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| 1 | Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifolia显示文摘Actinorhizal plants contain numerous antioxidants that may play a crucial role in preventing the formation of tumors.H-Ras p21,a member of the Ras-GTPase family,is a promising target to treat various kinds of cancers.An in silico docking study was carried out to identify the inhibitory potential of compounds of these plants against H-Ras by using Discovery Studio 3.5 and by using Autodock 4.2.Docking studies revealed that four compounds,isorhamnetin-7-rhamnoside,quercetin-3-glucoside-7-rhamnoside(present in H.rhamnoides),zeaxanthin,and translutein(present in H.salicifolia) significantly bind with binding energies-17.1534,-14.7936,-10.2105 and-17.2217 Kcal/mol,respectively,even though they slightly deviate from Lipinski's rule.Absorption,distribution,metabolism,excretion and toxicity(ADME/tox) analyses of these compounds and their stereoisomers showed that they were less toxic and non-mutagenic.Amongst them,isorhamntein-7-rhamnoside showed hepatotoxicity.Hence,these compounds can be further investigated in vivo to optimize their formulation and concentration and to develop potential chemical entities for the prevention and treatment of cancers. | Talambedu Usha Sushil Kumar Middha Arvind Kumar Goyal Mahesh Karthik DA Manoj Syed Faizan Peyush Goyal HP Prashanth Veena Pande | 2014 | The Journal of Biomedical Research2014，28，5： | 3 |
| 2 | Morphological phylogeny among 15 accessions of bamboos growing in Kokrajhar district of the Bodoland Territorial Area Districts,Assam显示文摘Bamboo is nature's wonderful gift historically associated with the rural population of the Bodoland Territorial Area Districts.However,indiscriminate use of the resource and the ambiguity in the identification of bamboos in the absence of flowering characters pose a potential risk to the bamboo germplasm.Therefore,we considered revising the taxonomic positions and phylogenetic relationships among 15 tropical bamboo species using 35 key morphological descriptors(MD) to assess the reliability of vegetative characters in identifying species.The phylogenetic tree constructed from the similarity matrix,derived from an unweighted pair group method of analysis(UPGMA) of the 35 MDs,marginally deviated from the conventional taxonomic positions of the bamboo species.While the two varieties,one forma of Bambusa vulgaris(var.Vittata,var.Vulgaris,fo.Waminii) and two species of the genus Dendrocalamus(D.giganteus and D.hamiltonii)clustered together in a single clade,and D.strictus was distantly placed from their congeners.This discrepancy with the conventional classification might have ensued since only vegetative characters such as culm anatomy,culm sheath,leaf,and leaf sheath were considered in the present study.While the phylogenetic relationship among the 15 tropical bamboos(computed from exhaustive MDs)grossly corroborate the conventional taxonomic grouping,a molecular-marker-based multidisciplinary approach should resolve the remaining conflicts in bamboo identification. | Anusriti Basumatary Sushil Kumar Middha Talambedu Usha Samik Bhattacharya Birendra Kumar Brahma Arvind Kumar Goyal | 2018 | Journal of Forestry Research2018，29，5： | 0 |
| 3 | Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21st century:A systematic review显示文摘BACKGROUND Diabetic foot ulcer(DFU) is a serious health issue of diabetes mellitus that affects innumerable people worldwide. Management and treatment of this complication are challenging, especially for those whose immune system is weak.AIM To discuss the plants and their parts used to heal DFU, along with the mode of their administration in diabetic patients.METHODS The original articles on “the plants for the treatment of DFU” studied in clinical cases only were obtained from various bibliographic databases using different keywords.RESULTS The search resulted in 22 clinical cases records with 20 medicinal plants belonging to 17 families on 1553 subjects. The fruits and leaves were the most preferentially used parts for DFU treatment, regardless of whether they were being administered orally or applied topically. Of the 20 medicinal plants, 19 reported their effectiveness in increasing angiogenesis, epithelialization, and granulation, thus hastening the wound-healing process. The efficacy of these botanicals might be attributed to their major bioactive compounds, such as actinidin and ascorbic acid(in Actinidia deliciosa), 7-O-(β-D-glucopyranosyl)-galactin(in Ageratina pichinchensis), omega-3-fatty acid(in Linum usitatissimum), isoquercetin(in Melilotus officinalis), anthocyanins(in Myrtus communis), and plantamajoside(in Plantago major).CONCLUSION The validation of mechanisms of action underlying these phytocompounds contributing to the management of DFU can aid in our better understanding of creating efficient treatment options for DFU and its associated problems. | Illora Narzary Amit Swarnakar Mrinal Kalita Sushil Kumar Middha Talambedu Usha Dinesh Babu Banjai Mochahary Sudem Brahma Jangila Basumatary Arvind Kumar Goyal | 2023 | World Journal of Clinical Cases2023，11，17： | 0 |
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