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| 1 | Artificial Intelligence in Steam Cracking Modeling: A Deep Learning Algorithm for Detailed Effluent Prediction显示文摘Chemical processes can bene t tremendously from fast and accurate ef uent composition prediction for plant design, control, and optimization. The Industry 4.0 revolution claims that by introducing machine learning into these elds, substantial economic and environmental gains can be achieved. The bottleneck for high-frequency optimization and process control is often the time necessary to perform the required detailed analyses of, for example, feed and product. To resolve these issues, a framework of four deep learning arti cial neural networks (DL ANNs) has been developed for the largest chemicals production process steam cracking. The proposed methodology allows both a detailed characterization of a naphtha feedstock and a detailed composition of the steam cracker ef uent to be determined, based on a limited number of commercial naphtha indices and rapidly accessible process characteristics. The detailed char- acterization of a naphtha is predicted from three points on the boiling curve and paraf ns, iso-paraf ns, ole ns, naphthenes, and aronatics (PIONA) characterization. If unavailable, the boiling points are also estimated. Even with estimated boiling points, the developed DL ANN outperforms several established methods such as maximization of Shannon entropy and traditional ANNs. For feedstock reconstruction, a mean absolute error (MAE) of 0.3 wt% is achieved on the test set, while the MAE of the ef uent predic- tion is 0.1 wt%. When combining all networks using the output of the previous as input to the next the ef uent MAE increases to 0.19 wt%. In addition to the high accuracy of the networks, a major bene t is the negligible computational cost required to obtain the predictions. On a standard Intel i7 processor, predictions are made in the order of milliseconds. Commercial software such as COILSIM1D performs slightly better in terms of accuracy, but the required central processing unit time per reaction is in the order of seconds. This tremendous speed-up and minimal accuracy loss make the presented framework highly suitable for the continuous monitoring of dif cult-to-access process parameters and for the envi- sioned, high-frequency real-time optimization (RTO) strategy or process control. Nevertheless, the lack of a fundamental basis implies that fundamental understanding is almost completely lost, which is not always well-accepted by the engineering community. In addition, the performance of the developed net- works drops signi cantly for naphthas that are highly dissimilar to those in the training set. | Pieter PPlehiers Steffen HSymoens Ismaël Amghizar Guy B.Marin Christian V.Stevens Kevin M.Van Geem | 2019 | Engineering2019，5，6： | 9 |
| 2 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 3 | New challenges in perioperative management of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma(PDAC)is the fourth leading cause of cancer-related death in the industrialized world.Despite progress in the understanding of the molecular and genetic basis of this disease,the5-year survival rate has remained low and usually does not exceed 5%.Only 20%-25%of patients present with potentially resectable disease and surgery represents the only chance for a cure.After decades of gemcitabine hegemony and limited therapeutic options,more active chemotherapies are emerging in advanced PDAC,like 5-Fluorouracil,folinic acid,irinotecan and oxaliplatin and nab-paclitaxel plus gemcitabine,that have profoundly impacted therapeutic possibilities.PDAC is considered a systemic disease because of the high rate of relapse after curative surgery in patients with resectable disease at diagnosis.Neoadjuvant strategies in resectable,borderline resectable,or locally advanced pancreatic cancer may improve outcomes.Incorporation of tissue biomarker testing and imaging techniques into preoperative strategies should allow clinicians to identify patients who may ultimately achieve curative benefit from surgery.This review summarizes current knowledge of adjuvant and neoadjuvant treatment for PDAC and discusses the rationale for moving from adjuvant to preoperative and perioperative therapeutic strategies in the current era of more active chemotherapies and personalized medicine.We also discuss the integration of good specimen collection,tissue biomarkers,and imaging tools into newly designed preoperative and perioperative strategies. | Francesco Puleo Raphaёl Maréchal Pieter Demetter Maria-Antonietta Bali Annabelle Calomme Jean Closset Jean-Baptiste Bachet Jacques Deviere Jean-Luc Van Laethem | 2015 | World Journal of Gastroenterology2015，21，8： | 4 |
| 4 | Ageing and Brugada syndrome: considerations and recommendations显示文摘Brugada syndrome is an inherited disease associated with an increased risk of lethal ventricular arrhythmias. Such arrhythmias stem from innate disruptions in cardiac electrophysiology. Typically, such arrhythmias occur in the third or fourth decade of life. However, Brugada syndrome may also affect geriatric patients. In this paper, we focus on the ageing patientwithBrugada syndrome, and specifically, on the interaction between Brugada syndrome and the more usually acquired clinical problems that may occur with increasing age, such as the use of cardiovascular and non-cardiovascular drugs, or the need for surgery. Such common conditionsmay also disrupt cardiac electrophysiology, thereby conferring added risk for Brugada syndrome patients. We present some considerations and recommendations that may serve as guidance to address these complexities. | Pieter G. Postema Hanno L Tan Arthur AM Wilde | 2013 | Journal of Geriatric Cardiology2013，10，1： | 2 |
| 5 | Protein kinase G from pathogenic mycobacteria promotes survival within macrophages显示文摘 | Walburger A Koul A Ferrari G Nguyen L PrescianottoBaschong C Huygen K Klebl B Thompson C Bacher G Pieters J | 2004 | Science2004，304，5678： | 1 |
| 6 | Antibacterial and antifungal activities of neocryptolepine, biscryptolepine and cryptoquindoline, alkaloids isolated from Cryptolepis sanguinolenta 显示文摘 | Cimanga K De Bruyne T Pieters L | 1998 | Phytomedicine1998，5，3： | 1 |
| 7 | Role of protein kinase G in growth and glutamine metabolism of Mycobacterium bovis BCG显示文摘 | Nguyen L Walburger A Houben E Koul A Muller S Morbitzer M Klebl B Ferrari G Pieters J | 2005 | J Bacteriol2005，187，16： | 1 |
| 8 | Evaluation of diagnostic PCR for the detection of Listeria monocytogenes in food products显示文摘 | Pieter AG Ilse L | 2005 | Food Technology and Biotechnology2005，43，2： | 1 |
| 9 | Mutation of tyrosine residues involved in the alkylation half reaction of epoxide hydrolase from Agrobacterium radiobacter AD1 results in improved enantioselectivity显示文摘 | Rink R Spelberg J H L Pieters R J | | 0，，32： | 1 |
| 10 | Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization显示文摘 | Lieben Liesbet Masuyama Ritsuko Torrekens Sophie Van Looveren Riet Schrooten Jan Baatsen Pieter Lafage-Proust Marie-Hélène Dresselaers Tom Feng Jian Q Bonewald Lynda F Meyer Mark B Pike J Wesley Bouillon Roger Carmeliet Geert | 2012 | EN2012，，5： | 1 |
| 11 | Valsartan benefits left ventricular structure and function in heart failure: Val-HeFT echocardiographic study显示文摘 | Maylene Wong Lidia Staszewsky Roberto Latini Simona Barlera Alberto Volpi Yann-Tong Chiang Raymond L Benza Sidney O Gottlieb Thomas D Kleemann Franco Rosconi Pieter M Vandervoort Jay N Cohn | 2002 | Journal of the American College of Cardiology2002，，： | 1 |
| 12 | Design of a ten-way conical transmission line power combiner显示文摘 | DIRK I L PIETER W PETRIE M | 2007 | IEEE Trans Microw Theory Tech2007，55，2： | 1 |
| 13 | Infrared spectroscopic analyses on the nature of water in montmorillonite显示文摘 | BISHOP J L PIETERS C M EDWARDS J O | 1994 | Clays Clay Miner1994，42，： | 1 |
| 14 | Synchronous primary neoplasms detected on 18F-FDG PET in staging of patients with esophageal cancer 显示文摘 | Henderik L van Westreenen Marinke Westerterp Pieter L Jager | 2005 | J Nucl Med2005，46，： | 1 |
| 15 | Infrared spectroscopic analyses on the nature of water in montmorillonite显示文摘 | BISHOP L L PIETER C M EDWARDS J O | | Clays and Clay Minerals0，42，： | 1 |
| 16 | Staging of carcinoid tumours with 18 F-DOPA PET: a prospective, diagnostic accuracy study显示文摘 | Klaas P Koopmans Elisabeth GE de Vries Ido P Kema Philip H Elsinga Oliver C Neels Wim J Sluiter Anouk NA van der Horst-Schrivers Pieter L Jager | 2006 | Lancet Oncology2006，，9： | 1 |
| 17 | Bacterial contamination of femoral head allografts from living donors显示文摘 | Stephan B W Vehmeyer Arnoud R M Slooff Rolf M Bloem Pieter L C Petit | 2002 | Acta Orthopaedica2002，，： | 1 |
| 18 | lne opucal properties of the finest fraction of lunar soil: Implications for space weathering 显示文摘 | Noble S K Pieters C M Taylor L A el al | 2001 | Meteoritics & Planetary Science2001，36，： | 1 |
| 19 | Mineralogical and chemical characterization of lunar highland soils: Insights irto the space weathering of soils on airless bodies显示文摘 | Taylor L A Pieters C Patchen A | 2010 | Journal of Geophysical Research2010，115，02： | 1 |
| 20 | Placental DNA hy- pomethylation in association with particulate air pollution in early life显示文摘 | Janssen BG Godderis L Pieters N | 2013 | Part Fibre Toxicol2013，10，1： | 1 |
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