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| 1 | Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is today considered the most common form of chronic liver disease, affecting a high proportion of the population worldwide. NAFLD encompasses a large spectrum of liver damage, ranging from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. Obesity, hyperglycemia, type 2 diabetes and hypertriglyceridemia are the most important risk factors. The pathogenesis of NAFLD and its progression to fibrosis and chronic liver disease is still unknown. Accumulating evidence indicates that mitochondrial dysfunction plays a key role in the physiopathology of NAFLD, although the mechanisms underlying this dysfunction are still unclear. Oxidative stress is considered an important factor in producing lethal hepatocyte injury associated with NAFLD. Mitochondrial respiratory chain is the main subcellular source of reactive oxygen species(ROS), which may damage mitochondrial proteins, lipids and mitochondrial DNA. Cardiolipin, a phospholipid located at the level of the inner mitochondrial membrane, plays an important role in several reactions and processes involved in mitochondrial bioenergetics as well as in mitochondrial dependent steps of apoptosis. This phospholipid is particularly susceptible to ROS attack. Cardiolipin peroxidation has been associated with mitochondrial dysfunction in multiple tissues in several physiopathological conditions, including NAFLD. In this review, we focus on the potential roles played by oxidative stress and cardiolipin alterations in mitochondrial dysfunction associated with NAFLD. | Giuseppe Paradies Valeria Paradies Francesca M Ruggiero Giuseppe Petrosillo | 2014 | World Journal of Gastroenterology2014，20，39： | 50 |
| 2 | Use of probiotics in the fight against Helicobacter pylori显示文摘After the discovery of Helicobacter pylori(H. pylori), and the evidence of its relationship with gastric diseas-es, antibiotic-based therapies were developed, which efficacy was however limited by antibiotic resistance and lack of patient compliance. A vaccine would over-come these drawbacks, but currently there is not any H. pylori vaccine licensed. In the frame of the studies aimed at finding alternative therapies or at increasing the efficacy of the current ones and/or reducing their side effects, the investigation on the use of probiotics plays an interesting role. In vitro and preclinical stud-ies have shown the feasibility of this approach. Several clinical trials indicated that administration of probiot-ics can reduce the side effects of H. pylori eradication treatment, increasing tolerability, and often increases the overall efficacy. The results of these trials vary, likely reflecting the variety of probiotics assessed and that of the eradication treatment, as well as the differ-ences in the geographic area that imply different H. py-lori strains distribution, host susceptibility, and therapy efficacy. In conclusion, the use of probiotics appears promising as an adjuvant for the current H. pylori erad-ication treatment, though it still requires optimization. | Paolo Ruggiero | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 8 |
| 3 | Management of cholelithiasis in Italian children:A national multicenter study显示文摘AIM:To evaluate the management of Italian children with cholelithiasis observed at Pediatric and Surgical Departments linked to Italian Society of Pediatric Gastroenterology Hepatology and Nutrition. METHODS: One-hundred-eighty children (90 males, median age at diagnosis 7.3 years; range, 0-18 years) with echographic evidence of cholelithiasis were enrolled in the study; the data were collected by an anonymous questionnaire sent to participating centers. RESULTS: One hundred seventeen patients were treated with ursodeoxycholic acid; in 8 children dissolution of gallstones was observed, but the cholelithiasis recurred in 3 of them. Sixty-five percent of symptomatic children treated became asymptomatic. Sixty-four patients were treated with cholecystectomy and in only 2 cases a postoperative complication was reported. Thirty- four children received no treatment and were followed with clinical and echographic controls; in no case thedevelopment of complications was reported. CONCLUSION: The therapeutic strategies were extremely heterogeneous. Ursodeoxycholic acid was ineffective in dissolution of gallstones but it had a positive effect on the symptoms. Laparoscopic cholecystectomy was confirmed to be an efficacy and safe treatment for pediatric gallstones. | Claudia Della Corte Diego Falchetti Gabriella Nebbia Marisa Calacoci Maria Pastore Ruggiero Francavilla Matilde Marcellini Pietro Vajro Raffaele Iorio | 2008 | World Journal of Gastroenterology2008，14，9： | 6 |
| 4 | Red wine and green tea reduce H pylori- or VacA-induced gastritis in a mouse model显示文摘AIM: To investigate whether red wine and green tea could exert anti-H pylori or anti-VacA activity in vivo in a mouse model of experimental infection.METHODS: Ethanol-free red wine and green tea concentrates were administered orally as a mixture of the two beverages to H pylori infected mice, or separately to VacA-treated mice. Gastric colonization and gastric in? ammation were quantifi ed by microbiological, histopathological, and immunohistochemical analyses. RESULTS: In H pylori -infected mice, the red wine and green tea mixture significantly prevented gastritis and limited the localization of bacteria and VacA to the surface of the gastric epithelium. Similarly, both beverages significantly prevented gastric epithelium damage in VacA-treated mice; green tea, but not red wine, also altered the VacA localization in the gastric epithelium. CONCLUSION: Red wine and green tea are able to prevent H pylori -induced gastric epithelium damage, possibly involving VacA inhibition. This observation supports the possible relevance of diet on the pathological outcome of H pylori infection. | Paolo Ruggiero Giacomo Rossi Francesco Tombola Laura Pancotto Laura Lauretti Giuseppe Del Giudice Mario Zoratti | 2007 | World Journal of Gastroenterology2007，13，3： | 6 |
| 5 | 国外铁路安全风险管理方法及启示显示文摘通过阐述风险管理的概念、所涉及的关键步骤和方法,以及在很多海外铁路机构中风险管理已成为标准做法的原因,运用实践中的具体案例说明如何进行风险管理,探讨如何将风险管理方法应用到中国铁路建设和运营中。 | Claire Ruggiero 徐为 | 2012 | 中国铁路2012，，4： | 5 |
| 6 | Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity显示文摘 | Luigi E. Adinolfi Michele Gambardella Augusto Andreana Marie-fran?oise Tripodi Riccardo Utili Giuseppe Ruggiero | 2001 | Hepatology2001，，6： | 4 |
| 7 | Concomitant, sequential, and hybrid therapy for H. pylori eradication: a pilot study.显示文摘 | Angelo Zullo Giuseppe Scaccianoce Vincenzo De Francesco Valentina Ruggiero Pasquale D’Ambrosio Luigi Castorini Leonilde Bonfrate Lucy Vannella Cesare Hassan Piero Portincasa | 2013 | Clinics and Research in Hepatology and Gastroenterology2013，，： | 4 |
| 8 | Helicobacter pylori infection and atopic diseases:Is there a relationship? A systematic review and meta-analysis显示文摘AIM:To review and conduct a meta-analysis of the existing literature on the relationship between Helicobacter pylori(H.pylori),atopy and allergic diseases.METHODS:Studies published in English assessing the prevalence of atopy and/or allergic diseases in patients with H.pylori infection and the prevalence of H.pylori infection in patients with atopy and/or allergic diseases were identified through a MEDLINE search(1950-2014).Random-effect model was used for the meta-analysis.RESULTS:Pooled results of case-control studies showed a significant inverse association of H.pylori infection with atopy/allergic disease or with exclusively atopy,but not with allergic disease,whereas pooled results of cross-sectional studies showed only a significant association between allergic disease and H.pylori infection.CONCLUSION:There is some evidence of an inverse association between atopy/allergic diseases and H.pylori infection,although further studied are needed. | Elena Lionetti Salvatore Leonardi Angela Lanzafame Maria Teresa Garozzo Martina Filippelli Stefania Tomarchio Viviana Ferrara Carmelo Salpietro Alfredo Pulvirenti Ruggiero Francavilla Carlo Catassi | 2014 | World Journal of Gastroenterology2014，20，46： | 3 |
| 9 | Chronic HCV infection is a risk of atherosclerosis. Role of HCV and HCV-related steatosis显示文摘 | Luigi E. Adinolfi Luciano Restivo Rosa Zampino Barbara Guerrera Amedeo Lonardo Laura Ruggiero Francesco Riello Paola Loria Anna Florio | 2012 | Atherosclerosis2012，，2： | 3 |
| 10 | Helicobacter Pylori and Inflammation显示文摘 | Paolo Ruggiero | 2010 | Current Pharmaceutical Design2010，，38： | 3 |
| 11 | Chronic HCV infection is a risk of atherosclerosis. Role of HCV and HCV-related steatosis显示文摘 | Luigi E. Adinolfi Luciano Restivo Rosa Zampino Barbara Guerrera Amedeo Lonardo Laura Ruggiero Francesco Riello Paola Loria Anna Florio | 2012 | Atherosclerosis2012，，2： | 2 |
| 12 | Graphene-loaded metal wire grating for deep and broadband THz modulation in total internal reflection geometry显示文摘We employed a metallic wire grating loaded with graphene and operating in total internal reflection (TIR) geometry to realize deep and broadband THz modulation. The non-resonant field enhancement effect of the evanescent wave in TIR geometry and in the subwavelength wire grating was combined to demonstrate a ~77% modulation depth (MD) in the frequency range of 0.2–1.4 THz. This MD, achieved electrically with a SiO_2∕Si gated graphene device, was 4.5 times higher than that of the device without a metal grating in transmission geometry. By optimizing the parameters of the metallic wire grating, the required sheet conductivity of graphene for deep modulation was lowered to 0.87 mS. This work has potential applications in THz communication and real-time THz imaging. | YIWEN SUN RICCARDO DEGLJINNOCENTI DAVID A.RITCHIE HARVEY E.BEERE LONG XIAO MICHAEL RUGGIERO J.AXEL ZEITLER RAYKO I.STANTCHEV DANNI CHEN ZHENGCHUN PENG EMMA MACPHERSON XUDONG LIU | 2018 | Photonics Research2018，6，12： | 2 |
| 13 | Interplay between oxidative stress and hepatic steatosis in the progression of chronic hepatitis C显示文摘 | Matteo Vidali Marie-Francoise Tripodi Alesandra Ivaldi Rosa Zampino Giuseppa Occhino Luciano Restivo Salvatore Sutti Aldo Marrone Giuseppe Ruggiero Emanuele Albano Luigi E. Adinolfi | 2007 | Journal of Hepatology2007，，3： | 2 |
| 14 | Role of rumination in the relationship between metacognition and shyness显示文摘AIM To explore the association between metacognitive beliefs, rumination and shyness in a non-clinical sample of adults. METHODS One hundred and three healthy subjects from the general population were enrolled in the study. Shyness was evaluated using the Revised Cheek and Buss Shyness Scale, rumination was assessed using the Ruminative Response Scale, metacognition was evaluated using the MetaCognitions Questionnaire 30, and anxiety levels were measured using the State Trait Anxiety Inventory form Y. Correlation analyses, mediation models and 95% bias-corrected and accelerated(BCaCI) bootstrapped analyses were performed. Mediation analyses were adjusted for sex and anxiety. RESULTS Shyness, rumination and metacognition were significantly correlated(P < 0.05). The relationship between metacognition and shyness was fully mediated by rumination(Indirect effect: 0.20; 95% BCaCI: 0.08-0.33).CONCLUSION These findings suggest an association between metacognition and shyness. Rumination mediated the relationship between metacognition and shyness, suggesting that rumination could be a cognitive strategy for shy people. Future research should explore the relationship between these constructs in more depth. | Sara Palmieri Giovanni Mansueto Simona Scaini Francesca Fiore Sandra Sassaroli Giovanni M Ruggiero Rosita Borlimi Bernardo J Carducci | 2018 | World Journal of Psychiatry2018，8，4： | 2 |
| 15 | Uric acid and inflammatory markers显示文摘 | Ruggiero C Cherubini A Ble A | 2006 | Eur Heart J2006，27，11： | 1 |
| 16 | Premonitory symptoms in migraine : an electronic diary study显示文摘 | Giffin NJ Ruggiero L Lipton RB | 2003 | Neu- rology2003，60，： | 1 |
| 17 | American Association of Oral and Maxillofacial Surgeons position paper:Bisphosphonate-Related Osteonecrosis of the jaws--2009 update:the need to refine the BRONJ definition显示文摘 | Ruggiero SL Dodson TB Assael LA | | 0，，12： | 1 |
| 18 | Compensation differences between male and female CEOs for publicly traded firms: a nonparametric analysis 显示文摘 | Mohan N Ruggiero J | 2003 | Journal of the Operational Research Society2003，54，： | 1 |
| 19 | Psychometric properties of the PTSD Checklist-Civilian version显示文摘 | Ruggiero KJ Del Ben K Scotti JR | 2003 | J Trauma Stress2003，16，5： | 1 |
| 20 | The Weighted Russell of Technical Efficiency 显示文摘 | Ruggiero J Bretschneider S | 1998 | European Journal of Operational Research1998，，108： | 1 |
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