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您的检索式：作者名="Francesca Luchetti"
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| 1 | Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes显示文摘Fas/CD95 表面受体调停各种各样的房间的快速的死亡打字,包括有为触发 autoimmunity 的潜力的 autoreactive T 房间。这里,我们表明那的船边交货的现在的新奇方面定义一种“社会”的尺寸到导致受体的 apoptosis。船边交货刺激很快导致在附近的 T 房间之间的广泛的膜 nanotube 形成。这极其依赖于 Rho GTPases 然而并非在 caspase 激活上。包括活跃 caspases 的膜和 cytosolic 元素的双向转移能被观察经由这些 nanotubes 发生。Nanotube 形成和死亡信号的细胞间的交换在从有在船边交货受体的自体免疫的 lymphoproliferative 症候群 harbouring 变化的病人的 T 淋巴细胞是有缺点的。我们断定调停 nanotube 的交换组成扩充在附近的 T 房间之间发信号的死亡的繁殖的细胞间的通讯的一种新奇形式。 | Peter D Arkwright Francesca Luchetti Julien Tour Charlotte Roberts Rahna Ayub Ana P Morales Jose J Rodriguez Andrew Gilmore Barbara Canonico Stefano Papa Mauro Degli Esposti | 2010 | Cell Research2010，20，1： | 4 |
| 2 | Melatonin,tunneling nanotubes,mesenchymal cells,and tissue regeneration显示文摘Mesenchymal stem cells are multipotent stem cells that reside in many human tissues and organs.Mesenchymal stem cells are widely used in experimental and clinical regenerative medicine due to their capability to transdifferentiate into various lineages.However,when transplanted,they lose part of their multipotency and immunomodulatory properties,and most of them die after injection into the damaged tissue.In this review,we discuss the potential utility of melatonin in preserving mesenchymal stem cells’survival and function after transplantation.Melatonin is a pleiotropic molecule regulating critical cell functions including apoptosis,endoplasmic reticulum stress,and autophagy.Melatonin is also synthesized in the mitochondria where it reduces oxidative stress,the opening of the mitochondrial permeability transition pore and the downstream caspase activation,activates uncoupling proteins,and curtails the proinflammatory response.In addition,recent findings showed that melatonin also promotes the formation of tunneling nanotubes and the transfer of mitochondria between cells through the connecting tubules.As mitochondrial dysfunction is a primary cause of mesenchymal stem cells death and senescence and a critical issue for survival after transplantation,we propose that melatonin by favoring mitochondria functionality and their transfer through tunneling nanotubes from healthy to suffering cells could improve mesenchymal stem cellbased therapy in a large number of diseases for which basic and clinical trials are underway. | Francesca Luchetti Silvia Carloni Maria G.Nasoni Russel J.Reiter Walter Balduini | 2023 | Neural Regeneration Research2023，18，4： | 0 |
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