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| 1 | Erosion behavior and failure mechanism of Ti/TiAlN multilayer coatings eroded by silica sand and glass beads显示文摘Severe erosion by hard particles is a crucial problem to engine blades when aircraft take off and land in harsh environments, especially for the developed lightweight titanium alloy components. Here, we deposited the Ti/TiAlN multilayer coatings with various cycles on Ti–6 Al–4 V substrates by a home-made hybrid multisource cathodic arc system. The effects of the silica sand and glass beads on erosion behavior of the coatings were focused. Results showed that the Ti/TiAlN multilayer coatings eroded by the silica sand exhibited the predominant 'layer by layer' failure mechanism. In particular, increasing the number of cycles led to the dramatic increase in erosion rate for Ti/TiAlN multilayer coatings, due to the deterioration of their mechanical properties. Different from the silica sand case, however, the erosion rate of the coatings treated by glass beads indicated faint dependence upon the number of cycles, where the coating failure was dominated by the 'piece by piece' failure mechanism. Noted that the Ti layers along with the formed interfaces enhanced the erosion resistance of the coatings, although the failure mechanisms were differently eroded by silica sand and glass beads. Meanwhile, the Ti layers and interfaces hindered the propagation of radial cracks and restrained the lateral cracks within one single TiAlN layer. | Jintao Shuai Xiao Zuo Zhenyu Wang Lili Sun Rende Chen Li Wang Aiying Wang Peiling Ke | 2021 | Journal of Materials Science & Technology2021，，21： | 8 |
| 2 | Optimized Bio-inspired Micro-pillar Dry Adhesive and Its Application for an Unmanned Aerial Vehicle Adhering on and Detaching from a Ceiling显示文摘Various bio-inspired dry adhesive materials have been investigated.In this work,lithography and silicon deep etching method were used to fabricate bio-inspired micro-pillar dry adhesive materials of which the parameters,such as side length,Height to Side length Aspect Ratio(HSAR),and inter-pillar Distance to Side length Aspect Ratio(DSAR)were comprehensively studied to obtain a dry adhesive with high adhesion.An orthogonal array method was designed and a series of fabrication experiments were conducted to identify optimum parameters,which resulted in a high normal adhesion of 2.98 N·cm^-2 and a shear adhesion of 9.59 N·cm^-2.An adhesion and desorption device was further designed on basis of the optimum dry adhesive,which enables an Unmanned Aerial Vehicle(UAV)to successfully adhere on and detach from a ceiling.This would allow an UAV to stay aloft for prolonged time,which could be invaluable to many applications,such as energy conservation and aerial detection. | Qingsong He Xianrui Xu Zhiwei Yu Kai Huo Zhaoyang Wang Nuo Chen Xuean Sun Gui Yin Peile Du Yang Li Zhendong Dai | 2020 | Journal of Bionic Engineering2020，17，1： | 2 |
| 3 | Efficiency against multidrug resistance by co-delivery of doxorubicin and curcumin with a legumain-sensitive nanocarrier显示文摘Multidrug 抵抗蛋白质(MDRP ) 在肿瘤在 multidrug 抵抗的调停被含有,代表主要障碍到成功的化疗。当 curcumin (杂种狗) 在 MDRP 的表示和功能上施加禁止的效果,为杂种狗和 doxorubicin (纪录影片) 的合作交货的 nanocarrier 被准备通过他们的 synergistic 效果克服 MDR 肿瘤。由于在肿瘤的 legumain 的 overexpression,从这 nanocarrier 的纪录影片的版本侧面被设计是调制的 legumain,它被与 legumain 敏感的肽衔接纪录影片到基本材料(chitosan ) 完成。与 nanoparticles 相比仅仅包含纪录影片,纪录影片和杂种狗的 coadministration 显著地禁止了 multidrug 抵抗(P < 0.05 ) 在一个 multidrug 抵抗的癌症房间模型(MCF-7/ADR 房间线) ,与到正常房间(L929 房间线) 的 cytotoxicity。如此的抑制能在 MCF-7/ADR 原子核被归功于到增加的纪录影片累积。合作交货系统整个延长发行量时间,改进指向肿瘤的效率,肿瘤抑制活动的举起,和 MDRP 表示的抑制展出了好 anticancer 效果。这些数据为癌症治疗揭示了这个合作交货系统的庞大的潜力,特别在 multidrug 抵抗可以发展的以后的阶段。 | Sen Lin Peiling Xie Mengmeng Luo Qing Li Ling Li Jinzhao Zhang Qinxiang Zheng Hao Chen Kaihui Nan | 2018 | Nano Research2018，11，7： | 2 |
| 4 | Direct liquefaction of Dunaliella tertiolecta for bio-oil in sub/supercritical ethanol-water 显示文摘 | Chen Yu Wu Yulong Zhang Peiling | 2012 | Bioresource Technol- ogy2012，124，： | 1 |
| 5 | 13.4 fs,0.1 Hz OPCPA Front End for the 100 PW-Class Laser Facility显示文摘Here,we report the recent progress on the front end developed for the 100 PW-class laser facility.Using 3 stages of optical parametric chirped-pulse amplification(OPCPA)based on lithium triborate(LBO)crystals,we realized a 5.26 J/0.1 Hz amplified output with a bandwidth over 200 nm near the center wavelength of 925 nm.After the compressor,we obtained a pulse duration of 13.4 fs.As the compression efficiency reached 67%,this OPCPA front end could potentially support a peak power of 263 TW at a repetition rate of 0.1 Hz.To the best of our knowledge,among all the 100 TW-level OPCPA systems,it shows the widest spectral width,the shortest pulse duration,and it is also the first OPCPA system working at a repetition-rate mode. | Xinliang Wang Xingyan Liu Xiaoming Lu Junchi Chen Yingbin Long Wenkai Li Haidong Chen Xun Chen Peile Bai Yanyan Li Yujie Peng Yanqi Liu Fenxiang Wu Cheng Wang Zhaoyang Li Yi Xu Xiaoyan Liang Yuxin Leng Ruxin Li | 2022 | Ultrafast Science2022，，3： | 1 |
| 6 | Mechanical and erosionresistance properties of slag α-Sialon ceramics 显示文摘 | Chen Weiwu Steel Joseph Zhang Yu Jiang Jiuxin Cheng Yibing Wang Peiling Yan Dongsheng | 2004 | Journal of the European Ceramic Society2004，24，9： | 1 |
| 7 | Cluster Randomization Trial of Sequence Mass Screening for Colorectal Cancer显示文摘 | Shu Zheng M.D. Kun Chen M.D. Xiyong Liu M.D. Xinyuan Ma M.D. Hai Yu Ph.D. Kang Chen Kaiyan Yao Lun Zhou M.D. Linbo Wang M.D. Peiling Qiu M.D. Yongchuan Deng M.D. Suzhan Zhang M.D | 2003 | Diseases of the Colon & Rectum2003，，1： | 1 |
| 8 | Isolation and identification of thiohomosildenafil and thiosildenafil in health supplements显示文摘 | Peng Zou Peiling Hou Sharon Sze-Yin Oh Y.M. Chong Bosco Chen Bloodworth Min-Yong Low Hwee-Ling Koh | 2008 | Journal of Pharmaceutical and Biomedical Analysis2008，，2： | 1 |
| 9 | Chrysanthemum CmWRKY53 negatively regulates the resistance of chrysanthemum to the aphid Macrosiphoniella sanborni显示文摘Chrysanthemum is frequently attacked by aphids,which greatly hinders the growth and ornamental value of this plant species.WRKY transcription factors play an important role in the response to biotic stresses such as pathogen and insect stresses.Here,chrysanthemum CmWRKY53 was cloned,and its expression was induced by aphid infestation.To verify the role of CmWRKY53 in resistance to aphids,CmWRKY53 transgenic chrysanthemum was generated.CmWRKY53 was found to mediate the susceptibility of chrysanthemum to aphids.The expression levels of secondary metabolite biosynthesis genes,such as peroxidase-and polyphenol oxidase-encoding genes,decreased in CmWRKY53-overexpressing(CmWRKY53-Oe)plants but dramatically increased in chimeric dominant repressor(CmWRKY53-SRDX)plants,suggesting that CmWRKY53 contributes to the susceptibility of chrysanthemum to aphids,possibly due to its role in the regulation of secondary metabolites. | Wanwan Zhang Tianwei Gao Peiling Li Chang Tian Aiping Song Jiafu Jiang Zhiyong Guan Weimin Fang Fadi Chen Sumei Chen | 2020 | Horticulture Research2020，7，1： | 1 |
| 10 | Immune‑Ageing Evaluation of Peripheral T and NK Lymphocyte Subsets in Chinese Healthy Adults显示文摘Ageing is often accompanied with a decline in immune system function,resulting in immune ageing.Numerous studies have focussed on the changes in different lymphocyte subsets in diseases and immunosenescence.The change in immune phenotype is a key indication of the diseased or healthy status.However,the changes in lymphocyte number and phenotype brought about by ageing have not been comprehensively analysed.Here,we analysed T and natural killer(NK)cell subsets,the phenotype and cell differentiation states in 43,096 healthy individuals,aged 20–88 years,without known diseases.Thirty-six immune parameters were analysed and the reference ranges of these subsets were established in different age groups divided into 5-year intervals.The data were subjected to random forest machine learning for immune-ageing modelling and confirmed using the neural network analysis.Our initial analysis and machine modelling prediction showed that na.ve T cells decreased with ageing,whereas central memory T cells(Tcm)and effector memory T cells(Tem)increased cluster of differentiation(CD)28-associated T cells.This is the largest study to investigate the correlation between age and immune cell function in a Chinese population,and provides insightful differences,suggesting that healthy adults might be considerably influenced by age and sex.The age of a person's immune system might be different from their chronological age.Our immune-ageing modelling study is one of the largest studies to provide insights into‘immune-age’rather than‘biological-age’.Through machine learning,we identified immune factors influencing the most through ageing and built a model for immune-ageing prediction.Our research not only reveals the impact of age on immune parameter differences within the Chinese population,but also provides new insights for monitoring and preventing some diseases in clinical practice. | Zhenghu Jia Zhiyao Ren Dongmei Ye Jiawei Li Yan Xu Hui Liu Ziyu Meng Chengmao Yang Xiaqi Chen Xinru Mao Xueli Luo Zhe Yang Lina Ma Anyi Deng Yafang Li Bingyu Han Junping Wei Chongcheng Huang Zheng Xiang Guobing Chen Peiling Li Juan Ouyang Peisong Chen Oscar Junhong Luo Yifang Gao Zhinan Yin | 2023 | Phenomics2023，3，4： | 1 |
| 11 | Effects of straw mulching on soil temperature, evaporation and yield of winter wheat : field experiments on the North China Plain显示文摘 | S Y Chen X Y Zhang D Peil | 2007 | WATER USE EFFICIENCY2007，150，3： | 1 |
| 12 | Asian,regional,and national burdens of respiratory tract cancers and associated risk factors from 1990 to 2019:A systematic analysis for the global burden of disease study 2019显示文摘Background:Respiratory cancer is the leading cause of cancer-related deaths worldwide,but its statistics vary between the East and West.This study aimed to estimate the burdens of tracheal,bronchus,and lung(TBL)cancer and larynx cancer and their attributable risks from 1990 to 2019 in Asia,and at regional and national levels.Methods:This research evaluated the incidence,mortality,years lived with disability,years of life lost,and disability-adjusted life years(DALYs)for respiratory tract cancers using the Global Burden of Diseases,Injuries,and Risk Factors Study(GBD)2019 database.Age-standardized rates were calculated for TBL cancer from 1990 to 2019,adjusted for smoking and socio-demographic index(SDI).Deaths from TBL cancer and larynx cancer attributable to each risk factor were estimated for 33 Asian countries.Results:The age-standardized incidence and death rates for TBL cancer in Asia declined from 2010 to 2019,while the incidence rate of larynx cancer increased.Smoking was the leading specific risk factor for deaths from both TBL and larynx cancers.The burden of TBL cancer in Asian countries was influenced by SDI and smoking,particularly among males in Central Asia.Deaths,DALYs,and incidences of larynx cancer in East Asia had not changed significantly over the past 30 years,but showed slight downward trends in males and both sexes combined,and an upward trend in females in recent years.Conclusions:The past decade saw increases in numbers of incident cases and deaths from TBL cancer and larynx cancer in Asia.SDI and smoking were the main factors influencing the disease burden of TBL cancer in Asian countries.This study highlights the need for tailored cancer control programs to address the burden of respiratory tract cancers in different Asian countries. | Ran Zhong Xiuyu Cai Jianfu Li Peiling Chen Runchen Wang Xinting Li Feng Li Shan Xiong Caichen Li Huiting Wang Yang Xiang Shuting Zhan Ziwen Yu Haixuan Wang Chunyan Li Lixuan Lin Wenhai Fu Xin Zheng Shen Zhao Kang Zhang Jianxing He | 2023 | Chinese Medical Journal Pulmonary and Critical Care Medicine2023，1，4： | 1 |
| 13 | Effect of additives on microstructure of Ca α - sialon显示文摘 | LI Yawen WANG Peiling CHEN Weiwu | 2001 | Mater Lett2001，47，： | 1 |
| 14 | The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting显示文摘Although somatic cells can be reprogrammed to pluripotent stem cells(PsCs)with pure chemicals,authentic pluripotency of chemically induced pluripotent stem celis(CipsCs)has never been achieved through tetraploid complementation assay.Spontaneous reprogramming of spermatogonial stem cells(ssCs)was another non-transgenic way to obtain PsCs,but this process lacks mechanistic explanation.Here,we reconstructed the trajectory of mouse SsC reprogramming and developed a five-chemical combination,boosting the reprogramming effciency by nearly 80-to 100-folds.More importantly,chemical induced germline-derived PsCs(5C-gPSCs),but not gpsCs and chemical induced pluripotent stem cells,had authentic pluripotency,as determined by tetraploid complementation.Mechanistically,ssCs traversed through an inverted pathway of in vivo germ ceil development,exhibiting the expression signatures and DNA methylation dynamics from spermatogonia to primordial germ cells and further to epiblasts.Besides,ssC-specific imprinting control regions switched from biallelic methylated states to monoallelic methylated states by imprinting demethylation and then re-methylation on one of the two alleles in 5c-gPsCs,which was apparently distinct with the imprinting reprogramming in vivo as DNA methylation simultaneously occurred on both alleles.Our work sheds ight on the unique regulatory network underpinning SsC reprogramming,providing insights to understand generic mechanisms for cell-fate decision and epigenetic-relateddisorders in regenerative medicine. | Yuhan Chen Jiansen Lu Yanwen Xu Yaping Huang Dazhuang Wang Peiling Liang Shaofang Ren Xuesong Hu Yewen Qin Wei Ke Ralf Jauch Andrew Paul Hutchins Mei Wang Fuchou Tang Xiao-Yang Zhao | 2023 | Protein & Cell2023，14，7： | 0 |
| 15 | Effects of mesencephalic astrocyte-derived neurotrophic factor on sepsis-associated acute kidney injury显示文摘BACKGROUND:To determine the protective role of mesencephalic astrocyte-derived neurotrophic factor(MANF) in regulating sepsis-associated acute kidney injury(S-AKI).METHODS:A total of 96 mice were randomly divided into the control group,control+MANF group,S-AKI group,and S-AKI+MANF group.The S-AKI model was established by injecting lipopolysaccharide(LPS) at 10 mg/kg intraperitoneally.MANF(200 μg/kg) was administered to the control+MANF and S-AKI+MANF groups.An equal dose of normal saline was administered daily intraperitoneally in the control and S-AKI groups.Serum and kidney tissue samples were obtained for biochemical analysis.Western blotting was used to detect the protein expression of MANF in the kidney,and enzyme-linked immunosorbent assay(ELISA) was used to determine expression of MANF in the serum,pro-inflammatory cytokines(tumor necrosis factor-α [TNF-α] and interleukin-6 [IL-6]).Serum creatinine(SCr),and blood urea nitrogen(BUN)were examined using an automatic biochemical analyzer.In addition,the kidney tissue was observed for pathological changes by hematoxylin-eosin staining.The comparison between two groups was performed by unpaired Student’s t-test,and statistics among multiple groups were carried out using Tukey’s post hoc test following one-way analysis of variance(ANOVA).A P-value <0.05 was considered statistically significant.RESULTS:At the early stage of S-AKI,MANF in the kidney tissue was up-regulated,but with the development of the disease,it was down-regulated.Renal function was worsened in the S-AKI group,and TNF-α and IL-6 were elevated.The administration of MANF significantly alleviated the elevated levels of SCr and BUN and inhibited the expression of TNF-α and IL-6 in the kidney.The pathological changes were more extensive in the S-AKI group than in the S-AKI+MANF group.CONCLUSION:MANF treatment may significantly alleviate renal injury,reduce the inflammatory response,and alleviate or reverse kidney tissue damage.MANF may have a protective effect on S-AKI,suggesting a potential treatment for S-AKI. | Saifeng Chen Xuewei Hao Guo Chen Guorong Liu Xiaoyan Yuan Peiling Shen Dongfeng Guo | 2023 | World Journal of Emergency Medicine2023，14，5： | 0 |
| 16 | Characteristics of Far-field Precursory Anomalies Before the M_S8.1 Earthquake in the West of Kunlun Mountains Pass显示文摘In this study, a number of typical precursory anomalies recorded by stations in Qinghai, Gansu, Sichuan, Xinjiang, Ningxia, Hebei and Shaanxi provinces and autonomous regions before the M_S8.1 earthquake in the west of Kunlun Mountains Pass are collected and checked. According to the standards of earthquake cases in China, the criteria of the precursory anomalies are determined, and 53 distinguished. The characteristics of these anomalies before the M_S8.1 earthquake are analyzed, with results showing a very large earthquake affected area. The precursory anomalies recorded by instruments were 2900 km away from the epicenter, and according to the study in this paper, reached 2100 km away. The results also show that the anomalies present characteristics of long duration, multi-measurement items and large-amplitude variation. The authors believe that in large earthquake monitoring, attention should be paid to the variation of data over a large area, ranging up to thousands kilometers, with much denser earthquake observation networks. | Chen Yuhua Dong Zhiping Wang Peiling Li Yongqiang | 2009 | Earthquake Research in China2009，23，3： | 0 |
| 17 | Seismic Sequence Characteristics and Precursory Anomalies of the M_S6.3 and M_S6.4 Da Qaidam Earthquakes in 2008~2009显示文摘In this paper,the seismogenic structures of the Da Qaidam strong earthquakes are preliminarily discussed by using the regional seismotectonic data and focal mechanism solutions. Analysis is done on the temporal and spatial distribution characteristics of the two strong earthquake sequences in Da Qaidam in combination with the sequence distribution characteristics of the M6. 6 earthquake of 2003 and the five strong earthquakes of about M5. 0 in 2004 in Delingha. At the same time,the regional characteristics of the historical seismic activity are also investigated. Preliminary analysis is done on the influence of the two M8. 0 earthquakes in the past 10 years on this region. Precursory anomalies and their characteristics are discussed in combination with the analysis of the precursor observation data of Qinghai Province. | Ma Yuhu Liu Wenbang Wang Peiling Yang Xiaoxia Chen Yuhua | 2013 | Earthquake Research in China2013，27，2： | 0 |
| 18 | PRRT2 gene and protein in human:characteristics,evolution and function显示文摘Background:This study was designed to characterize human PRRT2 gene and protein,in order to provide theoretical reference for research on regulation of PRRT2 expression and its involvement in the pathogenesis of paroxysmal kinesigenic dyskinesia and other related diseases.Method:Biological softwares Protparam,Protscale,MHMM,SignalP 5.0,NetPhos 3.1,Swiss-Model,Promoter 2.0,AliBaba2.1 and EMBOSS were used to analyze the sequence characteristics,transcription factors of human PRRT2 and their binding sites in the promoter region of the gene,as well as the physicochemical properties,signal peptides,hydrophobicity property,transmembrane regions,protein structure,interacting proteins and functions of PRRT2 protein.Results:(1)Evolutionary analysis of PRRT2 protein showed that the human PRRT2 had closest genetic distance from Pongo abelii.(2)The human PRRT2 protein was an unstable hydrophilic protein located on the plasma membrane.(3)The forms of random coil(67.65%)and alpha helix(23.24%)constituted the main secondary structure elements of PRRT2 protein.There were also multiple potential phosphorylation sites in the protein.(4)The results of ontology analysis showed that the cellular component of PRRT2 protein was located in the plasma membrane;the molecular function of PRRT2 included syntaxin-1 binding and SH3 domain binding;the PRRT2 protein is involved in biological processes of negative regulation of soluble NSF attachment protein receptor(SNAR E)complex assembly and calcium-dependent activation of synaptic vesicle fusion.(5)String database analysis revealed 10 proteins with close interactions with the human PRRT2 protein.(6)There were at least two promoter regions in the PRRT2 gene within 2000 bp upstream the 5'flank,a 304-bp CpG island in the promoter region and four GC boxes in the 5'regulatory region of PRRT2 gene and we found 13 transcription factors that could bind the promoter region of the PRRT2 gene.Conclusion:These results provide important information for further studies on the role of PRRT2 gene and identify their functions. | Yinchao Li Shuda Chen Chengzhe Wang Peiling Wang Xi Li Liemin Zhou | 2021 | Acta Epileptologica2021，3，1： | 0 |
| 19 | A Cloud-Based Evaluation System for Science- and-Engineering Students显示文摘 | Qian Huang Feng Ye Yong Chen Peiling Xu | 2018 | 国际计算机前沿大会会议论文集2018，，2： | 0 |
| 20 | Interaction between MAPKs and MKPs in hexaploid chrysanthemum illuminates functional paralogue diversification in polyploids显示文摘Mitogen-activated protein kinases(MAPKs,also known as MPKs)regulate diverse cellular and physiological functions,and dual-specificity MAPK phosphatases(MKPs)modulate MAPK signalling through MAPK dephosphorylation and inactivation.Due to lacking of overall understanding for the regulatory networks between Chrysanthemum morifolium MKPs(CmMKPs)and C.morifolium MAPKs(CmMPKs),we systematically studied the interactions between four groups of CmMPKs and eight identified CmMKPs in chrysanthemum and found that the interaction between the specific CmMKP and the specific CmMPK differed from those in other plants.Furthermore,the expression of CmMKP1 and CmMKP1-LIKE1showed opposite trends during the development of chrysanthemum flower buds under salt treatment and Alternaria alternata inoculation,but these genes could interact with the same CmMPKs,providing insight into the subfunctionalization of paralogues.Amino acid variations(M87V,T277P and V6L)in dual-specificity protein phosphatases(DsPTP1)-LIKE1/2/3 changed the interactions of these proteins with the four CmMPK groups in chrysanthemum,providing evidence for the de/neofunctionalization of paralogues in polyploids,suggesting that we can identify the key functional sites of proteins by studying polyploid paralogues. | Qi Yu Luyao Zhang Daojin Sun Yueheng Hu Peiling Li Xue Zhang Lian Ding Lijie Zhou Zhiyong Guan Weimin Fang Fadi Chen Aiping Song | 2023 | Horticultural Plant Journal2023，9，1： | 0 |
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