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| 1 | Contrast-enhanced 3D ultrasound in the radiofrequency ablation of liver tumors显示文摘Liver metastases and hepatocellular carcinomas are two of the most common causes of cancer deaths in the world.Radiofrequency ablation(RFA) is a well recognized,effective and minimally invasive means of treating malignant hepatic tumors.This article describes the use of contrast-enhanced 3D ultrasound(CE-3DUS) in the staging,targeting and follow-up of patients with liver tumors undergoing RFA.In particular,its value in the management of large hepatic lesions will be illustrated.Current limitations of CE-3DUS and future developments in the technique will also be discussed.In summary,CE-3DUS is useful in the RFA of liver tumors with improved detection and display of occult lesions and recurrence,in the assessment of lesional geometry and orientation for a more accurate planning and guidance of multiple RFA needle electrodes in large tumors and in the evaluation of residual or recurrent disease within the immediate and/or subsequent follow-up periods. | Edward Leen Senthil Kumar Shahid A Khan Gavin Low Keh Oon Ong Paul Tait Mike Averkiou | 2009 | World Journal of Gastroenterology2009，15，3： | 19 |
| 2 | Antioxidant activities of Indigofera cassioides Rottl.Ex.DC.using various in vitro assay models显示文摘Objective:To evaluate the antioxidant potential of methanolic leaf extract of Indigofera cassioides(MEIC) using various in vilro antioxidant assay systems.Methods:Antioxidant and free radical scavenging activity of MEIC was assayed by using different in vitro models like ABTS, DPPH,nitric oxide,superoxide,hydrogen peroxide and hydroxyl radical.Reductive ability of the extract was tested by the complex formation with potassium ferricyanide.Further total phenol and flavonoid contents of the crude extract were also determined.Rutin and ascorbic acid were used as standards.Results:MEIC exhibited potent and concentration dependent free radical scavenging activity in all the tested models.Reductive ability was also found to increase with increase in MEIC concentration.Total phenol and flavonoid content determination showed that the extract is rich in phenols and flavonoids.Conclusions:All the results of the in vitro antioxidant assays reveal potent antioxidant and free radical scavenging activity of the leaves of Indigofera cassioides,equivalent to that of standard ascorbic acid and rutin.This potent antioxidant activity may be attributed to its high phenolic and flavonoid contents. | R Senthil Kumar B Rajkapoor P Perumal | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 15 |
| 3 | A Review of Printable Flexible and Stretchable Tactile Sensors显示文摘Flexible and stretchable tactile sensors that are printable,nonplanar,and dynamically morphing are emerging to enable proprioceptive interactions with the unstructured surrounding environment.Owing to its varied range of applications in the field of wearable electronics,soft robotics,human-machine interaction,and biomedical devices,it is required of these sensors to be flexible and stretchable conforming to the arbitrary surfaces of their stiff counterparts.The challenges in maintaining the fundamental features of these sensors,such as flexibility,sensitivity,repeatability,linearity,and durability,are tackled by the progress in the fabrication techniques and customization of the material properties.This review is aimed at summarizing the recent progress of rapid prototyping of sensors,printable material preparation,required printing properties,flexible and stretchable mechanisms,and promising applications and highlights challenges and opportunities in this research paradigm. | Kirthika Senthil Kumar Po-Yen Chen Hongliang Ren | 2019 | Research2019，，1： | 12 |
| 4 | Antihyperglycemic and antioxidant effects of Solanum xanthocarpum leaves(field grown & in vitro raised) extracts on alloxan induced diabetic rats显示文摘Objective:To investigate antidiabetic efficacy of the extract of field grown and in vitro raised leaves of Solanum xanthocarpum(S.xanthocarpum) against alloxan induced diabetic rats. Methods:The antidiabetic activity of the crude methanol extracts of the field grown and in vitro raised leaves of S.xanthocarpum at different concentrations(100-200 mg/kg bw) was tested against alloxan induced diabetic rats.The antidiabetic efficacy was validated through various biochemical parameters and the antioxidant effect was also determined.The phytochemical analyses of field grown S.xanthocarpum and in vitro rasied 5.xanthocarpum leaves were done by estimating their chlorophyll,carotenoids,total sugar,protein,amino acid and minerals contents. Results:The results revealed that the methanol extracts of both the leaves(field grown and in vitro raised) of S.xanthocarpum was efficient anti hyperglycemic agents at a concentration of 200 mg/kg bw and posses potent antioxidant activity.However,the extracts of in vitro rasied S.xanthocarpum raised leaves exhibit higher efficacy than the field grown leaves in all tested concentrations.Proximal composition and mineral analysis of S.xanthocarpum revealed higher concentration of contents in in vitro rasied S.xanthocarpum than field grown S.xanthocarpum. Conclusions:From the results it can be concluded that the leaves extracts of S.xanthocarpum can be a potential candidate in treating the hyperglycemic conditions and suits to be an agent to reduce oxidative stress. | K Poongothai P Ponmurugan K Syed Zameer Ahmed B Senthil Kumar SA Sheriff | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 9 |
| 5 | Synthesis of Aligned ZnO Nanorod Array on Silicon and Sapphire Substrates by Thermal Evaporation Technique显示文摘High density ZnO nanorods were grown by thermal evaporation of Zn powder at 700?C on Si (100) and sapphire (0001) substrates at atmospheric pressure without adding any catalyst. The nanorods were characterizated in terms of their structural and optical properties. The nanorods grown on Si have a diameter of 350-400 nm and a length of 1.2 μm while those on sapphire have a diameter of 600-800 nm and a length of 2.5 μm. During the structural characterization, it is noticed that the rods grow along the (0002) plane with perfect hexagonal facet. The room temperature photoluminescence spectrum showed a strong UV emission peak at 385 nm with a weak green band emission, which confirms that nanorods have good optical properties. It is observed that the oxygen partial pressure plays an important role to control the shape and size of the nanorods in thermal evaporation growth technique. | K.M.K. Srivatsa Deepak Chhikara M. Senthil Kumar | 2011 | Journal of Materials Science & Technology2011，27，8： | 7 |
| 6 | Delayed migration of K-wire into popliteal fossa used for tension band wiring of patellar fracture显示文摘被用于破裂固定的 K 电线和不锈钢电线的破裂不是不平常的,但是移植是稀罕的。我们报导为髌紧张乐队配线使用到腿弯部的窝的破 K 电线的移植的一个案例。破硬件通过手术被移开。我们想建议那 K 电线和电线固定使用了因为膝盖骨的破裂的治疗能移居进膝的以后的分隔空间并且引起临床的症状。在曾经,骨折统一了识别电线的硬件破裂或运动和移动的存在的内部固定以后的近临床、放射学的后续能避免如此的复杂并发症。 | Sanjay Meena Hira Lal Nag Senthil Kumar Nilesh Barwar Samarth Mittal Amit Singla | 2013 | Chinese Journal of Traumatology2013，16，3： | 7 |
| 7 | Analysis on Critical Success Factors for Agile Manufacturing Evaluation in Original Equipment Manufacturing Industry-An AHP Approach显示文摘Manufacturing industries are facing challenges in the implementation of agile manufacturing in their products and processes.Agility is widely accepted as a new competitive concept in the manufacturing sector in fulfilling varying customer demand. Thus,evaluation of agile manufacturing in industries has become a necessity. The success of an organisation depends on its ability to manage finding the critical success factors and give them special and continued attention in order to bring about high performance. This paper proposes a set of critical success factors(CSFs) for evaluating agile manufacturing considered appropriate for the manufacturing sector.The analytical hierarchy process(AHP) method is applied for prioritizing the success factors, by summarizing the opinions of experts. It is believed that the proposed CSFs enable and assist manufacturing industries to achieve a higher performance in agile manufacturing so as to increase competitiveness. | C Ajay Guru Dev V S Senthil Kumar | 2016 | Chinese Journal of Mechanical Engineering2016，29，5： | 7 |
| 8 | In vitro and in vivo anticancer activity of Indigofera cassioides Rottl.Ex. DC.显示文摘Objective:To evaluate the antitumor,cytotoxic and antioxidant activities of methanolic leaf extract of Indigofera cassioides(MEIC) against transplantable tumors and human cancer cell lines.Methods:MEIC was investigated for its short term cytotoxicity on EAC and DLA cells by trypan blue dye exclusion method and in vitro cytotoxicity on HeLa,HEp-2,HEpG-2,MCF-7, HT-29,Vero and NIH 3T3 cells by MTT assay.In vivo antitumor activity was studied on EAC and DLA tumor bearing mice.Activity was assessed by monitoring the mean survival time,effect on hematological parameters,antioxidant enzyme levels and solid tumor volume.Results:MEIC exhibit potent in vitro cytotoxicity against all the tested cancer cell lines,but it was found to be safe on normal cells.The extract significantly(P<0.001) increase the mean survival time and also have a protective effect on the hemopoietic system at the tested dose levels(200 and 400 mg/kg). The extract prevented lipid peroxidation and restored the antioxidant enzymes catalase, superoxide dismutase,glutathione peroxidase and glutathione-s-transferase in the liver of tumor control animals.It also significandy(P<0.01) reduce the solid tumor volume.Conclusions:The results strongly support that MEIC shows potent antitumor and cytotoxic effects against EAC,DLA and human cancer cell lines.The extract prevents lipid peroxidation and promotes the enzymatic antioxidant defense system in tumor bearing animals which might be due to activities like scavenging of free radicals by the phytochemicals in MEIC. | Raju Senthil Kumar Balasubramanian Rajkapoor Perumal Perumal | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，5： | 6 |
| 9 | Myosin XI Is Required for Actin-Associated Movement of Plastid Stromules显示文摘Stromules 是从质体和偶尔相连的单个质体的表面延长的高度有活力的充满基质的小管,允许在互连的质体之间的复杂生物分子的运动。有细胞骨架汇编的禁止者的实验在 stromule 运动显示了一个基于肌动朊的系统的参与。然而,与系统联系的马达蛋白质没被识别。这里,我们肌浆球蛋白 XI 在烟草涉及 stromules 的形成和运动的现在的直接证据离开。2,3-butanedione 2-monoxime 的申请,肌浆球蛋白 ATPase 活动的一个禁止者,从烟草叶导致了 stromules 的损失表皮的细胞。在 Nicotiana benthamiana 的叶子的肌浆球蛋白 XI 的短暂 RNA 干扰也从表皮的房间导致了 stromules 的损失,没有为肌动朊或肌浆球蛋白 VIII 的抄本上的任何效果。在烟草叶的一个标注 GFP 的肌浆球蛋白 XI 尾巴领域的短暂表示表皮的房间证明对叶绿体,以及到线粒体和其它局部性的熔化蛋白质包细胞器。我们的调查结果作为涉及 stromules 的形成和运动的关键蛋白质识别肌浆球蛋白 XI。 | Senthil Kumar A. Natesan James A. Sullivan John C. Gray | 2009 | Molecular Plant2009，2，6： | 6 |
| 10 | 响应面方法在奥氏体不锈钢与铜合金异种材料摩擦焊接头的抗拉强度最大化和界面硬度最小化中的应用(英文)显示文摘在奥氏体不锈钢与铜合金异种材料摩擦焊接过程中,采用响应面方法优化摩擦焊接工艺参数,以获得抗拉强度最大和界面硬度最小的焊接接头。采用三因素、五水平中心复合正交矩阵来确定实验条件。得到20个焊接接头,测定了焊接接头的抗拉强度和界面硬度。采用方差分析(ANOVA)方法来确定起显著作用的、主要的及相互作用的参数,使用回归分析得到经验关系模型。用设计专家软件构造响应图和等高线图来优化摩擦焊接工艺参数。用得到的经验关系模型可以有效地预测焊接接头的抗拉强度和界面硬度,其置信水平达95%。从形成的等高线图可以得到所需的摩擦焊接的最佳条件。 | G. VAIRAMANI T. SENTHIL KUMAR S. MALARVIZHI V. BALASUBRAMANIAN | 2013 | Transactions of Nonferrous Metals Society of China2013，23，8： | 5 |
| 11 | Synthesis,characterization and sintering behavior influencing mechanical,thermal and physical properties of pure cordierite and cordierite-ceria显示文摘The study of cordierite ceramic is the need of the hour in present technological world for various advanced engineering applications.Cordierite,which has relatively poor mechanical properties,has induced the use of various dopants to study the improvement in mechanical properties.Thirst of seeking new materials with good mechanical properties has revived the research on ceria doped cordierite.Present research conducted on pure cordierite and ceria doped cordierite ceramics has investigated the results of characterization and studied their suitability.Pure cordierite and cordierite-ceria(CeO_(2))composite ceramics synthesized for various stoichiometric composition(5-20 wt%)were compacted at 240 MPa and sintered between 600℃and 1350℃for 3 h.The characterization techniques used in this study were X-ray diffraction(XRD),thermogravimetric(TG)analysis and Fourier transform infrared(FTIR).The density was calculated using the Archimedes principle.Influence of the ceria addition on cordierite’s mechanical properties such as hardness,flexural strength and fracture toughness and on thermal properties as thermal expansion was studied.XRD results confirmed the presence of cordierite and ceria in the samples heat treated at 1350℃.Results of FTIR and TG analyses revealed the formation of cordierite and the effect of ceria addition.The mechanical properties studied were found to be encouraging and confirmed the suitability of cordierite-ceria as an alternate material for cordierite. | Marikkannan SENTHIL KUMAR Ayyasamy ELAYA PERUMAL T.R.VIJAYARAM | 2015 | Journal of Advanced Ceramics2015，4，1： | 3 |
| 12 | Implications of the presence of an aberrant right hepatic artery in patients undergoing pancreaticoduodenectomy显示文摘AIM:To analyze the differences in outcomes and the clinical impact following pancreatoduodenectomy(PD)in patients with and without aberrant right hepatic artery(aRHA).METHODS:All patients undergoing PD between January 2008 and December 2012 were divided into two groups,one with aRHA and the other without.These groups were compared to identify differences in the intraoperative variables,the oncological clearance and the postoperative morbidity,mortality and hospital stay.RESULTS:A total of 225 patients underwent PD,of which 43(19.1%)patients were found to have eitheraccessory or replaced right hepatic arteries(aRHA group).The aRHA was preserved in 79%of the patients.There was no significant difference in the intraoperative blood loss but operative time was prolonged,reflecting the complexity of the procedure[420±44(240-540)min vs 480±45(300-600)min,P<0.05)].There were no differences in the incidence of postoperative complications(pancreatic leak,pancreatic fistula,delayed gastric emptying and mortality)and hospital stay.Oncological clearance in the form of positive resection margins[13(7.1%)vs 3(6.9%)]and lymph node yield were also similar in the two groups.CONCLUSION:An aRHA is found in approximately one fifth of patients undergoing PD.Preservation is technically possible in most patients and can increase the operative complexity but does not negatively affect the safety or oncological outcomes of the procedure. | Ashwin Rammohan Ravichandran Palaniappan Anbalagan Pitchaimuthu Kamalakannan Rajendran Senthil Kumar Perumal Kesavan Balaraman Ravi Ramasamy Jeswanth Sathyanesan Manoharan Govindan | 2014 | World Journal of Gastrointestinal Surgery2014，6，1： | 3 |
| 13 | Effect of C-reactive protein on vascular cells: evidence for a proinflammatory, proatherogenic role显示文摘 | Senthil Kumar Venugopal Sridevi Devaraj Ishwarlal Jialal | 2005 | Current Opinion in Nephrology and Hypertension2005，，1： | 3 |
| 14 | Antibacterial forsterite (Mg_(2)SiO_(4)) scaffold: A promising bioceramic for load bearing applications显示文摘In the current work,forsterite samples with different surface area were investigated for its antibacterial activity.Dissolution studies show that the lower degradation of forsterite compared to other silicate bioceramics,which is a desirable property for repairing bone defects.Forsterite scaffold shows superior compressive strength than the cortical bone after immersion in simulated body fluid.Bactericidal tests indicate that the forsterite had inhibition effect on the growth of clinical bacterial isolates.Forsterite may be a suitable candidate material for load bearing applications with enhanced mechanical properties and lower degradation rate. | Rajan Choudhary Ankita Chatterjee Senthil Kumar Venkatraman Sivasankar Koppala Jayanthi Abraham Sasikumar Swamiappan | 2018 | Bioactive Materials2018，3，3： | 3 |
| 15 | Multicentered prospective investigator initiated study to evaluate the clinical outcomes with extracorporeal cytokine adsorption device (CytoSorb®) in patients with sepsis and septic shock显示文摘BACKGROUND Sepsis is a severe clinical syndrome related to the host response to infection.The severity of infections is due to an activation cascade that will lead to an auto amplifying cytokine production:The cytokine storm.Hemoadsorption by CytoSorb®therapy is a new technology that helps to address the cytokine storm and to regain control over various inflammatory conditions.AIM To evaluate prospectively CytoSorb®therapy used as an adjunctive therapy along with standard of care in septic patients admitted to intensive care unit(ICU).METHODS This was a prospective,real time,investigator initiated,observational multicenter study conducted in patients admitted to the ICU with sepsis and septic shock.The improvement of mean arterial pressure and reduction of vasopressor needs were evaluated as primary outcome.The change in laboratory parameters,sepsis scores[acute physiology and chronic health evaluation(APACHE II)and sequential organ failure assessment(SOFA)]and vital parameters were considered as secondary outcome.The outcomes were also evaluated in the survivor and nonsurvivor group.Descriptive statistics were used;a P value<0.05 was considered RESULTS Overall,45 patients aged≥18 and≤80 years were included;the majority were men(n=31;69.0%),with mean age 47.16±14.11 years.Post CytoSorb®therapy,26 patients survived and 3 patients were lost to follow-up.In the survivor group,the percentage dose reduction in vasopressor was norepinephrine(51.4%),epinephrine(69.4%)and vasopressin(13.9%).A reduction in interleukin-6 levels(52.3%)was observed in the survivor group.Platelet count improved to 30.1%(P=0.2938),and total lung capacity count significantly reduced by 33%(P<0.0001).Serum creatinine and serum lactate were reduced by 33.3%(P=0.0190)and 39.4%(P=0.0120),respectively.The mean APACHE II score was 25.46±2.91 and SOFA scores was 12.90±4.02 before initiation of CytoSorb®therapy,and they were reduced significantly post therapy(APACHE II 20.1±2.47;P<0.0001 and SOFA 9.04±3.00;P=0.0003)in the survivor group.The predicted mortality in our patient population before CytoSorb®therapy was 56.5%,and it was reduced to 48.8%(actual mortality)after CytoSorb®therapy.We reported 75%survival rate in patients given treatment in<24 h of ICU admission and 68%survival rates in patients given treatment within 24-48 h of ICU admission.In the survivor group,the average number of days spent in the ICU was 4.44±1.66 d;while in the nonsurvivor group,the average number of days spent in ICU was 8.5±15.9 d.CytoSorb®therapy was safe and well tolerated with no adverse events reported.CONCLUSION CytoSorb®might be an effective adjuvant therapy in stabilizing sepsis and septic shock patients.However,it is advisable to start the therapy at an early stage(preferably within 24 h after onset of septic shock). | Rajib Paul Prachee Sathe Senthil Kumar Shiva Prasad Ma Aleem Prashant Sakhalvalkar | 2021 | World Journal of Critical Care Medicine2021，10，1： | 2 |
| 16 | AA7075铝合金熔化极气体保护焊十字接头根部失效疲劳寿命的预测(英文)显示文摘通过建立一经验公式来预测熔化极气体保护焊十字接头根部失效的疲劳寿命。采用高强可时效硬化的AA7075-T6铝合金作为基材进行焊接实验。实验设计概念被用来优化进行疲劳实验所需要的次数。在一伺服液压控制疲劳实验机上进行疲劳实验,实验采用恒定荷载。采用所建立的经验公式,预测的熔化极气体保护焊十字接头根部失效疲劳寿命可达到95%的可信度水平。详细讨论了十字接头尺寸对疲劳寿命的影响。 | B. RAVINDRA T. SENTHIL KUMAR V. BALASUBRAMANIAN | 2011 | Transactions of Nonferrous Metals Society of China2011，21，6： | 2 |
| 17 | 水泥基材料产生的粉末废弃物的潜在应用与挑战显示文摘目前,如何有效地回收和再利用那些建造与拆卸废料,对于减少建筑垃圾造成的环境问题十分重要。研究数据表明,在建筑废料回收的过程中,将产生大量的粉末废料,其数量占总混凝土废弃物的20%~50%。在已有的研究成果中,粉末废料可用作混凝土生产中水泥的替代物和熟料生产中原材料的替代物。同时,由于具有丰富的钙含量,它也可作为一种吸收CO2的潜在材料。综合已有的大量文献,概述了从建筑废料中提取的水泥基粉末废弃物在不同应用中的挑战和潜力。总的来讲,粉末废料具有很大的实际应用潜力,可用作建筑业中原材料的替代物,也是减少CO_2排放的重要途径之一,这些将切实有助于自然资源的保护和环境的可持续发展。 | 于皓 林忠财 李永学 Senthil Kumar | 2018 | 混凝土2018，，8： | 2 |
| 18 | Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology:Implications for Alzheimer's disease therapy显示文摘Alzheimer's disease(AD),characterized by the accumulation of protein aggregates including phosphorylated Tau aggregates,is the most common neurodegenerative disorder with limited therapeutic agents.Autophagy plays a critical role in the degradation of phosphorylated Tau aggregates,and transcription factor EB(TFEB)is a master regulator of autophagy and lysosomal biogenesis.Thus,small-molecule autophagy enhancers targeting TFEB hold promise for AD therapy.Here,we found that celastrol,an active ingredient isolated from the root extracts of Tripterygium wilfordii(Lei Gong Teng in Chinese)enhanced TFEB-mediated autophagy and lysosomal biogenesis in vitro and in mouse brains.Importantly,celastrol reduced phosphorylated Tau aggregates and attenuated memory dysfunction and cognitive deficits in P301S Tau and 3xTg mice,two commonly used AD animal models.Mechanistical studies suggest that TFEB-mediated autophagy-lysosomal pathway is responsible for phosphorylated Tau degradation in response to celastrol.Overall,our findings indicate that Celastrol is a novel TFEB activator that promotes the degradation of phosphorylated Tau aggregates and improves memory in AD animal models.Therefore,Celastrol shows potential as a novel agent for the treatment and/or prevention of AD and other tauopathies. | Chuanbin Yang Chengfu Su Ashok Iyaswamy Senthil Kumar Krishnamoorthi Zhou Zhu Sichang Yang Benjamin Chunkit Tong Jia Liu Sravan G.Sreenivasmurthy Xinjie Guan Yuxuan Kan Aston Jiaxi Wu Alexis Shiying Huang Jieqiong Tan Kingho Cheung Juxian Song Min Li | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 2 |
| 19 | PVD硬质合金刀具加工NimonicC-263合金表面粗糙度的建模和分析(英文)显示文摘研究了加工Nimonic C-263合金时,切削参数(切削速度、给进速度、切削深度等)对表面粗糙度的影响。采用正交方法设计实验。评估了切削参数对表面粗糙度的影响,获得最小粗糙度的最优切削条件。采用响应面方法建立了切削参数和表面粗糙度的二次多项式模型。实验结果表明:在所考察的切削参数中,给进速度对表面粗糙度的影响最为显著,其次是切削速度。模型预测结果与实际结果吻合较好,表明所建立的模型能够用来有效地预测加工Nimonic C-263合金时的表面粗糙度。最后,对预测结果用加成定律进行了验证。 | C. EZILARASAN V. S. SENTHIL KUMAR A. VELAYUDHAM K. PALANIKUMAR | 2011 | Transactions of Nonferrous Metals Society of China2011，21，9： | 2 |
| 20 | Effects of sulfide on microbial fuel cells with platinum and nitrogen-doped carbon powder cathodes显示文摘 | Yujie Feng Xinxin Shi Xin Wang He Lee Jia Liu Youpeng Qu Weihua He S.M. Senthil Kumar Byung Hong Kim Nanqi Ren | 2011 | Biosensors and Bioelectronics2011，，1： | 1 |
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