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| 1 | Non-coding landscapes of colorectal cancer显示文摘For two decades Vogelstein's model has been theparadigm for describing the sequence of molecular changes within protein-coding genes that would lead to overt colorectal cancer(CRC). This model is now too simplistic in the light of recent studies, which have shown that our genome is pervasively transcribed in RNAs other than m RNAs, denominated non-coding RNAs(nc RNAs). The discovery that mutations in genes encoding these RNAs [i.e., micro RNAs(mi RNAs), long non-coding RNAs, and circular RNAs] are causally involved in cancer phenotypes has profoundly modified our vision of tumour molecular genetics and pathobiology. By exploiting a wide range of different mechanisms, nc RNAs control fundamental cellular processes, such as proliferation, differentiation, migration, angiogenesis and apoptosis: these data have also confirmed their role as oncogenes or tumor suppressors in cancer development and progression. The existence of a sophisticated RNA-based regulatory system, which dictates the correct functioning of protein-coding networks, has relevant biological and biomedical consequences. Different mi RNAs involved in neoplastic and degenerative diseases exhibit potential predictive and prognostic properties. Furthermore, the key roles of nc RNAs make them very attractive targets for innovative therapeutic approaches. Several recent reports have shown that nc RNAs can be secreted by cells into the extracellular environment(i.e., blood and other body fluids): this suggests the existence of extracellular signalling mechanisms, which may be exploited by cells in physiology and pathology. In this review, we will summarize the most relevant issues on the involvement of cellular and extracellular nc RNAs in disease. We will then specifically describe their involvement in CRC pathobiology and their translational applications to CRC diagnosis, prognosis and therapy. | Marco Ragusa Cristina Barbagallo Luisa Statello Angelo Giuseppe Condorelli Rosalia Battaglia Lucia Tamburello Davide Barbagallo Cinzia Di Pietro Michele Purrello | 2015 | World Journal of Gastroenterology2015，21，41： | 6 |
| 2 | Effects of n -3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease显示文摘 | L. Spadaro O. Magliocco D. Spampinato S. Piro C. Oliveri C. Alagona G. Papa A.M. Rabuazzo F. Purrello | 2007 | Digestive and Liver Disease2007，，3： | 2 |
| 3 | Metabolic factors that beta-cell function and survival显示文摘 | PURRELLO F RABUAZZO A M | 2000 | Diabet Nutr Metab2000，13，2： | 2 |
| 4 | Update on pre-diabetes: Focus on diagnostic criteria and cardiovascular risk显示文摘Pre-diabetes, which is typically defined as blood glucose concentrations higher than normal but lower than thediabetes threshold, is a high-risk state for diabetes and cardiovascular disease development. As such, it represents three groups of individuals: Those with impaired fasting glucose(IFG), those with impaired glucose tolerance(IGT) and those with a glycated haemoglobin(HbA1c) between 39-46 mmol/mol. Several clinical trials have shown the important role of IFG, IGT and HbA1c -pre-diabetes as predictive tools for the risk of developing type 2 diabetes. Moreover, with regard to cardiovascular disease, pre-diabetes is associated with more advanced vascular damage compared with normoglycaemia, independently of confounding factors. In view of these observations, diagnosis of pre-diabetes is mandatory to prevent or delay the development of the disease and its complications; however, a number of previous studies reported that the concordance between pre-diabetes diagnoses made by IFG, IGT or HbA1c is scarce and there are conflicting data as to which of these methods best predicts cardiovascular disease. This review highlights recent studies and cur-rent controversies in the field. In consideration of the expected increased use of HbA1c as a screening tool to identify individuals with alteration of glycaemic homeo-stasis, we focused on the evidence regarding the ability of HbA1c as a diagnostic tool for pre-diabetes and as a useful marker in identifying patients who have an increased risk for cardiovascular disease. Finally, we reviewed the current evidence regarding non-traditional glycaemic biomarkers and their use as alternatives to or additions to traditional ones. | Antonino Di Pino Francesca Urbano Salvatore Piro Francesco Purrello Agata Maria Rabuazzo | 2016 | World Journal of Diabetes2016，7，18： | 2 |
| 5 | Metabolic factors that affect beta-cell function and survival显示文摘 | Purrello F Rabuazza A M | 2000 | J Diabetes NutrMetab2000，13，2： | 1 |
| 6 | Metabolic factors that affect beta-cell function and survival 显示文摘 | PURRELLO F RABUAZZA A M | 2000 | J Diabetes Nutr Metab2000，13，2： | 1 |
| 7 | Metabolic factors that affect Beta cell func- tion and survival显示文摘 | Purrello F Rabuazza AM | 2000 | Diabetes NutrMetab2000，13，1： | 1 |
| 8 | Metabolic factors that affect beta-cell function and survival显示文摘 | Rabuazza AM | 2000 | Diabetes Nutr Metab2000，13，2： | 1 |
| 9 | Metabolic factors that affect beta-cell function and survival 显示文摘 | Purrello F Rabuazza A M | 2000 | Diabet Nurt Metab2000，13，2： | 1 |
| 10 | Metabolic factors that affect beta cell function and surviva显示文摘 | Purrello F Rabuazza AM | 2000 | Diabet Nutr Metab2000，13，5： | 1 |
| 11 | Metabolic factors that affect beta-cell function and survival显示文摘 | Purrello F Rabuazza AM | 2000 | Diabet Nutr Metab2000，13，2： | 1 |
| 12 | Chiral H-and J-type aggregates of meso-tetrakis (4-sulfonatophenyl) porphine on a-helical polyglutamic acid induced by cationic porphyrins显示文摘 | PURRELLO R MONSU S L BELLACCHIO E | 1998 | Inorg Chem1998，37，： | 1 |
| 13 | Type 2 Diabetes Susceptibility Gene Expression in Normal or Diabetic Sorted Human Alpha and Beta Cells : Correlations with Age or BMI of Islet Donors显示文摘 | KIRKPATRICK CL MARCHETTI P PURRELLO F | 2010 | PLoS One2010，5，11： | 1 |
| 14 | Metabolic factors that affect betacell funciton and survival显示文摘 | Purrello F Rabuazza AM | 2000 | Diabet Nutr Metab2000，13，： | 1 |
| 15 | Metabolic factoss that affect betacell function and survival显示文摘 | Purrello F Rabuazza AM | 2000 | Diabect Nuts Metab2000，13，6： | 1 |
| 16 | Metabolic factors that affect beta- cell function and survival显示文摘 | Purrello F Rabuazza A M | 2003 | Diabet Nutr Metab2003，13，： | 1 |
| 17 | Metabolic factors that affect beta-cell function and survival显示文摘 | Purrello F Rabuazza AM | 2003 | Diabet Nutr Metab2003，13，1： | 1 |
| 18 | Metabolic factors that affect beta-cell function and survival显示文摘 | Purrello F Rabuazza AM | 2000 | Diabetes Nutr Metab2000，13，： | 1 |
| 19 | Metabolic factors that affect beta-cell function and survival显示文摘 | Purrello F Rabuazza AM | 2000 | Diabet Nutr Metab2000，13，2： | 1 |
| 20 | Metabolic factors that affect betacell function and survival显示文摘 | Purrello F Rabuazza AM | 2000 | Diabet Nutr Metab2000，13，： | 1 |
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