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| 1 | YODA-HSP90 Module Regulates Phosphorylation-Dependent Inactivation of SPEECHLESS to Control Stomatal Development under Acute Heat Stress in Arabidopsis显示文摘Stomatal ontogenesis,patterning,and function are hallmarks of environmental plant adaptation,especially to conditions limiting plant growth,such as elevated temperatures and reduced water availability.The specification and distribution of a stomatal cell lineage and its terminal differentiation into guard cells require a master regulatory protein phosphorylation cascade involving the YODA mitogen-activated protein kinase kinase kinase.YODA signaling results in the activation of MITOGEN-ACTIVATED PROTEIN KINASEs(MPK3 and MPK6),which regulate transcription factors,including SPEECHLESS(SPCH).Here,we report that acute heat stress affects the phosphorylation and deactivation of SPCH and modulates stomatal density.By using complem entary molecular,genetic,biochemical,and cell biology approaches,we provide solid evidence that HEAT SHOCK PROTEINS 90(HSP90s)play a crucial role in transducing heat-stress response through the YODA cascade.Genetic studies revealed that YODA and HSP90.1 are epistatic,and they likely function linearly in the same developmental pathway regulating stomata formation.HSP90s interact with YODA,affectits cellular polarization,and modulate the phosphorylation of downstream targets,such as MPK6 and SPCH,under both normal and heat-stress conditions.Thus,HSP90-mediated specification and differentiation of the stomatal cell lineage couples stomatal development to environmental cues,providing an adaptive heat stress response mechanism in plants. | Despina Samakovli Tereza Ticha Tereza Vavrdova Miroslav Ovecka Ivan Luptovciak Veronika Zapletalova Anna Kucharova Pavel Krenek Yuliya Krasylenko Theoni Margaritopoulou Loukia Roka Dimitra Milioni George Komis Polydefkis Hatzopoulos Jozef Samaj | 2020 | Molecular Plant2020，13，4： | 9 |
| 2 | Alternative Transcription Initiation and the AUG Context Configuration Control Dual-Organellar Targeting and Functional Competence of Arabidopsis Lon 1 Protease显示文摘细胞的动态平衡包括女伴和朊酶依靠蛋白质质量控制的部件。在细菌和 eukaryoticorganelles, Lon 朊酶在移开不能挽回地损坏的蛋白质并且从而阻止 accumulationof 起一个关键作用有害降级抵抗的总数。基因表示,实时房间的成像, immunobiochemical,和功能的 complementationapproaches 为对叶绿体和线粒体双指向的 Lon1 提供最后的证据。Dual-organellar depositionof Lon1 isoforms 经由漏的核糖体 scanningfrom 取决于 transcriptional 规定和其他的翻译开始从最佳 Kozak 一致广泛地背离的第一 8 月顺序上下文。在 Arabidopsis lon1-1 异种的部分互补的细胞器特定的 Lon1 targetingresults,而完整的互补被指向的 dual-organellar 完全完成。两最佳并且 non-optimalAUG 顺序上下文在酵母是功能的并且便于漏的核糖体扫描当 mitochondrial presequence 被使用时,补充 pim1 显型。生物信息的搜索与 Lon1 类型双指向的顺序组织识别了一小部分 Arabidopsis 基因。Lon4, Lon1 的 paralog,模糊 presequence 多半从祖先的象 Lon1 一样基因的成双的 presequences 演变,产生单个双目标的蛋白质 isoform。我们要求那 Lon1 和它的 subfunctional paralog Lon4 发展了 transcriptional 和 posttranscriptional 的互补子集对为 dual-organellar targeting.Key 词的 environmentalcues 应答的规章的部件: | Gerasimos Daras Stamatis Rigas Dikran Tsitsekian Hadas Zur Tamir Tuller Polydefkis Hatzopoulos | 2014 | Molecular Plant2014，7，6： | 4 |
| 3 | New insights into diabetic polyneuropathy显示文摘 | Polydefkis M Griffin JW McArthur J | 2003 | JAMA2003，290，： | 1 |
| 4 | Charac- teristics of bortezomib and thalidomide-induced peripheral neuropathy显示文摘 | Chaudhry V Comblath DR Polydefkis M | 2008 | J Peripher Nerv Syst2008，13，4： | 1 |
| 5 | Genomic organization of hsp90 gene family in Arabidopsis 显示文摘 | Dimitra M Polydefkis H | 1997 | Plant Molecular Biology1997，35，： | 1 |
| 6 | Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy显示文摘 | Polydefkis M Yiannoutsos CT Cohen BA | 2002 | Neurology2002，58，： | 1 |
| 7 | AFLP reveals structural details of genetic diversity within cultivated olive germplasm from the Eastern Mediterranean显示文摘 | Carolyn A. Owen Elena-Craita Bita Georgios Banilas Shady E. Hajjar Vardis Sellianakis Uygun Aksoy Serra Hepaksoy Rony Chamoun Salma N. Talhook Ioannis Metzidakis Polydefkis Hatzopoulos Panagiotis Kalaitzis | 2005 | Theoretical and Applied Genetics2005，，7： | 1 |
| 8 | The utility of skin biopsy for prediction of progression in suspected small fiber neuropathy显示文摘 | Gibbons CH Griffin JW Polydefkis M | 2006 | Neurology2006，66，2： | 1 |
| 9 | The spectrum of neuropathy in diabetes and impaired glucose tolerance显示文摘 | C.J. Sumner S. Sheth J.W. Griffin D.R. Cornblath M. Polydefkis | 2003 | Neurology2003，，： | 1 |
| 10 | Skin biopsy as a tool to assess distal small fiber innervation in diabetic neuropathy 显示文摘 | Polydefkis M Hauer P Griffin JW | 2001 | Diabetes Technol Ther2001，3，： | 1 |
| 11 | The spectrum of neuropathy in diabetes and impaired glucose tolerance显示文摘 | Sumner CJ Sheth S Griffin JW Comblath DR Polydefkis M | 2003 | Neurology2003，，： | 1 |
| 12 | Subclinical sensory neuropathy in late-onset restless legs syndrome显示文摘 | Polydefkis M Allen RP Hauer P | 2000 | Neurology2000，55，8： | 1 |
| 13 | New insights into diabetic polyneuropathy显示文摘 | Polydefkis M Griffin JW McArthur J | 2003 | JAMA2003，290，： | 1 |
| 14 | A seed-specific Brassica napus oleosin promoter interacts with a G-box-specific protein and may be bi-directional显示文摘 | James S. Keddie Miltos Tsiantis Pietro Piffanelli Rino Cella Polydefkis Hatzopoulos Denis J. Murphy | 1994 | Plant Molecular Biology1994，，2： | 1 |
| 15 | Tbe time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy 显示文摘 | Polydefkis M Hauer P Sheth S | 2004 | Brain2004，127，7： | 1 |
| 16 | Reduced intra- epidermal nerve fiber density in HIV associated sensory neuropathy 显示文摘 | Polydefkis M Yiannoutsos CT Cohen BA | 2002 | Neurology2002，58，： | 1 |
| 17 | The utility of skin biopsy for prediction of progression in suspected small fiber neuropathy显示文摘 | Gibbons CH Griffin JW Polydefkis M | 2006 | Neurology2006，66，： | 1 |
| 18 | Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy显示文摘 | Yiannoutsos CT Cohen BA | 2002 | Neurology2002，58，1： | 1 |
| 19 | Characteristics ofbortezomib-and thalidomide-induced peripheral neuropathy 显示文摘 | Chaudhry V Comblath DR Polydefkis M | 2008 | JPeripher Nerv Syst2008，13，4： | 1 |
| 20 | New insights into diabetic polyneuropathy显示文摘 | Polydefkis M Griffin JW McArthur J | 2003 | JAMA2003，290，10： | 1 |
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