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| 1 | Role of liver transplantation in the management of hepatoblastoma in the pediatric population显示文摘Hepatoblastoma(HB) is the most common primary liver tumor in children and accounts for two-thirds of all malignant liver neoplasms in the pediatric population. For patients with advanced HB(unresectable or unresponsive to chemotherapy), combined treatment with chemotherapy and liver transplantation is an excellent option. The etiology of HB is mostly obscure because of its extreme rarity although some inherited syndromes and very low birth weight have been associated with it. The prognosis for children with HB has significantly improved in the past three decades thanks to advancements in chemotherapy, surgical resection and postoperative care. In 2002 a surgical staging system called pretreatment extent of disease(PRETEXT) was designed to allow a universal, multidisciplinary approach to patients with HB. Between one-third to two-thirds of patients initially present with unresectable tumors or distant metastases, but up to 85% of these tumors become operable after neoadjuvant chemotherapy. Patients with PRETEXT categories 1, 2, and some 3 are referred for neoadjuvant chemotherapy followed by surgical resection with the goal of complete tumor removal. Classic treatments regimens include a combination of cisplatin, fluorouracil, and vincristine or cisplatin and doxorubicin. Liver transplantation is the only treatment option for unresectable HB. In 2010 the pediatric end-stage liver disease, a pediatric-specific scoring system that determines a patient's ranking on the liver transplant list, began to award additional 'exception' points for patients with HB. We analyzed the Standard Transplant Analysis and Research dataset to assess the impact of changes in exception point criteria for HB on outcomes after liver transplantation at Texas Children's Hospital in Houston, Texas. We found that patients who were listed for transplantation with current HB exception criteria experienced a shorter waitlist time but survival was similar between the two eras. | Saira Khaderi Jacfranz Guiteau Ronald T Cotton Christine O'Mahony Abbas Rana John A Goss | 2014 | World Journal of Transplantation2014，4，4： | 23 |
| 2 | Natural history of cytomegalovirus infection in a series of patients diagnosed with moderate-severe ulcerative colitis显示文摘AIM:To evaluate the natural history of human cytomegalovirus(HCMV) infection in a series of 28 ulcerative colitis patients in whom the search for HCMV was positive.METHODS:A series of 85 patients with moderate-severe ulcerative colitis flare-up were evaluated for a HCMV search by performing a haematoxylin and eosin stain,immunohistochemical assay and nested polymerase chain reaction on rectal biopsies.Among 85 screened patients(19 of whom were steroid resistant/dependant),28 were positive for HCMV;after remission the patients were followed up clinically and histologically.RESULTS:Among the 22 patients with complete followup,in 8(36%) patients HCMV-DNA persisted in the intestinal specimens.Among the HCMV positive patients,4(50%) experienced at least one moderate-severe flare-up of colitis without evidence of peripheral HCMV.Among the 14 HCMV negative patients,3 with pouches developed pouchitis and 5 out of 11(45%) experienced a colitis flare-up.CONCLUSION:Our preliminary results suggest that HCMV may remain in the colon after an acute colitis flareup despite remission;it seems that the virus is not responsible for the disease relapse. | Valeria Criscuoli Maria Rosa Rizzuto Luigi Montalbano Elena Gallo Mario Cottone | 2011 | World Journal of Gastroenterology2011，17，5： | 20 |
| 3 | Small intestine bacterial overgrowth and irritable bowel syndrome-related symptoms:Experience with Rifaximin显示文摘AIM:To estimate the prevalence of small intestinal bacterial overgrowth(SIBO) in our geographical area(Western Sicily,Italy) by means of an observational study,and to gather information on the use of locally active,non-absorbable antibiotics for treatment of SIBO.METHODS:Our survey included 115 patients fulfilling the Rome □ criteria for diagnosis of irritable bowel syndrome(IBS);a total of 97 patients accepted to perform a breath test with lactulose(BTLact),and those who had a positive test,received Rifaximin(Normix,Alfa Wassermann) 1200 mg/d for 7 d;3 wk after the end of treatment,the BTLact was repeated.RESULTS:Based on the BTLact results,SIBO was present in about 56% of IBS patients,and it was responsible for some IBS-related symptoms,such as abdominal bloating and discomfort,and diarrhoea.1-wk treatment with Rifaximin turned the BTLact to negative in about 50% of patients and significantly reduced the symptoms,especially in those patients with an alternated constipation/diarrhoea-variant IBS.CONCLUSION:SIBO should be always suspected in patients with IBS,and a differential diagnosis is done by means of a 'breath test'.Rifaximin may represent a valid approach to the treatment of SIBO. | Sergio Peralta Claudia Cottone Tiziana Doveri Piero Luigi Almasio Antonio Craxi | 2009 | World Journal of Gastroenterology2009，15，21： | 19 |
| 4 | Molecular mapping of Verticillium wilt resistance QTL clustered on chromosomes D7 and D9 in upland cotton显示文摘Verticillium wilt is a destructive disease with international consequences for cotton production. Breeding broad-spectrum resistant cultivars is considered to be one of the most effective means for reducing crop losses. A resistant cotton cultivar,60182,was crossed with a susceptible cultivar,Jun-mian 1,to identify markers for Verticillium resistance genes and validate the mode of its inheritance. Genetic segregation analysis for Verticillium wilt resistance was evaluated based upon infected leaf percentage in the seedling stage using major gene-polygene mixed inheritance models and joint analysis of P1,P2,F1,B1,B2 and F2 populations obtained from the cultivar cross. We found that resistance of upland cotton cultivar 60182 to isolates BP2,VD8 and T9,and their isoconcentration mixture was controlled by two major genes with additive-dominance-epistatic effects,and the inheritance of the major gene was dominant. Furthermore,a genetic linkage map was constructed using F2 segregating population and resistance phenotypic data were obtained using F2:3 families inoculated with different isolates and detected in different developmental stages. The genetic linkage map with 139 loci was comprised of 31 linkage groups covering 1165 cM,with an average distance of 8.38 cM between two markers,or 25.89% of the cotton genome length. From 60182,we found 4 QTL on chromosome D7 and 4 QTL on D9 for BP2,5 QTL on D7 and 9 QTL on D9 for VD8,4 QTL on D7 and 5 QTL on D9 for T9 and 3 QTL on D7 and 7 QTL on D7 for mixed pathogens. The QTL mapping results revealed that QTL clusters with high contribution rates were screened simultaneously on chromosomes D9 and D7 by multiple interval mapping (CIM),whether from resistance phenotypic data from different developmental stages or for different isolates. The result is consistent with the genetic model of two major genes in 60182 and suggests broad-spectrum resistance to both defoliating isolates of V. dahliae and nondefoliating isolates. The markers associated with resistance QTL may facilitate the use of Verticillium wilt resistance genes in improving breeding programs for cotton. | JIANG Feng,ZHAO Jun,ZHOU Lei,GUO WangZhen & ZHANG TianZhen National Key Laboratory of Crop Genetics & Germplasm Enhancement,Cotton Research Institute,Nanjing Agricultural University,Nanjing 210095,China | 2009 | Science China(Life Sciences)2009，52，9： | 18 |
| 5 | 一个缓慢移动的中尺度对流复合体内层状降水区的微结构分析显示文摘本文对一个中纬中尺度对流复合体层状降水区的微物理结构,结合雷达、卫星和其他飞机观测资料进行了分析.结果表明,MCC层状区内某些部位盛行冰晶聚合体,它们分布在相当厚的过冷气层内(0.5—-14℃或更冷).冰晶聚并过程足层状区内降水质点增长的主要机制.它起源于较高较冷的气层,在冰晶聚合体下降途中聚并效率渐趋增强,在0℃层附近形成一大的冰晶聚合带. 层状区中云滴液态含水量一般低于0.3g·m^(-3).0℃层以下降水质点数浓度较低,平均为0.8L^(-1)(2D-P资料)和2.3L^(-1)(2D-C资料),相应的平均体积中值直径分别为1.0和0.6mm.在0—-10c气层内,冰质点平均数浓度为27L^(-1)(2D-P资料)和133L^(-1)(2D-C),远人于0℃层以下的雨滴数浓度,相应的平均体积中值直径为0.8和0.4mm.冰质点数浓度随高度向上增加,在飞机垂直探测的顶部(6600m高度)观测到最大数浓度52L^(-1)(2D-P资料)和289L^(-1)(2D-C资料).冰质点大小则相反,是随高度下降而增大的.在0℃层附近冰晶聚合体较大较多,冰质点中15%以上是聚合体,2D-P探头观测的冰质点平均体积中值直径达1.8mm. 滴谱分析表明,负指数律分布能较好地拟合所有观测的降水质点大小谱分布.对水滴,斜率参数λ平均为17(±3.6)cm^(-1),相对变差不超过20%。 | 叶家东 范蓓芬 W.R. Cotton M.A.Fortune | 1992 | 大气科学1992，16，4： | 11 |
| 6 | Metabolic syndrome in hypertensive patients:An unholy alliance显示文摘For many years, it has been recognized that hypertension tends to cluster with various anthropometric and metabolic abnormalities including abdominal obesity, elevated triglycerides, reduced high-density lipoprotein cholesterol, glucose intolerance, insulin resistance and hyperuricemia. This constellation of various conditions has been transformed from a pathophysiological concept to a clinical entity, which has been defined metabolic syndrome(MetS). The consequences of the MetS have been difficult to assess without commonly accepted criteria to diagnose it. For this reason, on 2009 the International Diabetes Federation, the American Heart Association and other scientific organizations proposed a unified MetS definition. The incidence of the MetS has been increasing worldwide in parallel with an increase in overweight and obesity. The epidemic proportion reached by the MetS represents a major public health challenge, because several lines of evidence showed that the MetS, even without type 2 diabetes, confers an increased risk of cardiovascular morbidity and mortality in different populations including also hypertensive patients. It is likely that the enhanced cardiovascular risk associated with MetS in patients with high blood pressure may be largely mediated through an increased prevalence of preclinical cardiovascular and renal changes, such as left ventricular hypertrophy, early carotid atherosclerosis, impaired aortic elasticity, hypertensive retinopathy and microalbuminuria. Indeed, many reports support this notion, showing that hypertensive patients with MetS exhibit, more often than those without it, these early signs of end organ damage, most of which are recognized as significant independent predictors of adverse cardiovascular outcomes. | Giuseppe Mulè IIenia Calcaterra Emilio Nardi Giovanni Cerasola Santina Cottone | 2014 | World Journal of Cardiology2014，6，9： | 10 |
| 7 | Study on DNA Cytosine Methylation of Cotton (Gossypium hirsutum L.) Genome and Its Implication for Salt Tolerance显示文摘To study the relations between DNA methylation and abiotic stress responses in cotton (Gossypium hirsutum L.),the methylation-sensitive amplified polymorphism (MSAP) method was used to investigate the differences in methylation level and the change of cytosine methylation patterns under salt (NaCl) stress in two different salt-tolerant cotton lines.The results showed that the number of the cytosine methylation of CCGG sites in high salt-tolerant cotton line was less than that in low salt-tolerant line.Under salt stress,extensive cytosine methylation alterations including hypermethylation and demethylation as well as the potential conversion of methylation types occurred in the salt-treated cotton line compared with the corresponding control.Interestingly,salt stress-induced demethylation loci that occurred in high salt- tolerant cotton line were greater than those in low salt-tolerant cotton line,however,salt stress-induced hypermethylation loci in the high salt-tolerant cotton line were less than those in low salttolerant cotton line.It suggested that the demethylation positively contributed to salt tolerance and the hypermethylation had negative effect on salt tolerance in cotton. | ZHAO Yun-lei,YU Shu-xun,YE Wu-wei,WANG Hong-mei,WANG Jun-juan and FANG Bao-xing Cotton Research Institute,Chinese Academy of Agricultural Sciences (CAAS)/Key Laboratory of Cotton Genetic Improvement,Ministry of Agriculture,Anyang 455000,P.R.China | 2010 | Agricultural Sciences in China2010，9，6： | 10 |
| 8 | Differential Gene Expression Between Hybrids and Their Parents During the Four Crucial Stages of Cotton Growth and Development显示文摘The study aims to clarify the differential gene expression between cotton hybrids and their parents in order to better understand the molecular basis of cotton heterosis. The research focused on cotton heterotic and lower heterotic hybrids and their parents during the four crucial stages, which were analyzed using a differential display technique. The results indicated that there were both quantitative and qualitative differences in gene expression amongst them. The quantitative differences include over- and under-expression of parental genes and the dominant expression of highly-expressed parental genes in hybrids. In contrast, the qualitative differences are the following: (i) Bands were observed in both parents but not in the F1 hybrid (BPnF1); (ii) bands occurred in either of the parents but not in the F1 hybrid (UPnF1); (iii) bands presented only in the F1 hybrid but not in either of the parents (UF1nP); and (iv) bands were detected in either of the parents and the F1 hybrid (UPF1). Overall, the major differences of gene expression occurred in the qualitative level and four related differential patterns were observed. Furthermore, the amount of differential patterns during the flowering stage was relatively higher than those of other stages. At this juncture, both the amount of hybrid-specific expression patterns at flowering stage and the silenced expression patterns at boll-forming stage in highly heterotic hybrids were found higher than those in the lower heterotic ones. It was concluded that significant differences of gene expression in leaves were present between cotton hybrid and its parents during the whole growing stages. Hence, these differences might be responsible for the observed cotton heterosis. | ZHAO Yun-lei, YU Shu-xun, XING Chao-zhu, FAN Shu-li, SONG Mei-zhen and YE Wu-wei Cotton Research Institute, Chinese Academy of Agricultural Sciences(CAAS)/Key Laboratory of Cotton Genetic Improvement, Ministry of Agriculture, Anyang 455000, P.R.China | 2009 | Agricultural Sciences in China2009，8，2： | 8 |
| 9 | Cytomegalovirus and inflammatory bowel disease: Is there a link?显示文摘这份报告的目的是在煽动性的肠疾病(IBD ) 给 Cytomegalovirus (CMV ) 感染的流行病学、临床、诊断、治疗学的特征的一个全面看法。这个话题上的出版报告的评论被执行,与对在研究和采用的诊断方法包括的病人的选择给予的特别注意。CMV 经常与 IBD 被联系。在一些情况中, CMV 感染与差的结果被联系,但是哪个病人是更可能的被假装,不是清楚的并且在哪个疾病的舞台。在 IBD 的抗病毒的治疗的使用是争论的,有控制的实验研究被需要。与 IBD 的发展和治疗有关的 CMV 感染的自然科学没被澄清,但是因为病毒的坚持的可能性,在免疫在考虑拿它是重要的有免疫系统的损害主人和病毒的相互作用。 | Valeria Criscuoli Maria Rosa Rizzuto Mario Cottone | 2006 | World Journal of Gastroenterology2006，12，30： | 7 |
| 10 | Risk factors for complications after ERCP: a multivariate analysis of 11,497 procedures over 12 years显示文摘 | Peter B. Cotton Donald A. Garrow Joseph Gallagher Joseph Romagnuolo | 2009 | Gastrointestinal Endoscopy2009，，1： | 7 |
| 11 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 12 | Methodology for high-quality studies on course and prognosis of inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs) are characterized by a chronic course with an alternation of relapses and remissions.Questions about prognosis are important for the patient who wants to know how the disease will affect his/her life and also for clinicians to make management decisions.Correct selection of the patients is the basis for good methodological studies on the course of IBD.A great proportion of data on the course of IBD is derived from a limited number of cohort studies.Studies help to define the endpoints for clinical trials and to identify subsets of patients in whom the prognosis of the disease can be stratified according to clinical features.Specific scientific requirements for high-quality studies on prognosis are the following:use of inception cohort,description of referral patterns,completeness of follow-up,objective outcome criteria,blind outcome assessment,adjustment for extraneous prognostic factors and statistical issues.We analyzed each of these requirements in studies on IBDs.To date,prospective and populationbased cohort studies are the standard for an unbiased assessment of prognosis.A better knowledge of the course of disease of chronic disorders ideally requires:(1) data from population-based studies,to avoid selection bias from referral centers in which patients with a more severe disease are usually treated;(2) inclusion of patients seen at the onset of the disease excluding misdiagnosed cases;and(3) follow-up from the onset of the disease to the end without dropouts. | Irene Modesto Giovanni Perricone Ambrogio Orlando Mario Cottone | 2012 | World Journal of Gastroenterology2012，18，29： | 7 |
| 13 | 控制棉铃虫猖獗危害的区域性综合防治关键技术体系的研究显示文摘在跟踪推广应用“六五”以来所形成的综防技术基础上,进一步研究改进关键技术、加强病虫监测预报、组建综防技术体系,在1992、1993年棉铃虫猖獗发生的情况下,于河南省新乡棉花病虫害综防示范区0.67万hm2棉田上实施后,有效控制了棉铃虫危害。这套控制棉铃虫猖獗危害综合防治关键技术主要是:研究改进了棉铃虫中期预报方法;提出“一代监测、二代保顶、三代保蕾、四代保铃”为主的防治策略;制定推广适用于不同世代、不同水肥条件的科学防治指标;协调应用多种配套措施保护、利用自然天敌控害;系统监测和治理害虫抗药性;利用棉花种质资源和品种的抗病虫性;诱杀成虫;组建大面积综防技术体系。 | Cotton Insect Research Group(institute of Plant Protection, Chinese Acadmy of Agricultural Sciences,Beijing 100094) | 1995 | 中国农业科学1995，28，1： | 4 |
| 14 | Gene cloning and molecular breeding to improve fiber qualities in cotton显示文摘Cotton fiber is one of known natural resources comprising the highest purity cellulose. It plays an important role worldwide in the textile industry. With the acceleration of spinning speeds and the improvement of the peoples liv-ing level, the demand of improving cotton fiber qualities is getting stronger and stronger. So, making clear the develop-mental model of fiber cell and elucidating systematically the molecular mechanisms of cotton fiber development and regulation will produce a great significance to make full use of cotton gene resources, raise cotton yield and improve fiber quality, and even develop man-made fiber. In the paper, the status of the gene cloning and the molecular breeding to im-prove cotton fiber quality were reviewed, the importance and potential of gene cloning related with cotton fiber quality were put forward and the proposal and prospect on fiber quality improvement were made. Using national resources available and through the creative exploration in corre-sponding research, some international leading patents in genes or markers linked with cotton fiber development hav-ing Chinese own intellectual property should be licensed quickly. And they can be used to improve cotton fiber quality in cotton breeding practice. | GUO Wangzhen, SUN Jing & ZHANG Tianzhen National Key Laboratory of Crop Genetics & Germplasm Enhancement, Cotton Research Institute, Nanjing Agricultural University, Nanjing 210095, China Correspondence should be addressed to Guo Wangzhen (e-mail: cotton @njan.edu.cn) | 2003 | Chinese Science Bulletin2003，48，8： | 3 |
| 15 | Gastrointestinal lesions associated with spondyloarthropathies显示文摘Subclinical gut inflammation has been described in up to twothirds of patients with spondyloarthropathies(SpA).Arthritis represents an extraintestinal manifestation of several gastrointestinal diseases, including inflammatory bowel disease(IBD), Whipple's disease, Behcet's disease, celiac disease, intestinal bypass surgery, parasitic infections of the gut and pseudomembranous colitis.Moreover about two thirds of nonsteroidal antiinflammatory drug users demonstrate intestinal inflammation.Arthritis may manifest as a peripheral or axial arthritis.The spondyloarthropathy family consists of the following entities:ankylosing spondylitis, undifferentiated spondyloarthritis, reactive arthritis, psoriatic arthritis, spondyloarthritis associated with IBD, juvenile onset spondyloarthritis.This topic reviews the major gastrointestinal manifestations that can occur in patients with SpA and in nonsteroidal anti inflammatory drugs users. | Ambrogio Orlando Sara Renna Giovanni Perricone Mario Cottone | 2009 | World Journal of Gastroenterology2009，15，20： | 3 |
| 16 | Analysis of genomic rearrangement and subsequent gene deletion of the attenuated Orf virus strain D1701显示文摘 | Rosita Cottone Mathias Büttner Berthilde Bauer Marco Henkel Eduard Hettich Hanns-Joachim Rziha | 1998 | Virus Research1998，，1： | 3 |
| 17 | A lexicon for endoscopic adverse events: report of an ASGE workshop显示文摘 | Peter B. Cotton Glenn M. Eisen Lars Aabakken Todd H. Baron Matt M. Hutter Brian C. Jacobson Klaus Mergener Albert Nemcek Bret T. Petersen John L. Petrini Irving M. Pike Linda Rabeneck Joseph Romagnuolo John J. Vargo | 2010 | Gastrointestinal Endoscopy2010，，3： | 3 |
| 18 | 高血压患者颈动脉粥样硬化和脉压及肾血流动力学的关系显示文摘动脉粥样硬化结构性损害、动脉硬化、脉压和肾血流动力学之间可能相互作用与相互影响。肾阻力指数(renal resistance index,RRI)被认为是可预测全身血管变化的一个很好的指标。 | Geraci G MulèG Costanza G Mogavero M Geraci C Cottone S 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，6： | 3 |
| 19 | Percutaneous vertebroplasty for osteolytic metastases and myeloma:effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow-up显示文摘 | Cotton A Dewatre F Cortet B | 1996 | Radiology1996，200，2： | 2 |
| 20 | Is 5-ASA Still the Treatment of Choice for Ulcerative Colitis?显示文摘 | Mario Cottone Sara Renna Irene Modesto Ambrogio Orlando | 2011 | Current Drug Targets2011，，10： | 2 |
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