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| 1 | Inflammation in irritable bowel syndrome:Myth or newtreatment target?显示文摘Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome(IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications describing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanisms underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism. | Emanuele Sinagra Giancarlo Pompei Giovanni Tomasello Francesco Cappello Gaetano Cristian Morreale Georgios Amvrosiadis Francesca Rossi Attilio Ignazio Lo Monte Aroldo Gabriele Rizzo Dario Raimondo | 2016 | World Journal of Gastroenterology2016，22，7： | 16 |
| 2 | Mortality and Causes of Death in Celiac Disease in a Mediterranean Area显示文摘 | Mario Cottone Anna Termini Lorenzo Oliva Antonino Magliocco Ciro Marrone Ambrogio Orlando Filippo Pinzone Roberto Di Mitri Matteo Rosselli Aroldo Rizzo Luigi Pagliaro | 1999 | Digestive Diseases and Sciences1999，，12： | 1 |
| 3 | Kinetics of vacuum drying of pumpkin: Modeling with shrinkage 显示文摘 | Aroldo A Fernanda E X Murr | 2006 | Journal of Food Engineering2006，76，4： | 1 |
| 4 | Gynogenesis in the vine cacti Hylocereus and Selenicer eus(Cactaceae)显示文摘 | Reinerio Benega Garcia Aroldo Cisneros Bert Schneider Noemi Tel-Zur | 2009 | Plant Cell Rep2009，，28： | 1 |
| 5 | Sesquiterpenoid emmotins from two Poraqueiba species 显示文摘 | Marilia O F Goulart Edson De S Bento Aroldo Trainotti | 1995 | Phytochemistry1995，39，4： | 1 |
| 6 | Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis显示文摘 | Guillaume Fond Anderson Loundou Nora Hamdani Wahid Boukouaci Aroldo Dargel José Oliveira Matthieu Roger Ryad Tamouza Marion Leboyer Laurent Boyer | 2014 | European Archives of Psychiatry and Clinical Neuroscience2014，，8： | 1 |
| 7 | Diagnostic accuracy of sonohysterography,transvaginal sonography,and hysterosalpingography in patients with uterine cavity diseases显示文摘 | Sergio RS Marcos MB Aroldo FC | 2000 | Fertil Steril2000，73，2： | 1 |
| 8 | p63, a p53 Homologue, Is a Selective Nuclear Marker of Myoepithelial Cells of the Human Breast显示文摘 | Mattia Barbareschi Lorenza Pecciarini M. Giulia Cangi Ettore Macrì Aroldo Rizzo Giuseppe Viale Claudio Doglioni | 2001 | The American Journal of Surgical Pathology2001，，8： | 1 |
| 9 | Fractionation of Green Coffee Oil by Molecular Distillation: Modeling and Simulation显示文摘 | Melvin. Aroldo Duran Rubens Maciel Filho Maria Regina Wolf Maciel | 2011 | 材料科学与工程(中英文A版)2011，1，2X： | 0 |
| 10 | Utilization of Synthetic Coarse Aggregate of Calcined Clay in Asphalt Mixtures in the Amazon Region显示文摘 | Nilton de Souza Campelo Arlene Maria Lameo da Silva Campos Aroldo Figueiredo Aragao | 2018 | Journal of Geological Resource and Engineering2018，6，1： | 0 |
| 11 | Could JC virus provoke metastasis in colon cancer?显示文摘AIM: To evaluate the prevalence of John Cunningham virus(JC virus) in a small cohort of patients with colon cancer and to assess its presence in hepatic metastasis.METHODS: Nineteen consecutive patients with histologically diagnosed colon cancer were included in our study, together with ten subjects affected by histologically and serologically diagnosed hepatitis C virus infection. In the patients included in the colon cancer group, JC virus was searched for in the surgical specimen; in the control group, JC virus was searched for in the hepatic biopsy. The difference in the prevalence of JC virus in the hepatic biopsy between the two groups was assessed through the χ2 test.RESULTS: Four out of 19 patients with colon cancer had a positive polymerase chain reaction(PCR) test for JC virus, and four had liver metastasis. Among the patients with liver metastasis, three out of four had a positive PCR test for JC virus in the surgical specimen and in the liver biopsy; the only patient with liver metastasis with a negative test for JC virus also presented a negative test for JC virus in the surgical specimen. In the control group of patients with hepatitis C infection, none of the ten patients presented JC virus infection in the hepatic biopsy. The difference between the two groups regarding JC virus infection was statistically significant(χ2 = 9.55, P = 0.002).CONCLUSION: JC virus may play a broader role than previously thought, and may be mechanistically involved in the late stages of these tumors. | Emanuele Sinagra Dario Raimondo Elena Gallo Mario Stella Mario Cottone Ambrogio Orlando Francesca Rossi Emanuele Orlando Marco Messina Giovanni Tomasello Attilio Ignazio Lo Monte Ennio La Rocca Aroldo Gabriele Rizzo | 2014 | World Journal of Gastroenterology2014，20，42： | 0 |
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