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| 1 | Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth显示文摘AIM: Standard immunosuppression after organ transplantation stimulates tumor growth. Sirolimus has a strong antiproliferative and a tumor inhibiting effect. The purpose is to assess the effect on tumor growth of the immunosuppressive compounds sirolimus and tacrolimus alone and in combination on cells of human hepatocellular carcinoma.METHODS: We used the human cell lines SK-Hep 1 and Hep 3B derived from hepatocellular carcinoma. Proliferation analyses after treatment with sirolimus, tacrolimus, or the combination of both were performed. FACS analyses were done to reveal cell cycle changes and apoptotic cell death. The expression of apoptosis-related proteins was estimated by Western blots.RESULTS: Sirolimus alone or combined with tacrolimus inhibited the growth of both cell lines after 5 d by up to 35% in SK-Hep 1 cells, and by up to 68% in Hep 3B cells at 25 ng/mL. Tacrolimus alone stimulated the growth by 12% after 5 ng/mL and by 25% after 25 ng/mL in Hep 3B cells. We found an increase of apoptotic Hep 3B cells from 6 to 16%, and a G1-arrest in SK-Hep 1 cells with an increase of cells from 61 to 82%, when sirolimus and tacrolimus were combined. Bcl-2 was down-regulated in Hep 3B, but not in SK-Hep 1 cells after combined treatment.CONCLUSION: Sirolimus appears to inhibit the growth of hepatocellular carcinoma cells alone and in combination with tacrolimus. Sirolimus seems to inhibit the growth stimulation of tacrolimus. | Guido Schumacher Marijke Oidtmann Anne Rueggeberg Dietmar Jacob Sven Jonas Jan M. Langrehr Ruth Neuhaus Marcus Bahra Peter Neuhaus | 2005 | World Journal of Gastroenterology2005，11，10： | 14 |
| 2 | 基于智能电网构建的欧洲可再生能源电力系统现状和前景展望(英文)显示文摘可再生能源在欧盟未来的能源框架中扮演着重要角色。到2020年,在欧盟总的能源消耗量中,预期20%将来自可再生能源,并且能效将提高20%。智能电网将是未来电力系统接纳大规模可再生能源发电并网的基石。文中介绍了欧洲的可再生能源开发现状和规划以及能源政策,并讨论了欧盟在智能电网相关技术方面的研发进展。丹麦是欧盟国家中可再生能源使用和相关关键技术研发的领跑者,文中重点以其为例进行介绍和阐述。 | Yi DING Jacob OSTERGAARD Poul Ejnar SORENSEN Peter MEIBOM Qiuwei WU | 2011 | 电力系统自动化2011，35，22： | 11 |
| 3 | Matched-pair analysis of postoperative morbidity and mortality for pancreaticogastrostomy and pancreaticojejunostomy using mattress sutures in soft pancreatic tissue remnants显示文摘BACKGROUND:After pancreaticoduodenectomy,the incidence of postoperative pancreatic fistula remains high,especially in patients with 'soft' pancreatic tissue remnants.No 'gold standard' surgical technique for pancreaticoenteric anastomosis has been established.This study aimed to compare the postoperative morbidity and mortality of pancreaticogastrostomy and pancreaticojejunostomy for 'soft' pancreatic tissue remnants using modified mattress sutures.METHODS:Seventy-five patients who had undergone pancreaticogastrostomy and 75 who had undergone pancreaticojejunostomy after pancreaticoduodenectomy between 2002 and 2008 were retrospectively compared using matched-pair analysis.A modified mattress suture technique was used for the pancreaticoenteric anastomosis.Patients with an underlying 'hard' pancreatic tissue remnant,as in chronic pancreatitis,were excluded.Both groups were homogeneous for age,gender,and underlying disease.Postoperative morbidity,mortality,and preoperative and operative data were analyzed.RESULTS:There were no significant differences between the groups for the incidence of postoperative pancreatic fistula (10.7% in both).Postoperative morbidity and mortality,median operation time,median length of hospital stay,intraoperative blood loss,and the amount of intraoperatively transfused erythrocyte concentrates also did not significantly differ between the groups.Patient age >65 years (P=0.017),operation time >350minutes (P=0.001),and intraoperative transfusion of erythrocyte concentrates (P=0.038) were identified as risk factors for postoperative morbidity.CONCLUSIONS:Our results showed no significant differences between the groups in the pancreaticogastrostomy and pancreaticojejunostomy anastomosis techniques using mattress sutures for 'soft' pancreatic tissue remnants.In our experience,the mattress sutures are safe and simple to use,and pancreaticogastrostomy in particular is feasible and easy to learn,with good endoscopic accessibility to the anastomosis region.However,the location of the anastomosis and the surgical technique need to be individually evaluated to further reduce the incidence of postoperative pancreatic fistula. | Fritz Klein Marcus Bahra Matthias Glanemann Wladimir Faber Peter Warnick Andreas Andreou Safak Gül Dietmar Jacob | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 9 |
| 4 | 病原学和血清学检验方法在大山区血吸虫病流行区的应用显示文摘目的了解血吸虫病病原学及血清学检测方法在大山区流行区应用的效果,为制定防治对策提供科学依据。方法采用随机抽样法在大山区血吸虫病未控制县抽取流行程度轻、中、重的1个自然村,每村抽取35户作为调查对象。采用孵化法及Kato-Katz法进行病原学检查,同时采用检测抗体的ELISA和DDIA法对受试者进行血清学检查。结果总感染率为8.26%(29/351),孵化法三送三检与Kato-Katz法三送十二检2种病原学检查方法差异无统计学意义(χ2=1.831,P>0.05),孵化法一送一检与Kato-Katz法一送四检差异也无统计学意义(χ2=0.313,P>0.05)。不同流行程度村的查病结果Kato-Katz法差异无统计学意义(χ2=2.188,P>0.05),孵化法差异有统计学意义(χ2=7.203,P<0.05),DDIA和ELISA法在不同流行程度村的查病结果间差异均有统计学意义(χ2=22.36、36.282,P均<0.01)。ELISA、DDIA2种血清学筛检方法的敏感性、特异性和约登指数分别为65.52%、59.35%、0.25和44.83%、69.79%、0.15。ELISA法优于DDIA法(χ2=19.253,P<0.01)。ELISA结果与粪检有关联,但一致性较差(χ2=5.772,P<0.05,Kappa=0.076762),DDIA结果与粪检无关联(χ2=2.019,P>0.05)。结论防治实际工作中采用收集一次粪便孵化或制作三张Kato-Katz片,分别有62.07%、72.41%的感染者漏检,必将严重低估病情现状。检测血吸虫抗体的ELISA和DDIA2种血清学筛查方法将漏检34.48%、55.17%感染者,成为血吸虫病病情反弹的原因之一。 | 陈绍荣 陈凤 周晓农 李宏军 Peter Jacob Steinmann 杨忠 李远林 | 2007 | 寄生虫病与感染性疾病2007，5，1： | 7 |
| 5 | 云南省洱源县人体重要寄生虫病调查显示文摘目的了解云南省洱源县人体重要寄生虫感染的现状和特点,为制定防治对策提供科学依据。方法采用随机抽样法在全县抽取35个自然村为调查点,每个调查点随机抽取35户居民作为调查对象。对土源性线虫、绦虫和血吸虫感染等采用病原学检查,旋毛虫病、猪囊尾蚴病和血吸虫病采用血清学检查。结果寄生虫总感染率为23.34%(772/3308),其中坝区与山区人群感染率分别为19.55%(333/1703)和27.35%(439/1605),两者差异有统计学意义(P<0.01)。共查出7种寄生虫,感染率分别为蛔虫15.75%、钩虫0.33%、鞭虫1.87%、绦虫(包括链状带绦虫和微小膜壳绦虫)3.72%、蛲虫0.18%、血吸虫1.51%。混合感染人数占总感染人数的8.94%(69/772)。旋毛虫病、猪囊尾蚴病和血吸虫病的血清阳性率分别为57.30%(2103/3670)、18.20%(668/3670)、21.16%(958/3662)。本次调查结果寄生虫总感染率低于2004年全省调查的28.86%,而高于全国的19.56%。结论洱源县山区人群的人体重要寄生虫感染率明显高于坝区。感染虫种以蛔虫为主,其次为绦虫。绦虫病、猪囊尾蚴病、旋毛虫病和血吸虫病为今后该县寄生虫病防治工作的重点。 | 陈绍荣 杨忠 李远林 Peter Jacob Steinmann 李宏军 陈凤 李兰花 马俊华 贾铁武 王尚位 许静 方文 杨慧 段玉春 刘榆华 周晓农 | 2007 | 中国血吸虫病防治杂志2007，19，1： | 4 |
| 6 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | 2007 (9558)2007，，9558： | 3 |
| 7 | Oxy-fuel combustion of solid fuels显示文摘 | Maja B. Toftegaard Jacob Brix Peter A. Jensen Peter Glarborg Anker D. Jensen | 2010 | Progress in Energy and Combustion Science2010，，5： | 3 |
| 8 | BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc显示文摘 | Jake E. Delmore Ghayas C. Issa Madeleine E. Lemieux Peter B. Rahl Junwei Shi Hannah M. Jacobs Efstathios Kastritis Timothy Gilpatrick Ronald M. Paranal Jun Qi Marta Chesi Anna C. Schinzel Michael R. McKeown Timothy P. Heffernan Christopher R. Vakoc P. Lei | 2011 | Cell2011，，6： | 3 |
| 9 | Simple Non-Invasive Systems Predict Long-Term Outcomes of Patients With Nonalcoholic Fatty Liver Disease显示文摘 | Paul Angulo Elisabetta Bugianesi Einar S. Bjornsson Phunchai Charatcharoenwitthaya Peter R. Mills Francisco Barrera Svanhildur Haflidadottir Christopher P. Day Jacob George | 2013 | Gastroenterology2013，，： | 2 |
| 10 | A Relocation-based Initialization Scheme to Improve Track-forecasting of Tropical Cyclones显示文摘A relocation procedure to initialize tropical cyclones was developed to improve the representation of the initial conditions and the track forecast for Panasonic Weather Solutions Tropical Operational Forecasts. This scheme separates the vortex perturbation and environment field from the first guess, then relocates the initial vortex perturbations to the observed position by merging them with the environment field. The relationships of wind vector components with stream function and velocity potential are used for separating the vortex disturbance from first guess. For the separation of scalars, a low-pass Barnes filter is employed. The irregular-shaped relocation area corresponding to the specific initial conditions is determined by mapping the edge of the vortex radius in 36 directions.Then, the non-vortex perturbations in the relocation area are removed by a two-pass Barnes filter to retain the vortex perturbations, while the variable fields outside the perimeter of the modified vortex are kept identical to the original first guess. The potential impacts of this scheme on track forecasts were examined for three hurricane cases in the 2011–12 hurricane season. The experimental results demonstrate that the initialization scheme is able to effectively separate the vortex field from the environment field and maintain a relatively balanced and accurate relocated first guess. As the initial track error is reduced, the following track forecasts are considerably improved. The 72-h average track forecast error was reduced by 32.6% for the cold-start cases, and by 38.4% when using the full-cycling data assimilation because of the accumulated improvements from the initialization scheme. | GAO Feng Peter P. CHILDS Xiang-Yu HUANG Neil A. JACOBS Jinzhong MIN | 2014 | Advances in Atmospheric Sciences2014，31，1： | 2 |
| 11 | Vitamin D status does not predict sustained virologic response or fibrosis stage in chronic hepatitis C genotype 1 infection显示文摘 | Matthew T. Kitson Gregory J. Dore Jacob George Peter Button Geoffrey W. McCaughan Darrell H.G. Crawford William Sievert Martin D. Weltman Wendy S. Cheng Stuart K. Roberts | 2012 | Journal of Hepatology2012，，： | 2 |
| 12 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | The Lancet . 2007 (9558)2007，，9558： | 2 |
| 13 | Operative treatment of scapular fractures: A systematic review显示文摘 | Jacob M. Lantry Craig S. Roberts Peter V. Giannoudis | 2007 | Injury2007，，3： | 2 |
| 14 | Complications of ERCP: a prospective study显示文摘 | Merete Christensen Peter Matzen Svend Schulze Jacob Rosenberg | 2004 | Gastrointestinal Endoscopy2004，，5： | 2 |
| 15 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | The Lancet2007，，9558： | 2 |
| 16 | Environmental Pollution显示文摘 | de Boer Jacob Wester Peter G van der Horst Aschwin Leonard Pim E G | 2003 | 122 : 632003，122，： | 1 |
| 17 | Vitamin status and intake as primary determinants of homocysteinemia in an elderly population显示文摘 | Jacob S Paul FJ Peter WF | 1993 | JAM A1993，270，： | 1 |
| 18 | 2011 colposcopic terminology of the international federation for cervical pathology and colposcopy显示文摘 | Jacob B James B Peter B | 2012 | Obstetrics & Gynecology2012，120，1： | 1 |
| 19 | Hohlraum Manufacture for Inertial Confinement Fusion显示文摘 | Larry R Peter G Jacob B | 1994 | Fusion Technology1994，26，11： | 1 |
| 20 | Hohlraum manufacture for inertial confinement fusion显示文摘 | Larry R Peter G Jacob B | 1994 | Fusion Technology1994，26，11： | 1 |
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