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| 1 | High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis显示文摘AIM: To measure plasma D-dimer levels in cirrhotic patients with and without ascites, assessing the effect of ascites resolution in D-dimer concentration. METHODS: Seventy consecutive cirrhotic patients (M = 44, F = 26, mean age 65 years, SD ± 13), observed from October 2005 to March 2006 were enrolled. Circulating D-dimer levels were measured using a latex-enhanced, immunoturbidimetric test. In patients with ascites (n = 42) the test was repeated after ascites resolution. RESULTS: Ascites was present in 42 patients (group A) and absent in 28 (group B). Group A patients had more advanced liver disease. Hepatocellular carcinoma (HCC) was diagnosed in 14 patients and was more frequent in group B. Above normal range D-dimers were found in 45/70 patients. High D-dimers were more frequent in group A than in group B (P = 0.001). High D-dimers were associated with presence of HCC (P = 0.048) only in group B. After ascites resolution, obtained in all patients, mean D-dimer values decreased in those 34 patients with high basal levels (P = 0.007), returning to normal in 17. CONCLUSION: In patients with liver cirrhosis, ascites and HCC are the main factors associated with increased fibrinolytic activity. | Aldo Spadaro Vincenza Tortorella Carmela Morace Agostino Fortiguerra Paola Composto Caterina Bonfiglio Angela Alibrandi Carmelo Luigiano Giuseppe De Caro Antonino Ajello Oscar Ferraù Maria Antonietta Freni | 2008 | World Journal of Gastroenterology2008，14，10： | 19 |
| 2 | Serum chromogranin-A in hepatocellular carcinoma: Diagnostic utility and limits显示文摘AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable.High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC).METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD)as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, nonparametric combination test and confidence interval analysis were used for statistical analysis.RESULTS: Serum CgA above normal values (100 ng/mL)were found in 83% of HCC patients, in 48% of LC patients,in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1 046), in LC (249±369), in CH (87±94), in CRF (1 390±1 401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18).HCC patients had higher CgA values (P<0.01) than LC,CH, and IBD patients but did not differ from those with CRF or CHF. The 95% CI for the mean (250-1 289 ng/mL)in HCC patients was selected as a CgA range and the lower value of such range was assumed as cut-off.Sensitivity and specificity of CgA, calculated in relation to the cut-off in patients with cirrhosis and HCC, were respectively 61% (CI 48-73%) and 82% (CI 75-88%).Serum α-FP values were >200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between α-FP and CgA in patients with HCC and in patients with cirrhosis.CONCLUSION: When HCC is suspected and α-FP is normal or <200 ng/mL, CgA serum values represent a complementary diagnostic tool, unless kidney or heart failure is present. | Aldo Spadaro Antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo Carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato Santi Turiano Oscar Ferraù Maria Antonietta Freni | 2005 | World Journal of Gastroenterology2005，11，13： | 4 |
| 3 | Effects of n -3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease显示文摘 | L. Spadaro O. Magliocco D. Spampinato S. Piro C. Oliveri C. Alagona G. Papa A.M. Rabuazzo F. Purrello | 2007 | Digestive and Liver Disease2007，，3： | 2 |
| 4 | A new method for detection of five alternaria toxins in food matrices based on LC–APCI-MS显示文摘 | Ambra Prelle Davide Spadaro Angelo Garibaldi Maria Lodovica Gullino | 2013 | Food Chemistry (-)2013，，1： | 2 |
| 5 | How to account for CO 2 emissions from biomass in an LCA显示文摘 | Ari Rabl Anthony Benoist Dominique Dron Bruno Peuportier Joseph V. Spadaro Assaad Zoughaib | 2007 | The International Journal of Life Cycle Assessment2007，，5： | 2 |
| 6 | Beyond the joint: Subclinical atherosclerosis in rheumatoid arthritis显示文摘Rheumatoid arthritis is a chronic autoimmune inflammatory disease associated with increased cardiovascular risk and higher mortality in respect to general population.Beyond joint disease,inflammation is the major determinant of accelerated atherosclerosis observed in rheumatoid arthritis.We review the relationship between inflammation,atherosclerosis and cardiovascular risk in rheumatoid arthritis,focusing on the assessment of subclinical atherosclerosis by functional and morphological methods.These tools include flow mediated dilatation,carotid intima-media thickness,ankle/brachial index,coronary calcium content,pulse wave analysis and serum biomarker of subclinical atherosclerosis. | Antongiulio Scarno Fabio Massimo Perrotta Francesca Cardini Alessia Carboni Gianmarco Annibali Ennio Lubrano Antonio Spadaro | 2014 | World Journal of Orthopedics2014，5，3： | 2 |
| 7 | Myopathy in long-term AZT therapy : clinical, electrophysiological and biopsy study in 67 HIV + subjects显示文摘 | Spadaro M Tilia G Massara MC | 1993 | Ital J Neurol Sci1993，14，5： | 1 |
| 8 | Damage costs due to automotive air pollution and the influence of street canyons显示文摘 | Spadaro J V Rabl A | 2001 | Atmospheric Environment2001，35，： | 1 |
| 9 | Hybrid Cu–ZnO–ZrO 2 /H-ZSM5 system for the direct synthesis of DME by CO 2 hydrogenation显示文摘 | G. Bonura M. Cordaro L. Spadaro C. Cannilla F. Arena F. Frusteri | 2013 | Applied Catalysis B: Environmental2013，，： | 1 |
| 10 | H2 production for MC fuel cell by steam reforming of ethanol over MgO supported Pd, Rh, Ni and Co catalysts 显示文摘 | Frusteri F Freni S Spadaro L | 2004 | Catal Com-mun2004，5，： | 1 |
| 11 | AZT-induced mitochondrial myopathy显示文摘 | Tomelleri G Tonin P Spadaro M | 1992 | Ital J Neurol Sci1992，13，9： | 1 |
| 12 | Acute Respiratory Failure Onset in a Patient With Guillain–Barré Syndrome After Legionella-Associated Pneumonia: A Case Report显示文摘 | Simone Vigneri Savino Spadaro Ilaria Farinelli Riccardo Ragazzi Carlo A. Volta Jay G. Capone Elisabetta Sette Valeria Tugnoli | 2014 | Journal of Clinical Neuromuscular Disease2014，，2： | 1 |
| 13 | Soluble CD30 serum levels before and after treatment with alpha-interferon in patients with chronic hepatitis C 显示文摘 | Di Cesare E Spadaro A Ajello A | 2005 | Clin Chem Lab Med2005，43，8： | 1 |
| 14 | Hydroxyl radical mediated degradation of azo ayes: Evidence for benzene generation 显示文摘 | Spadaro J T Isabelle L Renganathan V | 1994 | Environ Sci Technol1994，28，： | 1 |
| 15 | Modes of ac-tion of the antagonist Aureobasidium pullulans PL5a-gainst postharvest pathogens of fruit:Production of hy-drolytic enzymes and competition for nutrients显示文摘 | Zhang D P Spadaro D Garibaldi A | 2010 | Bio-logical Control2010，54，： | 1 |
| 16 | Catalytic etherification of glycerol by tert -butyl alcohol to produce oxygenated additives for diesel fuel显示文摘 | F. Frusteri F. Arena G. Bonura C. Cannilla L. Spadaro O. Di Blasi | 2009 | Applied Catalysis A General2009，，1： | 1 |
| 17 | Moisture content variation in freshly harvested rice associated with kernel thickness 显示文摘 | WADSWORTH J L MATTHEW J SPADARO J J | 1982 | Transactions d the ASAE1982，25，4： | 1 |
| 18 | Occurrence of resistant strains of Botrytis cinerea to anilinopyrimidine fungicides in table grapes in Chile显示文摘 | Latorre B A Spadaro I Rioja M E | 2002 | Crop Protection2002，21，10： | 1 |
| 19 | Occurrence of resistant strains of Botrytis cinerea to anilinopyrimidine fungicides in table grapes in Chile显示文摘 | LATORR B A SPADARO I RIOJA M E | 2002 | Crop Protection2002，21，10： | 1 |
| 20 | State of the art and future prospects of the biological control of postharvest fruit diseases显示文摘 | SPADARO D GULLINO M L | 2004 | International Journal of Food Microbiology2004，91，： | 1 |
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