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| 1 | Glutamate and aspartate alleviate testicular/epididymal oxidative stress by supporting antioxidant enzymes and immune defense systems in boars显示文摘Several potential oxidative agents have damaging effects on mammalian reproductive systems.This study was conducted to investigate the effects of glutamate(Glu)and aspartate(Asp)supplementation on antioxidant enzymes and immune defense systems in the outer scrotum of boars injected with H2O2.A total of 24 healthy boars were randomly divided into 4 treatment groups:control(basal diet,saline-treated),H2O2(basal diet,H2O2-challenged outer scrotum(1 m L kg^–1 BW)),Glu(basal diet+2%Glu,H2O2-challenged),and Asp(basal diet+2%Asp,H2O2-challenged).Our results showed that both Glu and Asp supplementation improved testicular morphology and decreased the genital index in the H2O2-treated boars.Glu and Asp administration increased the antioxidant enzyme activities and affected the testicular inflammatory cytokine secretion but had no effect on sex hormone levels.Furthermore,the m RNA expression of CAT,Cu Zn SOD,and GPx4 was altered in the testes and epididymis of boars treated with Asp and Glu.Glu and Asp supplementation also modulated the expression of TGF-β1,IL-10,TNF-α,IL-6 and IL-1βin the testis and epididymis.These results indicate that dietary Glu and Asp supplementation might enhance antioxidant capacity and regulate the secretion and expression of inflammatory cytokines to protect the testes and epididymis of boars against oxidative stress. | Wenjie Tang Jian Wu Shunshun Jin Liuqin He Qinlu Lin Feijun Luo Xingguo He Yanzhong Feng Binsheng He Pingping Bing Tiejun Li Yulong Yin | 2020 | Science China(Life Sciences)2020，63，1： | 9 |
| 2 | Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease显示文摘 | Pingping Song Shanshan Li Hao Wu Ruize Gao Guanhua Rao Dongmei Wang Ziheng Chen Biao Ma Hongxia Wang Nan Sui Haiteng Deng Zhuohua Zhang Tieshan Tang Zheng Tan Zehan Han Tieyuan Lu Yushan Zhu Quan Chen | 2016 | Protein & Cell2016，7，2： | 8 |
| 3 | Multichannel DEM reconstruction method based on Markov random fields for bistatic SAR显示文摘It appears very interesting and particularly useful to perform DEM reconstruction with the configuration of multichannel bistatic SAR(Bi SAR) because of its considerable advantages. In typical processing flow of multichannel interferometric synthetic aperture radar(In SAR), techniques based on statistical methods or iterative methods does not work very well with limits of specific Bi SAR configurations. Moreover, the tradeoff between the correctness and precision of the reconstruction of different baselines needs to be overcome as well.Based on the advantages of multichannel Bi SAR configuration, basic idea is the joint utilization of amplitude data, iterative reconstruction results and ML results to help the optimization of the total MRF energy function.Thus, a multichannel DEM reconstruction method based on Markov Random Fields(MRFs) for Bi SAR, which concerns much about discontinuities and energy functions, is proposed to achieve not only correct but also more precise results. Afterward, the strategy to determine the weight parameter and processing flow is presented.Finally, simulated and real data experiments are given to validate the proposed method. | HONG Feng TANG JiangWen LU PingPing | 2015 | Science China(Information Sciences)2015，58，6： | 5 |
| 4 | Nano-hydroxyapatite accelerates vascular calcification via lysosome impairment and autophagy dysfunction in smooth muscle cells显示文摘Vascular calcification(VC)is a common characteristic of aging,diabetes,chronic renal failure,and atherosclerosis.The basic component of VC is hydroxyapatite(HAp).Nano-sized HAp(nHAp)has been identified to play an essential role in the development of pathological calcification of vasculature.However,whether nHAp can induce calcification in vivo and the mechanism of nHAp in the progression of VC remains unclear.We discovered that nHAp existed both in vascular smooth muscle cells(VSMCs)and their extracellular matrix(ECM)in the calcified arteries from patients.Synthetic nHAp had similar morphological and chemical properties as natural nHAp recovered from calcified artery.nHAp stimulated osteogenic differentiation and accelerated mineralization of VSMCs in vitro.Synthetic nHAp could also directly induce VC in vivo.Mechanistically,nHAp was internalized into lysosome,which impaired lysosome vacuolar H+-ATPase for its acidification,therefore blocked autophagic flux in VSMCs.Lysosomal re-acidification by cyclic-3′,5′-adenosine monophosphate(cAMP)significantly enhanced autophagic degradation and attenuated nHAp-induced calcification.The accumulated autophagosomes and autolysosomes were converted into calcium-containing exosomes which were secreted into ECM and accelerated vascular calcium deposit.Inhibition of exosome release in VSMCs decreased calcium deposition.Altogether,our results demonstrated a repressive effect of nHAp on lysosomal acidification,which inhibited autophagic degradation and promoted a conversion of the accumulated autophagic vacuoles into exosomes that were loaded with undissolved nHAp,Ca^(2+),Pi and ALP.These exosomes bud off the plasma membrane,deposit within ECM,and form calcium nodules.Vascular calcification was thus accelerated by nHAP through blockage of autophagic flux in VSMCs. | Qi Liu Yi Luo Yun Zhao Pingping Xiang Jinyun Zhu Wangwei Jing Wenjing Jin Mingyao Chen Ruikang Tang Hong Yu | 2022 | Bioactive Materials2022，7，2： | 5 |
| 5 | Recent advances in new trifluoromethoxylation reagents显示文摘The trifluoromethoxy(CF_3O) group has become a novel moiety in various fields because of its unique features. However, despite the promising applications, the synthesis of CF_3O-containing compounds is still a challenge due to indirect synthetical strategies and volatile reagent which is hard to handle. Until very recently, several innovative reagents were developed to facilitate the trifluoromethoxylation reaction and make CF_3O-containing compounds more accessible. This review mainly focuses on the recent advances in new trifluoromethoxylation reagents and their usage. | Xiaofei Zhang Pingping Tang | 2019 | Science China Chemistry2019，62，5： | 3 |
| 6 | Direct Ink Writing of Highly Conductive MXene Frames for Tunable Electromagnetic Interference Shielding and Electromagnetic Wave-Induced Thermochromism显示文摘The highly integrated and miniaturized next-generation electronic products call for high-performance electromagnetic interference(EMI)shielding materials to assure the normal operation of their closely assembled components.However,the most current techniques are not adequate for the fabrication of shielding materials with programmable structure and controllable shielding efficiency.Herein,we demonstrate the direct ink writing of robust and highly conductive Ti3C2Tx MXene frames with customizable structures by using MXene/AlOOH inks for tunable EMI shielding and electromagnetic wave-induced thermochromism applications.The as-printed frames are reinforced by immersing in AlCl_(3)/HCl solution to remove the electrically insulating AlOOH nanoparticles,as well as cross-link the MXene sheets and fuse the filament interfaces with aluminum ions.After freeze-drying,the resultant robust and porous MXene frames exhibit tunable EMI shielding efficiencies in the range of 25-80 dB with the highest electrical conductivity of 5323 S m−1.Furthermore,an electromagnetic wave-induced thermochromic MXene pattern is assembled by coating and curing with thermochromic polydimethylsiloxane on a printed MXene pattern,and its color can be changed from blue to red under the high-intensity electromagnetic irradiation.This work demonstrates a direct ink printing of customizable EMI frames and patterns for tuning EMI shielding efficiency and visualizing electromagnetic waves. | Xinyu Wu Tingxiang Tu Yang Dai Pingping Tang Yu Zhang Zhiming Deng Lulu Li Hao-Bin Zhang Zhong-Zhen Yu | 2021 | Nano-Micro Letters2021，13，10： | 3 |
| 7 | Clinical significance of extended high-risk human papillomavirus genotyping and viral load in cervical cancer and precancerous lesions显示文摘Persistent infections with specific high-risk human papillomavirus(HR-HPV)strains are the leading cause of cervical cancer and precancerous lesions.HPV-16 and HPV-18 are associated with more than 70%of cervical cancer.However,with recent widespread vaccination efforts against cervical cancer,the infection rates of HPV-16 and HPV-18 have decreased across all age groups,while the infection rates of other HR-HPV strains have increased.The non-16/18 HR-HPV strains play an important role in cervical lesions.These strains can be identified with extended genotyping,and the 2019 American Society for Colposcopy and Cervical Pathology(ASCCP)guidelines recommended an HPV-based testing to assess the risk of cervical disease in patients.We reviewed and analyzed the clinical benefits of applying extended HR-HPV genotyping,which was published by the International Agency for Research on Cancer(HPV-16,18,31,33,35,39,45,51,52,56,58,59,66,and 68),to cervical cancer screening.This review concluded that cervical cancer screening needs to include extended HR-HPV genotyping.The examination of extended HR-HPV genotyping in cervical intraepithelial lesions and cervical cancers can help guide clinical practices. | Pingping Su Jincheng Ma Lirui Yu Shuting Tang Pengming Sun | 2023 | Gynecology and Obstetrics Clinical Medicine2023，3，1： | 2 |
| 8 | Psychometric properties of the Chinese version of the Infertility Self-Efficacy Scale显示文摘Objective:To translate the English version of Infertility Self-Efficacy Scale into Chinese and to validate the psychometric properties of the Chinese version of the Infertility Self-Efficacy Scale(CISE).Method(s):Participants were recruited from the Gynecology Department of two city hospitals.Five main processes were involved in the formation of CISE[1]:scale translation based on expert consultation[2];pre-test questionnaire development with infertile women's feedback(N=20)[3];factor structure assessed by exploratory and confirmatory factor analysis(N=177)[4];assessment of reliability by internal consistency(N=177)and test-retest reliability(N=21);and[5]assessment of convergent validity with Self-rating Anxiety Scale,Self-rating Depression Scale,and Simplified Coping Style Questionnaire(N=177).Results:This study established a 16-item CISE.Factor analyses confirmed a onecomponent solution,which explained 54.59% of total variances and showed an acceptable model fit.Cronbach's a and test-retest correlation coefficients for the scale were 0.94 and 0.84,respectively.The CISE score was significantly correlated with anxiety(r=0.47),depression(r=0.60),positive coping style(r=0.37),and certain negative coping style items.Conclusion:This 16-item CISE is a reliable and valid measure to evaluate perceived selfefficacy among a sample of Chinese women who underwent infertility treatment. | Bing Fu Pingping Yan Hang Yin Shujuan Zhu Qing Liu Yulan Liu Chanyuan Dai Guanxiu Tang Chunli Yan Jun Lei | 2016 | International Journal of Nursing Sciences2016，3，3： | 2 |
| 9 | Advances in Enantioselective Construction of Trifluoromethoxylated Stereogenic Carbon Centers显示文摘In recent years,the trifluoromethoxy(OCF3)functional group has received extensive attention in phar-maceuticals,agrochemicals and material sciences.However,the methods for the enantioselective syn-thesis of trifluoromethoxylated stereogenic carbon centers are rare owing to the nature of easy decom-position of OCF3 anion and limited OCF3 reagent.And the asymmetric trifluoromethoxylation will be a hot research topic in near future due to the unique biological properties of a single isomer.This article mainly focuses on the recent advances in the enantioselectiveconstruction of trifluoromethoxylated stereogenic carbon centers. | Xiaohuan Jiang Pingping Tang | 2020 | Chinese Journal of Chemistry2020，38，1： | 2 |
| 10 | Gut Microbiota, Host Health, and Polysaccharides显示文摘 | Xiaofei Xu Pingping Xu Chungwah Ma Jian Tang Xuewu Zhang | 2012 | Biotechnology Advances2012，，： | 1 |
| 11 | Primary cilia support cartilage regeneration after injury显示文摘In growing children,growth plate cartilage has limited self-repair ability upon fracture injury always leading to limb growth arrest.Interestingly,one type of fracture injuries within the growth plate achieve amazing self-healing,however,the mechanism is unclear.Using this type of fracture mouse model,we discovered the activation of Hedgehog(Hh)signaling in the injured growth plate,which could activate chondrocytes in growth plate and promote cartilage repair. | Dike Tao Lei Zhang Yunpeng Ding Na Tang Xiaoqiao Xu Gongchen Li Pingping Niu Rui Yue Xiaogang Wang Yidong Shen Yao Sun | 2023 | International Journal of Oral Science2023，15，2： | 1 |
| 12 | Synthesis,structure and nonlinear optical properties of two novel two-photon absorption chromophores显示文摘Two triphenylamine-based derivatives that can be used as two-photon absorption chromophore,tris{4-[4-(3-trifluoromethyl-3-oxopanoyl)]phenyl}amine (1) and tris{4-[4-(3-phenyl-3-oxopanoyl)] phenyl} amine (2) were successfully synthesized and fully characterized by elemental analysis,IR,1H NMR and MS. The single crystal X-ray diffraction analysis showed that the molecules possess D-(π-A)3 structures. One-and two-photon absorption and fluorescence in various solvents were experimentally investigated. A data recording experiment proved the potential application of these chromophores. | CHENG LeHua LI Lin SUN PingPing ZHOU HongPing TIAN YuPeng TANG HuoHong | 2009 | Science China Chemistry2009，52，4： | 1 |
| 13 | U-Pb ages and Hf-O isotopes of zircons from Late Paleozoic mafic ultramafic units in the southern Central Asian Orogenic Belt:Tectonic implications and evidence for an Early-Permian mantle plume显示文摘 | Su Benxun Qin Kezhang Sakyi P A Li Xianhua Yang Yueheng Sun He Tang Dongmei Liu Pingping Xiao Qinghua Malaviarachchi S P K | | 0，，： | 1 |
| 14 | Synthesis of non-classical heteroaryl C-glycosides via Minisci-type alkylation of N‑heteroarenes with 4-glycosyl-dihydropyridines显示文摘A radical-mediated method was reported for diastereoselective synthesis of non-classical heteroaryl C-glycosides via Minisci-type alkylation of N-heteroarenes with 4-glycosyl-1,4-dihydropyridine(DHP)reagents.These DHP reagents serve as convenient precursors for various glycosyl radicals under the activation of single electron transfer(SET)oxidation by persulfate and visible light irradiation with or without photocatalyst. | Qingbing Wang Juan Duan Pingping Tang Gong Chen Gang He | 2020 | Science China Chemistry2020，63，11： | 1 |
| 15 | Research on the Pedestrian Re-Identification Method Based on Local Features and Gait Energy Images显示文摘The appearance of pedestrians can vary greatly from image to image,and different pedestrians may look similar in a given image.Such similarities and variabilities in the appearance and clothing of individuals make the task of pedestrian re-identification very challenging.Here,a pedestrian re-identification method based on the fusion of local features and gait energy image(GEI)features is proposed.In this method,the human body is divided into four regions according to joint points.The color and texture of each region of the human body are extracted as local features,and GEI features of the pedestrian gait are also obtained.These features are then fused with the local and GEI features of the person.Independent distance measure learning using the cross-view quadratic discriminant analysis(XQDA)method is used to obtain the similarity of the metric function of the image pairs,and the final similarity is acquired by weight matching.Evaluation of experimental results by cumulative matching characteristic(CMC)curves reveals that,after fusion of local and GEI features,the pedestrian re-identification effect is improved compared with existing methods and is notably better than the recognition rate of pedestrian re-identification with a single feature. | Xinliang Tang Xing Sun Zhenzhou Wang Pingping Yu Ning Cao Yunfeng Xu | 2020 | Computers, Materials & Continua2020，，8： | 1 |
| 16 | A Survey of Multimedia Big Data显示文摘Multimedia big data brings tremendous challenges as well as opportunities for multimedia applications/services. In this paper, we present a survey and tutorial for multimedia big data. After discussing the characteristics of multimedia big data such as human-centricity, multimodality, heterogeneity, unprecedented volume, and so on, this paper provides an overview of the state-of-the-art of multimedia big data, reviews the latest related technologies, and discusses the technical challenges. We conclude this paper with a discussion of open problems and future directions. | Zaijian Wang Shiwen Mao Lingyun Yang Pingping Tang | 2018 | China Communications2018，15，1： | 1 |
| 17 | Transcriptome analysis suggests mechanisms for a novel flowering type: Cleistogamous wheat显示文摘Wheat is one of the most important staple crops worldwide.Fusarium head blight severely reduces wheat yield and quality.Cultivation of a novel type of cleistogamous wheat mutant,ZK001,which was created by static magnetic field treatment,is a new strategy for controlling Fusarium head blight.However,little is known about the mechanism of cleistogamy in wheat.The present study demonstrated that anthers of ZK001 were retained on the glumes at all flowering stages,whereas those of YM18 were extruded from the paleae and lemmae.There was a clear difference in the morphological characteristics of lodicules between YM18 and ZK001.Lodicule calcium and potassium contents were significantly higher in YM18 than in ZK001 from white to yellow anther stages.In Fusarium head blight resistance,the diseased kernel rate and deoxynivalenol content of ZK001 were markedly lower than those of YM18 and QM725.Comparative transcriptome analysis of YM18 and ZK001 was performed to identify regulatory mechanisms of cleistogamy.The main differentially expressed genes identified in the spikelets of YM18 and ZK001 at the green anther stage were associated with cell walls,carbohydrates,phytohormones,water channel,and ion binding,transport,and homeostasis.These differentially expressed genes may play an important role in regulating cellular homeostasis,osmotic pressure,and lodicule development.The results indicate that ZK001 lost the ability to push the lemmae and paleae apart during the flowering stage because of the thin lodicules.ZK001 was speculated to provide structural barriers for Fusarium head blight during the flowering stage.The thin lodicule of ZK001 results from low levels of soluble sugar,calcium ions,and potassium ions in the lodicules.These levels are regulated by differentially expressed genes. | Caiguo Tang Minghao Li Minghui Cao Ruiju Lu Huilan Zhang Chenghong Liu Shengwei Huang Pingping Zhang Hao Hu Weiwei Zhao Lifang Wu | 2020 | The Crop Journal2020，8，2： | 1 |
| 18 | Metabolomic analysis of the response of growing pigs to dietary l-arginine supplementation显示文摘 | Qinghua He Xiangfeng Kong Guoyao Wu Pingping Ren Huiru Tang Fuhua Hao Ruilin Huang Tiejun Li Bie Tan Peng Li Zhiru Tang Yulong Yin Yongning Wu | 2009 | Amino Acids2009，，1： | 1 |
| 19 | Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy显示文摘治疗学的 nanoparticles (NP ) 基于 donor-acceptor-donor,结构化的小器官的分子 diketopyrrolopyrrole (SDPP ) 用一条简单降水途径被准备。这些在红外线附近的吸收放射的 NP 有高 photothermal 变换效率并且能有选择地通过提高的渗透和保留效果指向癌症纸巾。得益于这些优点, SDPP NP 能用作一个优秀治疗学的代理人为高度有效并且 noninvasive photoacoustic 指导成像的 photothermal 治疗。用老鼠肿瘤模型的实验证明 SDPP NP 在激光照耀下面展出了非凡的肿瘤脱离能力(660 nm, 1.0 W ? 敳獮瑩癩? 慮潮戭潩椠瑮牥慦散漠 ? 桴獩 ?? 楨牥牡档捩污祬猠牴 ' 壮肭?業牣景畬摩捩搠癥捩 ? 眠楨档猠潨敷 ? 楨桧攠晦捩敩据 ? 景 ?? 挠灡畴敲吗? | Yu Cai Weili Si Qianyun Tang Pingping Liang Chengwu Zhang Peng Chen QiZhang Wei Huang Xiaochen Dong | 2017 | Nano Research2017，10，3： | 1 |
| 20 | Collective Synthesis of Schilancidilactones A, B and Schilancitrilactones A, B, C, 20‐epi‐Schilancitrilactone A显示文摘Summary of main observation and conclusion Schisandraceae triterpenoids are novel natural products that contain highly fused ring systems bearing multiple chiral centers surrounding. Some of them exhibit promising bioactivities, such as antitumor, anti‐HIV, etc. In this article, we describe our efforts to the collective total synthesis of schilancidilactones A, B, schilancitrilactones A, B, C, and 20‐epi‐schilancitrilactone A from common precursors. An intramolecular radical cyclization, late‐stage halogenation and AIBN‐mediated or Ni‐catalyzed intermolecular radical cross coupling reaction were employed as the key steps. | Hengtao Wang Liang Wang Yihang Li Xiunan Zhang Pingping Tang | 2019 | Chinese Journal of Chemistry2019，37，3： | 1 |
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