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| 1 | Pediatric gastrointestinal bleeding: Perspectives from the Italian Society of Pediatric Gastroenterology显示文摘There are many causes of gastrointestinal bleeding(GIB) in children, and this condition is not rare, having a reported incidence of 6.4%. Causes vary with age, but show considerable overlap; moreover, while many of the causes in the pediatric population are similar to those in adults, some lesions are unique to children. The diagnostic approach for pediatric GIB includes definition of the etiology, localization of the bleeding site and determination of the severity of bleeding; timely and accurate diagnosis is necessary to reduce morbidity and mortality. To assist medical care providers in the evaluation and management of children with GIB, the 'Gastro-Ped Bleed Team' of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition(SIGENP) carried out a systematic search on MEDLINE via Pub Med(http://gffzz16a62c593b5540cehb0popbff6v6v6pf9.ffgz.tsg.suse.edu.cn/pubmed/) to identify all articles published in English from January 1990 to 2016; the following key words were used to conduct the electronic search: 'upper GIB' and 'pediatric' [all fields]; 'lower GIB' and 'pediatric' [all fields]; 'obscure GIB' and 'pediatric' [all fields]; 'GIB' and 'endoscopy' [all fields]; 'GIB' and 'therapy' [all fields]. The identified publications included articles describing randomized controlled trials, reviews, case reports, cohort studies, casecontrol studies and observational studies. References from the pertinent articles were also reviewed. This paper expresses a position statement of SIGENP that can have an immediate impact on clinical practice and for which sufficient evidence is not available in literature. The experts participating in this effort were selected according to their expertise and professional qualifications. | Claudio Romano Salvatore Oliva Stefano Martellossi Erasmo Miele Serena Arrigo Maria Giovanna Graziani Sabrina Cardile Federica Gaiani Gian Luigi de'Angelis Filippo Torroni | 2017 | World Journal of Gastroenterology2017，23，8： | 12 |
| 2 | Comorbidity, Hospitalization, and Mortality in COPD: Results from a Longitudinal Study显示文摘 | Claudio Terzano Vittoria Conti Fabio Di Stefano Angelo Petroianni Daniela Ceccarelli Elda Graziani Salvatore Mariotta Alberto Ricci Antonio Vitarelli Giovanni Puglisi Corrado De Vito Paolo Villari Luigi Allegra | 2010 | Lung2010，，4： | 2 |
| 3 | Ionized jet deposition of antimicrobial and stem cell friendly silver-substituted tricalcium phosphate nanocoatings on titanium alloy显示文摘Orthopedic infections pose severe societal and economic burden and interfere with the capability of the implanted devices to integrate in the host bone,thus significantly increasing implants failure rate.To address infection and promote integration,here nanostructured antibacterial and bioactive thin films are proposed,obtained,for the first time,by Ionized Jet Deposition(IJD)of silver-substituted tricalcium phosphate(Ag-TCP)targets on titanium.Coatings morphology,composition and mechanical properties are characterized and proof-of-concept of biocompatibility is shown.Antimicrobial efficacy is investigated against four Gram positive and Gram negative bacterial strains and against C.albicans fungus,by investigating the modifications in planktonic bacterial growth in the absence and presence of silver.Then,for all bacterial strains,the capability of the film to inhibit bacterial adhesion is also tested.Results indicate that IJD permits a fine control over films composition and morphology and deposition of films with suitable mechanical properties.Biological studies show a good efficacy against Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Enterococcus faecalis and against fungus Candida albicans,with evidences of efficacy against planktonic growth and significant reduction of bacterial cell adhesion.No cytotoxic effects are evidenced for equine adipose tissue derived mesenchymal stem cells(ADMSCs),as no reductions are caused to cells viability and no interference is assessed in cells differentiation towards osteogenic lineage,in the presence of silver.Instead,thanks to nanostructuration and biomimetic composition,tricalcium phosphate(TCP)coatings favor cells viability,also when silver-substituted.These findings show that silver-substituted nanostructured coatings are promising for orthopedic implant applications. | Gabriela Graziani Katia Barbaro Inna V.Fadeeva Daniele Ghezzi Marco Fosca Enrico Sassoni Gianluca Vadalà Martina Cappelletti Francesco Valle Nicola Baldini Julietta V.Rau | 2021 | Bioactive Materials2021，6，8： | 2 |
| 4 | Anti-tumor necrosis factor α therapy associates to type 17 helper T lymphocytes immunological shift and significant microbial changes in dextran sodium sulphate colitis显示文摘BACKGROUND Anti-tumor necrosis factor α(TNFα) represents the best therapeutic option to induce mucosal healing and clinical remission in patients with moderate-severe ulcerative colitis. On the other side gut microbiota plays a crucial role in pathogenesis of ulcerative colitis but few information exists on how microbiota changes following anti-TNFα therapy and on microbiota role in mucosal healing.AIM To elucidate whether gut microbiota and immune system changes appear following anti TNFα therapy during dextran sulfate sodium(DSS) colitis.METHODS Eighty C57 BL/6 mice were divided into four groups: 'No DSS', 'No DSS + antiTNFα', 'DSS' and 'DSS + anti-TNFα'. 'DSS' and 'DSS + anti-TNFα' were treated for 5 d with 3% DSS. At day 3, mice whithin 'No DSS+anti-TNFα' and'DSS+anti-TNFα' group received 5 mg/kg of an anti-TNFα agent. Forty mice were sacrificed at day 5, forty at day 12, after one week of recovery post DSS. The severity of colitis was assessed by a clinical score(Disease Activity Index), colon length and histology. Bacteria such as Bacteroides, Clostridiaceae, Enterococcaceae and Fecalibacterium prausnitzii(F. prausnitzii) were evaluated by quantitative PCR.Type 1 helper T lymphocytes(Th1), type 17 helper T lymphocytes(Th17) and CD4+ regulatory T lymphocytes(Treg) distributions in the mesenteric lymph node(MLN) were studied by flow cytometry.RESULTS Bacteria associated with a healthy state(i.e., such as Bacteroides, Clostridiaceae and F. prausnitzii) decreased during colitis and increased in course of anti-TNFαtreatment. Conversely, microorganisms belonging to Enterococcaceae genera,which are linked to inflammatory processes, showed an opposite trend.Furthermore, in colitic mice treated with anti-TNFα microbial changes were associated with an initial increase(day 5 of the colitis) in Treg cells and a consequent decrease(day 12 post DSS) in Th1 and Th17 frequency cells. Healthy mice treated with anti-TNFα showed the same histological, microbial and immune features of untreated colitic mice. 'No DSS + anti-TNFα' group showed a lymphomononuclear infiltrate both at 5 th and 12 th d at hematoxylin and eosin staining, an increase of in Th1 and Th17 frequency at day 12, an increase of Enterococcaceae at day 5, a decrease of Bacteroides and Clostridiaceae at day 12.CONCLUSION Anti-TNFα treatment in experimental model of colitis improves disease activity but it is associated to an increase in Th17 pathway together with gut microbiota alteration. | Valentina Petito Cristina Graziani Loris R Lopetuso Marco Fossati Alessandra Battaglia Vincenzo Arena Domenico Scannone Gianluca Quaranta Andrea Quagliariello Federica Del Chierico Lorenza Putignani Luca Masucci Maurizio Sanguinetti Alessandro Sgambato Antonio Gasbarrini Franco Scaldaferri | 2019 | World Journal of Gastroenterology2019，25，12： | 2 |
| 5 | Antioxidant capacities, carotenoids and polyphenols evaluation of fresh and refrigerated peach and nectarine cultivars from Italy显示文摘 | Claudio Vaio Giulia Graziani Luigi Marra Annunziata Cascone Alberto Ritieni | 2008 | European Food Research and Technology2008，，4： | 2 |
| 6 | MeTableolic profile of the bioactive compounds of burdock(Arctium lappa)seeds,roots and leaves显示文摘 | Rosalia Ferracane Giulia Graziani Monica Gallo | 2010 | Journal of Pharmaceutical and Biomedical Analysis2010，51，： | 1 |
| 7 | Vascular involvement in diabetic subjects with ischemic foot ulcer: a new morphologic categorization of disease severity 显示文摘 | Graziani L Silvestro A Bertone V | 2007 | Eur J Vasc Endovasc Surg2007，33，10： | 1 |
| 8 | Percutaneous transluminal angioplasty is feasible and effective in patients on chronic dialysis with severe peripheral artery disease显示文摘 | Graziani L Silvestro A Bertone V | 2007 | Nephrol Dial Transplant2007，22，4： | 1 |
| 9 | Potential clinical applications of poly ( ADP - ribose) polymerase (PARP) inhibitors 显示文摘 | TENTORI L PORTARENA I GRAZIANI G | 2002 | Pharmacol Res2002，45，2： | 1 |
| 10 | Autoimmune pancreatitis:CT patterns and their changes after steroid treatment显示文摘 | Manfredi R Graziani R Cicero C | | 0，，： | 1 |
| 11 | Ultrasonic distance sensorimprovement using a two-level neural network显示文摘 | A. Carullo F. Ferraris S. Graziani | | 0，，02： | 1 |
| 12 | Slructural Response of Grid-Reinforced Bituminous Pavement显示文摘 | Andrea Graziani Emiliano Pasquini Gilda Ferrolti | 2014 | Materials and Struclures2014，47，8： | 1 |
| 13 | Vascular Involvement in diabetic subjects with ischemic foot ulcer:a new morphologic categorization of disease severity显示文摘 | Graziani L Silvestro A Beaone V | 2007 | Eur J Vase Endovasc Surg2007，33，： | 1 |
| 14 | Clinical perspectives of PARP inhibitors显示文摘 | Graziani G Szabo C | 2005 | Pharmacol Res2005，52，1： | 1 |
| 15 | trans-resveratrol induces apoptosis in human breast cancer cells MCF-7by the activation of MAP kinases pathways显示文摘 | Filomeni G Graziani I Rotillio G | 2007 | Genes Nutr2007，2，3： | 1 |
| 16 | Regulation of cyclic amplevel and synthesis of DNA RNA and protein by quercetin in ehrlich ascites tumor cells 显示文摘 | Graziani Y Chayoth R | 1979 | Biochem Pharmacology1979，28，3： | 1 |
| 17 | Sudden death in diabetic Subjects:evidence for a peculiar circadian variation in occurance显示文摘 | Gallerani M Manfredini R Graziani R | 1994 | Panminerva Med1994，36，3： | 1 |
| 18 | Syndrome ofinappropriate secretion of antidiuretic hormone in traumatic brain injury : when tolvaptan becomes a life saving drug 显示文摘 | Graziani G Cucchiari D Aroldi A | 2012 | J Neurol Neurosurg Psychiatry2012，83，： | 1 |
| 19 | Technical and economic design of photovoltaic and battery energy storage system显示文摘 | Bortolini Marco Gamberi Mauro Graziani Alessandro | 2014 | Energy Conversion and Management2014，86，： | 1 |
| 20 | Adding noise to improve measuremeni 显示文摘 | Ando B Graziani S | 2001 | IEEE Instrumentation and Measurement Magazine2001，4，1： | 1 |
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