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| 1 | 选区激光熔化成形颗粒增强铝基复合材料综述显示文摘选区激光熔化(SLM)是一种新兴逐层增材制造技术,能够生成具有三维复杂结构的高性能构件。颗粒增强铝基复合材料(PAMCs)由于结合铝基体和增强相的优异特性在很多领域被认为是一种重要材料。基于SLM和PAMCs的综合优势,新型SLMPAMCs在近年来被陆续开发和研究。因而,本文总结当前有关SLMPAMCs的研究进展。首先,着重分析SLM PAMCs的凝固行为。其次,对高性能SLM PAMCs设计和制造中涉及的重要问题进行全面的讨论,其中包括增强相的选择、工艺参数对成形和微观结构的影响以及缺陷演变和相调控。第三,对SLM PAMCs的性能和增强机制进行系统讨论。最后,对高性能SLM PAMCs未来发展方向提出建设性的观点。 | 王沛 Jürgen ECKERT Konda-gokuldoss PRASHANTH 吴明伟 Ivan KABAN 席丽霞 Sergio SCUDINO | 2020 | Transactions of Nonferrous Metals Society of China2020，30，8： | 29 |
| 2 | 射电频率干扰的消减显示文摘一直以来,射电天文装备不断得到升级和发展,以使其具有更好的观测性能,包括提高数据记录的时间和频率分辨率以及获得更高的接收和记录带宽等.然而与之形成矛盾的是:国际电信联盟(International Telecommunication Union,ITU)仅为射电天文分配了非常有限的频谱资源,导致的后果是射电观测设备不可避免地受到日益增强的非天文信号的影响,后者的来源主要是人类的通信活动和日常生活,这就构成了通常射电天文中所说的射频干扰(Radio Frequency Interference,RFI).射频干扰会降低数据质量甚至导致数据无效,对科学结果的影响越来越严重.对RFI消减的需求进行分析,总结了RFI的特性、抑制和消减的技术和方案,并介绍了一些有代表性的射电望远镜(或阵列)中采用的RFI消减方法;还分析比较了4种常用方案,即预防、预检测、预相关和后相关的优势和不足.对RFI进行准确的识别和标记是减少数据损失从而有效提高数据质量的关键,也是发展RFI消减技术的最终目的.通过研究不难发现,上述4种方案的组合运用将具有更高的实用价值.近几年来,随着高速数字信号处理和高性能计算的迅速发展,依赖大量计算的实时模式下的预检测以及离线模式下从大型望远镜阵列所产生的大规模干涉相关数据中检测RFI已经成为可能. | 安涛 陈骁 MOHAN Prashanth 劳保强 | 2017 | 天文学报2017，58，5： | 9 |
| 3 | Development of polyvinylpyrrolidone/paclitaxel self-assemblies for breast cancer显示文摘The goal of this investigation was to develop and demonstrate a polymer/paclitaxel selfassembly(PTX-SA) formulation. Polymer/PTX-SAs were screened based on smaller size of formulation using dynamic light scattering analysis. Additionally, fluorescence microscopy and flow cytometry studies exhibited that polyvinylpyrrolidone(PVP)-based PTX-SAs(PVP/PTX-SAs) had superior cellular internalization capability in MCF7 and MDA-MB-231 breast cancer cells. The optimized PVP/PTXSAs exhibited less toxicity to human red blood cells indicating a suitable formulation for reducing systemic toxicity. The formation of PVP and PTX self-assemblies was confirmed using fluorescence quenching and transmission electron microscopy which indicated that the PVP/PTX-SAs were spherical in shape with an average size range of 53.81 nm as detected by transmission electron microscopy(TEM).FTIR spectral analysis demonstrates incorporation of polymer and paclitaxel functional groups in PVP/PTX-SAs. Both proliferation(MTS) and clonogenic(colony formation) assays were used to validate superior anticancer activity of PVP/PTX-SAs in breast cancer cells over paclitaxel. Such superior anticancer activity was also demonstrated by downregulation of the expression of pro-survival protein(Bcl-x L), upregulation of apoptosis-associated proteins(Bid, Bax, cleaved caspase 7, and cleaved PARP)and β-tubulin stabilization. These results support the hypothesis that PVP/PTX-SAs improved paclitaxel delivery to cancer cells. | Pallabita Chowdhury Prashanth K.B.Nagesh Sheema Khan Bilal B.Hafeez Subhash C.Chauhan Meena Jaggi Murali M.Yallapu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 7 |
| 4 | Prediction of flyrock distance induced by mine blasting using a novel Harris Hawks optimization-based multi-layer perceptron neural network显示文摘In mining or construction projects,for exploitation of hard rock with high strength properties,blasting is frequently applied to breaking or moving them using high explosive energy.However,use of explosives may lead to the flyrock phenomenon.Flyrock can damage structures or nearby equipment in the surrounding areas and inflict harm to humans,especially workers in the working sites.Thus,prediction of flyrock is of high importance.In this investigation,examination and estimation/forecast of flyrock distance induced by blasting through the application of five artificial intelligent algorithms were carried out.One hundred and fifty-two blasting events in three open-pit granite mines in Johor,Malaysia,were monitored to collect field data.The collected data include blasting parameters and rock mass properties.Site-specific weathering index(WI),geological strength index(GSI) and rock quality designation(RQD)are rock mass properties.Multi-layer perceptron(MLP),random forest(RF),support vector machine(SVM),and hybrid models including Harris Hawks optimization-based MLP(known as HHO-MLP) and whale optimization algorithm-based MLP(known as WOA-MLP) were developed.The performance of various models was assessed through various performance indices,including a10-index,coefficient of determination(R^(2)),root mean squared error(RMSE),mean absolute percentage error(MAPE),variance accounted for(VAF),and root squared error(RSE).The a10-index values for MLP,RF,SVM,HHO-MLP and WOA-MLP are 0.953,0.933,0.937,0.991 and 0.972,respectively.R^(2) of HHO-MLP is 0.998,which achieved the best performance among all five machine learning(ML) models. | Bhatawdekar Ramesh Murlidhar Hoang Nguyen Jamal Rostami XuanNam Bui Danial Jahed Armaghani Prashanth Ragam Edy Tonnizam Mohamad | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，6： | 6 |
| 5 | Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients显示文摘BACKGROUND Liver cirrhosis is the late stage of hepatic fibrosis and is characterized by portal hypertension that can clinically lead to decompensation in the form of ascites,esophageal/gastric varices or encephalopathy.The most common sequelae associated with liver cirrhosis are neurologic and neuropsychiatric impairments labeled as hepatic encephalopathy(HE).Well established triggers for HE include infection,gastrointestinal bleeding,constipation,and medications.Alterations to the gut microbiome is one of the leading ammonia producers in the body,and therefore may make patients more susceptible to HE.AIM To investigate the relationship between the use of proton pump inhibitors(PPIs)and HE in patients with cirrhosis.METHODS This is a single center,retrospective analysis.Patients were included in the study with an admitting diagnosis of HE.The degree of HE was determined from subjective and objective portions of hospital admission notes using the West Haven Criteria.The primary outcome of the study was to evaluate the grade of HE in PPI users versus non-users at admission to the hospital and throughout their hospital course.Secondary outcomes included rate of infection,gastrointestinal bleeding within the last 12 mo,mean ammonia level,and model for end-stage liver disease scores at admission.RESULTS The HE grade at admission using the West Haven Criteria was 2.3 in the PPI group compared to 1.7 in the PPI nonuser group(P=0.001).The average length of hospital stay in PPI group was 8.3 d compared to 6.5 d in PPI nonusers(P=0.046).Twenty-seven(31.8%)patients in the PPI user group required an Intensive Care Unit admission during their hospital course compared to 6 in the PPI nonuser group(16.7%)(P=0.138).Finally,10(11.8%)patients in the PPI group expired during their hospital stay compared to 1 in the PPI nonuser group(2.8%)(P=0.220).CONCLUSION Chronic PPI use in cirrhotic patients is associated with significantly higher average West Haven Criteria for HE compared to patients that do not use PPIs. | Matthew Fasullo Prashanth Rau Dong-Qi Liu Erik Holzwanger Jomol P Mathew Yurima Guilarte-Walker Gyongyi Szabo | 2019 | World Journal of Hepatology2019，11，6： | 4 |
| 6 | Submerged flexible vegetation impact on open channel flow velocity distribution: An analytical modelling study on drag and friction显示文摘In this paper,an analytical model that represents the streamwise velocity distribution for open channel flow with submerged flexible vegetation is studied.In the present vegetated flow modelling,the whole flow field has been separated into two layers vertically: a vegetated layer and a non-vegetated free-water layer.Within the vegetated layer,an analysis of the mechanisms affecting water flow through flexible vegetation has been conducted.In the non-vegetated layer,a modified log-law equation that represents the velocity profile varying with vegetation height has been investigated.Based on the studied analytical model,a sensitivity analysis has been conducted to assess the influences of the drag (CD) and friction (Cf ) coefficients on the flow velocity.The investigated ranges of CD and Cf have also been compared to published values.The findings suggest that the CD and Cf values are non-constant at different depths and vegetation densities,unlike the constant values commonly suggested in literature.This phenomenon is particularly clear for flows with flexible vegetation,which is characterised by large deflection. | Jaan H. Pu Awesar Hussain Ya-kun Guo Nikolaos Vardakastanis Prashanth R. Hanmaiahgari Dennis Lam | 2019 | Water Science and Engineering2019，12，2： | 4 |
| 7 | Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifolia显示文摘Actinorhizal plants contain numerous antioxidants that may play a crucial role in preventing the formation of tumors.H-Ras p21,a member of the Ras-GTPase family,is a promising target to treat various kinds of cancers.An in silico docking study was carried out to identify the inhibitory potential of compounds of these plants against H-Ras by using Discovery Studio 3.5 and by using Autodock 4.2.Docking studies revealed that four compounds,isorhamnetin-7-rhamnoside,quercetin-3-glucoside-7-rhamnoside(present in H.rhamnoides),zeaxanthin,and translutein(present in H.salicifolia) significantly bind with binding energies-17.1534,-14.7936,-10.2105 and-17.2217 Kcal/mol,respectively,even though they slightly deviate from Lipinski's rule.Absorption,distribution,metabolism,excretion and toxicity(ADME/tox) analyses of these compounds and their stereoisomers showed that they were less toxic and non-mutagenic.Amongst them,isorhamntein-7-rhamnoside showed hepatotoxicity.Hence,these compounds can be further investigated in vivo to optimize their formulation and concentration and to develop potential chemical entities for the prevention and treatment of cancers. | Talambedu Usha Sushil Kumar Middha Arvind Kumar Goyal Mahesh Karthik DA Manoj Syed Faizan Peyush Goyal HP Prashanth Veena Pande | 2014 | The Journal of Biomedical Research2014，28，5： | 3 |
| 8 | Counting CD4^(+) and CD8^(+) T cells in the spleen: a novel in vivo method for assessing biomaterial immunotoxicity显示文摘As immunotoxicity assessments of newly developed biomaterials are often restricted to use in assessment of local tissue response at the implantation site,they do not always show an immune response acceptable to qualify them for clinical use.We tested a new method to assess systemic toxicity:counting the CD4^(+) and CD8^(+) cells in the spleen.Three different biomaterials were subcutaneously implanted in three groups of rats for the same time period.After 31 days,their spleens were harvested,and CD4^(+) and CD8^(+) cells were counted.The mean CD4^(+)/CD8^(+) cell counts were 24.563.6/19.864.0(porous collagen matrix group),25.567.1/21.663.8[synthetic collagen matrix(DuragenVR)group]and 28.164.1/19.663.7(porcine dermis group).Differences in cell counts were not significant.The immunotoxic response generated against porous collagen matrix was comparable to that produced by a similar biomaterial already used clinically.This is,to the best of our knowledge,the first study on cytotoxic lymphocytes in the spleen to quantify systemic immune response to a biomaterial;however,such studies have been conducted with bacterial and viral antigens,and with vaccines.We believe that the present study provides a viable method for larger studies to confirm our current findings. | Shyh-Jou Shieh Prashanth Varkey Po-Yang Chen Su-Ya Chang Lynn L.H.Huang | 2014 | Regenerative Biomaterials2014，1，1： | 3 |
| 9 | High frequency oscillatory ventilation versus synchronized intermittent mandatory ventilation in preterm neonates with hyaline membrane disease: A randomized controlled trial显示文摘 | S. Singh G. Malik G. Prashanth Anita Singh Mala Kumar | 2012 | Indian Pediatrics2012，，5： | 3 |
| 10 | A rapid solid-state synthesis of electrochemically active Chevrel phases (Mo6T8; T = S, Se) for rechargeable magnesium batteries显示文摘 | Partha Saha Prashanth H. Jampani Moni K. Datta Daeho Hong Bharat Gattu Prasad Patel Karan S. Kadakia Ayyakkannu Manivannan Prashant N. Kumta | 2017 | Nano Research2017，10，12： | 2 |
| 11 | Chitin/chitosan: modifications and their unlimited application potential—an overview显示文摘 | K.V. Harish Prashanth R.N. Tharanathan | 2006 | Trends in Food Science & Technology2006，，3： | 2 |
| 12 | Mechanistic Aspects of Inflammation and Clinical Management of Inflammation in Acute Gouty Arthritis显示文摘 | Bruce N. Cronstein Prashanth Sunkureddi | 2013 | Journal of Clinical Rheumatology2013，，1： | 2 |
| 13 | In vitro anti- Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action显示文摘 | Mannanthendil Kumaran Asha Debnath Debraj D’souza Prashanth Jothie Richard Edwin H.S. Srikanth Nithyanantham Muruganantham Shekhar Michael Dethe Bhaskar Anirban Balachandran Jaya Mundkinajeddu Deepak Amit Agarwal | 2012 | Journal of Ethnopharmacology2012，，： | 2 |
| 14 | Molecular mapping of quantitative trait loci for plant growth, yield and yield related traits across three diverse locations in a doubled haploid rice population显示文摘 | Shailaja Hittalmani H.E. Shashidhar Prashanth G. Bagali Ning Huang J.S. Sidhu V.P. Singh G.S. Khush | 2002 | Euphytica2002，，2： | 2 |
| 15 | Poly(ADP-ribose) polymerase inhibition reveals a potential mechanism to promote neuroprotection and treat neuropathic pain显示文摘Neuropathic pain is triggered by the lesions to peripheral nerves which alter their structure and function. Neuroprotective approaches that limit the pathological changes and improve the behavioral outcome have been well explained in different experimental models of neuropathy but translation of such strategies to clinics has been disappointing. Experimental evidences revealed the role of free radicals, especially peroxynitrite after the nerve injury. They provoke oxidative DNA damage and consequent over-activation of the poly(ADP-ribose) polymerase(PARP) upregulates pro-inflammatory pathways, causing bioenergetic crisis and neuronal death. Along with these changes, it causes mitochondrial dysfunction leading to neuronal apoptosis. In related preclinical studies agents that neutralize the free radicals and pharmacological inhibitors of PARP have shown benefits in treating experimental neuropathy. This article reviews the involvement of PARP over-activation in trauma induced neuropathy and therapeutic significance of PARP inhibitors in the experimental neuropathy and neuropathic pain. | Prashanth Komirishetty Aparna Areti Ranadeep Gogoi Ramakrishna Sistla Ashutosh Kumar | 2016 | Neural Regeneration Research2016，11，10： | 2 |
| 16 | Liver Planning Software Accurately Predicts Postoperative Liver Volume and Measures Early Regeneration显示文摘 | Amber L. Simpson David A. Geller Alan W. Hemming William R. Jarnagin Logan W. Clements Michael I. D’Angelica Prashanth Dumpuri Mithat G?nen Ivan Zendejas Michael I. Miga James D. Stefansic | 2014 | Journal of the American College of Surgeons2014，，： | 2 |
| 17 | Spectral-Domain covariance estimation with a priori knowledge 显示文摘 | PRASHANTH R G NATHAN A G | 2006 | IEEE Transactions on Aerospace and Electronic system2006，42，3： | 1 |
| 18 | α-Glucosidase i nhibitory activity of Mangifera indica bark显示文摘 | Prashanth D Amit A Samiulla D S | 2001 | Fitoterapia2001，72，6： | 1 |
| 19 | Antioxidative responses mechanisms in halophytes: their role in stress defence 显示文摘 | Jithesh M Prashanth S Sugihara K | 2006 | Journal of Genetics2006，85，3： | 1 |
| 20 | Quorum sensing in streptococcal biofilm formation显示文摘 | Prashanth Suntharalingam Dennis G. Cvitkovitch | 2004 | Trends in Microbiology2004，，1： | 1 |
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