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| 1 | Euglycemic diabetic ketoacidosis:A missed diagnosis显示文摘Euglycemic diabetic ketoacidosis(DKA)is an acute life-threatening metabolic emergency characterized by ketoacidosis and relatively lower blood glucose(less than 11 mmol/L).The absence of hyperglycemia is a conundrum for physicians in the emergency department and intensive care units;it may delay diagnosis and treatment causing worse outcomes.Euglycemic DKA is an uncommon diagnosis but can occur in patients with type 1 or type 2 diabetes mellitus.With the addition of sodium/glucose cotransporter-2 inhibitors in diabetes mellitus management,euglycemic DKA incidence has increased.The other causes of euglycemic DKA include pregnancy,fasting,bariatric surgery,gastroparesis,insulin pump failure,cocaine intoxication,chronic liver disease and glycogen storage disease.The pathophysiology of euglycemic DKA involves a relative or absolute carbohydrate deficit,milder degree of insulin deficiency or resistance and increased glucagon/insulin ratio.Euglycemic DKA is a diagnosis of exclusion and should be considered in the differential diagnosis of a sick patient with a history of diabetes mellitus despite lower blood glucose or absent urine ketones.The diagnostic workup includes arterial blood gas for metabolic acidosis,serum ketones and exclusion of other causes of high anion gap metabolic acidosis.Euglycemic DKA treatment is on the same principles as for DKA with correction of dehydration,electrolytes deficit and insulin replacement.The dextrosecontaining fluids should accompany intravenous insulin to correct metabolic acidosis,ketonemia and to avoid hypoglycemia. | Prashant Nasa Sandeep Chaudhary Pavan Kumar Shrivastava Aanchal Singh | 2021 | World Journal of Diabetes2021，12，5： | 11 |
| 2 | Role of Moringa oleifera in regulation of diabetes-induced oxidative stress显示文摘Objective:To evaluate the antioxidant activity of aqueous extract of Atoringa oleifeta M.oleifera) young leaves by in vivo as well as in vitro assays.Methods:In vitro study included estimation of total phenolic,total ilavonol,total flavonoid and total antioxidant power(FRAP assay).Tn addition, in vivo study was done with the identified most effective dose of 200 nig/kg of its lyophilized powder on normal and diabetic rats.Its effect on different oxidative free radical scavenging enzymes,viz,superoxide dismutase(SOD),catalase(CAT),glutathione-S-transferase(GST),lipid peroxide(LPO) contents were measured.Results:Significant increase in activities of SOD.CAT, GST while,a decrease in LPO content was observed.Whereas,total phenolic,flavonoid and ilavonol contents in the extract were found to be 120 mg/g of CAK,40.5 mg/g of QEK and 12.12 mg/g of QE,respectively.On the other hand.FRAP assay results of M.oleifera leaves was(85.00±5.00)μM of Fe^+/g of extract powder.Conclusions:The significant antioxidant activities of M.oleifera leaves from both in vivo as well as in vitro studies suggests that the regular intake of its leaves through diet can protect normal as well as diabetic patients against oxidative damage. | Dolly Jaiswal Prashant Kumar Rai Shikha Mehta Sanjukta Chatterji Surekha Shukla Devendra Kumar Rai Gaurav Sharma Bechan Sharma Shahidul khair Geeta Watal | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，6： | 11 |
| 3 | Nonunion of coronal shear fracture of femoral condyle显示文摘大腿骨的髁的孤立的花冠破裂在成年人是稀罕的并且 Hoffa 骨折不属于工会被报导仅仅在文学的一些时间。我们分析了六个案例在三年的一个时期上的 Hoffa 破裂不属于工会。三个病人保存地被对待,三个病人有固定失败。表示的延期是到一年的 2 个月。治疗协议与膝 arthrolysis 一起由开的减小, pseudoarthrosis 的切除,骨头 grafting 和内部固定组成了。联合在平均数 16 星期在所有病人被完成。治疗 Hoffa 破裂不属于工会要求小心的外科手术前的计划和过细的外科的技术。关于在破裂管理和外科的技术的争吵的文学被考察。 | Ajay Pal Singh Ish Kumar Dhammi Raju Vaishya Anil Kumar Jain Arun Pal Singh Prashant Modi | 2011 | Chinese Journal of Traumatology2011，14，3： | 11 |
| 4 | Current Status of Conventional and Molecular Interventions for Blast Resistance in Rice显示文摘Pyricularia oryzae anamorph of Magnaporthe oryzae is one of the most notorious fungal pathogens causing severe economic loss in rice production worldwide. Various methods, viz. cultural, biological and molecular approaches, are utilized to counteract this pathogen. Moreover, some tolerant or resistant rice varieties have been developed with the help of breeding programmes. Isolation and molecular characterization of different blast resistance genes now open the gate for new possibilities to elucidate the actual allelic variants of these genes via various molecular breeding and transgenic approaches. However, the behavioral pattern of this fungus breakups the resistance barriers in the resistant or tolerant rice varieties. This host-pathogen barrier will be possibly countered in future research by comparative genomics data from available genome sequence data of rice and M. oryzae for durable resistance. Present review emphasized fascinating recent updates, new molecular breeding approaches, transgenic and genomics approaches(i.e. mi RNA and genome editing) for the management of blast disease in rice. The updated information will be helpful for the durable, resistance breeding programme in rice against blast pathogen. | Deepti SRIVASTAVA Md SHAMIM Mahesh KUMAR Anurag MISHRA Pramila PANDEY Deepak KUMAR Prashant YADAV Mohammed Harrish SIDDIQUI Kapildeo Narayan SINGH | 2017 | Rice science2017，24，6： | 8 |
| 5 | Monteggia fracture dislocation equivalents analysis of eighteen cases treated by open reduction and internal fixation显示文摘 | Ajay Pal Singh Ish Kumar Dhammi Anil Kumar Jain Rajeev Raman Prashant Modi | 2011 | Chinese Journal of Traumatology2011，14，4： | 4 |
| 6 | Assessment of performance,combustion and emissions characteristics of methanol-diesel dual-fuel compression ignition engine:A review显示文摘The energy security concern and rapidly diminishing fossil fuel resources demand the development of renewable and economically attractive fuel for reciprocating engines.Methanol is a promising renewable alternative fuel.Numerous studies have been carried out to explore the various aspects of the utilization of methanol in compression ignition(CI)engine.This review paper presents a detailed analysis of the effect of methanol on performance,combustion,and emission(NOx,CO,HC,and soot)characteristics of conventional CI-engine along with dual-fuel combustion mode.This study focuses on methanol utilization in dual-fuel mode,which is an advanced engine combustion mode.First,methanol production and solubility issues of methanol in diesel are briefly discussed.This study discusses the soot and nano-particle emission from the methanol fueled CI-engine,which is one of the main concerns in the current emission legislation.It was found that the utilization of methanol in CI-engine has the potential to improve the performance and simultaneously with a significant reduction in NOx,CO,soot,and nano-particle emissions in comparison to neat diesel operation.However,unburnt HC emission reduces for methanol-diesel blended fuel operation whereas HC emissions are higher for methanoldiesel dual-fuel operation. | Mohit Raj Saxena Rakesh Kumar Maurya Prashant Mishra | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，5： | 4 |
| 7 | Case report on an infant presenting with hypoglycemia,and milky serum显示文摘A 4-month-old male baby who presented in a moribund condition with seizures was found to have hepatomegaly,hypoglycemia and milky serum.Serum triglycerides were markedly elevated(3168 mg/dL) with cholesterol being 257 mg/dL and high density lipoprotein levels were low(19 mg/dL).The possibility of glycogen storage disease type Ⅰ was considered in the diagnosis.Infants with glycogen storage disease type Ⅰ may present like sepsis.The association of hepatomegaly, hypoglycemia and abnormal lipid profile stated above should alert the physician to consider glycogen storage disease type Ⅰ in the diagnosis. | Yogesh Kumar Gupta Anushre Prasad Pushpa Kini Prashant Naik Deepti Choprra Krishnananda Prabhu | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 3 |
| 8 | Glacier-Glacial Lake Interactions and Glacial Lake Development in the Central Himalaya,India(1994–2017)显示文摘Despite several regional glacier and glacier lake inventories, the relationship between receding glacier, glacial lake evolution(glacial-lake interactions) and their sensitivity to different forcing factors have not been properly understood yet. To better understand these processes, we used satellite images collected in 1994, 2015 and 2017 to monitor the spatially-explicit evolution of glacial lakes and glacier changes. The results show a total of 1 353 glacial lakes covering an area of 7.96 km;in the year 2015. Out of these, a total of 137 glacial lakes having an area of >0.01 km;and located within 2 km periphery of mother glacier have been selected for the monitoring of spatial development between 1994 and 2017. We found an increase in the total lake area from ~4.9 to ~7.73 km;between 1994 and 2017,corresponding to an overall expansion of ~57%. The total area covered by the glaciers associated with these lakes reduced from ~365 km;in 1994 to ~358 km^(2) in 2017, accounting for a glacier loss of ~7 km^(2) and corresponding to ~1.92% reduction. Our study results are in agreement with global glacier behavior, revealing a rapid glacier recession and accelerated glacial lake expansion under an unprecedented climate change scenario. In addition, the results suggest a significant reduction in the glacier area and a close relationship between the glacier melting and lake changes. | Pratima Pandey Sheikh Nawaz Ali Prashant Kumar Champati Ray | 2021 | Journal of Earth Science2021，32，6： | 3 |
| 9 | Technical challenges in tackling regulatory concerns for urban atmospheric nanoparticles显示文摘Recent Euro 5 and Euro 6 vehicle emission standards are the first ever initiative to control particles on a number basis at the source. Related standards are also desirable for ambient nanoparticles (taken in this article to be those below 300 nm) to protect against possible adverse effects on public health and the environment. However, there are a number of technical challenges that need to be tackled before developing a regulatory framework for atmospheric nanoparticles. Some of the challenges derive from a lack of standardisation of the key measurement parameters, including sampling, necessary for robust evaluation of particle number concentrations, especially in the context of insufficient knowledge of the physicochemical characteristics of emerging sources (i.e. bio-fuel derived and manufactured nanoparticles). Ideally, ambient concentrations of primary particles could be linked to primary particle emissions by use of nanoparticle dispersion models, and secondary nanoparticles using photochemical modeling tools. The limitations in these areas are discussed. Although there is inadequate information on the exact biological mechanism through which these particles cause harm, it is argued that this should not in itself delay the introduction of regulation. This article reviews the missing links between the existing knowledge of nanoparticle number concentrations and the advances required to tackle the technical challenges implied in developing regulations. | Prashant Kumar Alan Robins Sotiris Vardoulakis Paul Quincey | 2011 | Particuology2011，9，6： | 3 |
| 10 | Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats显示文摘Diabetic neuropathies are a family of nerve disorders caused by diabetes.Symptoms of the disease include nerve palsy,mononeuropathy,mononeuropathy multiplex,diabetic amyotrophy,painful polyneuropathy,autonomic neuropathy,and thoracoabdominal neuropathy.In this study,type 2 diabetes in rats was induced with nicotinamidestreptozotocin.Drug treatment was initiated on the d 15,with the combination regimen of metformin,pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin,amitriptyline and sitagliptin and led to significantly improved glycemic control,increased grip strength and paw jumping response on d 21,28 and 35(P < 0.001).Significant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21,28 and 35(P < 0.001).Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells,while administration of metformin and sitagliptin showed tissue regeneration and no body weight gain.In conclusion,treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain,but causes an increase in grip strength and pain sensitivity,exhibits neural protection,and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes. | Ashish Kumar Sharma Akash Sharma Rita Kumari Kunal Kishore Divya Sharma Bharthu Parthsarthi Srinivasan Ashok Sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Prashant Sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant Kumar Dhakad Davender Singh Kanawat Akanksha Mishra Anil Sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam | 2012 | The Journal of Biomedical Research2012，26，3： | 2 |
| 11 | Multicentered prospective investigator initiated study to evaluate the clinical outcomes with extracorporeal cytokine adsorption device (CytoSorb®) in patients with sepsis and septic shock显示文摘BACKGROUND Sepsis is a severe clinical syndrome related to the host response to infection.The severity of infections is due to an activation cascade that will lead to an auto amplifying cytokine production:The cytokine storm.Hemoadsorption by CytoSorb®therapy is a new technology that helps to address the cytokine storm and to regain control over various inflammatory conditions.AIM To evaluate prospectively CytoSorb®therapy used as an adjunctive therapy along with standard of care in septic patients admitted to intensive care unit(ICU).METHODS This was a prospective,real time,investigator initiated,observational multicenter study conducted in patients admitted to the ICU with sepsis and septic shock.The improvement of mean arterial pressure and reduction of vasopressor needs were evaluated as primary outcome.The change in laboratory parameters,sepsis scores[acute physiology and chronic health evaluation(APACHE II)and sequential organ failure assessment(SOFA)]and vital parameters were considered as secondary outcome.The outcomes were also evaluated in the survivor and nonsurvivor group.Descriptive statistics were used;a P value<0.05 was considered RESULTS Overall,45 patients aged≥18 and≤80 years were included;the majority were men(n=31;69.0%),with mean age 47.16±14.11 years.Post CytoSorb®therapy,26 patients survived and 3 patients were lost to follow-up.In the survivor group,the percentage dose reduction in vasopressor was norepinephrine(51.4%),epinephrine(69.4%)and vasopressin(13.9%).A reduction in interleukin-6 levels(52.3%)was observed in the survivor group.Platelet count improved to 30.1%(P=0.2938),and total lung capacity count significantly reduced by 33%(P<0.0001).Serum creatinine and serum lactate were reduced by 33.3%(P=0.0190)and 39.4%(P=0.0120),respectively.The mean APACHE II score was 25.46±2.91 and SOFA scores was 12.90±4.02 before initiation of CytoSorb®therapy,and they were reduced significantly post therapy(APACHE II 20.1±2.47;P<0.0001 and SOFA 9.04±3.00;P=0.0003)in the survivor group.The predicted mortality in our patient population before CytoSorb®therapy was 56.5%,and it was reduced to 48.8%(actual mortality)after CytoSorb®therapy.We reported 75%survival rate in patients given treatment in<24 h of ICU admission and 68%survival rates in patients given treatment within 24-48 h of ICU admission.In the survivor group,the average number of days spent in the ICU was 4.44±1.66 d;while in the nonsurvivor group,the average number of days spent in ICU was 8.5±15.9 d.CytoSorb®therapy was safe and well tolerated with no adverse events reported.CONCLUSION CytoSorb®might be an effective adjuvant therapy in stabilizing sepsis and septic shock patients.However,it is advisable to start the therapy at an early stage(preferably within 24 h after onset of septic shock). | Rajib Paul Prachee Sathe Senthil Kumar Shiva Prasad Ma Aleem Prashant Sakhalvalkar | 2021 | World Journal of Critical Care Medicine2021，10，1： | 2 |
| 12 | 基于RAPD-PCR标记的印度亚麻品种遗传多样性和指纹图谱分析(英文)显示文摘栽培的亚麻(L.usitatissimum)通常为亚麻籽,以其油分和纤维而被认为是具有较高经济价值的作物之一。开发亚麻遗传资源并进一步进行遗传改良,须了解其遗传变异的范围和结构。位于坎普尔的C.S.农业科技大学种质管理单位保存有广泛收集而来的2772份栽培和野生亚麻资源。从中选出23份不同基因型栽培亚麻品种包括5份两用品种、4份种用品种、14份具有不同形态和经济特性的引进种用品种以及1份野生品系(L.grandiflorum),采用RAPD标记进行遗传多样性分析。20条随机引物共产生242条带,每条引物扩增带数为1~20条,平均为10.95条。所有基因型和位点的RAPD多态性比例为90.49%。DICE系数相似矩阵分析揭示其遗传相似性为0.63~0.97,平均相似系数为82%,说明这些亚麻品种(系)的遗传背景较窄。采用UPGMA法以及NTSYS-pc软件的SAHN聚类分析模型对遗传相似矩阵进行聚类分析,发现属于L.uitatisimums的所有栽培品种在X轴上可聚为一类,而L.grandiflorum野生种单独在Y轴上聚为一类。主成分分析结果表明,除了Shekha(r优良种用品种)和野生种L.grandiflorum广泛分布外,其他所有种用品种、两用品种和外来品种聚类很近。由于亚麻栽培品种的遗传关系相近,须对亚麻种质的各种基因型进行鉴定,以拓宽今后育种计划中的遗传基础。 | Prashant Shekhar Gupta Sangeeta Srivastava Manoj Kumar Srivastava Abhilash Gupta | 2010 | 广西农业科学2010，41，3： | 2 |
| 13 | Probabilistic neural networks for pattern classification显示文摘 | Prashant Kumar Patra Manojranjan Nayak | 2002 | IEEE2002，2，5： | 1 |
| 14 | Safety assessment of Zanthoxylum alatum Roxb. essential oil, its antifungal, antiaflatoxin, antioxidant activity and efficacy as antimicrobial in preservation of Piper nigrum L. fruits显示文摘 | Bhanu Prakash Priyanka Singh Prashant Kumar Mishra N.K. Dubey | 2011 | International Journal of Food Microbiology2011，，1： | 1 |
| 15 | Effect of working gap and components by a magnetic field assisted finishing process显示文摘 | Jain V K Prashant Kumar Behera P K eL al | 2004 | Pre- cision Engineering2004，28，： | 1 |
| 16 | Hydrothermal-ly synthesized high silica mordenite as an efficient catalyst in al-kylation reaction under liquid phase condition 显示文摘 | Sujit Samanta Nawal Kishor Mai Prashant Kumar | 2004 | Journal of Mo-lecular Catalysis A : Chemical2004，，215： | 1 |
| 17 | Recombinant trehalose-6-phosphate phosphatase of Brugia malayi cross-reacts with human Wuchereria bancrofti immune sera and engenders a robust protective outcome in mice显示文摘 | Susheela Kushwaha Prashant Kumar Singh Jyoti Gupta Vishal Kumar Soni Shailja Misra-Bhattacharya | 2012 | Microbes and Infection2012，，14： | 1 |
| 18 | Mathematical model for smoking: Effect of determination and education显示文摘 | Anuradha Yadav Prashant K. Srivastava Anuj Kumar | 2015 | International Journal of Biomathematics2015，8，1： | 1 |
| 19 | Glycemic Properties of Trichosanthes dioica Leaves显示文摘 | Prashant Kumar Rai Dolly Jaiswal Rakesh Kumar Singh Rajesh Kumar Gupta Geeta Watal | 2008 | Pharmaceutical Biology2008，，12： | 1 |
| 20 | Evaluation of numerical schemes using different simulation methods for the continuous phase modeling of cyclone separators 显示文摘 | Kumar S S Prashant S Pradyumna G | 2011 | Advanced Powder Technology2011，22，2： | 1 |
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