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| 1 | Nanomodification of living organisms by biomimetic mineralization显示文摘在自然,象硅藻, magnetotactic 细菌,和鸡蛋那样的一些生活有机体开发了特定的矿物质结构,它能提供广泛的保护或唯一的功能。然而,大多数有机体没由于他们 biomineralization 能力的缺乏有如此的结构化的材料。构造 biomimetic 的 nanominerals 的人工的介绍是挑战性的,但是保持大诺言。在这概述,我们加亮矿物质生活建筑群系统的二种典型类型。一个人包含生物导致表面的 nanomaterials,它生产象 mineralencapsulated 酵母, cyanobacteria,细菌和病毒那样的人工的生活矿物质的核心壳结构。其它包含能赋予有机体以唯一的结构和性质的内部 nanominerals。这些 biomimetic 的应用程序产生了 nanominerals 进一步被讨论,主要在四个潜在的区域:存储,保护,秘密和交货。因为 biomineralization 联合化学药品, nano 和生物技术,我们建议那个 nanobiomimetic 矿化作用可以为学科交差的研究开创另一扇窗户。明确地,这是新奇基于材料的生物规定策略,有功能的 nanomaterials 的生活有机体的集成能为 biotechnological 惯例创造超级或聪明的 nanoscale 生活建筑群。 | Wei Chen Guangchuan Wang Ruikang Tang | 2014 | Nano Research2014，7，10： | 6 |
| 2 | Nano-hydroxyapatite accelerates vascular calcification via lysosome impairment and autophagy dysfunction in smooth muscle cells显示文摘Vascular calcification(VC)is a common characteristic of aging,diabetes,chronic renal failure,and atherosclerosis.The basic component of VC is hydroxyapatite(HAp).Nano-sized HAp(nHAp)has been identified to play an essential role in the development of pathological calcification of vasculature.However,whether nHAp can induce calcification in vivo and the mechanism of nHAp in the progression of VC remains unclear.We discovered that nHAp existed both in vascular smooth muscle cells(VSMCs)and their extracellular matrix(ECM)in the calcified arteries from patients.Synthetic nHAp had similar morphological and chemical properties as natural nHAp recovered from calcified artery.nHAp stimulated osteogenic differentiation and accelerated mineralization of VSMCs in vitro.Synthetic nHAp could also directly induce VC in vivo.Mechanistically,nHAp was internalized into lysosome,which impaired lysosome vacuolar H+-ATPase for its acidification,therefore blocked autophagic flux in VSMCs.Lysosomal re-acidification by cyclic-3′,5′-adenosine monophosphate(cAMP)significantly enhanced autophagic degradation and attenuated nHAp-induced calcification.The accumulated autophagosomes and autolysosomes were converted into calcium-containing exosomes which were secreted into ECM and accelerated vascular calcium deposit.Inhibition of exosome release in VSMCs decreased calcium deposition.Altogether,our results demonstrated a repressive effect of nHAp on lysosomal acidification,which inhibited autophagic degradation and promoted a conversion of the accumulated autophagic vacuoles into exosomes that were loaded with undissolved nHAp,Ca^(2+),Pi and ALP.These exosomes bud off the plasma membrane,deposit within ECM,and form calcium nodules.Vascular calcification was thus accelerated by nHAP through blockage of autophagic flux in VSMCs. | Qi Liu Yi Luo Yun Zhao Pingping Xiang Jinyun Zhu Wangwei Jing Wenjing Jin Mingyao Chen Ruikang Tang Hong Yu | 2022 | Bioactive Materials2022，7，2： | 5 |
| 3 | Polarization sensitive optical coherence tomography with single input for imaging depth-resolved collagen organizations显示文摘Collagen organization plays an important role in maintaining structural integrity and determining tissue function.Polarization-sensitive optical coherence tomography(PSOCT)is a promising noninvasive three-dimensional imaging tool for mapping collagen organization in vivo.While PSOCT systems with multiple polarization inputs have demonstrated the ability to visualize depth-resolved collagen organization,systems,which use a single input polarization state have not yet demonstrated sufficient reconstruction quality.Herein we describe a PSOCT based polarization state transmission model that reveals the depth-dependent polarization state evolution of light backscattered within a birefringent sample.Based on this model,we propose a polarization state tracing method that relies on a discrete differential geometric analysis of the evolution of the polarization state in depth along the Poincare sphere for depth-resolved birefringent imaging using only one single input polarization state.We demonstrate the ability of this method to visualize depth-resolved myocardial architecture in both healthy and infarcted rodent hearts(ex vivo)and collagen structures responsible for skin tension lines at various anatomical locations on the face of a healthy human volunteer(in vivo). | Peijun Tang Mitchell A.Kirby Nhan Le Yuandong Li Nicole Zeinstra G.Nina Lu Charles E.Murry Ying Zheng Ruikang K.Wang | 2021 | Light(Science & Applications)2021，10，12： | 2 |
| 4 | Influence of viscosity on the phase transformation of amorphous calcium carbonate in fluids:An understanding of the medium effect in biomimetic mineralization显示文摘Biological mineral generation via an amorphous precursor is a topic of great current interest. Various factors such as the temperature, solution composition and presence of organic molecules can influence this important inorganic process. Here we demonstrate that this mineral transformation can actually readily be regulated by solution viscosity, a fundamental but often overlooked property. In our experiment, amorphous calcium carbonate (ACC), a key model compound in biomimetic mineralization studies, is synthesized and dispersed into inert dispersants with different viscosities and the crystallization process is examined by using FT-IR spectroscopy and XRD. It is found that the inhibition of the transformation of ACC becomes more significant with increasing fluid viscosity. This phenomenon can be explained by the differences in ion diffusion in different media. Furthermore, the resulting crystals always have different morphologies and size distributions although they all have the calcite structure. This study implies that the importance of the fluid medium cannot be ignored in building a complete understanding of biological control of biomimetic crystallizations. | XIE YiDong, XU XuRong & TANG RuiKang Center for Biomaterials and Biopathways and Department of Chemistry, Zhejiang University, Hangzhou 310027, China | 2010 | Science China Chemistry2010，53，10： | 2 |
| 5 | Biomineralization: Biomimetic Synthesis of Materials and Biomimetic Regulation of Organisms显示文摘What is the most favorite and original chemistry developed in your research group?The discovery of ionic oligomers and their crosslinking following a new concept of inorganic ionic polymerization.How do you get into this specific field?Could you please share some experiences with our readers?I got into the field of biomineralization when I was a graduate student.A challenge in biomineralization community is how we can achieve a moldable construction of inorganic materials(biominerals). | Zaiqiang Ma Benke Li Ruikang Tang | 2021 | Chinese Journal of Chemistry2021，39，8： | 2 |
| 6 | Constant composition dissolution of mixed phases显示文摘 | Ruikang Tang Michael Hass Wenju Wu Stacey Gulde George H Nancollas | 2003 | Journal of Colloid And Interface Science2003，，2： | 1 |
| 7 | Inorganic ionic polymerization:From biomineralization to materials manufacturing显示文摘Biomineralization process regulates the growth of inorganic minerals by complex molecules,proteins,and cells,endowing bio-materials with marvels structures and excellent properties.The intricate structures and compositions found in biominerals have inspired scientists to design and synthesize numerous artificial biomimetic materials.The methodology for controlling the formation of inorganics plays a pivotal role in achieving biomimetic structures and compositions.However,the current approach predominantly relies on the classical nucleation theory,which hinders the precise preparation of inorganic materials by replicating the biomineralization strategy.Recently,the development of“inorganic ionic polymerization”strategy has enabled us to regulate the arrangement of inorganic ions from solution to solid phase,which establishes an artificial way to produce inorganic materials analogous to the biomineralization process.Based on inorganic ionic polymerization,a series of achievements have been realized for the biomimetic preparation,including moldable construction of inorganic materials,hard tissue regeneration,and high-performance biomimetic materials.Moreover,the utilization of inorganic ionic polymerization has also facilitated the production of numerous advanced materials,including novel structures that exceed the current knowledge of materials science.The inorganic ionic polymerization system provides new artificial strategies and methodologies for the controllable synthesis of inorganics,which mimics the biomineralization process,paving the way for the future development of more high-performance materials. | Yanhua Sang Kexin Qin Ruikang Tang Zhaoming Liu | 2024 | Nano Research2024，17，2： | 1 |
| 8 | Kinetics of dissolution of β-tricalcium phosphate 显示文摘 | TANG Ruikang WU Wenju MICHAEL Haas | 2001 | Langmuir2001，17，11： | 1 |
| 9 | Yeast cells with an artificial mineral shell:Protection and modification of living cells by biomimetic mineralization显示文摘 | WANG Ben LIU Peng TANG Ruikang | 2008 | Angew Chem Int Ed2008，47，： | 1 |
| 10 | Mechanism of promoted dipeptide formation on hydroxyapatite crystal surfaces显示文摘The formation of dipeptides from amino acids can be driven by hydroxyapatite at a relatively low temperature in air. For example, the formation of (Ala)2 from Ala is induced on hydroxyapatite at 110°C with considerable yield. Typically, condensing agents, high temperatures (>250°C) or high pressures (>25 MPa) are required to drive the condensation of amino acids. Similar effects are observed in the condensation of Gly, Glu and Asp. Experiments demonstrate that hydroxyapatite is an effective inorganic catalytic agent, reducing the activation barrier for the formation of dipeptides by more than 50%. HAP promotes condensation by adsorbing amino acid monomers in an organized manner, which decreases the distance between amino and carboxyl groups on neighboring molecules and extends the contact time of the reaction groups. This work provides a chemical understanding of the primitive condensation of amino acids and reveals a mechanism for enhancement of mineral catalysts. It is important that the conditions used for hydroxyapatite-assisted dipeptide formation are not harsh and can be readily achieved, revealing a possible mechanism for the chemical evolution of biomolecules over geologic ages. | WU Jia ZHANG ZhiShen YU XinWei PAN HaiHua JIANG WenGe XU XuRong TANG RuiKang | 2011 | Chinese Science Bulletin2011，56，7： | 1 |
| 11 | Microalgae-material hybrid for enhanced photosynthetic energy conversion:a promising path towards carbon neutrality显示文摘Photosynthetic energy conversion for high-energy chemicals generation is one of the most viable solutions in the quest for sustainable energy towards carbon neutrality.Microalgae are fascinating photosynthetic organisms,which can directly convert solar energy into chemical energy and electrical energy.However,microalgal photosynthetic energy has not yet been applied on a large scale due to the limitation of their own characteristics.Researchers have been inspired to couple microalgae with synthetic materials via biomimetic assembly and the resulting microalgae-material hybrids have become more robust and even perform new functions.In the past decade,great progress has been made in microalgae-material hybrids,such as photosynthetic carbon dioxide fixation,photosynthetic hydrogen production,photo electrochemical energy conversion and even biochemical energy conversion for biomedical therapy.The microalgae-material hybrid offers opportunities to promote artificially enhanced photosynthesis research and synchronously inspires investigation of biotic-abiotic interface manipulation.This review summarizes current construction methods of microalgae-material hybrids and highlights their implication in energy and health.Moreover,we discuss the current problems and future challenges for microalgae-material hybrids and the outlook for their development and applications.This review will provide inspiration for the rational design of the microalgae-based semi-natural biohybrid and further promote the disciplinary fusion of material science and biological science. | Wei Xiong Yiyan Peng Weimin Ma Xurong Xu Yueqi Zhao Jinhui Wu Ruikang Tang | 2023 | National Science Review2023，10，10： | 0 |
| 12 | Systemic and single cell level responses to 1 nm size biomaterials demonstrate distinct biological effects revealed by multi-omics atlas显示文摘Although ultra-small nanoclusters(USNCs,<2 nm)have immense application capabilities in biomedicine,the investigation on body-wide organ responses towards USNCs is scant.Here,applying a novel strategy of single-cell mass cytometry combined with Nano Genome Atlas of multi-tissues,we systematically evaluate the interactions between the host and calcium phosphate(CaP)USNCs at the organism level.Combining single-cell mass cytometry,and magnetic luminex assay results,we identify dynamic immune responses to CaP USNCs at the single cell resolution.The innate immune is initially activated and followed by adaptive immune activation,as evidenced by dynamic immune cells proportions.Furthermore,using Nano Genome Atlas of multi-tissues,we uncover CaP USNCs induce stronger activation of the immune responses in the cartilage and subchondral bone among the five local tissues while promote metabolic activities in the liver and kidney.Moreover,based on the immunological response profiles,histological evaluation of major organs and local tissue,and a body-wide transcriptomics,we demonstrate that CaP USNCs are not more hazardous than the Food and Drug Administration-approved CaP nanoparticles after 14 days of injection.Our findings provide valuable information on the future clinical applications of USNCs and introduce an innovative strategy to decipher the whole body response to implants. | Tao Zhang Tingyun Lei Ruojin Yan Bo Zhou Chunmei Fan Yanyan Zhao Shasha Yao Haihua Pan Yangwu Chen Bingbing Wu Yuwei Yang Lijuan Hu Shen Gu Xiaoyi Chen Fangyuan Bao Yu Li Hanqi Xie Ruikang Tang Xiao Chen Zi Yin | 2022 | Bioactive Materials2022，7，12： | 0 |
| 13 | 1700 nm broadband laser source enables deep brain optical biopsy显示文摘A commentary on the article:Zhu et al.“1700 nm optical coherence microscopy enables minimally invasive,label-free,in vivo optical biopsy deep in the mouse brain.”Light:Science&Applications 10,145(2021).High-resolution optical imaging techniques are valuable as they can be used to provide brain tissue information at the cellular level in rodents. | Peijun Tang Ruikang K.Wang | 2021 | Light(Science & Applications)2021，10，11： | 0 |
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