueira B Rajeshkumar NV | | 0，，02： | 1 |
| 10 | Effect of Picrorrhiza Kurroa extract on transplanted tumours and chemical carcinogenesis in mice显示文摘 | Joy KL Rajeshkumar NV Kullan G | 2000 | Phytotherapy Research2000，71，12： | 1 |
| 11 | Effi- cacy and pharmacodynamic effects of bosutinib ( SKI-606 ) , a Src/Abl inhibitor, in freshly generated human pancreas cancer xenografts显示文摘 | MESSERSMITH WA RAJESHKUMAR NV TAN AC | 2009 | Mol Cancer Ther2009，8，6： | 1 |
| 12 | Inhibition of chemical carci- nogenesis by berberine in rats and mice 显示文摘 | Anis KV Rajeshkumar NV Kuttan R | 2001 | J Pharm Pharmacol2001，53，5： | 1 |
| 13 | MK-1775, a potent Weel inhibitor, synergizes with gemcitabine to achieve tumor regres- sions, selectively in p53-defieient pancreatic cancer xenografts 显示文摘 | Rajeshkumar NV De Oliveira E Ottenhof N | 2011 | Clin Cancer Res2011，17，9： | 1 |
| 14 | Efficacy and pharmacodynamic effects of bosutinib (SKI-606), a Src/Abl inhibitor, in freshly generated human pancreas cancer xenografts显示文摘 | MESSERSMITH WA RAJESHKUMAR NV TAN AC | 2009 | Mol Cancer Ther2009，8，6： | 1 |
| 15 | Enhanced GABA (B) receptor in neoplastic rat liver: induction of DNA synthesis by baclofen in hepatocyte cultures显示文摘 | BIJU M P PYROJA S RAJESHKUMAR N V | 2002 | Journal of Bio- chemistry Molecular Biology and Biophysics2002，6，3： | 1 |
| 16 | Integrated preclinical and clinical development of S-trans, trans-Farnesyhhiosalicylic Acid (FTS, Salirasib) in pancreatic cancer显示文摘 | Laheru D Shah P Rajeshkumar NV | 2012 | Invest New Drugs2012，30，6： | 1 |
| 17 | Evaluation of Logistics Related Policies Between Two Different Levels of the Supply Chain Network: A Case Study显示文摘 | Rajeshkumar B C RameshBabu T | 2006 | Annals of Operations Research2006，143，1： | 1 |
| 18 | Antitumour and anticarcinogenic activity of Phyllanthus amarus extract显示文摘 | N.V. Rajeshkumar K.L. Joy Girija Kuttan R.S. Ramsewak Muraleedharan G. Nair Ramadasan Kuttan | 2002 | Journal of Ethnopharmacology2002，，1： | 1 |
| 19 | Development in therapeutic importance of most ught marine algal Polysaccharide Fucoidans 显示文摘 | Rajeshkumar S Vanaja M Malarkodi C | 2013 | International Journal of Research in Biomedicine and Biotechnology2013，3，2： | 1 |
| 20 | Preparation of aluminium matrix composites by using stir casting method显示文摘 | Rajeshkumar G B Parshuram M S | 2013 | Int J Eng Adv Technol2013，2，： | 1 |
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