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| 1 | Comparison of four proton pump inhibitors for the short-term treatment of esophagitis in elderly patients显示文摘AIM: To compare efficacy and tolerability of four proton pump inhibitors (PPIs) commonly used in the short-term therapy of esophagitis in elderly patients.METHODS: A total of 320 patients over 65 years with endoscopically diagnosed esophagitis were randomly assigned to one of the following treatments for 8 wk: (1) omeprazole 20 mg/d; (2) lansoprazole 30 mg/d; (3) pantoprazole 40 mg/d, or (4) rabeprazole 20 mg/d. Major symptoms, compliance, and adverse events were recorded. After 8 wk, endoscopy and clinical evaluation were repeated.RESULTS: Per protocol and intention to treat healing rates of esophagitis were: omeprazole = 81.0% and 75.0%, lansoprazole = 90.7% (P = 0.143 vs omeprazole) and 85.0%, pantoprazole = 93.5% (P = 0.04 vs omeprazole) and 90.0% (P = 0.02 vs omeprazole), rabeprazole = 94.6% (P = 0.02 vs omeprazole) and 88.8% (P = 0.04 vs omeprazole). Dividing patients according to the grades of esophagitis, omeprazole was significantly less effective than the three other PPIs in healing grade 1 esophagitis (healing rates: 81.8% vs 100%, 100% and 100%, respectively, P = 0.012). Pantoprazole and rabeprazole (100%) were more effective vs omeprazole (89.6%, P = 0.0001)and lansoprazole (82.4%, P = 0.0001) in decreasing heartburn. Pantoprazole and rabeprazole (92.2% and 90.1%, respectively) were also more effective vs lansoprazole (75.0%, P < 0.05) in decreasing acid regurgitation. Finally, pantoprazole and rabeprazole (95.2% and 100%) were also more effective vs lansoprazole (82.6%, P < 0.05) in decreasing epigastric pain.CONCLUSION: In elderly patients, pantoprazole and rabeprazole were significantly more effective than omeprazole in healing esophagitis and than omeprazole or lansoprazole in improving symptoms. H pylori infection did not influence the healing rates of esophagitis after a short-term treatment with PPI. | Alberto Pilotto Marilisa Franceschi Gioacchino Leandro Carlo Scarcelli Luigi Piero D'Ambrosio Francesco Paris Vito Annese Davide Seripa Angelo Andriulli Francesco Di Mario | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 2 | Concomitant, sequential, and hybrid therapy for H. pylori eradication: a pilot study.显示文摘 | Angelo Zullo Giuseppe Scaccianoce Vincenzo De Francesco Valentina Ruggiero Pasquale D’Ambrosio Luigi Castorini Leonilde Bonfrate Lucy Vannella Cesare Hassan Piero Portincasa | 2013 | Clinics and Research in Hepatology and Gastroenterology2013，，： | 4 |
| 3 | Immunology and immunotherapy of colorectal cancer显示文摘 | Piero D Cristina M Chiara C | 2003 | Crit Rev Oncol/Hematol2003，46，1： | 2 |
| 4 | Granulo-monocyto apheresis is more effective in mild ulcerative colitis than in moderate to severe disease显示文摘AIM:To evaluate whether the effectiveness of Granulomonocyto apheresis(GMA),a technique that consists of the extracorporeal removal of granulocytes and monocytes from the peripheral blood,might vary according to the severity of ulcerative colitis(UC)in patients with mild to moderate-severe disease UC activity.METHODS:We retrospectively reviewed prospectively collected data of patients undergoing GMA at our inflammatory bowel disease centre who had at least a 6 mo of follow-up.The demographics,clinical and laboratory data were extracted from the patients’charts and electronic records.The severity of UC was scored according to the Modified Truelove Witts Severity Index(MTWSI).A clinical response was defined as a decrease from baseline of≥2 points or a value of MTWSI≤2 points.RESULTS:A total of 41(24 males/17 females;meanage 47 years)patients were included in the study.After GMA cycle completion,21/28(75%)of mild UC patients showed a clinical response compared with 7/13(54%)of patients with moderate to severe disease(P=0.27).At 6-mo,14/28(50%)of the mild UC patients maintained a clinical response compared with 2/13(15%)of the patients with moderate to severe disease(P=0.04).After the GMA cycle completion and during the 6-mo follow up period,13/16(81%)and 9/16(56%)of mild UC patients with intolerance,resistance and contraindications to immunosuppressants and/or biologics showed a clinical response compared with 2/6(33%)and 0/6(0%)of patients with moderate to severe disease activity with these characteristics(P=0.05and P=0.04,respectively).CONCLUSION:Patients with mild UC benefit from GMA more than patients with moderate to severe disease in the short-term period.GMA should be considered a valid therapeutic option in cases of contraindications to immunosuppressants,corticosteroids and/or biologics. | Chiara De Cassan Edoardo Savarino Piero Marson Tiziana Tison Giorgia Hatem Giacomo Carlo Sturniolo Renata D'Incà | 2014 | World Journal of Gastroenterology2014，20，45： | 2 |
| 5 | New developments in the study of ancient pottery by colour measurement 显示文摘 | Piero M Patrizia D | 2004 | Archaeol Sci2004，，31： | 1 |
| 6 | Missing OH reactivity in a forest : evidence for unknown reactive biogenic VOCs 显示文摘 | Piero D C William H B Monica M | 2004 | Science2004，304，5671： | 1 |
| 7 | Failure of aldosterone suppression despite angiotensin-converting enzyme (ACE) inhibitor administration in chronic heart failure is associated with ACE DD genotype显示文摘 | Mariantonietta Cicoira Luisa Zanolla Andrea Rossi Giorgio Golia Lorenzo Franceschini Giulio Cabrini Alberto Bonizzato Maristella Graziani Stefan D Anker Andrew J.S Coats Piero Zardini | 2001 | Journal of the American College of Cardiology2001，，7： | 1 |
| 8 | Structural characterization of N-containing activated carbon fibers prepared from a low softening point petroleum pitch and a melamine resin显示文摘 | Piero E R Amors D C Solano A L | 2002 | Carbon2002，40，4： | 1 |
| 9 | Leukocytapheresis in the treatment of inflammatory bowel disease: Current position and perspectives显示文摘 | Piero Vernia Valeria D’Ovidio Donatella Meo | 2010 | Transfusion and Apheresis Science2010，，2： | 1 |
| 10 | Treatment of human papillomavirus infection with interferon alpha and ribavirin in a patient with acquired aplastic anemia显示文摘 | Clara Mosa Antonino Trizzino Angela Trizzino Floriana Di Marco Paolo D’Angelo Piero Farruggia | 2014 | International Journal of Infectious Diseases2014，，： | 1 |
| 11 | New evidence regarding hormone replacement therapies is urgently required显示文摘 | Maria Grazia Modena Piero Sismondi Alfred O. Mueck Frédérique Kuttenn Bruno de Lignières Johan Verhaeghe Jean Michel Foidart Anne Caufriez Andrea Riccardo Genazzani | 2005 | Maturitas2005，，1： | 1 |
| 12 | Pancreatic islets from type 2 diabetes patients have functional defects and increased apoptosis that are ameliorated by metformin显示文摘 | PIERO MARCHETTI SILVIA D G LORELLA M etal | 2004 | J Clin Endocrinol2004，89，： | 1 |
| 13 | Red wine polyphenols influence carcinogenesis,intestinal microflora,oxidative damage and gene expression profiles of colonic mucosa显示文摘 | Piero D Cristina L Cadotta D F | 2005 | Mutation research2005，591，： | 1 |
| 14 | Azetidine derivatives of tricyclic antidepressant agents 显示文摘 | Piero M Arturo D T Maurizio M | 1979 | Journal of Medicinal Chemistry1979，22，2： | 1 |
| 15 | Influence of Low-frequency Wind Speed Fluctuations on the Aeroelastic Stability of Suspension Bridges显示文摘 | Vincenzo S Piero D A | 2003 | Journal of Wind Engineering and Industrial Aerodynamics2003，91，10： | 1 |
| 16 | Atmospheric aerosol characterization by ion beam analysis technique: Recent improvements at the Van de Oraaff laboratory in Florence显示文摘 | MASSIMO C PIERO D C FRANCO L | 2004 | Nuclear Instruments and Methods in Physics Research2004，，： | 1 |
| 17 | Azetidine derivatives of tricyclic antidepressant agents显示文摘 | Piero M Arturo D T Maurizio M | 1979 | Journal of Medicinal Chemistry1979，22，2： | 1 |
| 18 | Predictive factors of clinical response in steroid-refractory ulcerative colitis treated with granulocyte-monocyte apheresis显示文摘AIM:To identify factors predicting the clinical response of ulcerative colitis patients to granulocyte-monocyte apheresis (GMA). METHODS:Sixty-nine ulcerative colitis patients (39 F,30 M) dependent upon/refractory to steroids were treated with GMA. Steroid dependency,clinical activity index (CAI),C reactive protein (CRP) level,erythrocyte sedimentation rate (ESR),values at baseline,use of immunosuppressant,duration of disease,and age and extent of disease were considered for statistical analysis as predictive factors of clinical response. Univariate and multivariate logistic regression models were used. RESULTS:In the univariate analysis,CAI (P = 0.039) and ESR (P = 0.017) levels at baseline were singled out as predictive of clinical remission. In the multivariate analysis steroid dependency [Odds ratio (OR) = 0.390,95% Confidence interval (CI):0.176-0.865,Wald 5.361,P = 0.0160] and low CAI levels at baseline (4 < CAI <7) (OR = 0.770,95% CI:0.425-1.394,Wald 3.747,P = 0.028) proved to be effective as factors predicting clinical response. CONCLUSION:GMA may be a valid therapeutic option for steroid-dependent ulcerative colitis patients with mild-moderate disease and its clinical efficacy seems to persist for 12 mo. | Valeria D'Ovidio Donatella Meo Angelo Viscido Giampaolo Bresci Piero Vernia Renzo Caprilli | 2011 | World Journal of Gastroenterology2011，17，14： | 1 |
| 19 | Structural characterization of N-containing activated carbon fibers prepared from a low softening point petroleum pitch and a melamine resin 显示文摘 | Piero E R Amors D C Solano A L etal | 2002 | Carbon2002，40，4： | 1 |
| 20 | Exogenous Hydrogen Sulfide Inhibits Superoxide Formation, NOX-1 Expression and Rac1 Activity in Human Vascular Smooth Muscle Cells显示文摘 | Muzaffar Saima Shukla Nilima Bond Mark Newby Andrew C Angelini Gianni D Sparatore Anna Del Soldato Piero Jeremy Jamie Y | 2008 | Journal of Vascular Research2008，，6： | 1 |
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