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| 1 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 2 | Electrochemical and spectroscopic characteristics of dissolved organic matter in a forest soil profile显示文摘Dissolved organic matter(DOM) represents one of the most mobile and reactive organic compounds in ecosystem and plays an important role in the fate and transport of soil organic pollutants, nutrient cycling and more importantly global climate change.Electrochemical methods were first employed to evaluate DOM redox properties, and spectroscopic approaches were utilized to obtain information concerning its composition and structure. DOM was extracted from a forest soil profile with five horizons. Diferential pulse voltammetry indicated that there were more redox-active moieties in the DOM from upper horizons than in that from lower horizons.Cyclic voltammetry further showed that these moieties were reversible in electron transfer. Chronoamperometry was employed to quantify the electron transfer capacity of DOM, including electron acceptor capacity and electron donor capacity, both of which decreased sharply with increasing depth. FT-IR, UV-Vis and fluorescence spectra results suggested that DOM from the upper horizons was enriched with aromatic and humic structures while that from the lower horizons was rich in aliphatic carbon, which supported the findings obtained by electrochemical approaches. Electrochemical approaches combined with spectroscopic methods were applied to evaluate the characteristics of DOM extracted along a forest soil profile. The electrochemical properties of DOM, which can be rapidly and simply obtained, provide insight into the migration and transformation of DOM along a soil profile and will aid in better understanding of the biogeochemical role of DOM in natural environments. | Ran Bi Qin Lu Tian Yuan Shungui Zhou Yong Yuan Yanfei Cai | 2013 | Journal of Environmental Sciences2013，25，10： | 11 |
| 3 | Quality control of Semen Ziziphi Spinosae standard decoction based on determination of multi-components using TOF-MS/MS and UPLC-PDA technology显示文摘A sensitive,fast and comprehensive method for the quality assessment of Semen Ziziphi Spinosae(SZS)standard decoction with characterization of its chemical components was developed and validated.UPLC-Q/TOF-MS/MS system was used to identify thirty-six chemical components of SZS standard decoction which included nucleosides,phenolic acids,alkaloids,and flavonoids.Furthermore,a UPLC-PDA method was validated to simultaneously determine adenosine,protocatechuic acid,magnoflorine,catechin,protocatechin,vicenin II,spinosin,kaempferol-3-rutinoside,and 6'''-feruloylspinosin which represent four species of characteristic compounds.The qualitative method had been validated according to Chinese Pharmacopoeia(2015 edition)in terms of lineary,repeatability,recovery and stability for all analytes,with the results showing good precision,accuracy and stability.In conclusion,the method using UPLC combined with MS and PDA provided a novel way for the standardization and identification of SZS standard decoction,and also offered a basis for qualitative analysis and quality assessment of the preparations for SZS standard decoction. | Di Wang Qing Li Ran Liu Huarong Xu Yidi Yin Yifan Wang Huijia Wang Kaishun Bi | 2019 | Journal of Pharmaceutical Analysis2019，9，6： | 6 |
| 4 | Bioremediation of Hexavalent Chromium Pollution by Sporosarcina saromensis M52 Isolated from Offshore Sediments in Xiamen, China显示文摘Objective Cr(VI)removal from industrial effluents and sediments has attracted the attention of environmental researchers.In the present study,we aimed to isolate bacteria for Cr(VI)bioremediation from sediment samples and to optimize parameters of biodegradation.Methods Strains with the ability to tolerate Cr(VI)were obtained by serial dilution and spread plate methods and characterized by morphology,16S r DNA identification,and phylogenetic analysis.Cr(VI)was determined using the 1,5-diphenylcarbazide method,and the optimum p H and temperature for degradation were studied using a multiple-factor mixed experimental design.Statistical analysis methods were used to analyze the results.Results Fifty-five strains were obtained,and one strain(Sporosarcina saromensis M52;patent application number:201410819443.3)having the ability to tolerate 500 mg Cr(VI)/L was selected to optimize the degradation conditions.M52 was found be able to efficiently remove 50-200 mg Cr(VI)/L in24 h,achieving the highest removal efficiency at p H 7.0-8.5 and 35°C.Moreover,M52 could completely degrade 100 mg Cr(VI)/L at p H 8.0 and 35°C in 24 h.The mechanism involved in the reduction of Cr(VI)was considered to be bioreduction rather than absorption.Conclusion The strong degradation ability of S.saromensis M52 and its advantageous functional characteristics support the potential use of this organism for bioremediation of heavy metal pollution. | ZHAO Ran WANG Bi CAI Qing Tao LI Xiao Xia LIU Min HU Dong GUO Dong Bei WANG Juan FAN Chun | 2016 | Biomedical and Environmental Sciences2016，29，2： | 4 |
| 5 | Utility Aware Offloading for Mobile-Edge Computing显示文摘Mobile-edge computing casts the computation-intensive and delay-sensitive applications of mobile devices onto network edges.Task offloading incurs extra communication latency and energy cost,and extensive efforts have focused on offloading schemes.Many metrics of the system utility are defined to achieve satisfactory quality of experience.However,most existing works overlook the balance between throughput and fairness.This study investigates the problem of finding an optimal offloading scheme in which the objective of optimization aims to maximize the system utility for leveraging between throughput and fairness.Based on Karush-Kuhn-Tucker condition,the expectation of time complexity is analyzed to derive the optimal scheme.A gradient-based approach for utility-aware task offloading is given.Furthermore,we provide an increment-based greedy approximation algorithm with 1+1/(e-1)ratio.Experimental results show that the proposed algorithms can achieve effective performance in utility and accuracy. | Ran Bi Qian Liu Jiankang Ren Guozhen Tan | 2021 | Tsinghua Science and Technology2021，26，2： | 3 |
| 6 | Restless legs syndrome following the use of ziprasidone: a case report显示文摘Restless legs syndrome(RLS)is a common sleep-related movement disorder characterised by an uncomfortable urge to move the legs that occurs during periods of inactivity.Although there have been many case reports on antipsychotic-induced RLS,ziprasidone has never been reported as a cause of RLS.We present a case of a female patient with schizophrenia who presented with symptoms of RLS following the administration of high doses of ziprasidone added to quetiapine and valproate.The patient’s symptoms of RLS occurred following the administration and titration of ziprasidone to 160 mg,and were relieved upon reducing the dose to 120 mg/day.Other potential causative medications and differential diagnoses that could have caused similar symptoms were excluded.Clinicians should be aware of the potential for ziprasidone-induced RLS.Dopamine and serotonin interaction could be the mechanism underlying ziprasidone-induced RLS. | Cuizhen Zhu Ran Bi Yuliang Hu Hui Zhou Daomin Zhu Brian Isaacson Qingwei Li Yezhe Lin | 2020 | General Psychiatry2020，33，2： | 3 |
| 7 | Construction of a three-dimensional bionic nerve conduit containing two neurotrophic factors with separate delivery systems for the repair of sciatic nerve defects显示文摘Previous studies of nerve conduits have investigated numerous properties,such as conduit luminal structure and neurotrophic factor incorporation,for the regeneration of nerve defects.The present study used a poly(lactic-co-glycolic acid)(PLGA) copolymer to construct a three-dimensional(3D) bionic nerve conduit,with two channels and multiple microtubule lumens,and incorporating two neurotrophic factors,each with their own delivery system,as a novel environment for peripheral nerve regeneration.The efficacy of this conduit in repairing a 1.5 cm sciatic nerve defect was compared with PLGA-alone and PLGA-microfilament conduits,and autologous nerve transplantation.Results showed that compared with the other groups,the 3D bionic nerve conduit had the fastest nerve conduction velocity,largest electromyogram amplitude,and shortest electromyogram latency.In addition,the nerve fiber density,myelin sheath thickness and axon diameter were significantly increased,and the recovery rate of the triceps surae muscle wet weight was lowest.These findings suggest that 3D bionic nerve conduits can provide a suitable microenvironment for peripheral nerve regeneration to efficiently repair sciatic nerve defects. | Zhiyue Li Qun Zhao Ran Bi Yong Zhuang Siyin Feng | 2011 | Neural Regeneration Research2011，6，13： | 3 |
| 8 | Andrographolide Inhibits Proliferation and Promotes Apoptosis in Bladder Cancer Cells by Interfering with NF-κB and PI3K/AKT Signaling In Vitro and In Vivo显示文摘Objective:To explore the influences of andrographolide(Andro)on bladder cancer cell lines and a tumor xenograft mouse model bearing 5637 cells.Methods:For in vitro experiments,T24 cells were stimulated with Andro(0-40μmol/L)and 5637 cells were stimulated with Andro(0 to 80μmol/L).Cell growth,migration,and infiltration were assessed using cel counting kit-8,colony formation,wound healing,and transwel assays.Apoptosis rate was examined using flow cytometry.In in vivo study,the antitumor effect of Andro(10 mg/kg)was evaluated by 5637 tumor-bearing mice,and levels of nuclear factorκB(NF-κB)and phosphoinositide 3-kinase/AKT related-proteins were determined by immunoblotting.Results:Andro suppressed growth,migration,and infiltraion of bladder cancer cells(P 0.05or P 0.01).Additionally,Andro induced intrinsic mitochondria-dependent apoptosis in bladder cancer cell lines.Furthermore,Andro inhibited bladder cancer growth in mice(P 0.01).The expression of p65,p-AKT were suppressed by Andro treatment in vitro and in vivo(P 0.05 or P 0.01).Conclusions:Andrographolide inhibits proliferation and promotes apoptosis in bladder cancer cel s by interfering with NF-κB and PI3K/AKT signaling in vitro and in vivo. | XUAN Lei HU Jing-hai BI Ran LIU Si-qi WANG Chun-xi | 2022 | Chinese Journal of Integrative Medicine2022，28，4： | 3 |
| 9 | 反思金融深化:新兴市场的稳定与发展显示文摘有深度和流动性良好的金融系统,加上有丰富的金融工具可抵御金融冲击,还可以增加一国金融的稳定性。但是金融发展或许存在一个边界,越过此边界进一步发展其收益或将下降。本文通过研究新兴市场发现:一、大部分新兴市场金融进一步发展仍然对经济的增长和稳定有利。二、金融发展对经济增长的促进作用是倒U型的,在越过高点之后金融深化对要素生产率的促进作用将下降。三、如果金融发展过快,快速深化的金融产业可能引发经济和金融动荡。四、提升金融稳定与金融发展之间没有太大冲突,更好的金融监管有助于提升金融稳定,促进金融发展。五、发展金融机构或金融市场不存在通用的顺序,尽管前者对经济的作用在下降而后者在上升。 | IMF课题组 Ratna Sahay Martin Cihak Papa N’Diaye Adolfo Barajas Ran Bi Diana Ayala Yuan Gao Annette Kyobe Lam Nguyen Christian Saborowski Katsiaryna Svirydzenka Seyed Reza Yousefi 胡妍斌 王辰 | 2015 | 新金融2015，0，10： | 2 |
| 10 | Quantitative Evaluation of the Compatibility Effects of Aidi Injection on the Treatment of Hepatocellular Carcinoma Using Targeted Metabolomics:A New Strategy on the Mechanism Study of an Anticancer Compound in Traditional Chinese Medicine显示文摘Objective:Compound traditional Chinese medicine(CTCM)with the application of compatibility from multiple active ingredients with multiple-specific targets can achieve a synergistic effect on cancer therapy.This study is aimed to observe the compatibility effects of Aidi injection on the treatment of hepatocellular carcinoma and to explore the mechanism of CTCM.Methods:Aidi injection is a clinical compound prescription containing Mylabris,Ginseng,Astragalus,and Acanthopanax,which can inhibit tumor growth and induce apoptosis.In this study,the anticancer activity of Aidi injection,as well as its disassembled and combined compositions,had been evaluated by varying levels of polyamine biomarkers on human hepatoma Hep-G2 cells detected using ultrahigh-performance liquid chromatography-tandem mass spectrometry.Results:According to the different variations in polyamine levels,it was revealed that Mylabris and Ginseng had an antitumor effect,while Astragalus acted as an assistant and Acanthopanax had weak anticancer activity.The increased level of polyamines in Hep-G2 cells had been found in HL-7702 cells.On combining Mylabris and Ginseng,polyamine levels went close to the normal level,which was even more marked when Astragalus was added.Aidi injection acted like the combination of Mylabris,Ginseng,and Astragalus.Conclusions:This study established a quantitative evaluation of the compatibility effects of Aidi injection based on polyamine biomarkers and evaluated the consistency of its anticancer effect,providing a manner to research the efficacy evaluation of CTCM.Moreover,the correlation between polyamine metabolism and anticancer activity can be used in anticancer drug screening. | Ran Liu Lin-Lin Zhu Chun-Yu Yu Ya-Ping Shuai Ling-Ling Sun Kai-Shun Bi Qing Li | 2021 | World Journal of Traditional Chinese Medicine2021，7，1： | 2 |
| 11 | The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease显示文摘Mammary and extramammary Paget’s Diseases(PD)are a malignant skin cancer characterized by the appearance of Paget cells.Although easily diagnosed,its pathogenesis remains unknown.Here,single-cell RNA-sequencing identified distinct cellular states,novel biomarkers,and signaling pathways—including mTOR,associated with extramammary PD.Interestingly,we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin,and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological,single-cell and molecular levels.Using this mouse model,we identified novel biomarkers of Paget-like cells that translated to human Paget cells.Furthermore,single-cell trajectory,RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion,supporting the in situ transformation theory of disease pathogenesis.Mechanistically,the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion,and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans,suggesting mTOR inhibition as a novel therapeutic treatment in PD. | Yongli Song Christian F.Guerrero-Juarez Zhongjian Chen Yichen Tang Xianghui Ma Cong Lv Xueyun Bi Min Deng Lina Bu Yuhua Tian Ruiqi Liu Ran Zhao Jiuzhi Xu Xiaole Sheng Sujuan Du Yeqiang Liu Yunlu Zhu Shi-jun Shan Hong-duo Chen Yiqiang Zhao Guangbiao Zhou Jianwei Shuai Fazheng Ren Lixiang Xue Zhaoxia Ying Xing Dai Christopher J.Lengner Bogi Andersen Maksim V.Plikus Qing Nie Zhengquan Yu-Show | 2020 | Cell Research2020，30，10： | 2 |
| 12 | Sampling-Based Approximate Skyline Query in Sensor Equipped IoT Networks显示文摘Mobile-edge computing casts the computation-intensive and delay-sensitive applications of mobile devices onto network edges.Task offloading incurs extra communication latency and energy cost,and extensive efforts have focused on offloading schemes.Many metrics of the system utility are defined to achieve satisfactory quality of experience.However,most existing works overlook the balance between throughput and fairness.This study investigates the problem of finding an optimal offloading scheme in which the objective of optimization aims to maximize the system utility for leveraging between throughput and fairness.Based on Karush-Kuhn-Tucker condition,the expectation of time complexity is analyzed to derive the optimal scheme.A gradient-based approach for utility-aware task offloading is given.Furthermore,we provide an increment-based greedy approximation algorithm with 1+1/(e-1)ratio.Experimental results show that the proposed algorithms can achieve effective performance in utility and accuracy. | Ran Bi Akshita Maradapu Vera Venkata Sai Xiuzhen Cheng Wei Cheng Zhi Tian Yingshu Li | 2021 | Tsinghua Science and Technology2021，26，2： | 2 |
| 13 | Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats显示文摘瞄准: 比较 cefuroxime 离氨酸的 pharmacokinetic 参数,一新头孢霉菌素抗菌素第二代静脉内(IV ) , intraperitoneal (IP ) ,否则肌内(IM ) 管理。 | Long-shan ZHAO Ran YIN Bin-bin WEI Qing LI Zhen-yuan JIANG Xiao-hui CHEN Kai-shun BI | 2012 | Acta Pharmacologica Sinica2012，33，11： | 2 |
| 14 | Study on changes of polyamine levels in mice with the development of U14 cervical cancer显示文摘This study was performed to investigate the possible involvement of polyamines in the development of cervical cancer. The objective of the present study was therefore to find the specific polyamine indicators, which could be used as useful markers for the early determination of cervical cancer. A simple method for the simultaneous determination of plasma concentrations of five polyamines in normal and U14 model mice was developed by using HPLC-MS. The samples were derivatized by benzoyl chloride. The derived polyamines were separated on a C18 column by a gradient elution with methanol-water, and then detected with HPLC-MS. The results showed that all polyamine levels in the U14 model mice were higher than those in normal ones. The cadaverine, putrescine and 1, 3-diaminopropane levels were significantly higher in U14 model mice plasma than those in normal mice plasma, especially the putrescine and 1, 3-diaminopropane (Po0.01). The cadaverine, putrescine and 1, 3-diaminopropane levels were significantly higher in U14 mice model urine than those in normal mice urine, especially the cadaverine and 1, 3-diaminopropane (Po0.01). Putrescine, cadaverine and 1, 3-diaminopropane might be the indicators of the cervical cancer. | Qian Wang Yi-Xiang Wang Ran Liu Yan Zhou Ying Jia Xiang-Lin Wang Yu Hu Kai-Shun Bi Qing Li | 2013 | Journal of Pharmaceutical Analysis2013，3，1： | 1 |
| 15 | Non-secretory multiple myeloma expressed as multiple extramedullary plasmacytoma with an endobronchial lesion mimicking metastatic cancer:A case report显示文摘BACKGROUND Non-secretory multiple myeloma(MM)is a rare condition that accounts for only 3%of MM cases and is defined by normal serum and urine immunofixation and a normal serum free light chain ratio.Non-secretory MM with multiple extramedullary plasmacytomas derived from endobronchial lesions is extremely rare and can be misdiagnosed as metastasis of solid cancer.CASE SUMMARY A 36-year-old man presented with progressive facial swelling and nasal congestion with cough.Various imaging studies revealed an endobronchial mass in the left bronchus and a large left maxillary mass with multiple destructive bone metastatic lesions.He initially presented with lung cancer and multiple metastases.However,pathologic reports showed multiple extramedullary plasmacytomas in the left maxilla and the left bronchus.There was no change in the serum and urine monoclonal protein levels,and no abnormalities were observed in laboratory examinations,including hemoglobin,calcium,and creatinine levels.The bone marrow was hypercellular,with 13.49%plasma cells.The patient was diagnosed with non-secretory MM expressed as multiple extramedullary plasmacytomas with endobronchial lesions in a rare location.Radiation therapy for symptomatic lesions with high-dose dexamethasone was started,and the size of the left maxillary sinus lesion dramatically decreased.In the future,chemotherapy will be administered to control lesions in other areas.CONCLUSION We present a rare case of non-secretory MM with multiple extramedullary plasmacytoma with an endobronchial lesion. | Seul Bi Lee Chi Young Park Hee Jeong Lee Ran Hong Woo Shin Kim Sang-Gon Park | 2022 | World Journal of Clinical Cases2022，10，22： | 1 |
| 16 | Balancing benefits of strength,plasticity and glass-forming ability in Co-based metallic glasses显示文摘Development of advanced metals materials with ultrahigh strength,large plasticity and high thermostability is one of the most attractive aims for materials researchers.Co-based bulk metallic glasses(BMGs)with the highest strength(up to 6 GPa)and special strength(up to 650 Nm/g)among all of metals materials so far we known have received extensive attentions.In this paper,a family of Co-Ta-B-Si BMGs with high glass-transition temperature(above 870 K),large compressive plasticity(up to 6.4%)and high strength(above 5.5 GPa),and high glass-forming ability(the critical diameter,Dc:up to 4 mm)was developed by accurately tuning metalloid element contents of Si and B in the parental alloy of Co_(55)Ta_(10)B_(35).The changes of glass formation and plasticity caused by the adjustment of the constituent metalloid elements were evaluated by the combination of experimental and calculated results.The reason for the significant improvement of plastic deformation is revealed by the analysis of the self-organization behaviors of high-density shear bands. | Yimeng Zhao Xuan Li Xiaobin Liu Jiazi Bi Yang Wu Ruijuan Xiao Ran Li Tao Zhang | 2021 | Journal of Materials Science & Technology2021，，27： | 1 |
| 17 | Trillin, a steroidal saponin isolated from the rhizomes of Dioscorea nipponica , exerts protective effects against hyperlipidemia and oxidative stress显示文摘 | Tiejie Wang Roy C.Y. Choi Jun Li Cathy W.C. Bi Wei Ran Xiaohui Chen Tina T.X. Dong Kaishun Bi Karl W.K. Tsim | 2011 | Journal of Ethnopharmacology2011，，1： | 1 |
| 18 | An Optimal Content Caching Framework for Utility Maximization显示文摘For desirable quality of service, content providers aim at covering content requests by large network caches. Content caching has been considered as a fundamental module in network architecture. There exist few studies on the optimization of content caching. Most existing works focus on the design of content measurement,and the cached content is replaced by a new one based on the given metric. Therefore, the performance for service provision with multiple levels is decreased. This paper investigates the problem of finding optimal timer for each content. According to the given timer, the caching policies determine whether to cache a content and which existing content should be replaced, when a content miss occurs. Aiming to maximize the aggregate utility with capacity constraint, this problem is formalized as an integer optimization problem. A linear programming based approximation algorithm is proposed, and the approximation ratio is proved. Furthermore, the problem of content caching with relaxed constraints is given. A Lagrange multiplier based approximation algorithm with polynomial time complexity is proposed. Experimental results show that the proposed algorithms have better performance. | Ran Bi Yingshu Li Xu Zheng | 2016 | Tsinghua Science and Technology2016，21，4： | 1 |
| 19 | Effect of dispersion and distribution of tungsten on W/HZSM-5 for selective catalytic reduction of NO by acetylene显示文摘在选择催化减小的 W/HZSM-5 的催化性能被乙炔不与 1600 ppm 在一个反应系统调查没有, C 2 H 2, 并且 9.95% O 2 在他。反应上的钨的宣传效果被催化剂准备条件和父母沸石的 Si/Al 比率强烈影响,这被发现。更多的 monomeric 钨种类在 8%W/HZSM-5 上被发现的 HZSM-5 上并且相对的钨的更好的分散与更低的 SiO 2/Al2 在 ammonic 铵钨酸盐答案和在更高的温度(550 ° C ) 的产生材料的锻烧的 O 3 比率(25 ) 。最高,到在反应系统的 86.3% 的 N 2 的变换都没在因此准备的催化剂上在 350 ° C 被获得。改进 C 2 H 2-SCR 能被归因于加速活跃硝酸盐种类的形成。 | Ran Bi Xinping Wang Zhiguang Liu Jing Chen | 2008 | Journal of Natural Gas Chemistry2008，17，4： | 1 |
| 20 | A novel missense variant in ACAA1 contributes to early-onset Alzheimer’s disease,impairs lysosomal function,and facilitates amyloid-p pathology and cognitive decline显示文摘Alzheimer’s disease(AD)is characterized by progressive synaptic dysfunction,neuronal death,and brain atrophy,with amyloid-p(Ap)plaque deposits and hyperphosphorylated tau neurofibrillary tangle accumulation in the brain tissue,which all lead to loss of cognitive function.Pathogenic mutations in the well-known AD causal genes including APP,PSEN1,and PSEN2 impair a variety of pathways,including protein processing,axonal transport,and metabolic homeostasis.Here we identified a missense variant rs117916664(c.896T>C,p.Asn299Ser[p.N299S])of the acetyl-CoA acyltransferase 1(ACM1)gene in a Han Chinese AD family by whole-genome sequencing and validated its association with early-onset familial AD in an independent cohort.Further in vitro and in vivo evidence showed that ACAA1 p.N299S contributes to AD by disturbing its enzymatic activity,impairing lysosomal function,and aggravating the Ap pathology and neuronal loss,which finally caused cognitive impairment in a murine model.Our findings reveal a fundamental role of peroxisome-mediated lysosomal dysfunction in AD pathogenesis. | Rongcan Luo Yu Fan Jing Yang Maosen Ye Deng-Feng Zhang Kun Guo Xiao Li Rui Bi Min Xu Lu-Xiu Yang Yu Li Xiaoqian Ran Hong-Yan Jiang Chen Zhang Liwen Tan Nengyin Sheng Yong-Gang Yao | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
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