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| 1 | Multisciplinary management of patients with liver metastasis from colorectal cancer显示文摘Colorectal cancer(CRC) is one of the leading causes of cancer-related death. Surgery, radiotherapy and chemotherapy have been till now the main therapeutic strategies for disease control and improvement of the overall survival. Twenty-five per cent(25%) of CRC patients have clinically detectable liver metastases at the initial diagnosis and approximately 50% develop liver metastases during their disease course. Twentythirty per cent(20%-30%) are CRC patients with metastases confined to the liver. Some years ago various studies showed a curative potential for liver metastases resection. For this reason some authors proposed the conversion of unresectable liver metastases to resectable to achieve cure. Since those results were published, a lot of regimens have been studied for resectability potential. Better results could be obtained by the combination of chemotherapy with targeted drugs, such as anti-VEGF and antiEGFR monoclonal antibodies. However an accurate selection for patients to treat with these regimens and to operate for liver metastases is mandatory to reduce the risk of complications. A multidisciplinary team approach represents the best way for a proper patient management. The team needs to include surgeons, oncologists, diagnostic and interventional radiologists with expertise in hepatobiliary disease, molecular pathologists, and clinical nurse specialists. This review summarizes the most important findings on surgery and systemic treatment of CRC-related liver metastases. | Kathleen De Greef Christian Rolfo Antonio Russo Thiery Chapelle Giuseppe Bronte Francesco Passiglia Andreia Coelho Konstantinos Papadimitriou Marc Peeters | 2016 | World Journal of Gastroenterology2016，22，32： | 22 |
| 2 | ASPECCT研究:帕尼单抗的疗效与西妥昔单抗相当显示文摘本研究中,参加试验的患者(来自北美,南美,欧洲,亚洲,非洲和澳大利亚治疗中心)年龄均在18岁以上,均为化疗难治性转移性结直肠癌,ECOG评分在2分或以下,KRAS外显子2的状态为野生型。使用计算机生成的随机序列,研究人员以1:1分配患者(按地理区域和ECOG评分进行分层)接受帕尼单抗(6 mg/kg,每2周一次)或西妥昔单抗(初始剂量为400 mg/m2,之后250 mg/m2,每周一次)治疗。 | Price TJ Peeters M Kim TW | 2014 | 中华结直肠疾病电子杂志2014，3，2： | 16 |
| 3 | Ghrelin在大鼠神经系统中的表达对胃黏膜的保护作用显示文摘目的:研究大鼠脑、小肠肌间神经丛神经元和血浆内Ghrelin的表达,探讨Ghrelin在水浸加束缚应激性胃溃疡中的作用及机制.方法:选择健康♂Wiater大鼠76只,随机分为 6组:水浸加束缚组(10只);侧脑室注射Ghrelin 组(24只);皮下注射L-NAME+侧脑室注射 Ghrelin组(8只)和相应的3个对照组(正常大鼠组18只,侧脑室注射生理盐水组8只,皮下注射 L-NAME+侧脑室注射生理盐水组8只).采用放射免疫分析、荧光免疫组化双染和神经生理学等实验方法,观察脑、小肠肌间神经丛和血浆内Ghrelin的表达,探讨Ghrelin对大鼠束缚加水浸诱导的应激性胃溃疡的影响及机制.结果:在正常大鼠小肠肌间神经丛内和原代培养的肠肌间神经丛神经元均可见有Ghrelin 样免疫反应阳性物(Ghrelin-IR)的表达,且 Ghrelin-IR与胆碱乙酰转移酶(CHAT)共同表达于同一神经元内,但Ghrelin-IR不与一氧化碳合酶(NOS)和消化道感觉性神经元内特有的钙结合蛋白(Calbindin,Calb)共存.在大鼠应激性胃溃疡产生的同时,其血浆内Ghrelin- IR的含量明显减少(198.3±29.6 ng/L vs 141.7 ±26.5 ng/L.P=0.026).而下丘脑、延脑、垂体和肌间神经丛神经元内Ghrelin-IR的含量明显升高(分别为96.2±18.1 pg/mg vs 153.2 ±11.6 pg/mg.P=0.006;89.8±16.5 pg/mg vs 144.4±13.9 pg/mg,P=0.007;108.3± 11.9 pg/mg vs 198.2±23.3 pg/mg,P=0.002; 48.8±12.8 pg/mg vs 86.2±21.5 pg/mg.P= 0.02);侧脑室注射Ghrelin大鼠应激性胃溃疡的产生明显减少,且呈明显的量效依赖关系(溃疡指数:生理盐水,86.7±6.2;50 ng Ghrelin,79.3±10.7 P=2.18;500 ng Ghrelin, 61.3±11.7,P=0.04;5 000 ng Ghrelin,35.6 ±10.8,P=0.005),经sc一氧化氮合酶抑制剂 L-NAME后,Ghrelin的胃黏膜细胞保护作用消失.结论:Ghrelin与ChAT共存表达于肠肌间神经丛胆碱能神经元;应激性胃溃疡发生时,中枢神经系统和血浆内Ghrelin的表达发生变化; 中枢Ghrelin对胃黏膜细胞具有保护作用,且呈明显的量效依赖关系. | 徐珞 孙向荣 韩晓华 钟凤 Inge Depoortere Theo Peeters | 2006 | 世界华人消化杂志2006，14，8： | 14 |
| 4 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 5 | Magnetic Resonance Elastography for the Noninvasive Staging of Liver Fibrosis显示文摘 | Laurent Huwart Christine Sempoux Eric Vicaut Najat Salameh Laurence Annet Etienne Danse Frank Peeters Leon C. ter Beek Jacques Rahier Ralph Sinkus Yves Horsmans Bernard E. Van Beers | 2008 | Gastroenterology2008，，1： | 4 |
| 6 | Controlled trial of metronidazole treatment for prevention of crohn’s recurrence after ileal resection显示文摘 | Paul Rutgeerts Martin Hiele Karel Geboes Marc Peeters Freddy Penninckx Raymond Aerts Raymond Kerremans | 1995 | Gastroenterology1995，，6： | 4 |
| 7 | 海南省HIV-1基因亚型分析显示文摘目的分析海南省人类免疫缺陷病毒-1(HIV-1)基因亚型,监测HIV毒株的流行状况。方法从88份HIV-1抗体阳性的血浆中提取RNA,逆转录后采用PCR法扩增HIV-1基因序列中的env及pol基因,对扩增产物进行核苷酸序列测定,经比对分析而确定基因亚型。构建最大似然(ML)进化树,分析感染者间的传播链。结果88份样品中,有83份样品被扩增出HIV-1的env及pol基因片段;共发现6种HIV-1亚型和重组型,其中CRF01-AE亚型70份,B′亚型8份,C亚型2份,B亚型和CRF08-BC、CRF01-AE/B′重组亚型各1份。在ML进化树上83份样品分成4个传播群(66/83)和非传播群(17/83),其中传播群1最庞大(59/83)。结论海南省HIV/AIDS的HIV-1基因亚型至少有6种,其中CRF01-AE为主要亚型,占84.33%(70/83),主要分布在静脉吸毒者及其性伴侣之间,形成了一个庞大的传播群。其次为B′亚型(9.6%)。另外的4种亚型(6%)仅见单个病例。提示海南省静脉吸毒为主要的感染途径(67.5%);经性接触传播的亚型种类复杂多样,包括本次检出的全部亚型和重组株。 | 符鹏 邓巍 鲍琳琳 Nicole Vidal 何启亚 秦川 Martine Peeters Eric Delaporte Jean-Marie Andrieu 王召乾 邝继深 张帆 胡玉銮 卢葳 | 2009 | 中国公共卫生2009，25，9： | 4 |
| 8 | The TME Trial After a Median Follow-up of 6 Years: Increased Local Control But No Survival Benefit in Irradiated Patients With Resectable Rectal Carcinoma显示文摘 | Koen C.M.J. Peeters Corrie A.M. Marijnen Iris D. Nagtegaal Elma Klein Kranenbarg Hein Putter Theo Wiggers Harm Rutten Lars Pahlman Bengt Glimelius Jan Willem Leer Cornelis J.H. van de Velde | 2007 | Annals of Surgery2007，，5： | 3 |
| 9 | Illumina Sequencing Technology as a Method of Identifying T-DNA Insertion Loci in Activation- Tagged Arabidopsis thaliana Plants显示文摘 | Joanna K. Polko Mohamed-Ramzi Temanni Martijn van Zanten Wilbert van Workum Sven Iburg Ronald Pierik Laurentius A.C.J. Voesenek Anton J.M. Peeters | 2012 | Molecular Plant2012，5，4： | 3 |
| 10 | Shedding Light on Large-Scale Chromatin Reorganization in Arabidopsis thaliana显示文摘植物需要从环境对轻信号的各种各样的类型快速并且适当地作出回应优化生长和开发。对 shading,减少的光子流动(低光) ,和变化在的立即的反应光谱质量在基因规定包含变化。在更坚持的色泽的情况中,植物在染色质的组织显示出一个戏剧的变化。两植物反应经由表明蛋白质的光敏电阻器被控制。最近,几研究响应各种各样的不能生活、关於生命的信号揭示了染色质重组的类似的特征,当其它揭开了向基因规定的轻发信号的复杂分子的网络时。这份意见报纸简短描述染色质(de ) 对的从一个轻发信号的观点的压缩反应提供在染色质和光敏电阻器和 E3 ubiquitin ligase 建筑群的分子的网络之间的一个连接。 | Martijn van Zanten Federico Tessadori Anton J.M. Peeters Paul Fransz | 2012 | Molecular Plant2012，5，3： | 3 |
| 11 | Reducing the Ecological Footprint of Inbound Tourism and Transport to Amsterdam显示文摘 | Paul Peeters Frans Schouten | 2005 | Journal of Sustainable Tourism2005，，2： | 3 |
| 12 | Biologic therapies in the metastatic colorectal cancer treatment continuum – Applying current evidence to clinical practice显示文摘 | Marc Peeters Timothy Price | 2011 | Cancer Treatment Reviews2011，，5： | 3 |
| 13 | The Treatment of Peritoneal Carcinomatosis of Colorectal Cancer with Complete Cytoreductive Surgery and Hyperthermic Intraperitoneal Peroperative Chemotherapy (HIPEC) with Oxaliplatin: A Belgian Multicentre Prospective Phase II Clinical Study显示文摘 | Daphne Hompes André D’Hoore Eric Cutsem Steffen Fieuws Wim Ceelen Marc Peeters Kurt Speeten Claude Bertrand Hugues Legendre Joseph Kerger | 2012 | Annals of Surgical Oncology2012，，7： | 3 |
| 14 | Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study显示文摘 | Timothy J Price Marc Peeters Tae Won Kim Jin Li Stefano Cascinu Paul Ruff Atilli Satya Suresh Anne Thomas Sergei Tjulandin Kathy Zhang Swaminathan Murugappan Roger Sidhu | 2014 | Lancet Oncology2014，，6： | 2 |
| 15 | Pancreatic imaging:Current status of clinical practices and small animal studies显示文摘Different causative factors acting on the pancreas can result in diseases such as pancreatitis, diabetes and pancreatic tumors. The high incidence and mortality of pancreatic diseases have placed diagnostic imaging in a crucial position in daily clinical practice. In this minireview article different pancreatic imaging techniques are discussed, from the standard clinical imaging modalities and state of the art clinical magnetic resonance imaging techniques to current situations in pre-clinical pancreatic imaging studies. In particular, the challenges of pre-clinical rodent pancreatic imaging are addressed, with both the image acquisition techniques and the post-processing methods for rodent pancreatic imaging elaborated. | Ting Yin Yewei Liu Ronald Peeters Yuanbo Feng Yicheng Ni | 2017 | World Journal of Methodology2017，7，3： | 2 |
| 16 | Reference-based stochastic subspace identification for output-only modal analysis显示文摘 | Peeters Bart De Roeck Guido | 1999 | Mechanical Systems and Signal Processing1999，13，6： | 2 |
| 17 | Proliferating cell nuclear antigen(PCNA):a new marker to study human colonic cell proliferation显示文摘 | Kubben FJ Peeters H Aesevoets A | 1994 | Gut1994，35，4： | 2 |
| 18 | Application of a new cubic turbulence model to piloted and bluff-body diffusion flames显示文摘 | Merci B Roekaerts D Peeters T W J | 2001 | Combust Flame2001，126，： | 2 |
| 19 | Intraoperative blood transfusion requirement is the main determinant of early surgical re-intervention after orthotopic liver transplantation显示文摘 | H. G. D. Hendriks J. Meer J. T. M. Wolf P. M. J. G. Peeters R. J. Porte K. Jong H. Lip W. J. Post M. J. H. Slooff | 2005 | Transplant International2005，，11： | 2 |
| 20 | Distance predicting functions and applied location-allocation models.显示文摘 | Dominique Peeters Isabelle Thomas | 2000 | Journal of Geographical Systems2000，，2： | 2 |
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