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| 1 | Extraintestinal manifestations in inflammatory bowel disease显示文摘Inflammatory bowel diseases (IBD) can be really considered to be systemic diseases since they are often associated with extraintestinal manifestations,complications, and other autoimmune disorders. Indeed,physicians who care for patients with ulcerative colitis and Crohn's disease, the two major forms of IBD, face a new clinical challenge every day, worsened by the very frequent rate of extraintestinal complications. The goal of this review is to provide an overview and an update on the extraintestinal complications occurring in IBD.Indeed, this paper highlights how virtually almost every organ system can be involved, principally eyes, skin,joints, kidneys, liver and biliary tracts, and vasculature (or vascular system) are the most common sites of systemic IBD and their involvement is dependent on different mechanisms. | Silvio Danese Stefano Semeraro Alfredo Papa Italia Roberto Franco Scaldaferri Giuseppe Fedeli Giovanni Gasbarrini Antonio Gasbarrini | 2005 | World Journal of Gastroenterology2005，11，46： | 24 |
| 2 | Role and mechanisms of action of escherichia coli nissle 1917 in the maintenance of remission in ulcerative colitis patients: an update显示文摘Ulcerative colitis(UC) is a chronic inflammatory disease, whose etiology is still unclear. Its pathogenesis involves an interaction between genetic factors, immune response and the 'forgotten organ', Gut Microbiota. Several studies have been conducted to assess the role of antibiotics and probiotics as additional or alternative therapies for Ulcerative Colitis. Escherichia coli Nissle(Ec N) is a nonpathogenic Gram-negative strain isolated in 1917 by Alfred Nissle and it is the active component of microbial drug Mutaflor®(Ardeypharm Gmb H, Herdecke, Germany and Ec N, Cadigroup, In Italy) used in many gastrointestinal disorder including diarrhea, uncomplicated diverticular disease and UC. It is the only probiotic recommended in ECCO guidelines as effective alternative to mesalazine in maintenance of remission in UC patients. In this review we propose an update on the role of Ec N 1917 in maintenance of remission in UC patients, including data about efficacy and safety. Further studies may be helpful for this subject to further the full use of potential of Ec N. | Franco Scaldaferri Viviana Gerardi Francesca Mangiola Loris Riccardo Lopetuso Marco Pizzoferrato Valentina Petito Alfredo Papa Jovana Stojanovic Andrea Poscia Giovanni Cammarota Antonio Gasbarrini | 2016 | World Journal of Gastroenterology2016，22，24： | 19 |
| 3 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 4 | 三株克里米亚刚果出血热病毒中国分离株糖蛋白基因的全序列测定与比较分析显示文摘目的 测定克里米亚 刚果出血热病毒 (CCHFV)中国分离株 (即新疆出血热病毒 ,XH FV)BA6 6 0 19、BA840 2及BA8816 6糖蛋白 (M)基因的全部序列并分析各毒株之间的相互关系。方法 病毒RNA在只与其保守末端互补的特异引物PCM Tag和随机引物的共同引发下逆转录成cDNA ,以单一PCM Tag和高保真DNA聚合酶扩增出完整的M基因。扩增产物纯化后作为模板进行序列测定 ,并将所得序列经计算机辅助分析其种系发生与编码策略。结果 XHFV代表株BA6 0 19的M基因与国际原型株IbAr10 2 0 0的M基因比较多 5个碱基 ,为 5 36 5bp ;比BA840 2、BA8816 6多 4个碱基 ,即5 36 4bp。 3株XHFV长ORF起始于M基因的第 78位碱基 ,比IbAr10 2 0 0株提前 15bp。编码的前体蛋白共 16 89个氨基酸 ,比IbAr10 2 0 0株多 6个。 4株病毒之间核苷酸序列的同源性分别为 :80 9%(IbAr10 2 0 0 BA6 6 0 19) ,80 2 % (IbAr10 2 0 0 BA840 2 ) ,80 2 % (IbAr10 2 0 0 BA8816 6 ) ,83 7% (BA6 6 0 19 BA840 2 ) ,83 6 % (BA6 6 0 19 BA8816 6 ) ,99 0 % (BA840 2 BA8816 6 ) ;对应的氨基酸序列的同源性分别为85 1% ,86 3 % ,86 6 % ,87 8% ,88 0 % ,98 8%。它们与Dugbe病毒在核苷酸和氨基酸的同源性较低 ,大约是 5 5 %和 37 7%。 | 马本江 杭长寿 Papa Anna 唐青 Antoniadis Antonis | 2001 | 中华实验和临床病毒学杂志2001，15，2： | 12 |
| 5 | Current approach in the treatment of hepatocellular ca显示文摘Hepatocellular carcinoma (HCC) is the most common malignant hepatobiliary disease; it is responsible for about 1 million deaths per year. Risk factors include hepatitis B and C, hepatic cirrhosis, including alcohol related hepatitis, metabolic and nutritional hepatic damage. The main modality of diffusion is intrahepatic in the natural course of the disease. There are two leading types of treatment: local and systemic. Surgical resection and liver transplantation constitute the most appropriate local treatments and are considered the only real possibility for recovery. Other local approaches include: radiofrequency ablation, percutaneous ethanol ablation, hepatic endoarterial chemoembolization and intrahepatic radiotherapy (SIRT: selective internal radiation therapy). These last treatments are used to control the disease when surgery or transplantation is not achievable; in some cases they are able to prolong survival while theyconstitute mainly a palliative treatment. Systemic treatments include: chemotherapy, immunological and hormonal therapies and, more recently, the introduction of new specific molecular target drugs. At the moment, in this group, the only drug that has given positive results during phase trials (SHARP study) is Sorafenib.Sorafenib represents the only primary systemic therapy that has demonstrated, unlike the other treatments previously described, an increase in survival rate in patients affected with advanced HCC. Currently, other studies are taking place that are further developing the potential of this drug. These studies, including phase trials, aredirected in order to test the activity and safety of new emerging drugs with targeted activity. Examples of these new agents are: Sunitinib, Gef itinib, Cetuximab, Bevacizumab and Erlotinib. | Luigi Rossi Federica Zoratto Anselmo Papa Francesca Iodice Marina Minozzi Luigi Frati Silverio Tomao | 2010 | World Journal of Gastrointestinal Oncology2010，2，9： | 11 |
| 6 | Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes显示文摘Fas/CD95 表面受体调停各种各样的房间的快速的死亡打字,包括有为触发 autoimmunity 的潜力的 autoreactive T 房间。这里,我们表明那的船边交货的现在的新奇方面定义一种“社会”的尺寸到导致受体的 apoptosis。船边交货刺激很快导致在附近的 T 房间之间的广泛的膜 nanotube 形成。这极其依赖于 Rho GTPases 然而并非在 caspase 激活上。包括活跃 caspases 的膜和 cytosolic 元素的双向转移能被观察经由这些 nanotubes 发生。Nanotube 形成和死亡信号的细胞间的交换在从有在船边交货受体的自体免疫的 lymphoproliferative 症候群 harbouring 变化的病人的 T 淋巴细胞是有缺点的。我们断定调停 nanotube 的交换组成扩充在附近的 T 房间之间发信号的死亡的繁殖的细胞间的通讯的一种新奇形式。 | Peter D Arkwright Francesca Luchetti Julien Tour Charlotte Roberts Rahna Ayub Ana P Morales Jose J Rodriguez Andrew Gilmore Barbara Canonico Stefano Papa Mauro Degli Esposti | 2010 | Cell Research2010，20，1： | 4 |
| 7 | circadian clock circuitry in colorectal cancer显示文摘Colorectal cancer is the most prevalent among digestive system cancers.Carcinogenesis relies on disrupted control of cellular processes,such as metabolism,proliferation,DNA damage recognition and repair,and apoptosis.Cell,tissue,organ and body physiology is characterized by periodic fluctuations driven by biological clocks operating through the clock gene machinery.Dysfunction of molecular clockworks and cellular oscillators is involved in tumorigenesis,and altered expression of clock genes has been found in cancer patients.Epidemiological studies have shown that circadian disruption,that is,alteration of bodily temporal organization,is a cancer risk factor,and an increased incidence of colorectal neoplastic disease is reported in shift workers.In this review we describe the involvement of the circadian clock circuitry in colorectal carcinogenesis and the therapeutic strategies addressing temporal deregulation in colorectal cancer. | Gianluigi Mazzoccoli Manlio Vinciguerra Gennaro Papa Ada Piepoli | 2014 | World Journal of Gastroenterology2014，20，15： | 4 |
| 8 | Predictive value of elevated neutrophil–lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease显示文摘 | Angela Papa Michele Emdin Claudio Passino Claudio Michelassi Debora Battaglia Franca Cocci | 2008 | Clinica Chimica Acta2008，，1： | 3 |
| 9 | Neural plasticity and adult neurogenesis: the deep biology perspective显示文摘The recognition that neurogenesis does not stop with adolescence has spun off research towards the reduction of brain disorders by enhancing brain regeneration. Adult neurogenesis is one of the tougher problems of developmental biology as it requires the generation of complex intracellular and pericellular anatomies, amidst the danger of neuroinflammation. We here review how a multitude of regulatory pathways optimized for early neurogenesis has to be revamped into a new choreography of time dependencies. Distinct pathways need to be regulated, ranging from neural growth factor induced differentiation to mitochondrial bioenergetics, reactive oxygen metabolism, and apoptosis. Requiring much Gibbs energy consumption, brain depends on aerobic energy metabolism, hence on mitochondrial activity. Mitochondrial fission and fusion, movement and perhaps even mitoptosis, thereby come into play. All these network processes are interlinked and involve a plethora of molecules. We recommend a deep thinking approach to adult neurobiology. | Anna Maria Colangelo Giovanni Cirillo Lilia Alberghina Michele Papa Hans V.Westerhoff | 2019 | Neural Regeneration Research2019，14，2： | 3 |
| 10 | Regional brain susceptibility to neurodegeneration: what is the role of glial cells?显示文摘The main pathological feature of the neurodegenerative diseases is represented by neuronal death that represents the final step of a cascade of adverse/hostile events.Early in the neurodegenerative process,glial cells (including astrocytes,microglial cells,and oligodendrocytes) activate and trigger an insidious neuroinflammatory reaction,metabolic decay,blood brain barrier dysfunction and energy impairment,boosting neuronal death.How these mechanisms might induce selective neuronal death in specific brain areas are far from being elucidated.The last two decades of neurobiological studies have provided evidence of the main role of glial cells in most of the processes of the central nervous system,from development to synaptogenesis,neuronal homeostasis and integration into,highly specific neuro-glial networks.In this mini-review,we moved from in vitro and in vivo models of neurodegeneration to analyze the putative role of glial cells in the early mechanisms of neurodegeneration.We report changes of transcriptional,genetic,morphological,and metabolic activity in astrocytes and microglial cells in specific brain areas before neuronal degeneration,providing evidence in experimental models of neurodegenerative disorders,including Parkinson’s and Alzheimer’s diseases.Understanding these mechanisms might increase the insight of these processes and pave the way for new specific glia-targeted therapeutic strategies for neurodegenerative disorders. | Andrea Beatriz Cragnolini Giorgia Lampitella Assunta Virtuoso Immacolata Viscovo Fivos Panetsos Michele Papa Giovanni Cirillo | 2020 | Neural Regeneration Research2020，15，5： | 3 |
| 11 | Preparation,characterization and catalytic behavior of Pt-Cu nanoparticles in methane combustion显示文摘Fine and well dispersed Pt-Cu bimetallic nanoparticles stabilized by polyvinyl pyrrolidone (PVP) were synthesized by alkaline polyol method. The molar ratio of Pt to Cu was 1 : 1. Further, the Pt-Cu bimetallic nanoparticles were supported on alumina and their catalytic behavior in methane combustion was investigated. The as-prepared as well as the supported Pt-Cu nanoparticles were characterized by transmission elec-tron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), fractal analysis and X-ray diffraction (XRD). The dependence of methane combustion on the morphology and surface composition of Pt-Cu nanoparticles was analyzed based on the experimental results. | Florica Papa Catalin Negrila Gianina Dobrescu Akane Miyazaki Ioan Balint | 2011 | Journal of Natural Gas Chemistry2011，20，5： | 3 |
| 12 | Focus on genetic and epigenetic events of colorectal cancer pathogenesis: implications for molecular diagnosis显示文摘 | Federica Zoratto Luigi Rossi Monica Verrico Anselmo Papa Enrico Basso Angelo Zullo Luigi Tomao Adriana Romiti Giuseppe Lo Russo Silverio Tomao | 2014 | Tumor Biology2014，，7： | 3 |
| 13 | 从中医整体观理解盆底整体论显示文摘近年来中医的整体观得到越来越多国外医学者的关注。据统计,澳大利亚的“补充和替代医疗”“(complementary and alternative medicine, CAM)”的年花费超过35亿美元,这一费用超出了国家基本药物福利计划支出的18亿美元,已成为民众医疗保健的重要组成部分。中医是“补充和替代医学”中最突出的诊疗方法。中医有数千年的历史,是公认的医学学科,近年来在西方国家越来越受欢迎。中医疗法中的冥想、运动、营养、针灸、中草药和按摩等系统疗法,已被证明效果显著,因此特别受到澳大利亚全科医生、物理治疗师和其他需要处理慢性疼痛的医疗从业者的青睐。 | Peter Papa Petros 丁曙晴 孙秀丽 | 2022 | 中国妇产科临床杂志2022，23，4： | 3 |
| 14 | Anisotropic damage model for the multiaxial static and fatigue behaviour of plain concrete 显示文摘 | PAPA E TALIERCIO A | 1996 | Eng Fract Mech1996，55，2： | 2 |
| 15 | Effects of n -3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease显示文摘 | L. Spadaro O. Magliocco D. Spampinato S. Piro C. Oliveri C. Alagona G. Papa A.M. Rabuazzo F. Purrello | 2007 | Digestive and Liver Disease2007，，3： | 2 |
| 16 | 反思金融深化:新兴市场的稳定与发展显示文摘有深度和流动性良好的金融系统,加上有丰富的金融工具可抵御金融冲击,还可以增加一国金融的稳定性。但是金融发展或许存在一个边界,越过此边界进一步发展其收益或将下降。本文通过研究新兴市场发现:一、大部分新兴市场金融进一步发展仍然对经济的增长和稳定有利。二、金融发展对经济增长的促进作用是倒U型的,在越过高点之后金融深化对要素生产率的促进作用将下降。三、如果金融发展过快,快速深化的金融产业可能引发经济和金融动荡。四、提升金融稳定与金融发展之间没有太大冲突,更好的金融监管有助于提升金融稳定,促进金融发展。五、发展金融机构或金融市场不存在通用的顺序,尽管前者对经济的作用在下降而后者在上升。 | IMF课题组 Ratna Sahay Martin Cihak Papa N’Diaye Adolfo Barajas Ran Bi Diana Ayala Yuan Gao Annette Kyobe Lam Nguyen Christian Saborowski Katsiaryna Svirydzenka Seyed Reza Yousefi 胡妍斌 王辰 | 2015 | 新金融2015，0，10： | 2 |
| 17 | Comparison of the action of different proteases on virulence properties related to the staphylococcal surface显示文摘 | M. Artini R. Papa G.L. Scoarughi E. Galano G. Barbato P. Pucci L. Selan | 2012 | J Appl Microbiol2012，，1： | 2 |
| 18 | C-Reactive Protein in Ischemic Stroke: An Independent Prognostic Factor显示文摘 | Mario Di Napoli Francesca Papa Vittorio Bocola | 2001 | Stroke: Journal of the American Heart Association2001，，4： | 2 |
| 19 | Can radical prostatectomy shortly after prostate biopsy affect intra-operative and postoperative outcomes?显示文摘 | Lucio Dell'Atti Gaetano Capparelli Stefano Papa Carmelo Ippolito | 2016 | Asian Journal of Andrology2016，18，3： | 2 |
| 20 | “Stop Ne(c)king around”: How interactomics contributes to functionally characterize Nek family kinases显示文摘Aside from Polo and Aurora, a third but less studied kinase family involved in mitosis regulation is the never in mitosis-gene A(NIMA)-related kinases(Neks). The founding member of this family is the sole member NIMA of Aspergillus nidulans, which is crucial for the initiation of mitosis in that organism. All 11 human Neks have been functionally assigned to one of the three core functions established for this family in mammals:(1) centrioles/mitosis;(2) primary ciliary function/ciliopathies; and(3) DNA damage response(DDR). Recent findings, especially on Nek 1 and 8, showed however, that several Neks participate in parallel in at least two of these contexts: primary ciliary function and DDR. In the core section of this in-depth review, we report the current detailed functional knowledge on each of the 11 Neks. In the discussion, we return to the cross-connections among Neks and point out how our and other groups' functional and interactomics studies revealed that most Neks interact with protein partners associated with two if not all three of the functional contexts. We then raise the hypothesis that Neks may be the connecting regulatory elements that allow the cell to fine tune and synchronize the cellular events associated with these three core functions. The new and exciting findings on the Nek family open new perspectives and should allow the Neks to finally claim the attention they deserve in the field of kinases and cell cycle biology. | Gabriela Vaz Meirelles Arina Marina Perez Edmárcia Elisa de Souza Ferna Luisa Basei Priscila Ferreira Papa Talita Diniz Melo Hanchuk Vanessa Bomfim Cardoso Jrg Kobarg | 2014 | World Journal of Biological Chemistry2014，5，2： | 2 |
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